JP2010520851A5 - - Google Patents
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- Publication number
- JP2010520851A5 JP2010520851A5 JP2009528597A JP2009528597A JP2010520851A5 JP 2010520851 A5 JP2010520851 A5 JP 2010520851A5 JP 2009528597 A JP2009528597 A JP 2009528597A JP 2009528597 A JP2009528597 A JP 2009528597A JP 2010520851 A5 JP2010520851 A5 JP 2010520851A5
- Authority
- JP
- Japan
- Prior art keywords
- preferred
- formula
- acyl
- alkyl
- ring members
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000002252 acyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000004429 atoms Chemical group 0.000 description 1
- 125000004432 carbon atoms Chemical group C* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 description 1
- 125000004430 oxygen atoms Chemical group O* 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 125000004434 sulfur atoms Chemical group 0.000 description 1
Description
本発明の好ましい実施態様では、Ａおよび／またはＢは５および／または６個の環原子であるように選択され、ＡおよびＢで表される環員はＣ、Ｏ、Ｓおよび／またはＮ原子からなる群から選択される。当然、４、５、または６員環が形成され、環員が‐ＣＨ２‐、‐Ｏ‐、‐Ｓ‐および
（ＲがＨ、アルキルまたはアシル）から構成されるような架橋環Ａ、Ｂを選択することも好ましい。
本発明の別の好ましい実施態様では、化合物は一般式２を有する：
Ｚ１、Ｚ２は式１で示したものと同じであり、その立体配置は式２に示され；
Ｒ１、Ｒ２がアルキル、アシル、ヘタリールおよび／またはスルホニルであり、
Ｘが‐ＣＨ２‐、‐Ｏ‐、‐Ｓ‐および／または
である。
Ｒ１、Ｒ２がアルキル、アシル、ヘタリールおよび／またはスルホニルであり、
Ｘが‐ＣＨ２‐、‐Ｏ‐、‐Ｓ‐および／または
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090178 | 2006-09-25 | ||
| EP06090178.2 | 2006-09-25 | ||
| EP06090179 | 2006-09-25 | ||
| EP06090179.0 | 2006-09-25 | ||
| DE102006057070.7 | 2006-11-29 | ||
| DE102006057070 | 2006-11-29 | ||
| EP07090095.6 | 2007-05-07 | ||
| EP07090095 | 2007-05-07 | ||
| PCT/DE2007/001768 WO2008040332A1 (de) | 2006-09-25 | 2007-09-25 | Strukturmimetika prolinreicher peptide und ihre pharmazeutische verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010520851A JP2010520851A (ja) | 2010-06-17 |
| JP2010520851A5 true JP2010520851A5 (ja) | 2011-09-01 |
| JP5588172B2 JP5588172B2 (ja) | 2014-09-10 |
Family
ID=38962788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009528597A Active JP5588172B2 (ja) | 2006-09-25 | 2007-09-25 | プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8242105B2 (ja) |
| EP (1) | EP2094711B8 (ja) |
| JP (1) | JP5588172B2 (ja) |
| WO (1) | WO2008040332A1 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8518933B2 (en) | 2009-04-23 | 2013-08-27 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
| US8546377B2 (en) | 2009-04-23 | 2013-10-01 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
| DE102009032902A1 (de) | 2009-07-10 | 2011-01-13 | Forschungsverbund Berlin E.V. | Induktion von α-Helix-Konformationen in Proteinen und Peptiden |
| US8362311B2 (en) | 2009-09-30 | 2013-01-29 | Massachusetts Institute Of Technology | Highly Z-selective olefins metathesis |
| EP2561873A1 (de) * | 2011-08-26 | 2013-02-27 | Forschungsverbund Berlin e.V. | Strukturmimetika prolinreicher Peptide und ihre Verwendung |
| WO2014147484A2 (en) | 2013-03-21 | 2014-09-25 | Caprion Proteomics Inc. | Brucellosis, q-fever, and lyme disease biomarkers and uses thereof |
| CA2913418C (en) | 2013-05-29 | 2021-11-23 | Vybion, Inc. | Single chain intrabodies that alter huntingtin mutant degradation |
| WO2016092069A1 (de) | 2014-12-11 | 2016-06-16 | Forschungsverbund Berlin E.V. | Inhibitoren zur hemmung der tumormetastasierung |
| KR101729236B1 (ko) * | 2015-06-01 | 2017-04-21 | (주)노터스생명과학 | Tlr7 항진제를 포함하는 비만 또는 간질환 예방 및 치료용 약학 조성물 |
| WO2017170924A1 (ja) * | 2016-03-31 | 2017-10-05 | 千寿製薬株式会社 | 神経保護ペプチド |
| EP3759108B1 (de) | 2018-02-26 | 2023-08-30 | Forschungsverbund Berlin E.V. | Polyprolin-mimetika des prolin-abgeleiteten moduls-15 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3860600A (en) * | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
| DD277681A1 (de) * | 1988-12-05 | 1990-04-11 | Akad Wissenschaften Ddr | Verfahren zur herstellung von (5h-2,3-dihydro-5-oxo-thiazolo-[2,3-b]chinazolinyl)-alkanoylaminosaeuren und deren estern |
| ATE233764T1 (de) * | 1997-09-29 | 2003-03-15 | Meiji Seika Kaisha | Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel |
| US6235877B1 (en) | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
| ITMI20050328A1 (it) | 2005-03-03 | 2006-09-04 | Univ Degli Studi Milano | Composti peptidomimetrici e preparazione di derivati biologicamente attivi |
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2007
- 2007-09-25 JP JP2009528597A patent/JP5588172B2/ja active Active
- 2007-09-25 WO PCT/DE2007/001768 patent/WO2008040332A1/de active Application Filing
- 2007-09-25 EP EP07817610.4A patent/EP2094711B8/de active Active
- 2007-09-25 US US12/442,681 patent/US8242105B2/en active Active