JP2015528502A5 - - Google Patents

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Publication number
JP2015528502A5
JP2015528502A5 JP2015532025A JP2015532025A JP2015528502A5 JP 2015528502 A5 JP2015528502 A5 JP 2015528502A5 JP 2015532025 A JP2015532025 A JP 2015532025A JP 2015532025 A JP2015532025 A JP 2015532025A JP 2015528502 A5 JP2015528502 A5 JP 2015528502A5
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JP
Japan
Prior art keywords
compound
pharmaceutical composition
effective amount
bacterial infections
treating bacterial
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Application number
JP2015532025A
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English (en)
Japanese (ja)
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JP6460991B2 (ja
JP2015528502A (ja
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Publication date
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Priority claimed from PCT/US2013/059310 external-priority patent/WO2014043272A1/en
Publication of JP2015528502A publication Critical patent/JP2015528502A/ja
Publication of JP2015528502A5 publication Critical patent/JP2015528502A5/ja
Application granted granted Critical
Publication of JP6460991B2 publication Critical patent/JP6460991B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2015532025A 2012-09-12 2013-09-11 抗菌剤として使用するための三環式ジャイレース阻害剤 Active JP6460991B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261700159P 2012-09-12 2012-09-12
US61/700,159 2012-09-12
PCT/US2013/059310 WO2014043272A1 (en) 2012-09-12 2013-09-11 Tricyclic gyrase inhibitors for use as antibacterial agents

Publications (3)

Publication Number Publication Date
JP2015528502A JP2015528502A (ja) 2015-09-28
JP2015528502A5 true JP2015528502A5 (enExample) 2016-11-04
JP6460991B2 JP6460991B2 (ja) 2019-01-30

Family

ID=49226575

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015532025A Active JP6460991B2 (ja) 2012-09-12 2013-09-11 抗菌剤として使用するための三環式ジャイレース阻害剤

Country Status (7)

Country Link
US (1) US10865216B2 (enExample)
EP (1) EP2895488B1 (enExample)
JP (1) JP6460991B2 (enExample)
CN (1) CN105189505B (enExample)
AR (1) AR092538A1 (enExample)
TW (1) TWI639602B (enExample)
WO (1) WO2014043272A1 (enExample)

