JP2016065085A5 - - Google Patents

Download PDF

Info

Publication number
JP2016065085A5
JP2016065085A5 JP2015225509A JP2015225509A JP2016065085A5 JP 2016065085 A5 JP2016065085 A5 JP 2016065085A5 JP 2015225509 A JP2015225509 A JP 2015225509A JP 2015225509 A JP2015225509 A JP 2015225509A JP 2016065085 A5 JP2016065085 A5 JP 2016065085A5
Authority
JP
Japan
Prior art keywords
compounds described
therapeutic methods
therapeutic
methods
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015225509A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016065085A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2016065085A publication Critical patent/JP2016065085A/ja
Publication of JP2016065085A5 publication Critical patent/JP2016065085A5/ja
Pending legal-status Critical Current

Links

JP2015225509A 2007-05-31 2015-11-18 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン Pending JP2016065085A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94124207P 2007-05-31 2007-05-31
US60/941,242 2007-05-31

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2013239442A Division JP2014062108A (ja) 2007-05-31 2013-11-20 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン

Publications (2)

Publication Number Publication Date
JP2016065085A JP2016065085A (ja) 2016-04-28
JP2016065085A5 true JP2016065085A5 (enExample) 2016-06-30

Family

ID=40094167

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010510560A Expired - Fee Related JP5420534B2 (ja) 2007-05-31 2008-06-02 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
JP2013239442A Withdrawn JP2014062108A (ja) 2007-05-31 2013-11-20 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
JP2015225509A Pending JP2016065085A (ja) 2007-05-31 2015-11-18 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2010510560A Expired - Fee Related JP5420534B2 (ja) 2007-05-31 2008-06-02 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
JP2013239442A Withdrawn JP2014062108A (ja) 2007-05-31 2013-11-20 モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン

Country Status (14)

Country Link
US (3) US8669291B2 (enExample)
EP (3) EP2154962A4 (enExample)
JP (3) JP5420534B2 (enExample)
KR (1) KR101581289B1 (enExample)
CN (3) CN108178733A (enExample)
AU (1) AU2008259841B2 (enExample)
BR (1) BRPI0811639A2 (enExample)
CA (1) CA2688493C (enExample)
IL (1) IL202405A (enExample)
MX (1) MX2009012685A (enExample)
NZ (1) NZ580429A (enExample)
RU (1) RU2470011C2 (enExample)
WO (1) WO2008151156A1 (enExample)
ZA (1) ZA200907171B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004312530A1 (en) * 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
CN101553217A (zh) 2005-07-06 2009-10-07 塞普拉科公司 艾司佐匹克隆与反式4-(3,4-二氯苯基)-1,2,3,4-四氢-n-甲基-1-萘胺或反式4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
KR101381768B1 (ko) 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
ES2594156T3 (es) * 2006-01-06 2016-12-16 Sunovion Pharmaceuticals Inc. Cicloalquilaminas como inhibidores de la recaptación de monoaminas
DK2816024T3 (en) 2006-03-31 2017-10-30 Sunovion Pharmaceuticals Inc CHIRALE AMINER
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
EP2049472B1 (en) 2006-06-23 2015-01-21 AbbVie Bahamas Ltd. Cyclopropyl amine derivatives as histamin h3 receptor modulators
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
EP2154962A4 (en) 2007-05-31 2012-08-15 Sepracor Inc PHENYL-SUBSTITUTED CYCLOALKYLAMINE AS A MONOAMINE RECOVERY INHIBITOR
WO2010017418A1 (en) * 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
WO2014018563A2 (en) * 2012-07-23 2014-01-30 The Board Of Trustees Of The Leland Stanford Junior University Methods for the treatment of cancer
US9381170B2 (en) * 2013-01-30 2016-07-05 MediSynergics, LLC Cycloalkyl-diamines for neurodegenerative disorders
US9283196B1 (en) * 2013-01-30 2016-03-15 MediSynergics, LLC Cycloalkyl-diamines for CNS disorders
US9126891B2 (en) * 2014-01-29 2015-09-08 MediSynergics, LLC Cycloalkyl-diamines
CA2955090A1 (en) * 2014-07-18 2016-01-21 Bayer Cropscience Aktiengesellschaft Substituted vinyl and alkynyl cyanocycloalkanols and vinyl and alkynyl cyanoheterocycloalkanols as active agents against abiotic plant stress
WO2017197101A1 (en) * 2016-05-12 2017-11-16 Research Triangle Institute Vinylogous phenethylamines as neurotransmitter releasers
WO2021241875A1 (ko) 2020-05-29 2021-12-02 재단법인 대구경북첨단의료산업진흥재단 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
KR102397705B1 (ko) 2020-05-29 2022-05-13 재단법인 대구경북첨단의료산업진흥재단 N을 하나 이상 포함하는 5원자의 헤테로아릴 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
JP2023528546A (ja) 2020-05-29 2023-07-04 テグ-キョンプク メディカル イノベーション ファウンデーション カルボキサミド誘導体およびそれを有効成分とする精神病の予防または治療に使用するための医薬組成物
WO2025232878A1 (zh) * 2024-05-09 2025-11-13 苏州旺山旺水生物医药股份有限公司 一类含取代的苯基的胺类化合物、其制备方法和用途

