JP2016518337A5 - - Google Patents

Download PDF

Info

Publication number
JP2016518337A5
JP2016518337A5 JP2016503044A JP2016503044A JP2016518337A5 JP 2016518337 A5 JP2016518337 A5 JP 2016518337A5 JP 2016503044 A JP2016503044 A JP 2016503044A JP 2016503044 A JP2016503044 A JP 2016503044A JP 2016518337 A5 JP2016518337 A5 JP 2016518337A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
inhibitor
selective cdk4
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016503044A
Other languages
English (en)
Japanese (ja)
Other versions
JP6435315B2 (ja
JP2016518337A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/029274 external-priority patent/WO2014144740A2/en
Publication of JP2016518337A publication Critical patent/JP2016518337A/ja
Publication of JP2016518337A5 publication Critical patent/JP2016518337A5/ja
Application granted granted Critical
Publication of JP6435315B2 publication Critical patent/JP6435315B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016503044A 2013-03-15 2014-03-14 高活性抗新生物薬及び抗増殖剤 Active JP6435315B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361798772P 2013-03-15 2013-03-15
US61/798,772 2013-03-15
US201361861374P 2013-08-01 2013-08-01
US61/861,374 2013-08-01
US201361911354P 2013-12-03 2013-12-03
US61/911,354 2013-12-03
US201461949795P 2014-03-07 2014-03-07
US61/949,795 2014-03-07
PCT/US2014/029274 WO2014144740A2 (en) 2013-03-15 2014-03-14 Highly active anti-neoplastic and anti-proliferative agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018202981A Division JP6703583B2 (ja) 2013-03-15 2018-10-29 高活性抗新生物薬及び抗増殖剤

Publications (3)

Publication Number Publication Date
JP2016518337A JP2016518337A (ja) 2016-06-23
JP2016518337A5 true JP2016518337A5 (enExample) 2017-04-20
JP6435315B2 JP6435315B2 (ja) 2018-12-05

Family

ID=51527866

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016503044A Active JP6435315B2 (ja) 2013-03-15 2014-03-14 高活性抗新生物薬及び抗増殖剤
JP2018202981A Active JP6703583B2 (ja) 2013-03-15 2018-10-29 高活性抗新生物薬及び抗増殖剤
JP2020082401A Pending JP2020128408A (ja) 2013-03-15 2020-05-08 高活性抗新生物薬及び抗増殖剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018202981A Active JP6703583B2 (ja) 2013-03-15 2018-10-29 高活性抗新生物薬及び抗増殖剤
JP2020082401A Pending JP2020128408A (ja) 2013-03-15 2020-05-08 高活性抗新生物薬及び抗増殖剤

Country Status (7)

