JP2016501520A5 - - Google Patents
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- Publication number
- JP2016501520A5 JP2016501520A5 JP2015543449A JP2015543449A JP2016501520A5 JP 2016501520 A5 JP2016501520 A5 JP 2016501520A5 JP 2015543449 A JP2015543449 A JP 2015543449A JP 2015543449 A JP2015543449 A JP 2015543449A JP 2016501520 A5 JP2016501520 A5 JP 2016501520A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkynyl
- alkenyl
- alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 1
- -1 bicyclic nucleoside Chemical class 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 125000002743 phosphorus functional group Chemical group 0.000 description 1
Description
いくつかの実施態様において、二環式ヌクレオシドは、式ＩＩＩ：
（式中、
Ｂｘはヘテロ環塩基部分であり；
Ｔａ及びＴｂは、各々独立して、Ｈ、ヒドロキシル保護基、コンジュゲート基、反応性リン基、リン部分、又は支持媒体への共有結合的付着であり；
Ｚ ｂ は、Ｃ１−Ｃ６アルキル、Ｃ２−Ｃ６アルケニル、Ｃ２−Ｃ６アルキニル、置換Ｃ１−Ｃ６アルキル、置換Ｃ２−Ｃ６アルケニル、置換Ｃ２−Ｃ６アルキニル、又は置換アシル（Ｃ（＝Ｏ）−）である）
を有する。
（式中、
Ｂｘはヘテロ環塩基部分であり；
Ｔａ及びＴｂは、各々独立して、Ｈ、ヒドロキシル保護基、コンジュゲート基、反応性リン基、リン部分、又は支持媒体への共有結合的付着であり；
Ｚ ｂ は、Ｃ１−Ｃ６アルキル、Ｃ２−Ｃ６アルケニル、Ｃ２−Ｃ６アルキニル、置換Ｃ１−Ｃ６アルキル、置換Ｃ２−Ｃ６アルケニル、置換Ｃ２−Ｃ６アルキニル、又は置換アシル（Ｃ（＝Ｏ）−）である）
を有する。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729922P | 2012-11-26 | 2012-11-26 | |
| US61/729,922 | 2012-11-26 | ||
| PCT/EP2013/074552 WO2014080004A1 (en) | 2012-11-26 | 2013-11-25 | Compositions and methods for modulation of fgfr3 expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016501520A JP2016501520A (ja) | 2016-01-21 |
| JP2016501520A5 true JP2016501520A5 (ja) | 2016-12-01 |
| JP6463687B2 JP6463687B2 (ja) | 2019-02-06 |
Family
ID=49639882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015543449A Expired - Fee Related JP6463687B2 (ja) | 2012-11-26 | 2013-11-25 | Ｆｇｆｒ３の発現の調節のための組成物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9725723B2 (ja) |
| EP (1) | EP2922955B1 (ja) |
| JP (1) | JP6463687B2 (ja) |
| KR (1) | KR20150088305A (ja) |
| CN (1) | CN104903448B (ja) |
| BR (1) | BR112015012051A2 (ja) |
| CA (1) | CA2889993A1 (ja) |
| DK (1) | DK2922955T3 (ja) |
| HK (1) | HK1208702A1 (ja) |
| MX (1) | MX2015006289A (ja) |
| RU (1) | RU2015120645A (ja) |
| WO (1) | WO2014080004A1 (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2744987C (en) | 2008-12-02 | 2018-01-16 | Chiralgen, Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
| BR112012000828A8 (pt) | 2009-07-06 | 2017-10-10 | Ontorii Inc | Novas pró-drogas de ácido nucleico e métodos de uso das mesmas |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| RU2014105311A (ru) | 2011-07-19 | 2015-08-27 | Уэйв Лайф Сайенсес Пте. Лтд. | Способы синтеза функционализованных нуклеиновых кислот |
| JP6268157B2 (ja) | 2012-07-13 | 2018-01-24 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | 不斉補助基 |
| SG10201912895PA (en) | 2012-07-13 | 2020-02-27 | Wave Life Sciences Ltd | Chiral control |
| WO2014080004A1 (en) | 2012-11-26 | 2014-05-30 | Santaris Pharma A/S | Compositions and methods for modulation of fgfr3 expression |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| KR102423317B1 (ko) | 2014-01-16 | 2022-07-22 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| KR20240014585A (ko) | 2016-03-04 | 2024-02-01 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양 치료용 제제 및 조성물 |
