JP2017514871A5 - - Google Patents
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- JP2017514871A5 JP2017514871A5 JP2016566909A JP2016566909A JP2017514871A5 JP 2017514871 A5 JP2017514871 A5 JP 2017514871A5 JP 2016566909 A JP2016566909 A JP 2016566909A JP 2016566909 A JP2016566909 A JP 2016566909A JP 2017514871 A5 JP2017514871 A5 JP 2017514871A5
- Authority
- JP
- Japan
- Prior art keywords
- glyx
- administering
- patient
- effective amount
- cognitive impairment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- GIBQQARAXHVEGD-BSOLPCOYSA-N rapastinel Chemical compound C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)N[C@@H]([C@@H](C)O)C(N)=O)CCC1 GIBQQARAXHVEGD-BSOLPCOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461989183P | 2014-05-06 | 2014-05-06 | |
| US61/989,183 | 2014-05-06 | ||
| PCT/US2015/029477 WO2015171770A1 (en) | 2014-05-06 | 2015-05-06 | Combinations of nmdar modulating compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020083060A Division JP2020138973A (ja) | 2014-05-06 | 2020-05-11 | Ｎｍｄａｒ調節化合物の組合せ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017514871A JP2017514871A (ja) | 2017-06-08 |
| JP2017514871A5 true JP2017514871A5 (enExample) | 2018-06-14 |
Family
ID=54392956
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016566909A Pending JP2017514871A (ja) | 2014-05-06 | 2015-05-06 | Ｎｍｄａｒ調節化合物の組合せ |
| JP2020083060A Pending JP2020138973A (ja) | 2014-05-06 | 2020-05-11 | Ｎｍｄａｒ調節化合物の組合せ |
| JP2022116942A Pending JP2022159322A (ja) | 2014-05-06 | 2022-07-22 | Ｎｍｄａｒ調節化合物の組合せ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020083060A Pending JP2020138973A (ja) | 2014-05-06 | 2020-05-11 | Ｎｍｄａｒ調節化合物の組合せ |
| JP2022116942A Pending JP2022159322A (ja) | 2014-05-06 | 2022-07-22 | Ｎｍｄａｒ調節化合物の組合せ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20170072005A1 (enExample) |
| EP (1) | EP3139943A4 (enExample) |
| JP (3) | JP2017514871A (enExample) |
| KR (2) | KR20220102662A (enExample) |
| CN (1) | CN106659762A (enExample) |
| AU (1) | AU2015256075B2 (enExample) |
| BR (1) | BR112016025910A8 (enExample) |
| CA (1) | CA2947976A1 (enExample) |
| MX (1) | MX2016014581A (enExample) |
| RU (1) | RU2721948C2 (enExample) |
| WO (1) | WO2015171770A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201701853YA (en) | 2014-09-15 | 2017-04-27 | Rugen Holdings Cayman Ltd | Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists |
| WO2016049048A1 (en) * | 2014-09-22 | 2016-03-31 | Rugen Holdings (Cayman) Limited | Treatment of anxiety disorders and autism spectrum disorders |
| EP3253761A4 (en) | 2015-02-04 | 2018-06-20 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists |
| SI3297619T1 (sl) * | 2015-05-22 | 2023-02-28 | Vistagen Therapeutics, Inc., | Terapevtske uporabe L-4-klorokinurenina |
| KR102613179B1 (ko) | 2015-06-01 | 2023-12-14 | 뤼겐 홀딩스 (케이맨) 리미티드 | Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물 |
| CN108289884A (zh) * | 2015-10-16 | 2018-07-17 | 塞西亚生物科学公司 | 用于治疗创伤性脑损伤的方法和组合物 |
| EP3362080A1 (en) * | 2015-10-16 | 2018-08-22 | Northwestern University | Pharmaceutical combination of an atypical antipsychotic and an nmda modulator for the treatment of schizophrenia,bipolar disorder, cognitive impairment and major depressive disorder |
| WO2017205666A1 (en) * | 2016-05-25 | 2017-11-30 | National Health Research Institutes | Method and composition for decreasing the psychotomimetic side effect and addictive disorder of ketamine |
| EP3544610A1 (en) | 2016-11-22 | 2019-10-02 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
| CN107550907A (zh) * | 2017-08-29 | 2018-01-09 | 昆明医科大学 | 治疗精神分裂症的药物及验证药物的动物模型构建方法 |