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE616646A (enExample)
DE1124485B (de) 1960-02-12 1962-03-01 Hoechst Ag Verfahren zur Herstellung von analeptisch wirksamen Phenylcycloalkylmethylaminen
US3496181A (en) 1966-10-24 1970-02-17 Upjohn Co 2 - aminocycloalkyl hydroquinones,esters,ethers and n-oxides thereof,and a process for preparing the same
GB1207731A (en) 1968-05-14 1970-10-07 Reckitt & Sons Ltd Derivatives of pyrrolidine
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3974157A (en) 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4287212A (en) * 1976-04-30 1981-09-01 American Hoechst Corporation 2-Aryl-1,2-dialkylcycloalkylamines
JPS6033106B2 (ja) 1977-10-07 1985-08-01 住友化学工業株式会社 カルボン酸エステル、その製造法およびそれを有効成分とする殺虫、殺ダニ剤
ZA817261B (en) 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4540690A (en) * 1982-02-09 1985-09-10 The Upjohn Company 2-(Phenylmethylene)cycloalkylamines and -azetidines
KR840002817A (ko) * 1982-02-09 1984-07-21 케네스 엠 사이러스 2-(페닐메틸렌)사이클로알킬아민 및 -아제티딘화합물의 제조방법
JPS58177915A (ja) 1982-04-12 1983-10-18 Green Cross Corp:The 抗血栓剤
JPS60172970A (ja) * 1984-02-15 1985-09-06 Shionogi & Co Ltd シス−アゾリルシクロアルカノ−ル誘導体およびその製造法ならびに農業用殺菌剤
DE3565769D1 (en) 1984-02-03 1988-12-01 Olympus Optical Co Calculus crushing apparatus
ZA855659B (en) 1984-07-30 1987-03-25 Schering Corp Novel process for the preparation of cis,endo-octahydrocyclopenta(b)pyrrole-2-carboxylate
DE3431541A1 (de) 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4738709A (en) 1985-01-10 1988-04-19 Ppg Industries, Inc. Herbicidally active substituted benzisoxazoles
US4751231A (en) 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
JPH01172388A (ja) 1987-12-25 1989-07-07 Sumitomo Chem Co Ltd チエノ〔3,2−b〕ピロロ〔2,3−d〕ピロール類およびその製法
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US4981870A (en) 1989-03-07 1991-01-01 Pfizer Inc. Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
PT93943A (pt) 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
FI915656A0 (fi) 1989-05-31 1991-11-29 Upjohn Co Terapeutiskt anvaendbara 2-aminotetralin derivat.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
CA2075181C (en) * 1990-02-02 1997-12-09 Theodros Asberom 4,5-bridged-2,3,4,5-tetrahydro-1h-3-benzazepine-7-ols
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
JPH0477476A (ja) 1990-07-19 1992-03-11 Sankyo Co Ltd 抗潰瘍剤
US5086054A (en) 1990-07-31 1992-02-04 Sri International Novel arylcycloalkanepolyalkylamines
JP3007138B2 (ja) 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とn―ヒドロキシ尿素誘導体およびそれらの組成物
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
GB9208492D0 (en) 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
AU674358B2 (en) 1992-10-28 1996-12-19 Toyama Chemical Co. Ltd. Novel 1,2-benzoisoxazole derivative or its salt and brain -protecting agent comprising the same
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
GB9304500D0 (en) 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
ES2081747B1 (es) 1993-09-07 1997-01-16 Esteve Labor Dr Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.
GB9321221D0 (en) 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
GB9326284D0 (en) 1993-12-23 1994-02-23 Erba Carlo Spa Pyrrolydenemethyl-derivatives and process for their preparation
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
CN1047384C (zh) 1994-07-28 1999-12-15 北京大学 雷米普利的合成方法
ATE253057T1 (de) 1994-08-30 2003-11-15 Sankyo Co Isoxazole
US5484763A (en) 1995-02-10 1996-01-16 American Cyanamid Company Substituted benzisoxazole and benzisothiazole herbicidal agents
US5620997A (en) 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
US5859042A (en) 1995-09-27 1999-01-12 Ono Pharmaceutical Co., Ltd. Five membered heterocyclic compounds
