JP2016028092A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016028092A5 JP2016028092A5 JP2015191866A JP2015191866A JP2016028092A5 JP 2016028092 A5 JP2016028092 A5 JP 2016028092A5 JP 2015191866 A JP2015191866 A JP 2015191866A JP 2015191866 A JP2015191866 A JP 2015191866A JP 2016028092 A5 JP2016028092 A5 JP 2016028092A5
- Authority
- JP
- Japan
- Prior art keywords
- compounds described
- therapeutic methods
- therapeutic
- methods
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34868310P | 2010-05-26 | 2010-05-26 | |
| US61/348,683 | 2010-05-26 | ||
| US41141010P | 2010-11-08 | 2010-11-08 | |
| US61/411,410 | 2010-11-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512231A Division JP5911476B2 (ja) | 2010-05-26 | 2011-05-26 | ヘテロアリール化合物及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016028092A JP2016028092A (ja) | 2016-02-25 |
| JP2016028092A5 true JP2016028092A5 (enExample) | 2016-06-30 |
Family
ID=45004801
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512231A Expired - Fee Related JP5911476B2 (ja) | 2010-05-26 | 2011-05-26 | ヘテロアリール化合物及びその使用方法 |
| JP2015191866A Pending JP2016028092A (ja) | 2010-05-26 | 2015-09-29 | ヘテロアリール化合物及びその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512231A Expired - Fee Related JP5911476B2 (ja) | 2010-05-26 | 2011-05-26 | ヘテロアリール化合物及びその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8969349B2 (enExample) |
| EP (2) | EP2576540B1 (enExample) |
| JP (2) | JP5911476B2 (enExample) |
| CN (1) | CN103038229B (enExample) |
| AU (1) | AU2011258217B2 (enExample) |
| CA (1) | CA2800618C (enExample) |
| IL (2) | IL223240B (enExample) |
| MX (1) | MX351368B (enExample) |
| NZ (2) | NZ705135A (enExample) |
| WO (1) | WO2011150156A2 (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| CA2711558C (en) | 2008-01-04 | 2016-12-13 | Intellikine, Inc. | Phosphatidyl inositol-3 kinase inhibiting compounds |
| EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| TWI487705B (zh) * | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
| CA2800618C (en) | 2010-05-26 | 2018-08-28 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| AU2012205669B2 (en) | 2011-01-10 | 2015-08-20 | Infinity Pharmaceuticals Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| CN107141309A (zh) | 2011-01-11 | 2017-09-08 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| MX2013009575A (es) | 2011-02-18 | 2014-10-14 | Exonhit Therapeutics Sa | Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a). |
| WO2013005798A1 (ja) * | 2011-07-06 | 2013-01-10 | 持田製薬株式会社 | 新規含窒素複素環誘導体 |
| WO2013050527A1 (en) * | 2011-10-05 | 2013-04-11 | H. Lundbeck A/S | Quinazoline derivatives as pde10a enzyme inhibitors |
| TWI570124B (zh) * | 2011-12-21 | 2017-02-11 | H 朗德貝克公司 | 作為pde10a酵素抑制劑的喹啉衍生物 |
| US9138494B2 (en) * | 2011-12-23 | 2015-09-22 | Abbvie Inc. | Radiolabeled PDE10A ligands |
| CN104364249B (zh) | 2012-05-30 | 2018-04-17 | 霍夫曼-拉罗奇有限公司 | 作为pde10抑制剂的三唑并化合物 |
| MX2014014308A (es) * | 2012-05-30 | 2015-02-12 | Hoffmann La Roche | Pirrolidino heterociclos. |
| US9556144B2 (en) * | 2012-06-15 | 2017-01-31 | Curegenix, Inc. | Compound as WNT signaling inhibitor, composition, and use thereof |
| KR20150021120A (ko) * | 2012-06-19 | 2015-02-27 | 선오비온 파마슈티컬스 인코포레이티드 | 헤테로아릴 화합물 및 이의 이용 방법 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| JP6193374B2 (ja) | 2012-08-13 | 2017-09-06 | 武田薬品工業株式会社 | Gpr6モジュレーターとしてのキノキサリン誘導体 |
