JP2015512883A5 - - Google Patents
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- Publication number
- JP2015512883A5 JP2015512883A5 JP2014560060A JP2014560060A JP2015512883A5 JP 2015512883 A5 JP2015512883 A5 JP 2015512883A5 JP 2014560060 A JP2014560060 A JP 2014560060A JP 2014560060 A JP2014560060 A JP 2014560060A JP 2015512883 A5 JP2015512883 A5 JP 2015512883A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- alkyl
- pharmaceutically acceptable
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atoms Chemical group C* 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Claims (1)
- R2は−C(=O)OR13であり、R13は炭素数2〜6のアルキル基、炭素数1〜6のヘテロアルキル基、炭素数1〜6のアルキル−アリール基、アリール基、またはヘテロアリール基であり;
R13は炭素数2〜6のアルキル基または炭素数1〜6のヘテロアルキル基であり;
R4はフェニル基であり、ここでR4は少なくとも2つのR11で置換されており;
各R11は独立してハロゲン、−SO2R14、−NR10SO2R10、または−SO2N(R10)2である、請求項10記載の化合物、または、その薬剤的に許容できる塩もしくは薬剤的に許容できる溶媒和物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261606160P | 2012-03-02 | 2012-03-02 | |
US61/606,160 | 2012-03-02 | ||
PCT/US2013/028438 WO2013130892A1 (en) | 2012-03-02 | 2013-02-28 | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018145589A Division JP6800922B2 (ja) | 2012-03-02 | 2018-08-02 | 皮膚の疾患、障害、および異常の治療のための肝臓x受容体(lxr)調節因子 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2015512883A JP2015512883A (ja) | 2015-04-30 |
JP2015512883A5 true JP2015512883A5 (ja) | 2016-04-28 |
JP6378630B2 JP6378630B2 (ja) | 2018-08-22 |
Family
ID=49083313
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014560060A Expired - Fee Related JP6378630B2 (ja) | 2012-03-02 | 2013-02-28 | 皮膚の疾患、障害、および異常の治療のための肝臓x受容体(lxr)調節因子 |
JP2018145589A Active JP6800922B2 (ja) | 2012-03-02 | 2018-08-02 | 皮膚の疾患、障害、および異常の治療のための肝臓x受容体(lxr)調節因子 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018145589A Active JP6800922B2 (ja) | 2012-03-02 | 2018-08-02 | 皮膚の疾患、障害、および異常の治療のための肝臓x受容体(lxr)調節因子 |
Country Status (25)
Country | Link |
---|---|
US (5) | US8987318B2 (ja) |
EP (2) | EP3441390A1 (ja) |
JP (2) | JP6378630B2 (ja) |
KR (1) | KR102112879B1 (ja) |
CN (1) | CN104284893B (ja) |
AU (1) | AU2013225840B2 (ja) |
BR (1) | BR112014021515A2 (ja) |
CA (1) | CA2866113C (ja) |
CY (1) | CY1120742T1 (ja) |
DK (1) | DK2820013T3 (ja) |
ES (1) | ES2691079T3 (ja) |
HK (1) | HK1206030A1 (ja) |
HR (1) | HRP20181623T1 (ja) |
HU (1) | HUE040231T2 (ja) |
IL (1) | IL234413B (ja) |
LT (1) | LT2820013T (ja) |
MX (1) | MX361349B (ja) |
NZ (1) | NZ629636A (ja) |
PL (1) | PL2820013T3 (ja) |
PT (1) | PT2820013T (ja) |
RS (1) | RS57863B9 (ja) |
SG (2) | SG10201607345YA (ja) |
SI (1) | SI2820013T1 (ja) |
TR (1) | TR201815013T4 (ja) |
WO (1) | WO2013130892A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2866113C (en) | 2012-03-02 | 2020-05-12 | Alexar Therapeutics, Inc. | Pyrazolyl derivatives as liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
WO2014152738A1 (en) * | 2013-03-15 | 2014-09-25 | Bristol-Myers Squibb Company | Lxr modulators |
