JP2015512883A5 - - Google Patents
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- Publication number
- JP2015512883A5 JP2015512883A5 JP2014560060A JP2014560060A JP2015512883A5 JP 2015512883 A5 JP2015512883 A5 JP 2015512883A5 JP 2014560060 A JP2014560060 A JP 2014560060A JP 2014560060 A JP2014560060 A JP 2014560060A JP 2015512883 A5 JP2015512883 A5 JP 2015512883A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- alkyl
- pharmaceutically acceptable
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261606160P | 2012-03-02 | 2012-03-02 | |
| US61/606,160 | 2012-03-02 | ||
| PCT/US2013/028438 WO2013130892A1 (en) | 2012-03-02 | 2013-02-28 | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018145589A Division JP6800922B2 (ja) | 2012-03-02 | 2018-08-02 | 皮膚の疾患、障害、および異常の治療のための肝臓ｘ受容体（ｌｘｒ）調節因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512883A JP2015512883A (ja) | 2015-04-30 |
| JP2015512883A5 true JP2015512883A5 (enExample) | 2016-04-28 |
| JP6378630B2 JP6378630B2 (ja) | 2018-08-22 |
Family
ID=49083313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560060A Expired - Fee Related JP6378630B2 (ja) | 2012-03-02 | 2013-02-28 | 皮膚の疾患、障害、および異常の治療のための肝臓ｘ受容体（ｌｘｒ）調節因子 |
| JP2018145589A Expired - Fee Related JP6800922B2 (ja) | 2012-03-02 | 2018-08-02 | 皮膚の疾患、障害、および異常の治療のための肝臓ｘ受容体（ｌｘｒ）調節因子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018145589A Expired - Fee Related JP6800922B2 (ja) | 2012-03-02 | 2018-08-02 | 皮膚の疾患、障害、および異常の治療のための肝臓ｘ受容体（ｌｘｒ）調節因子 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US8987318B2 (enExample) |
| EP (2) | EP3441390A1 (enExample) |
| JP (2) | JP6378630B2 (enExample) |
| KR (1) | KR102112879B1 (enExample) |
| CN (1) | CN104284893B (enExample) |
| AU (1) | AU2013225840B2 (enExample) |
| BR (1) | BR112014021515A2 (enExample) |
| CA (1) | CA2866113C (enExample) |
| CY (1) | CY1120742T1 (enExample) |
| DK (1) | DK2820013T3 (enExample) |
| ES (1) | ES2691079T3 (enExample) |
| HR (1) | HRP20181623T1 (enExample) |
| HU (1) | HUE040231T2 (enExample) |
| IL (1) | IL234413B (enExample) |
| LT (1) | LT2820013T (enExample) |
| MX (1) | MX361349B (enExample) |
| NZ (1) | NZ629636A (enExample) |
| PL (1) | PL2820013T3 (enExample) |
| PT (1) | PT2820013T (enExample) |
| RS (1) | RS57863B9 (enExample) |
| SG (2) | SG11201405378VA (enExample) |
| SI (1) | SI2820013T1 (enExample) |
| SM (1) | SMT201800630T1 (enExample) |
| TR (1) | TR201815013T4 (enExample) |
| WO (1) | WO2013130892A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3441390A1 (en) | 2012-03-02 | 2019-02-13 | Ralexar Therapeutics, Inc. | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
| US9751869B2 (en) * | 2013-03-15 | 2017-09-05 | Bristol-Myers Squibb Company | LXR modulators |
| CN104151300B (zh) * | 2013-05-15 | 2018-07-13 | 中国医学科学院医药生物技术研究所 | 一组2,3-二取代的苯并喹唑啉类的肝x受体的激动剂及用途 |
| SG11201601644RA (en) * | 2013-09-04 | 2016-04-28 | Alexar Therapeutics Inc | Liver x receptor (lxr) modulators |
| AU2014315280B2 (en) | 2013-09-04 | 2019-01-24 | Ellora Therapeutics, Inc. | Liver X receptor (LXR) modulators |
| EP3091970B1 (en) | 2014-01-10 | 2020-10-28 | Rgenix, Inc. | Lxr agonists and uses thereof |
| US20190365784A1 (en) | 2015-12-30 | 2019-12-05 | Raúl Enrique MASSONE | Use of brassinosteroid analogs for the treatment of dermal disorders by selectively modulating liver x receptors (lxr) and dermal disease treatment by brassinosteroid analogs acting as selective liver x receptor (lxr) modulators |
| US11648220B2 (en) | 2016-01-11 | 2023-05-16 | The Rockefeller University | Methods for the treatment of myeloid derived suppressor cells related disorders |
| AU2018373028A1 (en) | 2017-11-21 | 2020-04-30 | Inspirna, Inc. | Polymorphs and uses thereof |
