JP2015078230A5 - - Google Patents
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- Publication number
- JP2015078230A5 JP2015078230A5 JP2015006124A JP2015006124A JP2015078230A5 JP 2015078230 A5 JP2015078230 A5 JP 2015078230A5 JP 2015006124 A JP2015006124 A JP 2015006124A JP 2015006124 A JP2015006124 A JP 2015006124A JP 2015078230 A5 JP2015078230 A5 JP 2015078230A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- following formula
- acceptable salt
- compound
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16881399P | 1999-12-03 | 1999-12-03 | |
| US60/168,813 | 1999-12-03 | ||
| US20571900P | 2000-05-19 | 2000-05-19 | |
| US60/205,719 | 2000-05-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011153911A Division JP2011246475A (ja) | 1999-12-03 | 2011-07-12 | ホスホネート化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015078230A JP2015078230A (ja) | 2015-04-23 |
| JP2015078230A5 true JP2015078230A5 (enExample) | 2015-12-24 |
| JP5963894B2 JP5963894B2 (ja) | 2016-08-03 |
Family
ID=26864475
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541459A Expired - Lifetime JP4993649B2 (ja) | 1999-12-03 | 2000-12-04 | ホスホネート化合物 |
| JP2011153911A Withdrawn JP2011246475A (ja) | 1999-12-03 | 2011-07-12 | ホスホネート化合物 |
| JP2014002881A Expired - Lifetime JP5963787B2 (ja) | 1999-12-03 | 2014-01-10 | ホスホネート化合物 |
| JP2015006124A Expired - Lifetime JP5963894B2 (ja) | 1999-12-03 | 2015-01-15 | ホスホネート化合物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541459A Expired - Lifetime JP4993649B2 (ja) | 1999-12-03 | 2000-12-04 | ホスホネート化合物 |
| JP2011153911A Withdrawn JP2011246475A (ja) | 1999-12-03 | 2011-07-12 | ホスホネート化合物 |
| JP2014002881A Expired - Lifetime JP5963787B2 (ja) | 1999-12-03 | 2014-01-10 | ホスホネート化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (14) | US6716825B2 (enExample) |
| EP (1) | EP1233770B1 (enExample) |
| JP (4) | JP4993649B2 (enExample) |
| KR (1) | KR20020073342A (enExample) |
| CN (1) | CN1414854B (enExample) |
| AT (1) | ATE385797T1 (enExample) |
| AU (3) | AU785355B2 (enExample) |
| BR (1) | BR0016058A (enExample) |
| CA (2) | CA2747954C (enExample) |
| CY (1) | CY1107927T1 (enExample) |
| DE (1) | DE60038038T2 (enExample) |
| DK (2) | DK1914237T3 (enExample) |
| ES (2) | ES2300281T3 (enExample) |
| HK (1) | HK1050627B (enExample) |
| MX (1) | MXPA02005490A (enExample) |
| PT (2) | PT1914237E (enExample) |
| RU (1) | RU2258707C2 (enExample) |
| WO (1) | WO2001039724A2 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| BR0016058A (pt) * | 1999-12-03 | 2003-07-15 | Univ California San Diego | Compostos de fosfonato |
| US7163932B2 (en) * | 2001-06-20 | 2007-01-16 | Merck Frosst Canada & Co. | Aryldifluoromethylphosphonic acids for treatment of diabetes |
| WO2003008425A1 (fr) * | 2001-07-16 | 2003-01-30 | Universite Paris 13 | Nouveaux derives de bisphosphonates, leurs preparations et utilisations |
| FR2837490B1 (fr) * | 2002-03-21 | 2009-04-17 | Univ Paris 13 | Nouveaux derives de bisphosphonates, leurs preparations et utilisations |
| EP1490024B1 (en) * | 2002-03-06 | 2012-01-18 | EffRx Pharmaceuticals SA | Effervescent compositions comprising alendronate |
| US7488496B2 (en) | 2002-03-06 | 2009-02-10 | Christer Rosen | Effervescent compositions comprising bisphosphonates and methods related thereto |
| WO2003090691A2 (en) * | 2002-04-26 | 2003-11-06 | Gilead Sciences, Inc. | Method and compositions for identifying anti-hiv therapeutic compounds |
| RU2309747C2 (ru) * | 2002-09-18 | 2007-11-10 | Михаил Владимирович Кутушов | Применение 2-хлорэтилфосфоновой кислоты и ее солей в качестве противоопухолевого средства |
| AU2003901813A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Pharmaceutical derivatives |