| KR102229478B1 (ko) | 2012-11-01 | 2021-03-18 | 인피니티 파마슈티칼스, 인코포레이티드 | Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료 |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US9670230B2 (en) * | 2012-11-29 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| TW201441216A (zh) | 2012-12-21 | 2014-11-01 | Gilead Calistoga Llc | 肌醇磷酯3-激酶的抑制劑 |
| AU2013364070B2 (en) | 2012-12-21 | 2016-10-27 | Gilead Calistoga Llc | Isoquinolinone or quinazolinone phosphatidylinositol 3-kinase inhibitors |
| ES2480341B1 (es) | 2013-01-24 | 2015-01-22 | Palobiofarma S.L | Nuevos derivados de pirimidina como inhibidores de la fosfodiesterasa 10 (PDE-10) |
| WO2014124302A1 (en) | 2013-02-07 | 2014-08-14 | Scifluor Life Sciences, Llc | Fluorinated integrin antagonists |
| US8901144B2 (en) | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| KR102280614B1 (ko) | 2013-03-15 | 2021-07-21 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
| US9464076B2 (en) | 2013-03-15 | 2016-10-11 | Daiichi Sankyo Company, Limited | Benzothiophene derivative |
| US9302992B2 (en) | 2013-04-02 | 2016-04-05 | Annji Pharmaceutical Co., Ltd. | Multifunctional quinoline derivatives as anti-neurodegenerative agents |
| WO2014163622A1 (en) * | 2013-04-02 | 2014-10-09 | Annji Pharmaceutical Co., Ltd. | Multifunctional quinoline derivatives as anti-neurodegenerative agents |
| US9249163B2 (en) | 2013-06-11 | 2016-02-02 | Janssen Pharmaceutica Nv. | PDE10a inhibitors for the treatment of type II diabetes |
| WO2014200882A1 (en) | 2013-06-11 | 2014-12-18 | Janssen Pharmaceutica Nv | PDE10a INHIBITORS FOR THE TREATMENT OF TYPE II DIABETES |
| TR201806822T4 (tr) | 2013-06-14 | 2018-06-21 | Gilead Calistoga Llc | Fosfatidilinositol 3-kinaz inhibitörleri. |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| CA2930293A1 (en) * | 2013-11-28 | 2015-06-04 | F. Hoffmann-La Roche Ag | Imidazole derivatives |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| WO2015123505A1 (en) | 2014-02-14 | 2015-08-20 | Takeda Pharmaceutical Company Limited | Pyridopyrazines modulators of gpr6 |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2016134223A2 (en) | 2015-02-19 | 2016-08-25 | Scifluor Life Sciences, Inc. | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
| US10100015B2 (en) * | 2015-03-24 | 2018-10-16 | Shanghai Yingli Pharmaceutical Co., Ltd. | Condensed ring derivative, and preparation method, intermediate, pharmaceutical composition and use thereof |
| US10077289B2 (en) | 2015-03-31 | 2018-09-18 | Allergan, Inc. | Cyclosporins modified on the MeBmt sidechain by heterocyclic rings |
| EP3325473A4 (en) * | 2015-07-22 | 2019-06-26 | The Royal Institution for the Advancement of Learning / McGill University | Compounds and uses thereof in the treatment of cancer and other medical disorders |
| DE102015011861B4 (de) | 2015-09-10 | 2018-03-01 | Rudolf Schindler | Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren |
| US10550116B2 (en) | 2015-10-26 | 2020-02-04 | Bayer Cropscience Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| MA45244A (fr) | 2016-06-13 | 2019-04-17 | Cancer Research Tech Ltd | Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1 |
| MX391135B (es) | 2016-06-24 | 2025-03-21 | Infinity Pharmaceuticals Inc | Terapias de combinacion. |