Country Link
US (6) US20140271460A1 (enExample)
EP (1) EP2967050A4 (enExample)
JP (3) JP6435315B2 (enExample)
CN (2) CN107417691B (enExample)
CA (2) CA3152117A1 (enExample)
HK (1) HK1222766A1 (enExample)
WO (1) WO2014144740A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009061345A2 (en) 2007-11-07 2009-05-14 Cornell Research Foundation, Inc. Targeting cdk4 and cdk6 in cancer therapy
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
WO2013148748A1 (en) 2012-03-29 2013-10-03 Francis Xavier Tavares Lactam kinase inhibitors
US9527857B2 (en) 2013-03-15 2016-12-27 GI Therapeutics, Inc. HSPC-sparing treatments for RB-positive abnormal cellular proliferation
US20140271460A1 (en) 2013-03-15 2014-09-18 G1 Therapeutics, Inc. Highly Active Anti-Neoplastic and Anti-Proliferative Agents
WO2015161283A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic lactams for use in hspc-sparing treatments for rb-positive abnormal cellular proliferation
WO2016040858A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
WO2018005533A1 (en) * 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Antiproliferative pyrimidine-based compounds
CN109789142B (zh) * 2016-07-01 2022-08-23 G1治疗公司 N-(杂芳基)-吡咯并[3,2-d]嘧啶-2-胺的合成
EA201990187A1 (ru) 2016-07-01 2019-07-31 Г1 Терапьютикс, Инк. Антипролиферационные средства на основе пиримидина
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
MX2019006523A (es) 2016-12-05 2019-10-15 G1 Therapeutics Inc Conservacion de respuesta inmunitaria durante regimenes de quimioterapia.
TWI823845B (zh) * 2017-01-06 2023-12-01 美商G1治療公司 用於治療癌症的組合療法
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
EP4455146A3 (en) * 2017-06-29 2025-01-01 G1 Therapeutics, Inc. Morphic forms of git38 and methods of manufacture thereof
WO2019133864A1 (en) 2017-12-29 2019-07-04 Accutar Biotechnology DUAL INHIBITORS OF PARP1 and CDK
WO2019136451A1 (en) 2018-01-08 2019-07-11 G1 Therapeutics, Inc. G1t38 superior dosage regimes
WO2020224568A1 (en) 2019-05-05 2020-11-12 Qilu Regor Therapeutics Inc. Cdk inhibitors
CN116234803A (zh) 2019-12-23 2023-06-06 冰洲石生物科技公司 用于治疗癌症的雌激素受体降解剂和细胞周期蛋白依赖性激酶抑制剂的组合
EP4652997A3 (en) 2020-05-19 2026-03-04 Pharmacosmos Holding A/s Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
CN115698015A (zh) * 2020-06-11 2023-02-03 卢内拉生物技术有限公司 选择性cdk4/6抑制剂癌症治疗
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
CN117903147B (zh) * 2024-01-10 2025-07-25 沈阳药科大学 一种曲拉西利及其中间体的制备方法