| US11833151B2 (en) | 2018-03-19 | 2023-12-05 | Taiho Pharmaceutical Co., Ltd. | Pharmaceutical composition including sodium alkyl sulfate |
| TW202140025A (zh) * | 2020-01-31 | 2021-11-01 | 國立大學法人京都大學 | 軟骨發育異常症之治療 |
| WO2022211095A1 (ja) * | 2021-03-31 | 2022-10-06 | ルクサナバイオテク株式会社 | Ｆｇｆｒ３のアンチセンスオリゴヌクレオチド |
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| JPH08504559A (ja) | 1992-12-14 | 1996-05-14 | ハネウエル・インコーポレーテッド | 個別に制御される冗長巻線を有するモータシステム |
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| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
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| US20030087854A1 (en) * | 2001-09-10 | 2003-05-08 | Isis Pharmaceuticals Inc. | Antisense modulation of fibroblast growth factor receptor 3 expression |
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| EP1569661B1 (en) | 2002-11-18 | 2009-09-09 | Santaris Pharma A/S | Antisense design |
| WO2004106356A1 (en) | 2003-05-27 | 2004-12-09 | Syddansk Universitet | Functionalized nucleotide derivatives |
| DK1661905T3 (da) | 2003-08-28 | 2012-07-23 | Takeshi Imanishi | Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype |
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| PL2314594T3 (pl) | 2006-01-27 | 2014-12-31 | Isis Pharmaceuticals Inc | Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych |
| WO2007134014A2 (en) | 2006-05-05 | 2007-11-22 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of gcgr |
| DK2066684T3 (da) | 2006-05-11 | 2012-10-22 | Isis Pharmaceuticals Inc | 5´-Modificerede bicycliske nukleinsyreanaloge |
| BRPI0716823A2 (pt) | 2006-09-15 | 2015-05-26 | Enzon Pharmaceuticals Inc | Conjunto poliméricos contendo porções positivamente carregadas |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
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| DK2149605T3 (da) | 2007-03-22 | 2013-09-30 | Santaris Pharma As | Korte RNA antagonist forbindelser til modulering af det ønskede mRNA |
| ES2388590T3 (es) | 2007-05-30 | 2012-10-16 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido. |
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| WO2014080004A1 (en) | 2012-11-26 | 2014-05-30 | Santaris Pharma A/S | Compositions and methods for modulation of fgfr3 expression |
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-
2013
- 2013-11-25 WO PCT/EP2013/074552 patent/WO2014080004A1/en active Application Filing
- 2013-11-25 DK DK13795243.8T patent/DK2922955T3/da active
- 2013-11-25 KR KR1020157016841A patent/KR20150088305A/ko not_active Application Discontinuation
- 2013-11-25 US US14/647,430 patent/US9725723B2/en active Active
- 2013-11-25 CN CN201380061132.9A patent/CN104903448B/zh not_active Expired - Fee Related
- 2013-11-25 CA CA2889993A patent/CA2889993A1/en not_active Abandoned
- 2013-11-25 EP EP13795243.8A patent/EP2922955B1/en not_active Not-in-force
- 2013-11-25 BR BR112015012051A patent/BR112015012051A2/pt active Search and Examination
- 2013-11-25 RU RU2015120645A patent/RU2015120645A/ru not_active Application Discontinuation
- 2013-11-25 MX MX2015006289A patent/MX2015006289A/es unknown
- 2013-11-25 JP JP2015543449A patent/JP6463687B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-21 HK HK15109264.3A patent/HK1208702A1/xx not_active IP Right Cessation