| ES2963563T3 (es) | 2016-07-07 | 2024-03-27 | Cyclerion Therapeutics Inc | Procesos novedosos para preparar estimuladores de guanilato ciclasa soluble |
| MX2019000536A (es) | 2016-07-14 | 2019-04-01 | Pfizer | Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1. |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| AU2017359030A1 (en) | 2016-11-08 | 2019-06-20 | Bristol-Myers Squibb Company | Pyrrole amides as alpha v integrin inhibitors |
| WO2018172984A1 (en) | 2017-03-23 | 2018-09-27 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| WO2019055877A1 (en) * | 2017-09-15 | 2019-03-21 | Forma Therapeutics, Inc. | TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300 |
| US11292802B2 (en) | 2017-11-07 | 2022-04-05 | Bristol-Myers Squibb Company | Substituted tetrahydropyrrolo[1,2-a]pyrazines as alpha v integrin inhibitors |
| CN107793353A (zh) * | 2017-11-08 | 2018-03-13 | 中山大学 | 牛奶树碱类化合物及其应用 |
| EP3587418B1 (en) * | 2018-06-29 | 2021-09-01 | Forma Therapeutics, Inc. | Inhibitors of creb binding protein (cbp) |
| KR20250067962A (ko) * | 2018-06-29 | 2025-05-15 | 포르마 세라퓨틱스 인크. | Creb 결합 단백질(cbp)의 저해 |
| WO2020061103A1 (en) | 2018-09-18 | 2020-03-26 | Nikang Therapeutics, Inc. | Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| BR112021018266A2 (pt) * | 2019-03-15 | 2022-02-01 | Forma Therapeutics Inc | Composições e métodos para tratar formas positivas de receptor andrógeno de câncer |
| US12351577B2 (en) | 2019-03-15 | 2025-07-08 | Forma Therapeutics, Inc. | Inhibiting cyclic AMP-responsive element-binding protein (CREB) |
| WO2021070957A1 (ja) * | 2019-10-09 | 2021-04-15 | 国立大学法人東北大学 | ベンゼン縮合環化合物、およびそれを含有する医薬組成物 |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| CN117247360A (zh) * | 2023-09-18 | 2023-12-19 | 成都伊诺达博医药科技有限公司 | 一种2-甲氧基-3-(1-甲基-1h-1,2,4-三唑-3-基)苯胺的制备方法 |
| WO2025227032A1 (en) * | 2024-04-26 | 2025-10-30 | Remix Therapeutics Inc. | Methods for degradation of cyclin k and inhibition of cyclin dependent kinases |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH348967A (de) * | 1956-12-21 | 1960-09-30 | Geigy Ag J R | Verfahren zur Herstellung von Benzimidazolen |
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| NL7204972A (enExample) | 1971-04-21 | 1972-10-24 | ||
| US3897432A (en) * | 1971-04-21 | 1975-07-29 | Merck & Co Inc | Substituted benzimidazole derivatives |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4036840A (en) | 1972-06-07 | 1977-07-19 | Icn Pharmaceuticals | 2-Substituted-s-triazolo[1,5a]pyrimidines |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| US4045564A (en) | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| JP2598100B2 (ja) * | 1988-08-31 | 1997-04-09 | キヤノン株式会社 | 電子写真感光体 |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5217980A (en) * | 1990-07-19 | 1993-06-08 | Janssen Pharmaceutica N.V. | Oxazolyl and piperidinyl substituted benimidazolyl compounds |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| JP2646995B2 (ja) * | 1993-01-28 | 1997-08-27 | 武田薬品工業株式会社 | キノリンまたはキナゾリン誘導体およびそれらを含んでなる医薬 |
| IL108524A0 (en) * | 1993-02-03 | 1994-05-30 | Gensia Inc | Imidazodiazepine analogs |
| US5380738A (en) * | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
| EP0634169B1 (en) * | 1993-06-29 | 2000-01-05 | Takeda Chemical Industries, Ltd. | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis |
| JPH0769890A (ja) * | 1993-06-29 | 1995-03-14 | Takeda Chem Ind Ltd | キノリンまたはキナゾリン誘導体を含んでなる医薬組成物 |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| JPH1067658A (ja) * | 1995-09-13 | 1998-03-10 | Takeda Chem Ind Ltd | 免疫抑制剤 |
| AU715100B2 (en) * | 1996-04-25 | 2000-01-13 | Takeda Chemical Industries Ltd. | Thienopyridine derivatives and their use |
| WO1999044612A1 (en) * | 1998-03-02 | 1999-09-10 | Cocensys, Inc. | Substituted quinazolines and analogs and the use thereof |
| JPH11279177A (ja) * | 1998-03-27 | 1999-10-12 | Taisho Pharmaceut Co Ltd | ベンゾチアゾール誘導体 |
| JP2002534512A (ja) * | 1999-01-15 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 非ペプチドglp−1アゴニスト |
| US6465486B1 (en) * | 1999-03-12 | 2002-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl/quinolinyl imidazoles |
| US6355638B1 (en) * | 1999-11-25 | 2002-03-12 | Merck Sharp & Dohme Ltd. | Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition |
| US8124625B2 (en) * | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
| US20050260126A1 (en) * | 2002-08-30 | 2005-11-24 | Yukitsuka Kudo | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein |
| MXPA05006587A (es) * | 2002-12-20 | 2005-12-14 | Pharmacia Corp | Compuestos de tiazol como derivados de antagonistas del receptor de la integrina. |
| EP1590348A1 (en) * | 2002-12-20 | 2005-11-02 | 3M Innovative Properties Company | Aryl / hetaryl substituted imidazoquinolines |
| JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ,インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
| EP1599473B1 (en) * | 2003-02-25 | 2006-09-20 | ALTANA Pharma AG | Imidazo 4,5-b quinoline-derivatives and their use as no-synthase inhibitors |
| BRPI0415034A (pt) | 2003-10-01 | 2006-12-12 | Altana Pharma Ag | derivados de aminopiridina como inibidores de não-sintase induzìveis |
| CA2540242A1 (en) * | 2003-10-01 | 2005-04-07 | Altana Pharma Ag | Imidazopyridine-derivatives as inducible no-synthase inhibitors |
| EA012211B1 (ru) * | 2005-01-07 | 2009-08-28 | Пфайзер Продактс Инк. | Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10 |
| AR056319A1 (es) * | 2005-04-22 | 2007-10-03 | Kalypsys Inc | Inhibidores de orto-terfinilo de p38 quinasa, composicion farmaceutica y compuestos intermedios |
| NL2000397C2 (nl) * | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| AU2007221049A1 (en) * | 2006-02-28 | 2007-09-07 | Amgen Inc. | Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors |
| CA2647338A1 (en) * | 2006-04-28 | 2007-11-08 | Avexa Limited | Integrase inhibitors-3 |
| JP2009535394A (ja) * | 2006-05-02 | 2009-10-01 | ファイザー・プロダクツ・インク | Pde10阻害剤としての二環式ヘテロアリール化合物 |
| TW200815436A (en) * | 2006-05-30 | 2008-04-01 | Elbion Ag | 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| UY30437A1 (es) * | 2006-06-26 | 2008-01-31 | Enanta Pharm Inc | Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c |
| WO2008020302A2 (en) * | 2006-08-17 | 2008-02-21 | Pfizer Products Inc. | Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors |
| GB0619325D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| AU2007312390B2 (en) * | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| US9101628B2 (en) * | 2007-09-18 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and composition of treating a flaviviridae family viral infection |
| ES2549379T3 (es) * | 2008-01-22 | 2015-10-27 | Dow Agrosciences Llc | Derivados de 4-amino5-fluoropirimidina como fungicidas |
