JP2014507446A5 - - Google Patents

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Publication number
JP2014507446A5
JP2014507446A5 JP2013555647A JP2013555647A JP2014507446A5 JP 2014507446 A5 JP2014507446 A5 JP 2014507446A5 JP 2013555647 A JP2013555647 A JP 2013555647A JP 2013555647 A JP2013555647 A JP 2013555647A JP 2014507446 A5 JP2014507446 A5 JP 2014507446A5
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JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
following
compound
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013555647A
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English (en)
Japanese (ja)
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JP2014507446A (ja
JP5635708B2 (ja
Filing date
Publication date
Priority claimed from US13/478,361 external-priority patent/US8426450B1/en
Application filed filed Critical
Publication of JP2014507446A publication Critical patent/JP2014507446A/ja
Publication of JP2014507446A5 publication Critical patent/JP2014507446A5/ja
Application granted granted Critical
Publication of JP5635708B2 publication Critical patent/JP5635708B2/ja
Active legal-status Critical Current
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JP2013555647A 2011-11-29 2012-11-28 Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン Active JP5635708B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161564537P 2011-11-29 2011-11-29
US61/564,537 2011-11-29
US13/478,361 2012-05-23
US13/478,361 US8426450B1 (en) 2011-11-29 2012-05-23 Substituted 4-phenyl pyridines having anti-emetic effect
PCT/US2012/066778 WO2013082102A1 (en) 2011-11-29 2012-11-28 Substituted 4 - phenyl - pyridines for the treatment of nk-1 receptor related diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014210716A Division JP6023146B2 (ja) 2011-11-29 2014-10-15 Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン

Publications (3)

Publication Number Publication Date
JP2014507446A JP2014507446A (ja) 2014-03-27
JP2014507446A5 true JP2014507446A5 (enExample) 2014-06-19
JP5635708B2 JP5635708B2 (ja) 2014-12-03

Family

ID=48094815

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2013555647A Active JP5635708B2 (ja) 2011-11-29 2012-11-28 Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン
JP2014210716A Active JP6023146B2 (ja) 2011-11-29 2014-10-15 Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン
JP2016034427A Active JP6074083B2 (ja) 2011-11-29 2016-02-25 Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014210716A Active JP6023146B2 (ja) 2011-11-29 2014-10-15 Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン
JP2016034427A Active JP6074083B2 (ja) 2011-11-29 2016-02-25 Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン

Country Status (50)

Country Link
US (7) US8426450B1 (enExample)
EP (1) EP2785706B1 (enExample)
JP (3) JP5635708B2 (enExample)
KR (1) KR101979050B1 (enExample)
CN (6) CN106518924B (enExample)
AP (1) AP2014007729A0 (enExample)
AR (1) AR089019A1 (enExample)
AU (1) AU2012346133B2 (enExample)
BR (1) BR112014012878B1 (enExample)
CA (1) CA2850644C (enExample)
CL (1) CL2014001280A1 (enExample)
CO (1) CO6990728A2 (enExample)
CR (1) CR20140312A (enExample)
CY (2) CY1118416T1 (enExample)
DK (1) DK2785706T3 (enExample)
DO (1) DOP2014000115A (enExample)
EA (1) EA026553B1 (enExample)
EC (1) ECSP14003642A (enExample)
ES (1) ES2603958T3 (enExample)
FI (1) FIC20200022I1 (enExample)
FR (1) FR20C1029I2 (enExample)
GE (1) GEP201706695B (enExample)
GT (1) GT201400102A (enExample)
HR (1) HRP20161708T1 (enExample)
HU (2) HUE032288T2 (enExample)
IL (1) IL232859B (enExample)
IN (1) IN2014CN04907A (enExample)
JO (1) JO3202B1 (enExample)
LT (2) LT2785706T (enExample)
MA (1) MA35836B1 (enExample)
MD (1) MD4539C1 (enExample)
ME (1) ME02561B (enExample)
MX (1) MX2014006423A (enExample)
MY (1) MY165514A (enExample)
NI (1) NI201400043A (enExample)
NL (1) NL301047I2 (enExample)
PE (1) PE20141421A1 (enExample)
PH (1) PH12014501199A1 (enExample)
PL (1) PL2785706T3 (enExample)
PT (1) PT2785706T (enExample)
RS (1) RS55448B1 (enExample)
SG (1) SG11201402044XA (enExample)
SI (1) SI2785706T1 (enExample)
SM (2) SMT201600467T1 (enExample)
TN (1) TN2014000165A1 (enExample)
TW (1) TWI638806B (enExample)
UA (1) UA115136C2 (enExample)
UY (1) UY34472A (enExample)
WO (1) WO2013082102A1 (enExample)
ZA (1) ZA201404787B (enExample)