| EP3720464A1 (en) * | 2017-12-05 | 2020-10-14 | Naurex Inc. | Nmda receptor modulators (rapastinel) combination for use in combined treatment (sleep and cns disorder) |
| EP3505157B1 (en) | 2017-12-29 | 2021-12-08 | Celon Pharma S.A. | Dry powder ketamine composition for pulmonary administration in treatment-resistant depression |
| CN110343050B (zh) | 2018-04-04 | 2021-09-24 | 上海键合医药科技有限公司 | 芳香类化合物及其制备方法和用途 |
| CN109223785A (zh) * | 2018-10-29 | 2019-01-18 | 中国药科大学 | 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用 |
| CN113557028A (zh) * | 2019-01-11 | 2021-10-26 | 诺雷克斯股份有限公司 | 雷帕替奈的盐和晶型 |
| EP3923938B1 (en) * | 2019-02-14 | 2025-04-16 | Seyltx, Inc. | Ifenprodil or radiprodil for treating idiopathic pulmonary fibrosis |
| CA3155464A1 (en) | 2019-10-28 | 2021-05-06 | Mark Williams | Use of glutamate 2b receptor antagonists and sigma receptor agonsists as antitussives |
| CN113234036B (zh) * | 2021-05-12 | 2023-07-14 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| KR20230056971A (ko) * | 2021-10-21 | 2023-04-28 | 삼육대학교산학협력단 | 신규 케타민 유도체를 포함하는 우울증 예방 또는 치료용 약학적 조성물 |
| US20240100062A1 (en) | 2022-09-14 | 2024-03-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of Treatment With an Iboga Alkaloid |
| WO2025065271A1 (en) * | 2023-09-26 | 2025-04-03 | Liangzhu Laboratory | Methods and devices for treating depression |
| WO2025124571A1 (zh) * | 2023-12-14 | 2025-06-19 | 斯莱普泰(上海)生物医药科技有限公司 | Nmda受体拮抗剂及其用途 |
| CN119174765A (zh) * | 2024-09-04 | 2024-12-24 | 复旦大学附属中山医院 | Gsdme蛋白的小分子抑制剂在肿瘤及其免疫治疗中的作用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5597809A (en) * | 1994-06-23 | 1997-01-28 | Massachusetts Eye & Ear Infirmary | Treatment of optic neuritis |
| AU2004251636B2 (en) * | 2003-05-27 | 2006-11-09 | Merz Pharma Gmbh & Co. Kgaa | Combination of an NMDA receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders |
| GB0523998D0 (en) * | 2005-11-25 | 2006-01-04 | Merck Sharp & Dohme | Therapeutic agents |
| US20090275597A1 (en) * | 2008-05-02 | 2009-11-05 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
| PE20100094A1 (es) * | 2008-07-03 | 2010-02-18 | Amira Pharmaceuticals Inc | Antagonistas heteroalquilo de receptores de prostaglandina d2 |
| KR20110117087A (ko) * | 2008-12-29 | 2011-10-26 | 벤더르빌트 유니버시티 | 3.1.0 비시클릭 ｇｌｙｔ1 억제제 및 그것을 제조 및 사용하는 방법 |
| US8951968B2 (en) * | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| US8846765B2 (en) * | 2010-06-15 | 2014-09-30 | Gruenenthal Gmbh | Pharmaceutical combination |
| US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US20130236573A1 (en) * | 2012-03-12 | 2013-09-12 | Janssen Pharmaceutica Nv | Esketamine for the treatment of treatment-refractory or treatment-resistant depression |
-
2015
- 2015-05-06 KR KR1020227022906A patent/KR20220102662A/ko not_active Ceased
- 2015-05-06 EP EP15789211.8A patent/EP3139943A4/en not_active Withdrawn
- 2015-05-06 CA CA2947976A patent/CA2947976A1/en not_active Abandoned
- 2015-05-06 KR KR1020167034031A patent/KR20170013890A/ko not_active Ceased
- 2015-05-06 BR BR112016025910A patent/BR112016025910A8/pt not_active Application Discontinuation
- 2015-05-06 WO PCT/US2015/029477 patent/WO2015171770A1/en not_active Ceased
- 2015-05-06 CN CN201580031430.2A patent/CN106659762A/zh active Pending
- 2015-05-06 RU RU2016146714A patent/RU2721948C2/ru active
- 2015-05-06 US US15/309,390 patent/US20170072005A1/en not_active Abandoned
- 2015-05-06 JP JP2016566909A patent/JP2017514871A/ja active Pending
- 2015-05-06 AU AU2015256075A patent/AU2015256075B2/en not_active Ceased
- 2015-05-06 MX MX2016014581A patent/MX2016014581A/es unknown
-
2020
- 2020-05-11 JP JP2020083060A patent/JP2020138973A/ja active Pending
-
2022
- 2022-07-22 JP JP2022116942A patent/JP2022159322A/ja active Pending
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