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EP2651417B1 (en) 2010-12-16 2016-11-30 Calchan Limited Ask1 inhibiting pyrrolopyrimidine derivatives
AR085806A1 (es) * 2011-03-15 2013-10-30 Trius Therapeutics Inc Inhibidores triciclicos de girasa
EP4545530A1 (en) 2013-09-11 2025-04-30 Merck Sharp & Dohme LLC Tricyclic gyrase inhibitors
WO2016067009A1 (en) * 2014-10-28 2016-05-06 Redx Pharma Plc Compounds with activity against bacteria and mycobacteria
CA3024273A1 (en) 2016-06-01 2017-12-07 Universite De Montreal Selection of human hematopoetic stem cells using epcr
CN106588731B (zh) * 2016-12-08 2018-06-29 河北桑迪亚医药技术有限责任公司 环丙基二苯基锍三氟甲磺酸盐的合成方法
AU2018239711A1 (en) 2017-03-24 2019-11-07 Taisho Pharmaceutical Co., Ltd. 2(1h)-quinolinone derivative
WO2018178041A1 (en) 2017-03-30 2018-10-04 F. Hoffmann-La Roche Ag Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
PL3619196T3 (pl) 2017-05-04 2022-08-29 Bayer Cropscience Aktiengesellschaft Pochodne 2-{[2-(fenyloksymetylo)pirydyn-5-yl]oksy}-etanoaminy i związki pokrewne jako środki do zwalczania szkodników np. do ochrony upraw
US11542248B2 (en) * 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE
EP3755355A4 (en) 2018-02-20 2022-01-05 Universite De Montreal Expansion of nk and dc cells in vivo mediating immune response
JP7443351B2 (ja) * 2018-09-26 2024-03-05 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の治療及び予防のための、置換ピリドインドール
TWI831855B (zh) 2018-10-26 2024-02-11 日商大鵬藥品工業股份有限公司 新穎吲唑化合物或其鹽
CN113195503A (zh) * 2018-12-20 2021-07-30 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的氧代吡啶并[1,2-a]嘧啶化合物
WO2020225077A1 (en) * 2019-05-03 2020-11-12 Idorsia Pharmaceuticals Ltd Pyrimido[4,5-b]indol derivatives as pdhk1 inhibitors
PH12022551027A1 (en) 2019-10-28 2023-05-29 Merck Sharp & Dohme Llc Small molecule inhibitors of kras g12c mutant
WO2021106230A1 (ja) 2019-11-29 2021-06-03 大鵬薬品工業株式会社 新規なフェノール化合物又はその塩
CN112574085A (zh) * 2020-12-18 2021-03-30 南通药明康德医药科技有限公司 一种5-氨基-2-氮杂螺[3.4]辛烷-2-羧酸叔丁酯的制备方法
CN112552222B (zh) * 2020-12-18 2022-08-23 南通药明康德医药科技有限公司 一种2-(2-(叔-丁氧羰基)-2-氮杂螺[3.4]辛烷-5-基)乙酸的制备方法
CN114763357B (zh) * 2021-01-15 2024-06-18 中国科学院上海药物研究所 吲哚并嘧啶三环类化合物及其制备方法和用途
CN113372352B (zh) * 2021-06-10 2022-08-26 青岛农业大学 吲哚3,4位并九元中环化合物及其制备方法
CA3264754A1 (en) * 2022-09-21 2024-03-28 Bristol-Myers Squibb Company PROCESS FOR THE PREPARATION OF TERT-BUTYL(2-AZABICYCLO[2.2.1]HEPTAN-4-YL)CARBAMATE AND ASSOCIATED COMPOUNDS
EP4615847A1 (en) * 2022-11-11 2025-09-17 Merck Sharp & Dohme LLC Small molecule inhibitors of kras proteins
WO2024233776A1 (en) * 2023-05-09 2024-11-14 Merck Sharp & Dohme Llc Small molecule inhibitors of kras g12d mutant
TW202535891A (zh) 2023-10-20 2025-09-16 美商默沙東有限責任公司 Ｋｒａｓ蛋白之小分子抑制劑
WO2025240742A1 (en) * 2024-05-15 2025-11-20 Merck Sharp & Dohme Llc Protein degraders of kras g12d mutant

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DE4030059A1 (de) 1990-09-22 1992-03-26 Bayer Ag Verfahren zur herstellung von 5-hydroxy-3,4,5,6-tetrahydro-pyrimidin-derivaten
DE4032560A1 (de) 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
US5279359A (en) 1992-06-26 1994-01-18 Erickson Donald C Rotary trisorption heat pump
US5527910A (en) 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
AP2002002603A0 (en) 2000-01-24 2002-09-30 Warner Lambert Co 3-aminoquinazolin-2,4-dione antibacterial agents.
US20090143399A1 (en) 2003-10-14 2009-06-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
US20090099165A1 (en) 2003-10-14 2009-04-16 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
DK1678166T3 (da) 2003-10-14 2009-11-09 Univ Arizona State Proteinkinaseinhibitorer
US20080051414A1 (en) 2003-10-14 2008-02-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Protein Kinase Inhibitors
US7776855B2 (en) 2006-07-27 2010-08-17 Janssen Pharmaceutica N.V. Antimicrobial oxazolidinone prodrugs
EP2475666A2 (en) * 2009-09-11 2012-07-18 Trius Therapeutics, Inc. Gyrase inhibitors
AR085806A1 (es) * 2011-03-15 2013-10-30 Trius Therapeutics Inc Inhibidores triciclicos de girasa
EP4545530A1 (en) * 2013-09-11 2025-04-30 Merck Sharp & Dohme LLC Tricyclic gyrase inhibitors

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