CN104151300B (zh) * | 2013-05-15 | 2018-07-13 | 中国医学科学院医药生物技术研究所 | 一组2,3-二取代的苯并喹唑啉类的肝x受体的激动剂及用途 |
BR112016004904B1 (pt) | 2013-09-04 | 2023-01-24 | Ellora Therapeutics, Inc. | Compostos moduladores de receptor x do fígado (lxr), seu uso e composição farmaceutica compreendendo os mesmos |
US9981913B2 (en) | 2013-09-04 | 2018-05-29 | Ralexar Therapeutics, Inc. | Liver X receptor (LXR) modulators |
AU2015204572B2 (en) | 2014-01-10 | 2020-07-30 | Inspirna, Inc. | LXR agonists and uses thereof |
WO2017115319A2 (en) | 2015-12-30 | 2017-07-06 | Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet) | Use of brassinosteroid analogs for the treatment of dermal disorders by selectively modulating liver x receptors (lxr) and dermal disease treatment by brassinosteroid analogs acting as selective liver x receptor (lxr) modulators |
JP7025022B2 (ja) | 2016-01-11 | 2022-02-24 | ザ ロックフェラー ユニバーシティー | 骨髄系由来抑制細胞関連障害の治療のための方法 |
US11214536B2 (en) | 2017-11-21 | 2022-01-04 | Inspirna, Inc. | Polymorphs and uses thereof |
CN114126618A (zh) | 2019-07-15 | 2022-03-01 | 诺华股份有限公司 | 用肝脏x受体激动剂治疗睑板腺功能障碍的方法 |
WO2021119397A1 (en) | 2019-12-13 | 2021-06-17 | Rgenix, Inc. | Metal salts and uses thereof |
WO2022249006A1 (en) * | 2021-05-24 | 2022-12-01 | Novartis Ag | Use of 1,2,4-oxadiazole derivatives as liver x receptor agonists |
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DE60107449T2 (de) | 2000-09-18 | 2005-12-08 | Glaxo Group Ltd., Greenford | Substituierte aminopropoxyarylderivate als lxr agonisten |
AUPR738301A0 (en) | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
WO2003099769A1 (en) | 2002-05-24 | 2003-12-04 | Pharmacia Corporation | Anilino liver x-receptor modulators |
BR0311282A (pt) | 2002-05-24 | 2005-04-19 | Pharmacia Corp | Moduladores sulfona de receptor-x do fìgado |
US7265131B2 (en) | 2002-12-20 | 2007-09-04 | Exelixis, Inc. | Isoquinolinone derivatives and their use as therapeutic agents |
JP2006193426A (ja) | 2003-09-05 | 2006-07-27 | Sankyo Co Ltd | 置換された縮環ピリミジン−4(3h)−オン化合物 |
WO2005113499A1 (ja) | 2004-05-20 | 2005-12-01 | Sankyo Company, Limited | インドール化合物 |
TW200606133A (en) | 2004-06-30 | 2006-02-16 | Sankyo Co | Substituted benzene compounds |
EP1773781A2 (en) | 2004-08-03 | 2007-04-18 | Wyeth | Indazoles useful in treating cardiovascular diseases |
US20070060589A1 (en) * | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
WO2006109633A1 (ja) | 2005-04-07 | 2006-10-19 | Daiichi Sankyo Company, Limited | 置換インドール化合物 |
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CN101309915A (zh) | 2005-11-14 | 2008-11-19 | Irm责任有限公司 | 作为lxr调节剂的化合物和组合物 |
EP1849781A1 (en) | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments |
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JPWO2012020820A1 (ja) * | 2010-08-11 | 2013-10-28 | 大正製薬株式会社 | ヘテロアリール−ピラゾール誘導体 |
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AR088728A1 (es) | 2011-03-25 | 2014-07-02 | Bristol Myers Squibb Co | Moduladores de lxr como prodroga de imidazol |
