JP2015530362A5 - - Google Patents
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- Publication number
- JP2015530362A5 JP2015530362A5 JP2015522082A JP2015522082A JP2015530362A5 JP 2015530362 A5 JP2015530362 A5 JP 2015530362A5 JP 2015522082 A JP2015522082 A JP 2015522082A JP 2015522082 A JP2015522082 A JP 2015522082A JP 2015530362 A5 JP2015530362 A5 JP 2015530362A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- formula
- saturated
- substituents
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920006395 saturated elastomer Polymers 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000002837 carbocyclic group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000004122 cyclic group Chemical group 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- -1 tetrahydro-2H-pyran-2-yloxy Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000003821 2-(trimethylsilyl)ethoxymethyl group Chemical group [H]C([H])([H])[Si](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(OC([H])([H])[*])([H])[H] 0.000 claims 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000001567 anti-fibrinolytic effect Effects 0.000 claims 1
- 229940030225 antihemorrhagics Drugs 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- VLAIYVJJCPMDSF-UHFFFAOYSA-N methyl 4-(benzenesulfonyl)-1-oxaspiro[2.4]heptane-4-carboxylate Chemical compound C=1C=CC=CC=1S(=O)(=O)C1(C(=O)OC)CCCC11CO1 VLAIYVJJCPMDSF-UHFFFAOYSA-N 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382285 | 2012-07-18 | ||
| EP12382285.0 | 2012-07-18 | ||
| PCT/EP2013/065071 WO2014012964A1 (en) | 2012-07-18 | 2013-07-17 | New antifibrinolytic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530362A JP2015530362A (ja) | 2015-10-15 |
| JP2015530362A5 true JP2015530362A5 (enExample) | 2016-09-08 |
| JP6203257B2 JP6203257B2 (ja) | 2017-09-27 |
Family
ID=48793275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015522082A Active JP6203257B2 (ja) | 2012-07-18 | 2013-07-17 | 新規の抗繊維素溶解化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9440989B2 (enExample) |
| EP (1) | EP2877446B9 (enExample) |
| JP (1) | JP6203257B2 (enExample) |
| AU (1) | AU2013292076B2 (enExample) |
| CA (1) | CA2917604C (enExample) |
| ES (1) | ES2603740T3 (enExample) |
| WO (1) | WO2014012964A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201216127D0 (en) * | 2012-09-11 | 2012-10-24 | Jaguar Cars | A method for determining the change in a vehicle battery |
| EP3215505B1 (en) * | 2014-11-03 | 2019-07-24 | Bayer Pharma Aktiengesellschaft | Piperidinylpyrazolopyrimidinones and their use |
| JP2018502144A (ja) | 2014-11-03 | 2018-01-25 | スロンボリティクス，リミテッド・ライアビリティ・カンパニー | 抗線維素溶解化合物 |
| WO2026114960A1 (en) | 2024-11-27 | 2026-06-04 | Hemostatics Pharmaceuticals, S.L. | Process for the synthesis of (r)-n-hydroxy-2-((4-(4-(methylcarbamoyl)phenoxy)phenyl)sulfonyl)-8-azaspiro[4.5]decane-2-carboxamide and intermediates thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1271732A (en) * | 1969-07-22 | 1972-04-26 | Science Union & Cie | New isobutyl cyclohexenyl derivatives and process for preparing them |
| EP0079872B1 (en) | 1981-11-17 | 1985-03-20 | KabiVitrum AB | Antifibrinolytically active compounds |
| US6172057B1 (en) * | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| AU748998B2 (en) * | 1997-02-27 | 2002-06-13 | Wyeth Holdings Corporation | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| US6197791B1 (en) * | 1997-02-27 | 2001-03-06 | American Cyanamid Company | N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| CN1213021C (zh) * | 1998-02-19 | 2005-08-03 | 惠氏控股公司 | 作为基质金属蛋白酶抑制剂的 n －羟基－ 2 － (烷基、芳基或杂芳基硫烷基、亚磺酰基或磺酰基 ) － 3 －取代的烷 |
| US6225311B1 (en) * | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
| US20020099035A1 (en) * | 2001-01-24 | 2002-07-25 | Sandanayaka Vincent P. | Method for preparing alpha-sulfonyl hydroxamic acid derivatives |
| US20040024024A1 (en) * | 2001-05-11 | 2004-02-05 | Freskos John N. | Aromatic sulfone hydroxamates and their use as protease inhibitors |
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2013
- 2013-07-17 AU AU2013292076A patent/AU2013292076B2/en active Active
- 2013-07-17 US US14/415,474 patent/US9440989B2/en active Active
- 2013-07-17 WO PCT/EP2013/065071 patent/WO2014012964A1/en not_active Ceased
- 2013-07-17 EP EP13737275.1A patent/EP2877446B9/en active Active
- 2013-07-17 ES ES13737275.1T patent/ES2603740T3/es active Active
- 2013-07-17 CA CA2917604A patent/CA2917604C/en active Active
- 2013-07-17 JP JP2015522082A patent/JP6203257B2/ja active Active