JP2016518337A5 - - Google Patents
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- Publication number
- JP2016518337A5 JP2016518337A5 JP2016503044A JP2016503044A JP2016518337A5 JP 2016518337 A5 JP2016518337 A5 JP 2016518337A5 JP 2016503044 A JP2016503044 A JP 2016503044A JP 2016503044 A JP2016503044 A JP 2016503044A JP 2016518337 A5 JP2016518337 A5 JP 2016518337A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- inhibitor
- selective cdk4
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 16
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 208000000389 T-cell leukemia Diseases 0.000 claims 6
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 6
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- YPJRHEKCFKOVRT-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)cnc1Nc1ncc(cc2[n]3C4(CCCCC4)CNC2=O)c3n1 Chemical compound CC(C)N(CC1)CCN1c(cc1)cnc1Nc1ncc(cc2[n]3C4(CCCCC4)CNC2=O)c3n1 YPJRHEKCFKOVRT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798772P | 2013-03-15 | 2013-03-15 | |
| US61/798,772 | 2013-03-15 | ||
| US201361861374P | 2013-08-01 | 2013-08-01 | |
| US61/861,374 | 2013-08-01 | ||
| US201361911354P | 2013-12-03 | 2013-12-03 | |
| US61/911,354 | 2013-12-03 | ||
| US201461949795P | 2014-03-07 | 2014-03-07 | |
| US61/949,795 | 2014-03-07 | ||
| PCT/US2014/029274 WO2014144740A2 (en) | 2013-03-15 | 2014-03-14 | Highly active anti-neoplastic and anti-proliferative agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018202981A Division JP6703583B2 (ja) | 2013-03-15 | 2018-10-29 | 高活性抗新生物薬及び抗増殖剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518337A JP2016518337A (ja) | 2016-06-23 |
| JP2016518337A5 true JP2016518337A5 (enExample) | 2017-04-20 |
| JP6435315B2 JP6435315B2 (ja) | 2018-12-05 |
Family
ID=51527866
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503044A Active JP6435315B2 (ja) | 2013-03-15 | 2014-03-14 | 高活性抗新生物薬及び抗増殖剤 |
| JP2018202981A Active JP6703583B2 (ja) | 2013-03-15 | 2018-10-29 | 高活性抗新生物薬及び抗増殖剤 |
| JP2020082401A Pending JP2020128408A (ja) | 2013-03-15 | 2020-05-08 | 高活性抗新生物薬及び抗増殖剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018202981A Active JP6703583B2 (ja) | 2013-03-15 | 2018-10-29 | 高活性抗新生物薬及び抗増殖剤 |
| JP2020082401A Pending JP2020128408A (ja) | 2013-03-15 | 2020-05-08 | 高活性抗新生物薬及び抗増殖剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US20140271460A1 (enExample) |
| EP (1) | EP2967050A4 (enExample) |
| JP (3) | JP6435315B2 (enExample) |
| CN (2) | CN107417691B (enExample) |
| CA (2) | CA2906157C (enExample) |
| HK (1) | HK1222766A1 (enExample) |
| WO (1) | WO2014144740A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009061345A2 (en) | 2007-11-07 | 2009-05-14 | Cornell Research Foundation, Inc. | Targeting cdk4 and cdk6 in cancer therapy |
| US8691830B2 (en) | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| WO2013148748A1 (en) | 2012-03-29 | 2013-10-03 | Francis Xavier Tavares | Lactam kinase inhibitors |
| US9464092B2 (en) | 2013-03-15 | 2016-10-11 | G1 Therapeutics, Inc. | Transient protection of normal cells during chemotherapy |
| CN107417691B (zh) | 2013-03-15 | 2020-06-26 | G1治疗公司 | 高效的抗赘生剂和抗增生剂 |
| WO2015161288A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use as anti-neoplastic and anti-proliferative agents |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| WO2018005860A1 (en) * | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based antiproliferative agents |
