JP2015528502A5 - - Google Patents

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Publication number
JP2015528502A5
JP2015528502A5 JP2015532025A JP2015532025A JP2015528502A5 JP 2015528502 A5 JP2015528502 A5 JP 2015528502A5 JP 2015532025 A JP2015532025 A JP 2015532025A JP 2015532025 A JP2015532025 A JP 2015532025A JP 2015528502 A5 JP2015528502 A5 JP 2015528502A5
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JP
Japan
Prior art keywords
compound
pharmaceutical composition
effective amount
bacterial infections
treating bacterial
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Application number
JP2015532025A
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English (en)
Japanese (ja)
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JP2015528502A (ja
JP6460991B2 (ja
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Priority claimed from PCT/US2013/059310 external-priority patent/WO2014043272A1/en
Publication of JP2015528502A publication Critical patent/JP2015528502A/ja
Publication of JP2015528502A5 publication Critical patent/JP2015528502A5/ja
Application granted granted Critical
Publication of JP6460991B2 publication Critical patent/JP6460991B2/ja
Active legal-status Critical Current
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JP2015532025A 2012-09-12 2013-09-11 抗菌剤として使用するための三環式ジャイレース阻害剤 Active JP6460991B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261700159P 2012-09-12 2012-09-12
US61/700,159 2012-09-12
PCT/US2013/059310 WO2014043272A1 (en) 2012-09-12 2013-09-11 Tricyclic gyrase inhibitors for use as antibacterial agents

Publications (3)

Publication Number Publication Date
JP2015528502A JP2015528502A (ja) 2015-09-28
JP2015528502A5 true JP2015528502A5 (enExample) 2016-11-04
JP6460991B2 JP6460991B2 (ja) 2019-01-30

Family

ID=49226575

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015532025A Active JP6460991B2 (ja) 2012-09-12 2013-09-11 抗菌剤として使用するための三環式ジャイレース阻害剤

Country Status (7)

Country Link
US (1) US10865216B2 (enExample)
EP (1) EP2895488B1 (enExample)
JP (1) JP6460991B2 (enExample)
CN (1) CN105189505B (enExample)
AR (1) AR092538A1 (enExample)
TW (1) TWI639602B (enExample)
WO (1) WO2014043272A1 (enExample)

Families Citing this family (28)