| CN114126618A (zh) | 2019-07-15 | 2022-03-01 | 诺华股份有限公司 | 用肝脏x受体激动剂治疗睑板腺功能障碍的方法 |
| EP4073025B1 (en) | 2019-12-13 | 2024-03-27 | Inspirna, Inc. | Metal salts and uses thereof |
| WO2022249006A1 (en) * | 2021-05-24 | 2022-12-01 | Novartis Ag | Use of 1,2,4-oxadiazole derivatives as liver x receptor agonists |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1199771A (en) * | 1915-07-01 | 1916-10-03 | Bates Valve Bag Co | Wire-twisting machine. |
| US20040072868A1 (en) | 2000-09-18 | 2004-04-15 | Collins Jon Loren | Substitued aminopropoxyaryl derivatives useful as agonists for lxr |
| AUPR738301A0 (en) | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| CA2486651A1 (en) | 2002-05-24 | 2003-12-04 | Pharmacia Corporation | Sulfone liver x-receptor modulators |
| US6900244B2 (en) | 2002-05-24 | 2005-05-31 | Pharmacia Corporation | Anilino liver X-receptor modulators |
| EP1572660B1 (en) | 2002-12-20 | 2011-01-26 | X-Ceptor Therapeutics, Inc. | Isoquinolinone derivatives and their use as therapeutic agents |
| JP2006193426A (ja) | 2003-09-05 | 2006-07-27 | Sankyo Co Ltd | 置換された縮環ピリミジン−４（３ｈ）−オン化合物 |
| WO2005113499A1 (ja) | 2004-05-20 | 2005-12-01 | Sankyo Company, Limited | インドール化合物 |
| TW200606133A (en) | 2004-06-30 | 2006-02-16 | Sankyo Co | Substituted benzene compounds |
| AU2005271737A1 (en) | 2004-08-03 | 2006-02-16 | Wyeth | Indazoles useful in treating cardiovascular diseases |
| US20070060589A1 (en) * | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
| WO2006109633A1 (ja) | 2005-04-07 | 2006-10-19 | Daiichi Sankyo Company, Limited | 置換インドール化合物 |
| US7213797B2 (en) | 2005-05-20 | 2007-05-08 | Garland Jerome Gaskins | Deck board straightener |
| CN101248049B (zh) * | 2005-06-27 | 2013-08-28 | 埃克塞利希斯专利有限责任公司 | 咪唑类lxr调节剂 |
| WO2007002563A1 (en) * | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Imidazole based lxr modulators |
| AU2006290442B2 (en) | 2005-09-16 | 2010-07-29 | Arrow Therapeutics Limited | Biphenyl derivatives and their use in treating hepatitis C |
| WO2007034279A2 (en) | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | C3a antagonists and pharmaceutical compositions thereof |
| WO2007092065A2 (en) | 2005-11-14 | 2007-08-16 | Irm Llc | Compounds and compositions as lxr modulators |
| EP1849781A1 (en) | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments |
| TW200825054A (en) | 2006-10-18 | 2008-06-16 | Wyeth Corp | Quinoline compounds |
| WO2008073825A1 (en) | 2006-12-08 | 2008-06-19 | Exelixis, Inc. | Lxr and fxr modulators |
| US8338437B2 (en) * | 2007-02-28 | 2012-12-25 | Methylgene Inc. | Amines as small molecule inhibitors |
| MX2009012474A (es) | 2007-05-18 | 2009-12-18 | Wyeth Corp | Compuestos de quinazolina. |
| US20090069288A1 (en) | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
| CN103772299A (zh) | 2007-08-13 | 2014-05-07 | 霍夫曼-拉罗奇有限公司 | 新型哌嗪酰胺衍生物 |
| BRPI0822237A2 (pt) | 2007-12-21 | 2015-06-30 | Wyeth Llc | Compostos de imidazo [1,2-a] piridina |
| BRPI0821315A2 (pt) | 2007-12-21 | 2019-09-24 | Wyeth Llc | compostos benzimidazol |
| US20120015988A1 (en) * | 2008-05-13 | 2012-01-19 | Boehringer Ingelheim International Gmbh | Sulfone Compounds Which Modulate The CB2 Receptor |
| US8063088B2 (en) | 2008-06-11 | 2011-11-22 | Hoffmann-La Roche Inc. | Imidazolidine derivatives |
| JP2012508250A (ja) | 2008-11-07 | 2012-04-05 | ワイス・エルエルシー | キノキサリン系のｌｘｒモジュレーター |
| EP2367801A1 (en) | 2008-11-19 | 2011-09-28 | Wyeth LLC | Polar quinazolines as liver x receptors ( lxrs ) modulators |
| CA2747744A1 (en) | 2008-12-22 | 2010-07-01 | Theodros Asberom | Gamma secretase modulators |