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591855A (en) 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5628984A (en) 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
DE69839338T2 (de) 1997-02-05 2008-07-10 Warner-Lambert Company Llc Pyrido (2,3-d) pyrimidine und 4-amino-pyrimidine als inhibitoren der zellulären proliferation
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US20040006074A1 (en) 1998-04-28 2004-01-08 The Government Of The United States Of America Cyclin dependent kinase (CDK)4 inhibitors and their use for treating cancer
CA2335115C (en) 1998-06-16 2009-01-27 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fused azepinone cyclin dependent kinase inhibitors
DE60037394T2 (de) 1999-01-29 2009-01-02 The Board Of Trustees For The University Of Illinois, Urbana VERWENDUNG VON p53 INHIBITOREN ZUR BEHANDLUNG VON NEBENERSCHEINUNGEN BEI DER KREBSTHERAPIE
US6958333B1 (en) 1999-07-26 2005-10-25 Banyu Pharmaceutical Co., Ltd. Biarylurea derivatives
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
WO2001044247A2 (en) 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US7053070B2 (en) 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
PL359563A1 (pl) 2000-06-26 2004-08-23 Pfizer Products Inc. Związki pirolo [2,3-d] pirymidynowe jako środki immunosupresyjne
DK1325011T3 (da) 2000-09-29 2004-08-16 Lilly Co Eli Fremgangsmåder og forbindelser til behandling af proliferative sygdomme
AU2002228692A1 (en) 2000-12-01 2002-06-11 Bristol-Myers Squibb Pharma Company 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors
US6667346B2 (en) 2001-02-28 2003-12-23 Temple University - Of The Commonwealth System Of Higher Education Method for protecting cells and tissues from ionizing radiation toxicity with α, β unsaturated aryl sulfones
JP2004533449A (ja) * 2001-05-11 2004-11-04 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム Cd26を発現している細胞に関連する疾患の治療としての抗cd26モノクローナル抗体
DE60303009T2 (de) 2002-01-22 2006-07-13 Warner-Lambert Co. Llc 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-one
WO2003093469A2 (en) 2002-05-01 2003-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
JP2006516561A (ja) 2003-01-17 2006-07-06 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 細胞増殖の阻害剤としての2−アミノピリジン置換ヘテロ環類
US7482354B2 (en) 2003-05-22 2009-01-27 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
JP4053073B2 (ja) 2003-07-11 2008-02-27 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 選択的cdk4阻害剤のイセチオン酸塩
MXPA06004305A (es) 2003-10-23 2006-06-05 Hoffmann La Roche Derivados de triaza-espiropiperidina para uso como inhibidores del transformador de glicina 1 en tratamiento de enfermedades neurologicas y neuropsiquiatricas.
GB0327380D0 (en) 2003-11-25 2003-12-31 Cyclacel Ltd Method
WO2005094830A1 (en) 2004-03-30 2005-10-13 Pfizer Products Inc. Combinations of signal transduction inhibitors
US8603763B2 (en) 2004-04-08 2013-12-10 Cornell Research Foundation, Inc. Functional immunohistochemical cell cycle analysis as a prognostic indicator for cancer
ITMI20040874A1 (it) 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici ed azaindolici con azione antitumorale
ES2411975T3 (es) 2005-01-14 2013-07-09 Janssen Pharmaceutica Nv Pirimidinas heterocíclicas anilladas de 5 miembros como inhibidores de cinasas
EP1845975A1 (en) 2005-01-21 2007-10-24 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors and further antitumor agents
NZ564065A (en) 2005-05-20 2011-03-31 Vertex Pharma Pyrrolopyridines useful as inhibitors of protein kinase
WO2007025090A2 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
US7579351B2 (en) 2005-12-09 2009-08-25 Hoffmann-La Roche Inc. Tricyclic amide derivatives
BRPI0620151A2 (pt) 2005-12-22 2010-06-29 Wyeth Corp composto; composição farmacêutica; método de tratar ou inibir o crescimento de células tumorais cancerosas em um mamìfero que deste necessita; método; e processo
WO2007124252A2 (en) 2006-04-05 2007-11-01 Novartis Ag Combinations of therapeutic agents for treating cancer
US20070270362A1 (en) 2006-05-18 2007-11-22 The University Of Washington Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders
CA2656290A1 (en) 2006-07-05 2008-01-10 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
EP2109450A2 (en) 2006-12-14 2009-10-21 Panacea Pharmaceuticals, Inc. Methods of neuroprotection by cyclin-dependent kinase inhibition
AU2007336933A1 (en) 2006-12-22 2008-07-03 Novartis Ag Heteroaryl-heteroaryl compounds as CDK inhibitors for the treatment of cancer, inflammation and viral infections
WO2009003003A2 (en) 2007-06-25 2008-12-31 Neurogen Corporation Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues
WO2009061345A2 (en) 2007-11-07 2009-05-14 Cornell Research Foundation, Inc. Targeting cdk4 and cdk6 in cancer therapy
WO2009085185A1 (en) 2007-12-19 2009-07-09 Amgen Inc. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
EP2320903B1 (en) 2008-07-29 2017-01-18 Nerviano Medical Sciences S.r.l. THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT
KR101353857B1 (ko) * 2008-08-22 2014-01-21 노파르티스 아게 Cdk 억제제로서 피롤로피리미딘 화합물
CN102231983A (zh) 2008-10-01 2011-11-02 北卡罗来纳大学查珀尔希尔分校 使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗电离辐射的造血防护
JP2012504646A (ja) 2008-10-01 2012-02-23 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 選択的サイクリン依存性キナーゼ4/6阻害剤を用いた化学療法化合物に対する造血系の防護
PA8852901A1 (es) 2008-12-22 2010-07-27 Lilly Co Eli Inhibidores de proteina cinasa
CA2761896A1 (en) 2009-05-13 2010-11-18 The University Of North Carolina At Chapel Hill Cyclin dependent kinase inhibitors and methods of use
WO2011103485A1 (en) 2010-02-18 2011-08-25 Medivation Technologies, Inc. Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
UY33226A (es) * 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6
UY33227A (es) 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
MX379532B (es) * 2010-10-25 2025-03-10 G1 Therapeutics Inc Inhibidores de cdk.
AU2011323455B2 (en) 2010-11-02 2017-07-27 Promega Corporation Coelenterazine derivatives and methods of using same
WO2012068381A2 (en) 2010-11-17 2012-05-24 The University Of North Carolina At Chapel Hill Protection of renal tissues from schema through inhibition of the proliferative kisses cdk4 and cdk6
HUE024504T2 (en) 2010-12-23 2016-01-28 Sanofi Sa Pyrimidine derivatives, a process for their preparation and their use in medicine
PT2688887E (pt) * 2011-03-23 2015-07-06 Amgen Inc Inibidores duais tricíclicos fusionados de cdk 4/6 e flt3
MY161237A (en) 2011-07-01 2017-04-14 Novartis Ag Combination therapy comprising a cdk4/6 inhibitor and a p13k inhibitor for use in the treatment of cancer
WO2013148748A1 (en) 2012-03-29 2013-10-03 Francis Xavier Tavares Lactam kinase inhibitors
MY175254A (en) 2012-04-26 2020-06-17 G1 Therapeutics Inc Synthesis of lactams
US9241941B2 (en) 2012-09-20 2016-01-26 Memorial Sloan-Kettering Cancer Center Methods for treatment of lymphomas with mutations in cell cycle genes
US20140271460A1 (en) 2013-03-15 2014-09-18 G1 Therapeutics, Inc. Highly Active Anti-Neoplastic and Anti-Proliferative Agents
US20140274896A1 (en) 2013-03-15 2014-09-18 G1 Therapeutics, Inc. Transient Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
US9527857B2 (en) 2013-03-15 2016-12-27 GI Therapeutics, Inc. HSPC-sparing treatments for RB-positive abnormal cellular proliferation
WO2014168975A1 (en) 2013-04-08 2014-10-16 Pharmacyclics, Inc. Ibrutinib combination therapy
US20160257688A1 (en) 2013-10-24 2016-09-08 Francis Xavier Tavares Process for Synthesis of Lactams
WO2015084892A1 (en) 2013-12-02 2015-06-11 Cornell University Methods for treating b cell proliferative disorders
WO2015161283A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic lactams for use in hspc-sparing treatments for rb-positive abnormal cellular proliferation
WO2016040858A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
US20160220569A1 (en) 2015-02-03 2016-08-04 G1 Therapeutics, Inc. CDK4/6 Inhibitor Dosage Formulations For The Protection Of Hematopoietic Stem And Progenitor Cells During Chemotherapy