EP0940387B1 (en) 1995-10-26 2003-05-07 Mitsubishi Pharma Corporation Phenylethanolamine compounds useful as beta3 agonist, process for producing the same, and intermediates in the production of the same
KR100454781B1 (ko) 1996-01-31 2005-04-08 알타나 파마 아게 신규한페난트리딘
DE19711785A1 (de) 1997-03-21 1998-09-24 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US6503582B1 (en) 1997-08-19 2003-01-07 Mattel, Inc. Fluid-swellable composition, device and method for using the same
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
WO1999018065A1 (en) 1997-10-03 1999-04-15 Chirotech Technology Limited Chiral amines
GB9803228D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
JP2002507598A (ja) 1998-03-26 2002-03-12 スージェン・インコーポレーテッド チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6632836B1 (en) 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors
CA2350635A1 (en) * 1998-12-02 2000-06-08 Hazel Bardsley Therapeutic product and its use
US6828460B2 (en) * 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
DE19915601A1 (de) * 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung
FR2795733B1 (fr) 1999-06-30 2001-09-07 Aventis Pharma Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
EP1391460A1 (en) 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
DK1088824T3 (da) 1999-09-30 2004-04-13 Pfizer Prod Inc Bicykliske pyrrolylamider som glycogen phosphorylase inhibitorer
ECSP003699A (es) 1999-10-08 2002-04-23 Smithkline Beecham Corp Inhibidores de fab i
ES2307537T3 (es) * 1999-12-08 2008-12-01 Eli Lilly And Company Derivados de ciclopentil sulfonamida.
DE19960917A1 (de) 1999-12-17 2001-06-21 Bayer Ag Neue 3-Oxo-2,1-benzisoxazol-1(3H)-carboxamide zur Behandlung von ZNS-Erkrankungen
DE10000312A1 (de) 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
US6632417B2 (en) 2000-03-07 2003-10-14 Chevron U.S.A. Inc. Process for preparing zeolites
JP2001247462A (ja) 2000-03-07 2001-09-11 Otsuka Pharmaceut Co Ltd ウレアーゼ阻害剤
EP1136071A3 (en) 2000-03-22 2003-03-26 Pfizer Products Inc. Use of glycogen phosphorylase inhibitors
WO2001079208A1 (en) 2000-04-19 2001-10-25 Kaneka Corporation Novel azetidine derivative and process for preparation thereof
GB0012214D0 (en) 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
JP2004505982A (ja) 2000-08-04 2004-02-26 イーライ・リリー・アンド・カンパニー 新規なsPLA2インヒビター
GB0021831D0 (en) 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
EP1330515A4 (en) 2000-10-06 2005-12-07 Affinium Pharm Inc METHOD FOR AGONIZATION AND ANTAGONIZATION OF FABK
JP2004511540A (ja) * 2000-10-13 2004-04-15 イーライ・リリー・アンド・カンパニー シクロアルキルフルオロスルホンアミド誘導体
SE0003810D0 (sv) 2000-10-20 2000-10-20 Pharmacia Ab Novel compounds their use and preparations
TWI283575B (en) 2000-10-31 2007-07-11 Eisai Co Ltd Medicinal compositions for concomitant use as anticancer agent
DE10063992A1 (de) 2000-12-21 2002-07-04 Max Planck Gesellschaft Tryptophan-Analoga in Proteinen, Peptiden und peptidischen Leitstrukturen
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US20020123490A1 (en) 2001-03-01 2002-09-05 Pfizer Inc. Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
GB0115602D0 (en) 2001-06-26 2001-08-15 Syngenta Participations Ag Organic compounds
DE10132747A1 (de) 2001-07-05 2003-01-23 Gruenenthal Gmbh Substituierte 1-Aryl-but-3-enylamin- und 1-Aryl-but-2-enylaminverbindungen
US6603000B2 (en) 2001-07-11 2003-08-05 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis for heteroarylamine compounds
ES2383749T3 (es) 2001-08-09 2012-06-26 Daiichi Sankyo Company, Limited Derivados de diamina
US7045543B2 (en) 2001-11-05 2006-05-16 Enzrel Inc. Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites
US20030162825A1 (en) 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
US6780891B2 (en) * 2001-11-30 2004-08-24 Sepracor Inc. Tramadol analogs and uses thereof
DE10164581A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte Aminoalkohole
DE10161809A1 (de) 2001-12-14 2003-06-26 Gruenenthal Gmbh Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
ATE431844T1 (de) * 2002-02-11 2009-06-15 Rhodia Chimie Sa Waschmittel mit blockcopolymer
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
JPWO2003091213A1 (ja) 2002-04-25 2005-09-02 アステラス製薬株式会社 新規なアミド誘導体又はその塩
JP2005538047A (ja) 2002-05-03 2005-12-15 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ボンベシンアンタゴニスト
FR2841487B1 (fr) 2002-06-26 2004-08-20 Solystic Procede de detection de plis simples et de plis en prise multiple dans une installation de tri postal
DE10233048A1 (de) 2002-07-19 2004-01-29 Grünenthal GmbH Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
US20050182131A1 (en) * 2002-07-19 2005-08-18 Gruenenthal Gmbh 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence
US7576204B2 (en) 2002-07-31 2009-08-18 Mercian Corporation Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same
US7537891B2 (en) 2002-08-27 2009-05-26 Bristol-Myers Squibb Company Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
PT1543011E (pt) 2002-09-06 2006-08-31 Janssen Pharmaceutica Nv Composto de tienopirrolilo e furanopirrolilo e sua utilizacao como ligandos do receptor h4 da histamina
CA2498175A1 (en) 2002-09-16 2004-03-25 Sepracor Inc. Treatment of cns disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine
KR101067045B1 (ko) 2002-09-16 2011-09-22 선오비온 파마슈티컬스 인코포레이티드 트랜스 4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로-1-나프탈렌아민을 사용한 cns 장애의 치료
TW200418838A (en) * 2002-09-18 2004-10-01 Bristol Myers Squibb Co Compounds for the treatment of premature ejaculation
US20040106681A1 (en) 2002-10-03 2004-06-03 Cypress Bioscience, Inc. Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders
GB0222912D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
US20040097554A1 (en) 2002-10-30 2004-05-20 Pfizer Inc Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents
CA2503727A1 (en) 2002-11-07 2004-05-21 Pfizer Products Inc. Anti-diabetic agents
PT1595866T (pt) 2003-01-31 2016-09-14 Sanwa Kagaku Kenkyusho Co Cianopirrolidinas úteis para o tratamento entre outras de síndrome metabólica
DE602004027171D1 (de) 2003-04-11 2010-06-24 High Point Pharmaceuticals Llc Verbindungen mit Aktivität an der 11Beta-Hydroxasteroiddehydrogenase
BRPI0409952A (pt) 2003-04-30 2006-04-25 Pfizer Prod Inc agentes anti-diabéticos
WO2004113345A1 (ja) 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
SI1362864T1 (sl) 2003-06-30 2007-08-31 Servier Lab Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
JP4745226B2 (ja) 2003-07-07 2011-08-10 チバ ホールディング インコーポレーテッド フロピロールの製造法
KR20060073584A (ko) 2003-07-29 2006-06-28 시그너쳐 알 앤드 디 홀딩스, 엘엘씨 아미노산 프로드럭
GB0318463D0 (en) 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0319759D0 (en) 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
WO2005020986A1 (en) 2003-08-29 2005-03-10 Astrazeneca Ab Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity
GB0320422D0 (en) 2003-08-30 2003-10-01 Astrazeneca Ab Chemical compounds
CA2543308C (en) 2003-10-23 2012-03-06 F. Hoffman-La Roche Ag Triaza-spiropiperidine derivatives for use as glyt-1 inhibitors in the treatment of neurological and neuropsychiatric disorders
US7396940B2 (en) 2003-10-23 2008-07-08 Hoffmann-La Roche Inc. Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid
ES2282586T3 (es) 2003-11-19 2007-10-16 Les Laboratoires Servier Procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
AU2004312530A1 (en) 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