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AU2012273652B2 (en) 2011-06-22 2015-09-03 Purdue Pharma L.P. TRPV1 antagonists including dihydroxy substituent and uses thereof
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
WO2015068744A1 (ja) 2013-11-08 2015-05-14 キッセイ薬品工業株式会社 カルボキシメチルピペリジン誘導体
WO2015171489A1 (en) * 2014-05-05 2015-11-12 Apicore Us Llc Methods of making netupitant and intermediates thereof
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
TW201613888A (en) * 2014-09-26 2016-04-16 Helsinn Healthcare Sa Crystalline forms of an NK-1 antagonist
TW202140422A (zh) 2014-10-06 2021-11-01 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
CN105061303A (zh) * 2015-08-03 2015-11-18 成都欣捷高新技术开发有限公司 一种制备奈妥吡坦关键中间体n-甲基-4-(2-甲基苯基)-6-(4-甲基-1-哌嗪基)-3-吡啶胺的新方法
US10005803B2 (en) 2015-10-06 2018-06-26 Helsinn Healthcare Sa Crystalline forms of fosnetupitant
CN106892864A (zh) * 2015-12-21 2017-06-27 上海科胜药物研发有限公司 一种奈妥皮坦游离碱的晶型a及其制备方法
EP3436446B1 (en) 2016-03-31 2023-06-07 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EA036605B1 (ru) * 2016-06-06 2020-11-27 Хелсинн Хелскеа Са Физиологически сбалансированный состав для инъекций, включающий фоснетупитант
JOP20190042B1 (ar) 2016-09-30 2021-08-17 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
HRP20201946T1 (hr) 2016-12-09 2021-01-22 Vertex Pharmaceuticals Incorporated Modulator regulatora transmembranske provodljivosti cistične fibroze, farmaceutski sastavi, postupci liječenja, i postupak za dobivanje modulatora
CN108619525B (zh) * 2017-03-15 2020-12-29 和龙 奈妥吡坦-mPEG-PLA纳米粒及其制备方法和用途
MA54105A (fr) 2017-06-08 2021-09-15 Vertex Pharma Méthodes de traitement de la fibrose kystique
EA202090180A1 (ru) 2017-06-30 2020-05-26 Чейс Терапьютикс Корпорейшн Композиции nk1-антагониста и способы лечения депрессии
BR112020000941A2 (pt) 2017-07-17 2020-07-21 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
WO2019028228A1 (en) 2017-08-02 2019-02-07 Vertex Pharmaceuticals Incorporated PROCESSES FOR THE PREPARATION OF PYRROLIDINE COMPOUNDS
CN107698500A (zh) * 2017-10-17 2018-02-16 扬子江药业集团四川海蓉药业有限公司 一种奈妥匹坦的制备方法
WO2019079760A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS
AU2018380426B2 (en) 2017-12-08 2023-05-18 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
EP3737378B1 (en) * 2018-01-12 2023-04-19 Orion Corporation Palonosetron eye drops for the treatment or prevention of nausea and vomiting
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
WO2019200246A1 (en) 2018-04-13 2019-10-17 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
JP7156154B2 (ja) * 2019-04-18 2022-10-19 株式会社島津製作所 培地処理システム及び培地処理方法
CN112174881B (zh) * 2019-07-04 2022-06-21 上海森辉医药有限公司 一种奈妥匹坦的衍生物及其制备方法
CN112778370B (zh) * 2019-11-06 2025-09-26 扬子江药业集团江苏海慈生物药业有限公司 一种制备福奈妥匹坦的方法
BR112022018876A2 (pt) 2020-04-03 2022-11-22 Nerre Therapeutics Ltd Antagonista de receptor de nk-1 para tratar uma doença selecionada a partir de sepse, choque séptico, síndrome de desconforto respiratório agudo (ards) ou síndrome de disfunção múltipla dos órgãos
IL298589A (en) 2020-06-02 2023-01-01 Nerre Therapeutics Ltd Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs
US12097197B2 (en) 2021-12-21 2024-09-24 Slayback Pharma Llc Stable liquid compositions of netupitant and palonosetron
WO2025036703A1 (en) 2023-08-13 2025-02-20 Helsinn Healthcare Sa Fosnetupitant for administration via intravenous bolus

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