| US20120058133A1 (en) | 2009-02-19 | 2012-03-08 | President And Fellows Of Harvard College | Inhibition of trna synthetases and therapeutic applications thereof |
| WO2010096777A1 (en) | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| HRP20170194T1 (hr) | 2009-05-28 | 2017-05-19 | Exelixis Patent Company Llc | Lxr modulatori |
| GB0919757D0 (en) | 2009-11-12 | 2009-12-30 | Johnson Matthey Plc | Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs |
| EP2501696B1 (en) | 2009-10-15 | 2016-12-28 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| WO2012019093A1 (en) | 2010-08-05 | 2012-02-09 | Human Biomolecular Research Institute | Synthetic compounds and methods to decrease nicotine self-administration |
| WO2012020820A1 (ja) * | 2010-08-11 | 2012-02-16 | 大正製薬株式会社 | ヘテロアリール－ピラゾール誘導体 |
| CN103180316A (zh) | 2010-08-27 | 2013-06-26 | 钙医学公司 | 调节细胞内钙的化合物 |
| AR088728A1 (es) | 2011-03-25 | 2014-07-02 | Bristol Myers Squibb Co | Moduladores de lxr como prodroga de imidazol |
| EP3441390A1 (en) | 2012-03-02 | 2019-02-13 | Ralexar Therapeutics, Inc. | Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions |
| ES2765573T3 (es) | 2012-08-13 | 2020-06-09 | Univ Rockefeller | Tratamiento y diagnóstico de melanoma |
| AU2014315280B2 (en) | 2013-09-04 | 2019-01-24 | Ellora Therapeutics, Inc. | Liver X receptor (LXR) modulators |
| SG11201601644RA (en) | 2013-09-04 | 2016-04-28 | Alexar Therapeutics Inc | Liver x receptor (lxr) modulators |
-
2013
- 2013-02-28 EP EP18182346.9A patent/EP3441390A1/en not_active Withdrawn
- 2013-02-28 WO PCT/US2013/028438 patent/WO2013130892A1/en not_active Ceased
- 2013-02-28 ES ES13754329.4T patent/ES2691079T3/es active Active
- 2013-02-28 MX MX2014010537A patent/MX361349B/es active IP Right Grant
- 2013-02-28 PT PT13754329T patent/PT2820013T/pt unknown
- 2013-02-28 SG SG11201405378VA patent/SG11201405378VA/en unknown
- 2013-02-28 TR TR2018/15013T patent/TR201815013T4/tr unknown
- 2013-02-28 CN CN201380018482.7A patent/CN104284893B/zh not_active Expired - Fee Related
- 2013-02-28 DK DK13754329.4T patent/DK2820013T3/en active
- 2013-02-28 LT LTEP13754329.4T patent/LT2820013T/lt unknown
- 2013-02-28 SI SI201331198T patent/SI2820013T1/sl unknown
- 2013-02-28 HR HRP20181623TT patent/HRP20181623T1/hr unknown
- 2013-02-28 AU AU2013225840A patent/AU2013225840B2/en not_active Ceased
- 2013-02-28 NZ NZ629636A patent/NZ629636A/en not_active IP Right Cessation
- 2013-02-28 KR KR1020147027825A patent/KR102112879B1/ko not_active Expired - Fee Related
- 2013-02-28 JP JP2014560060A patent/JP6378630B2/ja not_active Expired - Fee Related
- 2013-02-28 PL PL13754329T patent/PL2820013T3/pl unknown
- 2013-02-28 SG SG10201607345YA patent/SG10201607345YA/en unknown
- 2013-02-28 SM SM20180630T patent/SMT201800630T1/it unknown
- 2013-02-28 RS RS20181179 patent/RS57863B9/sr unknown
- 2013-02-28 HU HUE13754329A patent/HUE040231T2/hu unknown
- 2013-02-28 CA CA2866113A patent/CA2866113C/en not_active Expired - Fee Related
- 2013-02-28 EP EP13754329.4A patent/EP2820013B9/en active Active
- 2013-02-28 BR BR112014021515-4A patent/BR112014021515A2/pt active Search and Examination
-
2014
- 2014-09-01 IL IL234413A patent/IL234413B/en active IP Right Grant
- 2014-09-02 US US14/474,490 patent/US8987318B2/en not_active Expired - Fee Related
-
2015
- 2015-02-12 US US14/621,255 patent/US9637481B2/en not_active Expired - Fee Related
-
2017
- 2017-04-03 US US15/477,140 patent/US20170334897A1/en not_active Abandoned
-
2018
- 2018-04-18 US US15/956,389 patent/US20180370959A1/en not_active Abandoned
- 2018-08-02 JP JP2018145589A patent/JP6800922B2/ja not_active Expired - Fee Related
- 2018-10-08 CY CY181101037T patent/CY1120742T1/el unknown
-
2020
- 2020-05-13 US US15/931,403 patent/US20210101895A1/en not_active Abandoned