CA2866113C (en) | 2012-03-02 | 2020-05-12 | Alexar Therapeutics, Inc. | Pyrazolyl derivatives as liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
EP2882496B1 (en) | 2012-08-13 | 2019-10-09 | The Rockefeller University | Treatment and diagnosis of melanoma |
US9981913B2 (en) | 2013-09-04 | 2018-05-29 | Ralexar Therapeutics, Inc. | Liver X receptor (LXR) modulators |
BR112016004904B1 (pt) | 2013-09-04 | 2023-01-24 | Ellora Therapeutics, Inc. | Compostos moduladores de receptor x do fígado (lxr), seu uso e composição farmaceutica compreendendo os mesmos |
-
2013
- 2013-02-28 CA CA2866113A patent/CA2866113C/en not_active Expired - Fee Related
- 2013-02-28 EP EP18182346.9A patent/EP3441390A1/en not_active Withdrawn
- 2013-02-28 LT LTEP13754329.4T patent/LT2820013T/lt unknown
- 2013-02-28 PT PT13754329T patent/PT2820013T/pt unknown
- 2013-02-28 ES ES13754329.4T patent/ES2691079T3/es active Active
- 2013-02-28 AU AU2013225840A patent/AU2013225840B2/en not_active Ceased
- 2013-02-28 WO PCT/US2013/028438 patent/WO2013130892A1/en active Application Filing
- 2013-02-28 CN CN201380018482.7A patent/CN104284893B/zh not_active Expired - Fee Related
- 2013-02-28 NZ NZ629636A patent/NZ629636A/en not_active IP Right Cessation
- 2013-02-28 BR BR112014021515-4A patent/BR112014021515A2/pt active Search and Examination
- 2013-02-28 SG SG10201607345YA patent/SG10201607345YA/en unknown
- 2013-02-28 HU HUE13754329A patent/HUE040231T2/hu unknown
- 2013-02-28 MX MX2014010537A patent/MX361349B/es active IP Right Grant
- 2013-02-28 JP JP2014560060A patent/JP6378630B2/ja not_active Expired - Fee Related
- 2013-02-28 KR KR1020147027825A patent/KR102112879B1/ko active IP Right Grant
- 2013-02-28 PL PL13754329T patent/PL2820013T3/pl unknown
- 2013-02-28 EP EP13754329.4A patent/EP2820013B9/en active Active
- 2013-02-28 TR TR2018/15013T patent/TR201815013T4/tr unknown
- 2013-02-28 SI SI201331198T patent/SI2820013T1/sl unknown
- 2013-02-28 DK DK13754329.4T patent/DK2820013T3/en active
- 2013-02-28 RS RS20181179 patent/RS57863B9/sr unknown
- 2013-02-28 SG SG11201405378VA patent/SG11201405378VA/en unknown
-
2014
- 2014-09-01 IL IL234413A patent/IL234413B/en active IP Right Grant
- 2014-09-02 US US14/474,490 patent/US8987318B2/en not_active Expired - Fee Related
-
2015
- 2015-02-12 US US14/621,255 patent/US9637481B2/en active Active
- 2015-07-14 HK HK15106713.6A patent/HK1206030A1/xx not_active IP Right Cessation
-
2017
- 2017-04-03 US US15/477,140 patent/US20170334897A1/en not_active Abandoned
-
2018
- 2018-04-18 US US15/956,389 patent/US20180370959A1/en not_active Abandoned
- 2018-08-02 JP JP2018145589A patent/JP6800922B2/ja active Active
- 2018-10-08 CY CY181101037T patent/CY1120742T1/el unknown
- 2018-10-09 HR HRP20181623TT patent/HRP20181623T1/hr unknown
-
2020
- 2020-05-13 US US15/931,403 patent/US20210101895A1/en not_active Abandoned
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