KR20170013890A - Nmdar 조절 화합물의 조합물 - Google Patents

Nmdar 조절 화합물의 조합물 Download PDF

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Publication number
KR20170013890A
KR20170013890A KR1020167034031A KR20167034031A KR20170013890A KR 20170013890 A KR20170013890 A KR 20170013890A KR 1020167034031 A KR1020167034031 A KR 1020167034031A KR 20167034031 A KR20167034031 A KR 20167034031A KR 20170013890 A KR20170013890 A KR 20170013890A
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South Korea
Prior art keywords
nmdar antagonist
glyx
group
nmdar
antagonist
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Ceased
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KR1020167034031A
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Korean (ko)
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조셉 알. 모스칼
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노쓰웨스턴유니버시티
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Priority to KR1020227022906A priority Critical patent/KR20220102662A/ko
Publication of KR20170013890A publication Critical patent/KR20170013890A/ko
Ceased legal-status Critical Current

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167034031A 2014-05-06 2015-05-06 Nmdar 조절 화합물의 조합물 Ceased KR20170013890A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227022906A KR20220102662A (ko) 2014-05-06 2015-05-06 Nmdar 조절 화합물의 조합물

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461989183P 2014-05-06 2014-05-06
US61/989,183 2014-05-06
PCT/US2015/029477 WO2015171770A1 (en) 2014-05-06 2015-05-06 Combinations of nmdar modulating compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227022906A Division KR20220102662A (ko) 2014-05-06 2015-05-06 Nmdar 조절 화합물의 조합물

Publications (1)

Publication Number Publication Date
KR20170013890A true KR20170013890A (ko) 2017-02-07

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Family Applications (2)

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KR1020227022906A Ceased KR20220102662A (ko) 2014-05-06 2015-05-06 Nmdar 조절 화합물의 조합물
KR1020167034031A Ceased KR20170013890A (ko) 2014-05-06 2015-05-06 Nmdar 조절 화합물의 조합물

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KR1020227022906A Ceased KR20220102662A (ko) 2014-05-06 2015-05-06 Nmdar 조절 화합물의 조합물

Country Status (11)

Country Link
US (1) US20170072005A1 (enExample)
EP (1) EP3139943A4 (enExample)
JP (3) JP2017514871A (enExample)
KR (2) KR20220102662A (enExample)
CN (1) CN106659762A (enExample)
AU (1) AU2015256075B2 (enExample)
BR (1) BR112016025910A8 (enExample)
CA (1) CA2947976A1 (enExample)
MX (1) MX2016014581A (enExample)
RU (1) RU2721948C2 (enExample)
WO (1) WO2015171770A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023068830A1 (ko) * 2021-10-21 2023-04-27 삼육대학교산학협력단 신규 케타민 유도체를 포함하는 우울증 예방 또는 치료용 약학적 조성물

