JP2016532667A5 - - Google Patents
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- Publication number
- JP2016532667A5 JP2016532667A5 JP2016521758A JP2016521758A JP2016532667A5 JP 2016532667 A5 JP2016532667 A5 JP 2016532667A5 JP 2016521758 A JP2016521758 A JP 2016521758A JP 2016521758 A JP2016521758 A JP 2016521758A JP 2016532667 A5 JP2016532667 A5 JP 2016532667A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical combination
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- GOTYRUGSSMKFNF-UHFFFAOYSA-N Nc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O Chemical compound Nc1cccc2c1CN(C(CCC(N1)=O)C1=O)C2=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018225287A JP7403950B2 (ja) | 2013-10-11 | 2018-11-30 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361889640P | 2013-10-11 | 2013-10-11 | |
| US61/889,640 | 2013-10-11 | ||
| US201361911089P | 2013-12-03 | 2013-12-03 | |
| US61/911,089 | 2013-12-03 | ||
| PCT/US2014/059387 WO2015054175A1 (en) | 2013-10-11 | 2014-10-07 | Combinations of histone deactylase inhibitors and immunomodulatory drugs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018225287A Division JP7403950B2 (ja) | 2013-10-11 | 2018-11-30 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016532667A JP2016532667A (ja) | 2016-10-20 |
| JP2016532667A5 true JP2016532667A5 (enExample) | 2017-11-16 |
Family
ID=52810182
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521758A Pending JP2016532667A (ja) | 2013-10-11 | 2014-10-07 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
| JP2018225287A Active JP7403950B2 (ja) | 2013-10-11 | 2018-11-30 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
| JP2021020680A Pending JP2021073314A (ja) | 2013-10-11 | 2021-02-12 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
| JP2023184173A Pending JP2024010118A (ja) | 2013-10-11 | 2023-10-26 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018225287A Active JP7403950B2 (ja) | 2013-10-11 | 2018-11-30 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
| JP2021020680A Pending JP2021073314A (ja) | 2013-10-11 | 2021-02-12 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
| JP2023184173A Pending JP2024010118A (ja) | 2013-10-11 | 2023-10-26 | ヒストンデアセチラーゼ阻害薬及び免疫調節薬の組み合わせ |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20150105358A1 (enExample) |
| EP (1) | EP3054939A4 (enExample) |
| JP (4) | JP2016532667A (enExample) |
| KR (1) | KR20160060143A (enExample) |
| CN (1) | CN105722507A (enExample) |
| AU (1) | AU2014332147A1 (enExample) |
| CA (1) | CA2926808A1 (enExample) |
| CL (1) | CL2016000838A1 (enExample) |
| CR (1) | CR20160200A (enExample) |
| EA (1) | EA201690753A1 (enExample) |
| IL (1) | IL244923A0 (enExample) |
| MX (1) | MX2016004604A (enExample) |
| NI (1) | NI201600051A (enExample) |
| PE (1) | PE20161342A1 (enExample) |
| PH (1) | PH12016500649A1 (enExample) |
| SG (1) | SG11201602791RA (enExample) |
| WO (1) | WO2015054175A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ601655A (en) | 2010-01-22 | 2014-10-31 | Acetylon Pharmaceuticals Inc | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
| PL2640709T3 (pl) | 2010-11-16 | 2016-10-31 | Związki pirymidynohydroksyamidowe jako inhibitory deacetylazy białkowej oraz sposoby ich stosowania” | |
| EP2839037B1 (en) | 2012-04-19 | 2018-12-26 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| WO2015054099A1 (en) * | 2013-10-08 | 2015-04-16 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase inhibitors and either her2 inhibitors or pi3k inhibitors |
| ES2862126T3 (es) * | 2013-10-10 | 2021-10-07 | Acetylon Pharmaceuticals Inc | Compuestos de pirimidín-hidroxiamida como inhibidores de histona desacetilasa |
| KR20160060143A (ko) * | 2013-10-11 | 2016-05-27 | 에이스틸론 파마수티컬스 인코포레이티드 | 히스톤 디아세틸라아제 억제제와 면역조절성 약물의 조합물 |
| US10660890B2 (en) | 2013-10-24 | 2020-05-26 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Nih Division Of Extramural Inventions And Technology Resources (Deitr) | Treatment of polycystic diseases with an HDAC6 inhibitor |
| ES2806258T3 (es) | 2013-12-03 | 2021-02-17 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona desacetilasa y fármacos inmunomoduladores |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| SG11201700094TA (en) | 2014-07-07 | 2017-02-27 | Acetylon Pharmaceuticals Inc | Treatment of leukemia with histone deacetylase inhibitors |
