MX338327B - Inhibidores de cdk. - Google Patents

Inhibidores de cdk.

Info

Publication number
MX338327B
MX338327B MX2013004681A MX2013004681A MX338327B MX 338327 B MX338327 B MX 338327B MX 2013004681 A MX2013004681 A MX 2013004681A MX 2013004681 A MX2013004681 A MX 2013004681A MX 338327 B MX338327 B MX 338327B
Authority
MX
Mexico
Prior art keywords
cdk inhibitors
cdk
inhibitors
formulae
iii
Prior art date
Application number
MX2013004681A
Other languages
English (en)
Other versions
MX2013004681A (es
Inventor
Francis X Tavares
Jay C Strum
Original Assignee
G1 Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46024778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX338327(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by G1 Therapeutics Inc filed Critical G1 Therapeutics Inc
Publication of MX2013004681A publication Critical patent/MX2013004681A/es
Publication of MX338327B publication Critical patent/MX338327B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se describen compuestos de las fórmulas I, II o III, y sales farmacéuticamente aceptables de los mismos, que son útiles como inhibidores de CDK.
MX2013004681A 2010-10-25 2011-10-25 Inhibidores de cdk. MX338327B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40649810P 2010-10-25 2010-10-25
PCT/US2011/057749 WO2012061156A1 (en) 2010-10-25 2011-10-25 Cdk inhibitors

Publications (2)

Publication Number Publication Date
MX2013004681A MX2013004681A (es) 2013-10-17
MX338327B true MX338327B (es) 2016-04-12

Family

ID=46024778

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2019010602A MX379532B (es) 2010-10-25 2011-10-25 Inhibidores de cdk.
MX2016004581A MX367795B (es) 2010-10-25 2011-10-25 Inhibidores de cdk.
MX2013004681A MX338327B (es) 2010-10-25 2011-10-25 Inhibidores de cdk.
MX2020005498A MX385616B (es) 2010-10-25 2011-10-25 Inhibidores de cdk

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2019010602A MX379532B (es) 2010-10-25 2011-10-25 Inhibidores de cdk.
MX2016004581A MX367795B (es) 2010-10-25 2011-10-25 Inhibidores de cdk.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020005498A MX385616B (es) 2010-10-25 2011-10-25 Inhibidores de cdk

Country Status (25)

Country Link
US (2) US8598197B2 (es)
EP (6) EP3381920B1 (es)
JP (4) JP5923509B2 (es)
KR (4) KR102186969B1 (es)
CN (5) CN104045654A (es)
AU (5) AU2011323739B2 (es)
BR (1) BR112013010018B1 (es)
CA (2) CA2961937C (es)
CY (1) CY1118004T1 (es)
DK (1) DK2632467T3 (es)
ES (1) ES2592515T3 (es)
HK (2) HK1197067A1 (es)
HR (1) HRP20161092T1 (es)
HU (1) HUE030714T2 (es)
IL (5) IL225940A0 (es)
LT (1) LT2632467T (es)
MX (4) MX379532B (es)
PL (1) PL2632467T3 (es)
PT (1) PT2632467T (es)
RS (1) RS55135B1 (es)
RU (1) RU2621674C2 (es)
SG (2) SG10201508715YA (es)
SI (1) SI2632467T1 (es)
SM (1) SMT201600311B (es)
WO (1) WO2012061156A1 (es)

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