Similar Documents

Publication Publication Date Title
JP2016518337A5 (enExample)
JP2017509667A5 (enExample)
JP2013014622A5 (enExample)
JP2014507446A5 (enExample)
MX2024010140A (es) Nuevos metodos.
JP2016515522A5 (enExample)
JP2014221779A5 (enExample)
JP2017186358A5 (enExample)
JP2017537066A5 (enExample)
JP2013525444A5 (enExample)
JP2015078230A5 (enExample)
JP2017514871A5 (enExample)
HRP20250119T1 (hr) Kdm1a inhibitor i njegova primjena u terapiji
JP2016508134A5 (enExample)
EP4663636A3 (en) Trifluoromethyl substituted pyrazoles as human plasma kallikrein inhibitors
JP2015503422A5 (enExample)
EA201691918A1 (ru) Фармацевтические составы ингибитора киназ семейства raf, способы их получения и способы их применения
WO2015179823A3 (en) Lung localized inhibitors of alpha(v)beta 6
WO2015173701A3 (en) Pharmaceutical compositions comprising danirixin for treating infectious diseases
JP2016540030A5 (enExample)
JP2017537912A5 (enExample)
JP2016532632A5 (enExample)
JP2015516419A5 (enExample)
WO2016015798A9 (en) Orodispersible film composition comprising enalapril for the treatment of hypertension in a pediatric population
JP2014148552A5 (enExample)