JP2015528502A5 - - Google Patents
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- Publication number
- JP2015528502A5 JP2015528502A5 JP2015532025A JP2015532025A JP2015528502A5 JP 2015528502 A5 JP2015528502 A5 JP 2015528502A5 JP 2015532025 A JP2015532025 A JP 2015532025A JP 2015532025 A JP2015532025 A JP 2015532025A JP 2015528502 A5 JP2015528502 A5 JP 2015528502A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- effective amount
- bacterial infections
- treating bacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700159P | 2012-09-12 | 2012-09-12 | |
| US61/700,159 | 2012-09-12 | ||
| PCT/US2013/059310 WO2014043272A1 (en) | 2012-09-12 | 2013-09-11 | Tricyclic gyrase inhibitors for use as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528502A JP2015528502A (ja) | 2015-09-28 |
| JP2015528502A5 true JP2015528502A5 (enExample) | 2016-11-04 |
| JP6460991B2 JP6460991B2 (ja) | 2019-01-30 |
Family
ID=49226575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532025A Active JP6460991B2 (ja) | 2012-09-12 | 2013-09-11 | 抗菌剤として使用するための三環式ジャイレース阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10865216B2 (enExample) |
| EP (1) | EP2895488B1 (enExample) |
| JP (1) | JP6460991B2 (enExample) |
| CN (1) | CN105189505B (enExample) |
| AR (1) | AR092538A1 (enExample) |
| TW (1) | TWI639602B (enExample) |
| WO (1) | WO2014043272A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5927201B2 (ja) | 2010-12-16 | 2016-06-01 | カルチャン リミテッド | Ａｓｋ１阻害ピロロピリミジン誘導体 |
| TWI527818B (zh) * | 2011-03-15 | 2016-04-01 | 特留斯治療學有限公司 | 三環旋轉酶抑制劑 |
| EP3044225B1 (en) * | 2013-09-11 | 2024-12-18 | Merck Sharp & Dohme LLC | Tricyclic gyrase inhibitors |
| WO2016067009A1 (en) * | 2014-10-28 | 2016-05-06 | Redx Pharma Plc | Compounds with activity against bacteria and mycobacteria |
| US11725187B2 (en) | 2016-06-01 | 2023-08-15 | Universite De Montreal | Selection of human hematopoetic stem cells using EPCR |
| CN106588731B (zh) * | 2016-12-08 | 2018-06-29 | 河北桑迪亚医药技术有限责任公司 | 环丙基二苯基锍三氟甲磺酸盐的合成方法 |
| CN110446699A (zh) | 2017-03-24 | 2019-11-12 | 大正制药株式会社 | 2（1h）-喹啉酮衍生物 |
| CN110475777B (zh) | 2017-03-30 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物 |
| CN119528804A (zh) | 2017-05-04 | 2025-02-28 | 发现号收购集团 | 作为例如用于保护植物的害虫防治剂的2-{[2-(苯氧基甲基)吡啶-5-基]氧基}乙胺衍生物及相关化合物 |
| WO2018226976A1 (en) * | 2017-06-08 | 2018-12-13 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
| WO2019060365A1 (en) | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE |
| US12011460B2 (en) | 2018-02-20 | 2024-06-18 | Universite De Montreal | Expansion of NK and DC cells in vivo mediating immune response |
| EP3856747B1 (en) * | 2018-09-26 | 2023-07-19 | F. Hoffmann-La Roche AG | Substituted pyridoindoles for the treatment and prophylaxis of bacterial infection |
| JP7451419B2 (ja) | 2018-10-26 | 2024-03-18 | 大鵬薬品工業株式会社 | 新規なインダゾール化合物又はその塩 |
| WO2020127624A1 (en) * | 2018-12-20 | 2020-06-25 | F. Hoffmann-La Roche Ag | Oxopyrido[1,2-a]pyrimidine compounds for the treatment and prophylaxis of bacterial infection |
| WO2020225077A1 (en) * | 2019-05-03 | 2020-11-12 | Idorsia Pharmaceuticals Ltd | Pyrimido[4,5-b]indol derivatives as pdhk1 inhibitors |