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017002775A (es) 2014-09-15 2017-08-10 Rugen Holdings (Cayman) Ltd Derivados de pirrolopirimidina como antagonistas del receptor de n-metil-d-aspartato (nmda), subunidad nr2b.
US20180271869A1 (en) * 2014-09-22 2018-09-27 Jie Liu Treatment of anxiety disorders and autism spectrum disorders
US10221182B2 (en) 2015-02-04 2019-03-05 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
EP3297619B1 (en) * 2015-05-22 2022-07-06 Vistagen Therapeutics, Inc. Therapeutic uses of l-4-chlorokynurenine
CN107849010B (zh) 2015-06-01 2021-11-09 卢郡控股(开曼)有限公司 作为nr2b nmda受体拮抗剂的3,3‐二氟哌啶氨基甲酸酯杂环化合物
US20180303793A1 (en) * 2015-10-16 2018-10-25 Scythian Biosciences Inc. Methods and compositions for treating traumatic brain injury
CA3002070A1 (en) * 2015-10-16 2017-04-20 Northwestern University Pharmaceutical combination of an atypical antipsychotic and an nmda modulator for the treatment of schizophrenia,bipolar disorder, cognitive impairment and major depressive disorder
TWI648049B (zh) * 2016-05-25 2019-01-21 National Health Research Institutes 用於減低ｋ他命之致精神病狀副作用及成癮疾患的方法與組成物
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
CN107550907A (zh) * 2017-08-29 2018-01-09 昆明医科大学 治疗精神分裂症的药物及验证药物的动物模型构建方法
KR20200096946A (ko) * 2017-12-05 2020-08-14 노렉스, 인크. 조합된 치료(수면 및 cns 장애)용 nmda 수용체 조절자(라파스티넬) 조합물
PT3505157T (pt) 2017-12-29 2022-02-18 Celon Pharma Sa Composição de cetamina em pó seco para administração pulmonar em depressão resistente ao tratamento
CN110343050B (zh) * 2018-04-04 2021-09-24 上海键合医药科技有限公司 芳香类化合物及其制备方法和用途
CN109223785A (zh) * 2018-10-29 2019-01-18 中国药科大学 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用
WO2020146878A1 (en) * 2019-01-11 2020-07-16 Naurex Inc. Salt and crystalline forms of rapastinel
JP7433331B2 (ja) * 2019-02-14 2024-02-19 アルジャーノン・ファーマスーティカルズ・インコーポレイテッド 特発性肺線維症を治療するための組成物及び方法
US12472170B2 (en) 2019-10-28 2025-11-18 Seyltx, Inc. Use of glutamate 2B receptor antagonists and sigma receptor agonists as antitussives
CN113234036B (zh) * 2021-05-12 2023-07-14 斯莱普泰(上海)生物医药科技有限公司 Nmda受体拮抗剂及其用途
US20240100061A1 (en) 2022-09-14 2024-03-28 The Board Of Trustees Of The Leland Stanford Junior University Compositions of Iboga Alkaloids and Methods of Treatment
WO2025065271A1 (en) * 2023-09-26 2025-04-03 Liangzhu Laboratory Methods and devices for treating depression
WO2025124571A1 (zh) * 2023-12-14 2025-06-19 斯莱普泰(上海)生物医药科技有限公司 Nmda受体拮抗剂及其用途
CN119174765A (zh) * 2024-09-04 2024-12-24 复旦大学附属中山医院 Gsdme蛋白的小分子抑制剂在肿瘤及其免疫治疗中的作用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597809A (en) * 1994-06-23 1997-01-28 Massachusetts Eye & Ear Infirmary Treatment of optic neuritis
CA2528622C (en) * 2003-05-27 2010-08-03 Forest Laboratories, Inc. Combination of an nmda receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders
GB0523998D0 (en) * 2005-11-25 2006-01-04 Merck Sharp & Dohme Therapeutic agents
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
MX2010014172A (es) * 2008-07-03 2011-02-22 Amira Pharmaceuticals Inc Antagonistas de receptores de prostaglandina d2.
JP2012514006A (ja) * 2008-12-29 2012-06-21 バンダービルト ユニバーシティ ３．１．０二環式ＧｌｙＴ１阻害剤ならびにその作製および使用の方法
US8951968B2 (en) * 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases
EP2582366B1 (en) * 2010-06-15 2015-10-28 Grünenthal GmbH Pharmaceutical combination for the treatment of pain
US9737531B2 (en) * 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
MX2014010939A (es) * 2012-03-12 2014-11-13 Janssen Pharmaceutica Nv Esketamina para el tratamiento de la depresion refractaria al tratamiento o resistente al tratamiento.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023068830A1 (ko) * 2021-10-21 2023-04-27 삼육대학교산학협력단 신규 케타민 유도체를 포함하는 우울증 예방 또는 치료용 약학적 조성물

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JP2020138973A (ja) 2020-09-03
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