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Publication number Priority date Publication date Assignee Title
JP5927201B2 (ja) 2010-12-16 2016-06-01 カルチャン リミテッド Ａｓｋ１阻害ピロロピリミジン誘導体
PH12013501800A1 (en) * 2011-03-15 2013-10-14 L Livermore Nat Security Llc Tricyclic gyrase inhibitors
CN105899511B (zh) * 2013-09-11 2019-06-07 默沙东公司 三环促旋酶抑制剂
WO2016067009A1 (en) * 2014-10-28 2016-05-06 Redx Pharma Plc Compounds with activity against bacteria and mycobacteria
CA3024273A1 (en) 2016-06-01 2017-12-07 Universite De Montreal Selection of human hematopoetic stem cells using epcr
CN106588731B (zh) * 2016-12-08 2018-06-29 河北桑迪亚医药技术有限责任公司 环丙基二苯基锍三氟甲磺酸盐的合成方法
US20210070747A1 (en) 2017-03-24 2021-03-11 Taisho Pharmaceutical Co., Ltd. 2(1h)-quinolinone derivative
CN110475777B (zh) 2017-03-30 2022-04-15 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物
HUE059057T2 (hu) 2017-05-04 2022-10-28 Bayer Cropscience Ag 2-{[2-(feniloximetil)piridin-5-il]oxi}-etánamin-származékok és rokon vegyületek mint peszticidek, például növényvédelemre
US11542248B2 (en) * 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
TW201920170A (zh) 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法
CN112135618A (zh) 2018-02-20 2020-12-25 蒙特利尔大学 体内介导免疫应答的nk和dc细胞的扩增
EP3856747B1 (en) * 2018-09-26 2023-07-19 F. Hoffmann-La Roche AG Substituted pyridoindoles for the treatment and prophylaxis of bacterial infection
TWI831855B (zh) 2018-10-26 2024-02-11 日商大鵬藥品工業股份有限公司 新穎吲唑化合物或其鹽
JP7531492B2 (ja) * 2018-12-20 2024-08-09 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の処置および予防のためのオキソピリド［１，２－ａ］ピリミジン化合物
WO2020225077A1 (en) * 2019-05-03 2020-11-12 Idorsia Pharmaceuticals Ltd Pyrimido[4,5-b]indol derivatives as pdhk1 inhibitors
CA3158793A1 (en) 2019-10-28 2021-05-06 Merck Sharp & Dohme Corp. Small molecule inhibitors of kras g12c mutant
WO2021106230A1 (ja) 2019-11-29 2021-06-03 大鵬薬品工業株式会社 新規なフェノール化合物又はその塩
CN115335043B (zh) 2020-01-23 2025-03-28 迈欧伏特治疗公司 Pgdh抑制剂以及制备和使用方法
CN112574085A (zh) * 2020-12-18 2021-03-30 南通药明康德医药科技有限公司 一种5-氨基-2-氮杂螺[3.4]辛烷-2-羧酸叔丁酯的制备方法
CN112552222B (zh) * 2020-12-18 2022-08-23 南通药明康德医药科技有限公司 一种2-(2-(叔-丁氧羰基)-2-氮杂螺[3.4]辛烷-5-基)乙酸的制备方法
CN114763357B (zh) * 2021-01-15 2024-06-18 中国科学院上海药物研究所 吲哚并嘧啶三环类化合物及其制备方法和用途
CN113372352B (zh) * 2021-06-10 2022-08-26 青岛农业大学 吲哚3,4位并九元中环化合物及其制备方法
WO2024064726A1 (en) * 2022-09-21 2024-03-28 Bristol-Myers Squibb Company Process for the preparation of tert-butyl (2-azabicyclo[2.2.1]heptan-4-yl)carbamate and related compounds
WO2024103010A1 (en) * 2022-11-11 2024-05-16 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
WO2024233776A1 (en) * 2023-05-09 2024-11-14 Merck Sharp & Dohme Llc Small molecule inhibitors of kras g12d mutant
WO2025085748A1 (en) 2023-10-20 2025-04-24 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
WO2025240742A1 (en) * 2024-05-15 2025-11-20 Merck Sharp & Dohme Llc Protein degraders of kras g12d mutant

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IN157280B (enExample) 1983-07-15 1986-02-22 Hoechst India
DE4030059A1 (de) 1990-09-22 1992-03-26 Bayer Ag Verfahren zur herstellung von 5-hydroxy-3,4,5,6-tetrahydro-pyrimidin-derivaten
DE4032560A1 (de) 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
US5279359A (en) 1992-06-26 1994-01-18 Erickson Donald C Rotary trisorption heat pump
US5527910A (en) 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
YU55902A (sh) 2000-01-24 2006-01-16 Warner-Lambert Company 3-aminohinazolin-2,4-dioni kao antibakterijska sredstva
US20090099165A1 (en) 2003-10-14 2009-04-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
US20090143399A1 (en) 2003-10-14 2009-06-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
ES2344007T3 (es) * 2003-10-14 2010-08-16 The Arizona Board Of Regents On Behalf Of The University Of Arizona Inhibidores proteina quinasa.
US20080051414A1 (en) 2003-10-14 2008-02-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
US7776855B2 (en) 2006-07-27 2010-08-17 Janssen Pharmaceutica N.V. Antimicrobial oxazolidinone prodrugs
WO2011032050A2 (en) * 2009-09-11 2011-03-17 Trius Therapeutics, Inc. Gyrase inhibitors
PH12013501800A1 (en) * 2011-03-15 2013-10-14 L Livermore Nat Security Llc Tricyclic gyrase inhibitors
CN105899511B (zh) * 2013-09-11 2019-06-07 默沙东公司 三环促旋酶抑制剂

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