| CR20220230A (es) | 2019-10-28 | 2022-06-15 | Merck Sharp & Dohme | Inhibidores de pequeñas moléculas de mutante g12c de kras |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| KR20220146458A (ko) * | 2020-01-23 | 2022-11-01 | 마이오포르테 테라퓨틱스 인코포레이티드 | Pgdh 억제제 및 그의 제조 및 사용 방법 |
| CN112574085A (zh) * | 2020-12-18 | 2021-03-30 | 南通药明康德医药科技有限公司 | 一种5-氨基-2-氮杂螺[3.4]辛烷-2-羧酸叔丁酯的制备方法 |
| CN112552222B (zh) * | 2020-12-18 | 2022-08-23 | 南通药明康德医药科技有限公司 | 一种2-(2-(叔-丁氧羰基)-2-氮杂螺[3.4]辛烷-5-基)乙酸的制备方法 |
| CN114763357B (zh) * | 2021-01-15 | 2024-06-18 | 中国科学院上海药物研究所 | 吲哚并嘧啶三环类化合物及其制备方法和用途 |
| CN113372352B (zh) * | 2021-06-10 | 2022-08-26 | 青岛农业大学 | 吲哚3,4位并九元中环化合物及其制备方法 |
| CA3264754A1 (en) * | 2022-09-21 | 2024-03-28 | Bristol-Myers Squibb Company | PROCESS FOR THE PREPARATION OF TERT-BUTYL(2-AZABICYCLO[2.2.1]HEPTAN-4-YL)CARBAMATE AND ASSOCIATED COMPOUNDS |
| WO2024103010A1 (en) * | 2022-11-11 | 2024-05-16 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2024233776A1 (en) * | 2023-05-09 | 2024-11-14 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras g12d mutant |
| TW202535891A (zh) | 2023-10-20 | 2025-09-16 | 美商默沙東有限責任公司 | Ｋｒａｓ蛋白之小分子抑制劑 |
| WO2025240742A1 (en) * | 2024-05-15 | 2025-11-20 | Merck Sharp & Dohme Llc | Protein degraders of kras g12d mutant |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN157280B (enExample) * | 1983-07-15 | 1986-02-22 | Hoechst India | |
| DE4030059A1 (de) | 1990-09-22 | 1992-03-26 | Bayer Ag | Verfahren zur herstellung von 5-hydroxy-3,4,5,6-tetrahydro-pyrimidin-derivaten |
| DE4032560A1 (de) | 1990-10-13 | 1992-04-16 | Bayer Ag | 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate |
| US5279359A (en) | 1992-06-26 | 1994-01-18 | Erickson Donald C | Rotary trisorption heat pump |
| US5527910A (en) | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
| OA12316A (en) | 2000-01-24 | 2006-05-15 | Warner Lambert Co | 3-Aminoquinazolin-2,4-dione antibacterial agents. |
| ES2344007T3 (es) * | 2003-10-14 | 2010-08-16 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Inhibidores proteina quinasa. |
| US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| US20080051414A1 (en) | 2003-10-14 | 2008-02-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| US20090143399A1 (en) | 2003-10-14 | 2009-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
| US7776855B2 (en) | 2006-07-27 | 2010-08-17 | Janssen Pharmaceutica N.V. | Antimicrobial oxazolidinone prodrugs |
| WO2011032050A2 (en) * | 2009-09-11 | 2011-03-17 | Trius Therapeutics, Inc. | Gyrase inhibitors |
| TWI527818B (zh) * | 2011-03-15 | 2016-04-01 | 特留斯治療學有限公司 | 三環旋轉酶抑制劑 |
| EP3044225B1 (en) * | 2013-09-11 | 2024-12-18 | Merck Sharp & Dohme LLC | Tricyclic gyrase inhibitors |
-
2013
- 2013-09-11 US US14/427,611 patent/US10865216B2/en active Active
- 2013-09-11 JP JP2015532025A patent/JP6460991B2/ja active Active
- 2013-09-11 CN CN201380058803.6A patent/CN105189505B/zh active Active
- 2013-09-11 WO PCT/US2013/059310 patent/WO2014043272A1/en not_active Ceased
- 2013-09-11 TW TW102132841A patent/TWI639602B/zh active
- 2013-09-11 EP EP13765905.8A patent/EP2895488B1/en active Active
- 2013-09-12 AR ARP130103259A patent/AR092538A1/es active IP Right Grant
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