| CA2523083C (en) | 2003-04-25 | 2014-07-08 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| JP2006524710A (ja) | 2003-04-25 | 2006-11-02 | ギリアード サイエンシーズ, インコーポレイテッド | キナーゼインヒビターホスホネート抱合体 |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| US7273717B2 (en) | 2003-10-24 | 2007-09-25 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds with GS-9005 ester hydrolase B |
| WO2005044279A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
| JP4692283B2 (ja) * | 2003-12-12 | 2011-06-01 | アステラス製薬株式会社 | 悪性黒色腫治療剤 |
| JP2007515495A (ja) | 2003-12-22 | 2007-06-14 | ギリアード サイエンシーズ, インコーポレイテッド | 4’−置換カルボビル誘導体およびアバカビル誘導体ならびにhivおよびhcv抗ウイルス活性を有する関連化合物 |
| WO2005090370A1 (en) | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| WO2006076015A2 (en) * | 2004-04-30 | 2006-07-20 | The Regents Of The University Of California | 1-[2-(phosphonomethoxy)ethyl]-cytosine and analogs thereof |
| PL216369B1 (pl) | 2004-07-27 | 2014-03-31 | Gilead Sciences | Pochodne fosfonianowe, kompozycje farmaceutyczne zawierające te pochodne oraz zastosowanie tych pochodnych do wytwarzania leku do hamowania wirusa HIV |
| US7504389B2 (en) * | 2004-11-15 | 2009-03-17 | Ceptyr, Inc. | Protein tyrosine phosphatase inhibitors and methods of use thereof |
| EP1831235B1 (en) | 2004-12-16 | 2013-02-20 | The Regents of The University of California | Lung-targeted drugs |
| US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| US20060219637A1 (en) * | 2005-03-29 | 2006-10-05 | Killeen Kevin P | Devices, systems and methods for liquid chromatography |
| WO2006130217A2 (en) * | 2005-04-01 | 2006-12-07 | The Regents Of The University Of California | Substituted phosphate esters of nucleoside phosphonates |
| JP2008535862A (ja) * | 2005-04-08 | 2008-09-04 | キメリクス,インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| EP1865967A4 (en) * | 2005-04-08 | 2011-02-09 | Chimerix Inc | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS AND OTHER DISEASES |
| WO2006114064A2 (en) * | 2005-04-25 | 2006-11-02 | Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic | Use of compounds to enhance processivity of telomerase |
| US7914810B2 (en) * | 2005-05-06 | 2011-03-29 | Synthes Usa, Llc | Methods for the in situ treatment of bone cancer |
| US8114843B2 (en) * | 2005-11-18 | 2012-02-14 | The Regents Of The University Of California | Photoreactive regulator of protein function and methods of use thereof |
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| ES2609095T3 (es) * | 2007-04-27 | 2017-04-18 | Chimerix, Inc. | Métodos de reducción de la nefrotoxicidad en sujetos a quienes se administra nucleósido |
| JP2011508740A (ja) * | 2007-12-27 | 2011-03-17 | エピファニー バイオサイエンシズ, インク. | 抗ウイルス化合物 |
| AU2009206673B2 (en) * | 2008-01-25 | 2015-04-23 | Chimerix, Inc. | Methods of treating viral infections |
| JP5620376B2 (ja) | 2008-07-08 | 2014-11-05 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv阻害剤化合物の塩 |
| US8628812B2 (en) * | 2008-12-30 | 2014-01-14 | Pepsico, Inc. | Preservative system for acidic beverages based on sequestrants |
| EP2270021A1 (en) * | 2009-06-18 | 2011-01-05 | Centre National de la Recherche Scientifique | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
| WO2011005510A2 (en) * | 2009-06-22 | 2011-01-13 | Cerapedics, Inc. | Peptide conjugates and uses thereof |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| WO2011017253A1 (en) | 2009-08-03 | 2011-02-10 | Chimerix, Inc. | Composition and methods of treating viral infections and viral induced tumors |
| CN102639545B (zh) * | 2009-10-02 | 2016-08-03 | 施里特马克控股公司 | 制备氨基羟基二膦酸的方法 |
| EP3216789A1 (en) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Methods of treating viral infection |
| WO2011130557A2 (en) | 2010-04-14 | 2011-10-20 | The Regents Of The University Of California | Phosphonates with reduced toxicity for treatment of viral infections |
| CA2797601A1 (en) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
