JP2015504081A5 - - Google Patents
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- Publication number
- JP2015504081A5 JP2015504081A5 JP2014552655A JP2014552655A JP2015504081A5 JP 2015504081 A5 JP2015504081 A5 JP 2015504081A5 JP 2014552655 A JP2014552655 A JP 2014552655A JP 2014552655 A JP2014552655 A JP 2014552655A JP 2015504081 A5 JP2015504081 A5 JP 2015504081A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- different
- phenyl
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 48
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 150000002367 halogens Chemical class 0.000 claims 18
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 15
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 12
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 11
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12152193.4 | 2012-01-23 | ||
| EP12152193 | 2012-01-23 | ||
| PCT/EP2013/051097 WO2013110585A1 (en) | 2012-01-23 | 2013-01-22 | 5, 8 -dihydro- 6h- pyrazolo [3, 4 -h] quinazolines as igf-lr/lr inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504081A JP2015504081A (ja) | 2015-02-05 |
| JP2015504081A5 true JP2015504081A5 (enExample) | 2016-03-10 |
| JP6128133B2 JP6128133B2 (ja) | 2017-05-17 |
Family
ID=47605520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014552655A Active JP6128133B2 (ja) | 2012-01-23 | 2013-01-22 | Ｉｇｆ−１ｒ／ｉｒ阻害剤としての５，８−ジヒドロ−６ｈ−ピラゾロ［３，４−ｈ］キナゾリン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9150578B2 (enExample) |
| EP (1) | EP2807166B1 (enExample) |
| JP (1) | JP6128133B2 (enExample) |
| AR (1) | AR089776A1 (enExample) |
| TW (1) | TW201343648A (enExample) |
| UY (1) | UY34586A (enExample) |
| WO (1) | WO2013110585A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106795154B (zh) * | 2014-09-02 | 2019-07-05 | 皮埃尔法布雷医药公司 | 用于治疗癌症的异喹啉酮衍生物 |
| WO2016180843A1 (en) * | 2015-05-13 | 2016-11-17 | Boehringer Ingelheim International Gmbh | New 5,8-dimethyl-9-phenyl-5,8-dihydro-6h-pyrazolo[3,4-h]quinazolin-2- yl)-(1 h-pyrazol-3-yl)-amines and derivatives as igf-1 r/ir inhibitors |
| JP7233743B2 (ja) * | 2017-08-11 | 2023-03-07 | 晟科薬業（江蘇）有限公司 | プロテインキナーゼ阻害剤としての１ｈ－ピラゾロ［４，３－ｈ］キナゾリン系化合物 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| CN116348458A (zh) | 2019-08-14 | 2023-06-27 | 因赛特公司 | 作为cdk2抑制剂的咪唑基嘧啶基胺化合物 |
| CA3152740A1 (en) | 2019-08-28 | 2021-03-04 | Horizon Therapeutics Ireland Dac | Methods for the treatment of thyroid eye disease |
| CN119930611A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| CA3243695A1 (en) * | 2022-02-04 | 2023-08-10 | Retune Pharma Inc. | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND PROCESSES |
| WO2024153237A1 (zh) * | 2023-01-19 | 2024-07-25 | 北京普祺医药科技股份有限公司 | 一种igf-1r酪氨酸激酶抑制剂、药物组合物及其用途 |
| CN120569391A (zh) * | 2023-01-19 | 2025-08-29 | 北京普祺医药科技股份有限公司 | 一种吡唑并环类化合物、药物组合物及其用途 |
| CN116473073A (zh) * | 2023-05-08 | 2023-07-25 | 广东方中高新材料有限公司 | 一种含镓配合物的吡唑醚菌酯增效悬浮制剂及其制备方法 |
| CN116473077B (zh) * | 2023-05-08 | 2025-04-11 | 广东方中高新材料有限公司 | 一种n,n配位的镓配合物抗菌剂的合成和应用 |
| CN116458513A (zh) * | 2023-05-08 | 2023-07-21 | 广东方中高新材料有限公司 | 一种含镓配合物的咪鲜胺增效水乳制剂及其制备方法 |
| TW202509078A (zh) | 2023-07-07 | 2025-03-01 | 美商維里迪恩醫療股份有限公司 | 治療慢性甲狀腺眼病之方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60232510D1 (de) | 2001-06-15 | 2009-07-16 | Vertex Pharma | 5-(2-aminopyrimidin-4-yl)benzisoxazole als proteinkinasehemmer |
| US7348335B2 (en) | 2002-11-05 | 2008-03-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
| EA010904B1 (ru) | 2003-05-22 | 2008-12-30 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ |
| US20050075358A1 (en) | 2003-10-06 | 2005-04-07 | Carboni Joan M. | Methods for treating IGF1R-inhibitor induced hyperglycemia |
| CN1897950A (zh) * | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| JP5241704B2 (ja) * | 2006-05-11 | 2013-07-17 | アイアールエム・リミテッド・ライアビリティ・カンパニー | プロテインキナーゼ阻害剤としての化合物および組成物 |
| US8735386B2 (en) | 2010-07-23 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Aminopyrazoloquinazolines |
-
2013
- 2013-01-22 WO PCT/EP2013/051097 patent/WO2013110585A1/en not_active Ceased
- 2013-01-22 TW TW102102378A patent/TW201343648A/zh unknown
- 2013-01-22 EP EP13701426.2A patent/EP2807166B1/en active Active
- 2013-01-22 US US13/746,411 patent/US9150578B2/en active Active
- 2013-01-22 JP JP2014552655A patent/JP6128133B2/ja active Active
- 2013-01-22 AR ARP130100189A patent/AR089776A1/es unknown
- 2013-01-23 UY UY0001034586A patent/UY34586A/es unknown
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