| NZ749275A (en) * | 2016-07-01 | 2023-06-30 | G1 Therapeutics Inc | Synthesis of n-(heteroaryl)-pyrrolo[2,3-d]pyrimidin-2-amines |
| WO2018005863A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| WO2018005533A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Antiproliferative pyrimidine-based compounds |
| KR20240024296A (ko) | 2016-12-05 | 2024-02-23 | 쥐원 쎄라퓨틱스, 인크. | 화학요법 레지멘 동안의 면역 반응의 보존 |
| MX2019008158A (es) * | 2017-01-06 | 2019-12-09 | G1 Therapeutics Inc | Terapia de combinacion para el tratamiento del cancer. |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| RU2019142591A (ru) | 2017-06-29 | 2021-07-29 | Г1 Терапьютикс, Инк. | Морфологические формы g1t38 и способы их получения |
| WO2019133864A1 (en) * | 2017-12-29 | 2019-07-04 | Accutar Biotechnology | DUAL INHIBITORS OF PARP1 and CDK |
| AU2019205821C1 (en) * | 2018-01-08 | 2025-02-13 | Pharmacosmos Holding A/S | G1T38 superior dosage regimes |
| US20220296595A1 (en) | 2019-05-05 | 2022-09-22 | Qilu Regor Therapeutics Inc. | Cdk inhibitors |
| CA3161892A1 (en) | 2019-12-23 | 2021-07-01 | Jie Fan | Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer |
| EP4652997A2 (en) | 2020-05-19 | 2025-11-26 | Pharmacosmos Holding A/s | Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders |
| AU2021287380A1 (en) * | 2020-06-11 | 2023-01-05 | Lunella Biotech, Inc. | Selective CDK4/6 inhibitor cancer therapeutics |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| CN117903147B (zh) * | 2024-01-10 | 2025-07-25 | 沈阳药科大学 | 一种曲拉西利及其中间体的制备方法 |
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| CN107417691B (zh) | 2013-03-15 | 2020-06-26 | G1治疗公司 | 高效的抗赘生剂和抗增生剂 |
| CN105263496A (zh) | 2013-04-08 | 2016-01-20 | 药品循环有限责任公司 | 依鲁替尼联合疗法 |
| WO2015061407A1 (en) | 2013-10-24 | 2015-04-30 | Francis Xavier Tavares | Process for synthesis of lactams |
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| WO2015161288A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use as anti-neoplastic and anti-proliferative agents |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| US20160220569A1 (en) | 2015-02-03 | 2016-08-04 | G1 Therapeutics, Inc. | CDK4/6 Inhibitor Dosage Formulations For The Protection Of Hematopoietic Stem And Progenitor Cells During Chemotherapy |
-
2014
- 2014-03-14 CN CN201710147181.4A patent/CN107417691B/zh active Active
- 2014-03-14 CA CA2906157A patent/CA2906157C/en active Active
- 2014-03-14 CN CN201480027263.XA patent/CN105407723A/zh active Pending
- 2014-03-14 US US14/213,784 patent/US20140271460A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/029274 patent/WO2014144740A2/en not_active Ceased
- 2014-03-14 HK HK16110954.5A patent/HK1222766A1/zh unknown
- 2014-03-14 EP EP14764016.3A patent/EP2967050A4/en active Pending
- 2014-03-14 CA CA3152117A patent/CA3152117A1/en active Pending
- 2014-03-14 JP JP2016503044A patent/JP6435315B2/ja active Active
-
2016
- 2016-07-01 US US15/201,286 patent/US20160310499A1/en not_active Abandoned
-
2017
- 2017-09-22 US US15/713,385 patent/US20180015096A1/en not_active Abandoned
-
2018
- 2018-10-29 JP JP2018202981A patent/JP6703583B2/ja active Active
- 2018-12-20 US US16/228,308 patent/US10709711B2/en active Active
-
2020
- 2020-05-08 JP JP2020082401A patent/JP2020128408A/ja active Pending
- 2020-07-10 US US16/926,035 patent/US20200345743A1/en not_active Abandoned
-
2022
- 2022-08-17 US US17/890,130 patent/US20230248733A1/en active Pending
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