| AU2015201895B2 (en) * | 2010-08-31 | 2016-11-17 | Emergent Biodefence Operations Lansing Llc | Phosphonate ester derivatives and methods of synthesis thereof |
| AU2011295937B2 (en) * | 2010-08-31 | 2015-04-16 | Emergent Biodefence Operations Lansing Llc | Phosphonate ester derivatives and methods of synthesis thereof |
| US8884027B2 (en) | 2010-10-22 | 2014-11-11 | University Of Rochester | Melampomagnolide B derivatives as antileukemic and cytotoxic agents |
| US9216225B2 (en) * | 2011-08-31 | 2015-12-22 | Mallinckrodt Llc | Remote assembly of targeted nanoparticles using H-phosphate ENE/-YNE hydrophosphonylation reactions |
| WO2013095684A1 (en) | 2011-12-22 | 2013-06-27 | Geron Corporation | Guanine analogs as telomerase substrates and telomere length affectors |
| US20150209273A1 (en) * | 2012-08-28 | 2015-07-30 | Glaxosmithkline Llc | Pharmaceutical Compositions |
| CN107056838A (zh) * | 2013-03-15 | 2017-08-18 | 加利福尼亚大学董事会 | 无环核苷膦酸二酯 |
| CN105899215A (zh) | 2013-11-15 | 2016-08-24 | 奇默里克斯公司 | 十六烷氧基丙基膦酸酯的形态 |
| AU2015217221A1 (en) | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| BR112016020233B1 (pt) | 2014-03-14 | 2022-07-19 | Alltech Inc. | Composições de compostos seleno orgânicos e seus usos |
| JP2017520545A (ja) | 2014-07-02 | 2017-07-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | プロドラッグ化合物およびそれらの使用 |
| SG11201701957XA (en) | 2014-09-15 | 2017-04-27 | Univ California | Nucleotide analogs |
| US10160778B2 (en) | 2014-10-27 | 2018-12-25 | Concert Pharmaceuticals, Inc. | Pyrimidine phosphonic acid esters |
| GEAP202215528A (en) | 2015-03-06 | 2022-11-10 | Atea Pharmaceuticals Inc | B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT |
| CN108135863B (zh) * | 2015-04-27 | 2021-07-27 | 特拉维夫医疗中心医学研究基础设施和保健服务基金会 | 用于治疗炎性和过度增殖性病况的egr1靶向分子 |
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| WO2017048956A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Nucleotide analogs |
| ES3037596T3 (en) | 2016-06-28 | 2025-10-03 | Emergent Biodefense Operations Lansing Llc | Formulations of brincidofovir |
| RU2628456C1 (ru) * | 2016-06-29 | 2017-08-17 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Новые пиримидиновые ингибиторы репликации аденовируса человека |
| LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| BR112019004297A2 (pt) | 2016-09-07 | 2019-05-28 | Atea Pharmaceuticals Inc | método, uso de uma quantidade eficaz de um composto, composto, e, composição farmacêutica. |
| EP3661937B1 (en) | 2017-08-01 | 2021-07-28 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) for treating viral infections |
| RU2670204C1 (ru) * | 2017-12-01 | 2018-10-19 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Производные 2-тиоурацила, обладающие противоаденовирусной активностью |
| JP7076158B2 (ja) * | 2017-12-21 | 2022-05-27 | 深▲チェン▼市塔吉瑞生物医薬有限公司 | 新規抗ウイルス性ヌクレオシド系逆転写酵素阻害剤 |
| CA3087932A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
| EP4017499A4 (en) | 2019-08-22 | 2024-01-10 | Emory University | Nucleoside prodrugs and uses related thereto |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| EP4200301B1 (en) | 2020-08-24 | 2025-02-26 | Gilead Sciences, Inc. | Phospholipid compounds and uses thereof |
| TWI811812B (zh) | 2020-10-16 | 2023-08-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| CN117285566A (zh) * | 2022-06-24 | 2023-12-26 | 润佳(苏州)医药科技有限公司 | 一种膦酸酯类化合物及其医药用途 |
| KR20250052378A (ko) | 2022-07-21 | 2025-04-18 | 안티바 바이오사이언시즈, 인크. | Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US1944530A (en) | 1929-04-08 | 1934-01-23 | Ig Farbenindustrie Ag | Phosphoric acid esters |
| DE2009341C3 (de) | 1970-02-27 | 1979-06-21 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung |
| US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| FR2586685B1 (fr) * | 1985-09-03 | 1987-12-11 | Protex Manuf Prod Chimiq | Procede de preparation de nouveaux agents dispersants cationiques |