| US9937174B2 (en) | 2014-12-05 | 2018-04-10 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| BR112017012504A2 (pt) | 2014-12-12 | 2018-01-09 | Acetylon Pharmaceuticals, Inc. | derivados de piperidina como inibidores de hdac1/2 |
| TW201718516A (zh) | 2015-06-08 | 2017-06-01 | 艾斯特隆製藥公司 | 組蛋白去乙醯酶抑制劑之晶形 |
| CN107922352B (zh) | 2015-06-08 | 2021-08-06 | 埃斯泰隆制药公司 | 制备蛋白质脱乙酰酶抑制剂的方法 |
| WO2017143237A1 (en) * | 2016-02-17 | 2017-08-24 | Acetylon Pharmaceuticals, Inc. | Increasing expression of interferon regulated genes with combinatons of histone deacetylase inhibitors and immunomodulatory drugs |
| WO2017184774A1 (en) | 2016-04-19 | 2017-10-26 | Acetylon Pharmaceuticals, Inc. | Hdac inhibitors, alone or in combination with btk inhibitors, for treating chronic lymphocytic leukemia |
| US11298354B2 (en) | 2016-06-09 | 2022-04-12 | Dana-Farber Cancer Institute, Inc. | Methods of use and pharmaceutical combinations of HDAC inhibitors with BET inhibitors |
| ES2929032T3 (es) | 2016-08-08 | 2022-11-24 | Acetylon Pharmaceuticals Inc | Combinaciones farmacéuticas de inhibidores de histona desacetilasa 6 y anticuerpos inhibidores de CD20 y usos de los mismos |
| KR102002581B1 (ko) * | 2016-10-04 | 2019-07-22 | 주식회사 종근당 | 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물 |
| EP3544612A4 (en) * | 2016-11-23 | 2020-05-13 | Acetylon Pharmaceuticals, Inc. | PHARMACEUTICAL COMBINATIONS COMPRISING A HISTONE DEACETYLASE INHIBITOR AND A CD38 INHIBITOR AND METHODS OF USING THE SAME |
| WO2018098168A1 (en) * | 2016-11-23 | 2018-05-31 | Acetylon Pharmaceuticals, Inc. | Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (pd-l1) inhibitor and methods of use thereof |
| CN114980887A (zh) | 2019-12-20 | 2022-08-30 | 特纳亚治疗股份有限公司 | 氟代烷基-噁二唑及其用途 |
| IL307883A (en) | 2021-04-23 | 2023-12-01 | Tenaya Therapeutics Inc | HDAC6 inhibitors for use in the treatment of dilated myocardial disease |
| WO2022235842A1 (en) | 2021-05-04 | 2022-11-10 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| EP2361619A1 (en) | 2005-11-10 | 2011-08-31 | TopoTarget UK Limited | Histone deacetylase (hdac) inhibitors (pxd-101) alone for the treatment of hematological cancer |
| NZ601655A (en) * | 2010-01-22 | 2014-10-31 | Acetylon Pharmaceuticals Inc | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
| PL2640709T3 (pl) * | 2010-11-16 | 2016-10-31 | Związki pirymidynohydroksyamidowe jako inhibitory deacetylazy białkowej oraz sposoby ich stosowania” | |
| JP6169076B2 (ja) * | 2011-07-20 | 2017-07-26 | ザ ジェネラル ホスピタル コーポレイション | 骨疾患の処置のためのヒストン脱アセチル化酵素６選択的阻害剤 |
| KR20160060143A (ko) * | 2013-10-11 | 2016-05-27 | 에이스틸론 파마수티컬스 인코포레이티드 | 히스톤 디아세틸라아제 억제제와 면역조절성 약물의 조합물 |
-
2014
- 2014-10-07 KR KR1020167011860A patent/KR20160060143A/ko not_active Withdrawn
- 2014-10-07 PE PE2016000490A patent/PE20161342A1/es not_active Application Discontinuation
- 2014-10-07 CR CR20160200A patent/CR20160200A/es unknown
- 2014-10-07 JP JP2016521758A patent/JP2016532667A/ja active Pending
- 2014-10-07 SG SG11201602791RA patent/SG11201602791RA/en unknown
- 2014-10-07 CN CN201480062094.3A patent/CN105722507A/zh active Pending
- 2014-10-07 US US14/508,072 patent/US20150105358A1/en not_active Abandoned
- 2014-10-07 WO PCT/US2014/059387 patent/WO2015054175A1/en not_active Ceased
- 2014-10-07 EA EA201690753A patent/EA201690753A1/ru unknown
- 2014-10-07 AU AU2014332147A patent/AU2014332147A1/en not_active Abandoned
- 2014-10-07 CA CA2926808A patent/CA2926808A1/en not_active Abandoned
- 2014-10-07 EP EP14851888.9A patent/EP3054939A4/en not_active Withdrawn
- 2014-10-07 MX MX2016004604A patent/MX2016004604A/es unknown
-
2016
- 2016-04-05 IL IL244923A patent/IL244923A0/en unknown
- 2016-04-08 PH PH12016500649A patent/PH12016500649A1/en unknown
- 2016-04-11 CL CL2016000838A patent/CL2016000838A1/es unknown
- 2016-04-11 NI NI201600051A patent/NI201600051A/es unknown
-
2018
- 2018-11-30 JP JP2018225287A patent/JP7403950B2/ja active Active
-
2019
- 2019-11-15 US US16/684,809 patent/US20200323849A1/en not_active Abandoned
-
2021
- 2021-02-12 JP JP2021020680A patent/JP2021073314A/ja active Pending
-
2023
- 2023-10-26 JP JP2023184173A patent/JP2024010118A/ja active Pending
-
2025
- 2025-03-05 US US19/071,232 patent/US20260021093A1/en active Pending
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