CA2552098A1 (en) 2003-12-29 2005-07-21 Sepracor Inc. Benzo[d]isoxazol-3-ol daao inhibitors
US20070197610A1 (en) 2004-03-16 2007-08-23 Janssen Pharmaceutica N.V. Benzisoxazoles
JP4173191B2 (ja) 2004-05-07 2008-10-29 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー H3リガンドとして有用な3‐または4‐一置換フェノールおよびチオフェノール誘導体
NZ551288A (en) * 2004-05-14 2010-10-29 Janssen Pharmaceutica Nv Carboxamido opioid compounds that are derivatives of tramadol
WO2006001958A2 (en) * 2004-05-21 2006-01-05 Merck & Co., Inc. Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
CN101723900B (zh) 2004-05-26 2012-08-22 卫材R&D管理有限公司 肉桂酰胺类化合物
WO2005123677A1 (en) 2004-06-16 2005-12-29 Actelion Pharmaceuticals Ltd 4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents
PL1775298T3 (pl) 2004-07-01 2013-08-30 Daiichi Sankyo Co Ltd Pochodna tienopirazolowa wykazująca aktywność hamowania PDE7
US7276631B2 (en) * 2004-07-20 2007-10-02 Bristol-Myers Squibb Company Cyclopentylamine and cyclohexylamine derivatives as NK-1/SSRI antagonists
JO2629B1 (en) 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
US7411093B2 (en) * 2004-12-20 2008-08-12 Hoffman-La Roche Inc. Aminocycloalkanes as DPP-IV inhibitors
CA2594665A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Thienopyrroles useful in the treatment of inflammation
CN100391945C (zh) 2005-05-31 2008-06-04 浙江大学 一种s-(-)-吲哚啉-2-羧酸的合成方法
WO2007039773A1 (en) 2005-10-06 2007-04-12 Merck Sharp & Dohme Limited Use of fused pyrrole carboxylic acids for the treatment of neurodegenerative and psychiatric diseases as d-amino acid oxidase inhibitors
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
ES2594156T3 (es) 2006-01-06 2016-12-16 Sunovion Pharmaceuticals Inc. Cicloalquilaminas como inhibidores de la recaptación de monoaminas
KR101381768B1 (ko) 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
DK2816024T3 (en) 2006-03-31 2017-10-30 Sunovion Pharmaceuticals Inc CHIRALE AMINER
US20080058395A1 (en) 2006-06-30 2008-03-06 Sepracor Inc. Fused heterocyclic inhibitors of D-amino acid oxidase
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
JP2009542683A (ja) 2006-06-30 2009-12-03 セプラコア インコーポレーテッド D−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤
US7579370B2 (en) 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
CN1962656A (zh) 2006-11-29 2007-05-16 沈阳药科大学 吲哚美辛5-氟尿嘧啶甲酯药用化合物及其制剂和制备方法
TW200838497A (en) 2006-12-21 2008-10-01 Abbott Lab Sphingosine-1-phosphate receptor agonist and antagonist compounds
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP2010516697A (ja) 2007-01-18 2010-05-20 セプラコール インク. D−アミノ酸オキシダーゼ阻害剤
EP2154962A4 (en) * 2007-05-31 2012-08-15 Sepracor Inc PHENYL-SUBSTITUTED CYCLOALKYLAMINE AS A MONOAMINE RECOVERY INHIBITOR
WO2010017418A1 (en) 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase

Similar Documents

Publication Publication Date Title
JP2016028092A5 (enExample)
JP2016065085A5 (enExample)
IL285650B (en) Hydroponic planter
JP2016028081A5 (enExample)
JP2016196495A5 (enExample)
JP2016502162A5 (enExample)
JP2017214405A5 (enExample)
LT3513809T (lt) Medicininė kompozicija, apimanti tivozanibą
LT3230281T (lt) 1,3-tiazol-2-ilu pakeisti benzamidai
JP2017137500A5 (enExample)
JP2018533683A5 (enExample)
KR20180084876A (ko) 내플라즈마성 부재
DK3402782T3 (da) 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decanderivater
JP2015173751A5 (enExample)
IL262851A (en) Combination prime: boost therapy
JP2015016294A5 (enExample)
JP2019505548A5 (enExample)
UY4430S (es) “motocicleta”.
JP2017149782A5 (enExample)
JP2017528459A5 (enExample)
JP2016053220A5 (enExample)
JP2016047837A5 (enExample)
EP3449805A4 (en) Resectoscope
JP2016054715A5 (enExample)
JP2015043197A5 (enExample)