| SU1594953A1 (ru) * | 1988-12-30 | 1991-05-15 | Институт Молекулярной Биологии Им.В.А.Энгельгардта | Аммонийна соль 9-(4-гидрофосфорил-2-оксабутил)гуанина, обладающа избирательной активностью против вируса простого герпеса |
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| IL134619A0 (en) * | 1997-08-18 | 2001-04-30 | Univ Kingston | Phosphono-carboxylate compounds for treating amyloidosis |
| FR2781228B1 (fr) * | 1998-07-16 | 2000-09-29 | Pf Medicament | Phosphonates insatures derives d'indole |
| BR0016058A (pt) * | 1999-12-03 | 2003-07-15 | Univ California San Diego | Compostos de fosfonato |
-
2000
- 2000-12-04 BR BR0016058-0A patent/BR0016058A/pt not_active Application Discontinuation
- 2000-12-04 PT PT80014087T patent/PT1914237E/pt unknown
- 2000-12-04 CA CA2747954A patent/CA2747954C/en not_active Expired - Lifetime
- 2000-12-04 CA CA2393410A patent/CA2393410C/en not_active Expired - Lifetime
- 2000-12-04 AT AT00982468T patent/ATE385797T1/de active
- 2000-12-04 EP EP00982468A patent/EP1233770B1/en not_active Expired - Lifetime
- 2000-12-04 RU RU2002118327/04A patent/RU2258707C2/ru active
- 2000-12-04 ES ES00982468T patent/ES2300281T3/es not_active Expired - Lifetime
- 2000-12-04 US US10/148,374 patent/US6716825B2/en not_active Expired - Lifetime
- 2000-12-04 DK DK08001408.7T patent/DK1914237T3/da active
- 2000-12-04 JP JP2001541459A patent/JP4993649B2/ja not_active Expired - Lifetime
- 2000-12-04 DK DK00982468T patent/DK1233770T3/da active
- 2000-12-04 PT PT00982468T patent/PT1233770E/pt unknown
- 2000-12-04 DE DE60038038T patent/DE60038038T2/de not_active Expired - Lifetime
- 2000-12-04 ES ES08001408.7T patent/ES2498046T3/es not_active Expired - Lifetime
- 2000-12-04 HK HK03101480.2A patent/HK1050627B/en not_active IP Right Cessation
- 2000-12-04 WO PCT/US2000/033079 patent/WO2001039724A2/en not_active Ceased
- 2000-12-04 KR KR1020027007074A patent/KR20020073342A/ko not_active Ceased
- 2000-12-04 CN CN00818111.XA patent/CN1414854B/zh not_active Expired - Lifetime
- 2000-12-04 MX MXPA02005490A patent/MXPA02005490A/es active IP Right Grant
- 2000-12-04 AU AU19497/01A patent/AU785355B2/en not_active Ceased
-
2004
- 2004-01-15 US US10/759,345 patent/US7034014B2/en not_active Expired - Lifetime
-
2005
- 2005-04-06 US US11/100,882 patent/US7094772B2/en not_active Expired - Lifetime
- 2005-04-06 US US11/101,259 patent/US7098197B2/en not_active Expired - Lifetime
-
2006
- 2006-08-17 US US11/506,292 patent/US7452898B2/en not_active Expired - Lifetime
- 2006-12-15 AU AU2006252074A patent/AU2006252074B2/en not_active Ceased
-
2007
- 2007-03-07 US US11/715,604 patent/US7790703B2/en not_active Expired - Fee Related
- 2007-10-26 US US11/925,309 patent/US7687480B2/en not_active Expired - Fee Related
-
2008
- 2008-04-30 CY CY20081100465T patent/CY1107927T1/el unknown
-
2010
- 2010-02-05 US US12/701,410 patent/US8008308B2/en not_active Expired - Fee Related
- 2010-12-20 AU AU2010257309A patent/AU2010257309B2/en not_active Ceased
-
2011
- 2011-07-12 JP JP2011153911A patent/JP2011246475A/ja not_active Withdrawn
- 2011-08-29 US US13/220,548 patent/US8309565B2/en not_active Expired - Fee Related
-
2012
- 2012-10-04 US US13/645,105 patent/US8710030B2/en not_active Expired - Fee Related
-
2013
- 2013-10-21 US US14/059,365 patent/US8889658B2/en not_active Expired - Fee Related
-
2014
- 2014-01-10 JP JP2014002881A patent/JP5963787B2/ja not_active Expired - Lifetime
- 2014-10-29 US US14/527,156 patent/US9206208B2/en not_active Expired - Fee Related
-
2015
- 2015-01-15 JP JP2015006124A patent/JP5963894B2/ja not_active Expired - Lifetime
- 2015-11-16 US US14/942,926 patent/US9649321B2/en not_active Expired - Fee Related
-
2017
- 2017-05-15 US US15/595,496 patent/US10071110B2/en not_active Expired - Fee Related
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