| EP2300470A2 (en) * | 2008-05-19 | 2011-03-30 | Sepracor Inc. | Imidazo[1,2-a]pyridine compounds as gaba-a receptor modulators |
| TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
| EP2168965A1 (en) | 2008-09-25 | 2010-03-31 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine, imidazopyrazine, imidazopyridazine and imidazopyrimidine derivatives as melanocortin-4 receptor antagonists |
| CA2742317A1 (en) * | 2008-11-06 | 2010-05-14 | Schering Corporation | Gamma secretase modulators |
| EP2424860A4 (en) | 2009-04-28 | 2012-10-17 | Msd Kk | HETEROARYLTHIOMETHYLPYRIDINDERIVAT |
| CA2762680C (en) | 2009-05-21 | 2018-04-17 | Chlorion Pharma, Inc. | Methyl sulfanyl pyrmidmes useful as antiinflammatories, analgesics, and antiepileptics |
| US8349830B2 (en) * | 2009-10-30 | 2013-01-08 | Merck Sharp & Dohme | Aryl aminopyridine PDE10 inhibitors |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| WO2011122815A2 (en) * | 2010-03-29 | 2011-10-06 | Dong-A Pharm.Co.,Ltd. | Novel quinoxaline derivatives |
| CA2800618C (en) | 2010-05-26 | 2018-08-28 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
-
2011
- 2011-05-26 CA CA2800618A patent/CA2800618C/en active Active
- 2011-05-26 EP EP11787386.9A patent/EP2576540B1/en active Active
- 2011-05-26 CN CN201180036842.7A patent/CN103038229B/zh not_active Expired - Fee Related
- 2011-05-26 MX MX2012013624A patent/MX351368B/es active IP Right Grant
- 2011-05-26 US US13/700,051 patent/US8969349B2/en active Active
- 2011-05-26 WO PCT/US2011/038057 patent/WO2011150156A2/en not_active Ceased
- 2011-05-26 AU AU2011258217A patent/AU2011258217B2/en not_active Ceased
- 2011-05-26 NZ NZ705135A patent/NZ705135A/en not_active IP Right Cessation
- 2011-05-26 EP EP17205058.5A patent/EP3318561B1/en not_active Not-in-force
- 2011-05-26 NZ NZ60378911A patent/NZ603789A/en not_active IP Right Cessation
- 2011-05-26 JP JP2013512231A patent/JP5911476B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-25 IL IL223240A patent/IL223240B/en active IP Right Grant
-
2015
- 2015-02-20 US US14/627,355 patent/US9834564B2/en not_active Expired - Fee Related
- 2015-09-29 JP JP2015191866A patent/JP2016028092A/ja active Pending
-
2017
- 2017-10-19 US US15/787,880 patent/US10562916B2/en active Active
-
2019
- 2019-04-21 IL IL266168A patent/IL266168A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016065085A5 (enExample) | ||
| IL285650B (en) | Hydroponic planter | |
| JP2016028081A5 (enExample) | ||
| JP2016196495A5 (enExample) | ||
| JP2016502162A5 (enExample) | ||
| JP2017214405A5 (enExample) | ||
| EP3463464A4 (en) | ASSOCIATION TREATMENT | |
| LT3513809T (lt) | Medicininė kompozicija, apimanti tivozanibą | |
| LT3230281T (lt) | 1,3-tiazol-2-ilu pakeisti benzamidai | |
| JP2017137500A5 (enExample) | ||
| JP2018533683A5 (enExample) | ||
| KR20180084876A (ko) | 내플라즈마성 부재 | |
| JP2017149782A5 (enExample) | ||
| DK3402782T3 (da) | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decanderivater | |
| JP2015173751A5 (enExample) | ||
| IL262851A (en) | Combination prime: boost therapy | |
| JP2015016294A5 (enExample) | ||
| JP2019505548A5 (enExample) | ||
| UY4430S (es) | “motocicleta”. | |
| JP2017528459A5 (enExample) | ||
| JP2016053220A5 (enExample) | ||
| JP2016047837A5 (enExample) | ||
| JP2016054715A5 (enExample) | ||
| JP2015043197A5 (enExample) | ||
| JP2017201524A5 (enExample) |