JP2016518337A5 - - Google Patents
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- JP2016518337A5 JP2016518337A5 JP2016503044A JP2016503044A JP2016518337A5 JP 2016518337 A5 JP2016518337 A5 JP 2016518337A5 JP 2016503044 A JP2016503044 A JP 2016503044A JP 2016503044 A JP2016503044 A JP 2016503044A JP 2016518337 A5 JP2016518337 A5 JP 2016518337A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- inhibitor
- selective cdk4
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 16
- 239000011780 sodium chloride Substances 0.000 claims 16
- 102100019398 CDK4 Human genes 0.000 claims 14
- 101700008359 CDK4 Proteins 0.000 claims 14
- 239000003112 inhibitor Substances 0.000 claims 14
- 230000002401 inhibitory effect Effects 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 208000000389 T-Cell Leukemia Diseases 0.000 claims 6
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 2
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 201000005510 acute lymphocytic leukemia Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- YPJRHEKCFKOVRT-UHFFFAOYSA-N CC(C)N(CC1)CCN1c(cc1)cnc1Nc1ncc(cc2[n]3C4(CCCCC4)CNC2=O)c3n1 Chemical compound CC(C)N(CC1)CCN1c(cc1)cnc1Nc1ncc(cc2[n]3C4(CCCCC4)CNC2=O)c3n1 YPJRHEKCFKOVRT-UHFFFAOYSA-N 0.000 description 1
Claims (26)
- 群
から選択される構造を有する選択的ＣＤＫ４／６阻害剤、またはその薬学的に許容可能な塩。 - 前記構造が、
- 前記構造が、
- 前記構造が、
- 前記構造が、
- 前記構造が、
- 前記構造が、
- 群
から選択される構造を有する選択的ＣＤＫ４／６阻害剤、またはその薬学的に許容可能な塩と、薬学的に許容可能な賦形剤とを含有する、医薬組成物。 - 前記選択的ＣＤＫ４／６阻害剤が、
- 前記選択的ＣＤＫ４／６阻害剤が、
- 前記選択的ＣＤＫ４／６阻害剤が、
- 前記選択的ＣＤＫ４／６阻害剤が、
- 前記選択的ＣＤＫ４／６阻害剤が、
- 前記選択的ＣＤＫ４／６阻害剤が、
- 対象におけるＴ細胞白血病の治療のための医薬を製造するための、化合物Ｔまたはその薬学的に許容可能な塩の使用
- 前記Ｔ細胞白血病が、急性リンパ芽球性白血病である、請求項１５に記載の使用。
- 前記Ｔ細胞白血病が、慢性リンパ性白血病である、請求項１５に記載の使用。
- 対象がヒトである、請求項１５に記載の使用。
- 対象がヒトである、請求項１６に記載の使用。
- 対象がヒトである、請求項１７に記載の使用。
- 対象におけるＴ細胞白血病の治療のための医薬を製造するための、化合物ＧＧまたはその薬学的に許容可能な塩の使用
- 前記Ｔ細胞白血病が、急性リンパ芽球性白血病である、請求項２１に記載の使用。
- 前記Ｔ細胞白血病が、慢性リンパ性白血病である、請求項２１に記載の使用。
- 対象がヒトである、請求項２１に記載の使用。
- 対象がヒトである、請求項２２に記載の使用。
- 対象がヒトである、請求項２３に記載の使用。
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798772P | 2013-03-15 | 2013-03-15 | |
| US61/798,772 | 2013-03-15 | ||
| US201361861374P | 2013-08-01 | 2013-08-01 | |
| US61/861,374 | 2013-08-01 | ||
| US201361911354P | 2013-12-03 | 2013-12-03 | |
| US61/911,354 | 2013-12-03 | ||
| US201461949795P | 2014-03-07 | 2014-03-07 | |
| US61/949,795 | 2014-03-07 | ||
| PCT/US2014/029274 WO2014144740A2 (en) | 2013-03-15 | 2014-03-14 | Highly active anti-neoplastic and anti-proliferative agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018202981A Division JP6703583B2 (ja) | 2013-03-15 | 2018-10-29 | 高活性抗新生物薬及び抗増殖剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518337A JP2016518337A (ja) | 2016-06-23 |
| JP2016518337A5 true JP2016518337A5 (ja) | 2017-04-20 |
| JP6435315B2 JP6435315B2 (ja) | 2018-12-05 |
Family
ID=51527866
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503044A Active JP6435315B2 (ja) | 2013-03-15 | 2014-03-14 | 高活性抗新生物薬及び抗増殖剤 |
| JP2018202981A Active JP6703583B2 (ja) | 2013-03-15 | 2018-10-29 | 高活性抗新生物薬及び抗増殖剤 |
| JP2020082401A Pending JP2020128408A (ja) | 2013-03-15 | 2020-05-08 | 高活性抗新生物薬及び抗増殖剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018202981A Active JP6703583B2 (ja) | 2013-03-15 | 2018-10-29 | 高活性抗新生物薬及び抗増殖剤 |
| JP2020082401A Pending JP2020128408A (ja) | 2013-03-15 | 2020-05-08 | 高活性抗新生物薬及び抗増殖剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US20140271460A1 (ja) |
| EP (1) | EP2967050A4 (ja) |
| JP (3) | JP6435315B2 (ja) |
| CN (2) | CN107417691B (ja) |
| CA (2) | CA3152117A1 (ja) |
| HK (1) | HK1222766A1 (ja) |
| WO (1) | WO2014144740A2 (ja) |
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| CA2868966C (en) | 2012-03-29 | 2021-01-26 | Francis Xavier Tavares | Lactam kinase inhibitors |
| JP6435315B2 (ja) | 2013-03-15 | 2018-12-05 | ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 高活性抗新生物薬及び抗増殖剤 |
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| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
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-
2014
- 2014-03-14 JP JP2016503044A patent/JP6435315B2/ja active Active
- 2014-03-14 CA CA3152117A patent/CA3152117A1/en active Pending
- 2014-03-14 EP EP14764016.3A patent/EP2967050A4/en active Pending
- 2014-03-14 CN CN201710147181.4A patent/CN107417691B/zh active Active
- 2014-03-14 WO PCT/US2014/029274 patent/WO2014144740A2/en active Application Filing
- 2014-03-14 US US14/213,784 patent/US20140271460A1/en not_active Abandoned
- 2014-03-14 CN CN201480027263.XA patent/CN105407723A/zh active Pending
- 2014-03-14 CA CA2906157A patent/CA2906157C/en active Active
-
2016
- 2016-07-01 US US15/201,286 patent/US20160310499A1/en not_active Abandoned
- 2016-09-18 HK HK16110954.5A patent/HK1222766A1/zh unknown
-
2017
- 2017-09-22 US US15/713,385 patent/US20180015096A1/en not_active Abandoned
-
2018
- 2018-10-29 JP JP2018202981A patent/JP6703583B2/ja active Active
- 2018-12-20 US US16/228,308 patent/US10709711B2/en active Active
-
2020
- 2020-05-08 JP JP2020082401A patent/JP2020128408A/ja active Pending
- 2020-07-10 US US16/926,035 patent/US20200345743A1/en not_active Abandoned
-
2022
- 2022-08-17 US US17/890,130 patent/US20230248733A1/en active Pending
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