JP2016028092A5 - - Google Patents

Download PDF

Info

Publication number
JP2016028092A5
JP2016028092A5 JP2015191866A JP2015191866A JP2016028092A5 JP 2016028092 A5 JP2016028092 A5 JP 2016028092A5 JP 2015191866 A JP2015191866 A JP 2015191866A JP 2015191866 A JP2015191866 A JP 2015191866A JP 2016028092 A5 JP2016028092 A5 JP 2016028092A5
Authority
JP
Japan
Prior art keywords
compounds described
therapeutic methods
therapeutic
methods
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015191866A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016028092A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2016028092A publication Critical patent/JP2016028092A/ja
Publication of JP2016028092A5 publication Critical patent/JP2016028092A5/ja
Pending legal-status Critical Current

Links

JP2015191866A 2010-05-26 2015-09-29 ヘテロアリール化合物及びその使用方法 Pending JP2016028092A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34868310P 2010-05-26 2010-05-26
US61/348,683 2010-05-26
US41141010P 2010-11-08 2010-11-08
US61/411,410 2010-11-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2013512231A Division JP5911476B2 (ja) 2010-05-26 2011-05-26 ヘテロアリール化合物及びその使用方法

Publications (2)

Publication Number Publication Date
JP2016028092A JP2016028092A (ja) 2016-02-25
JP2016028092A5 true JP2016028092A5 (enExample) 2016-06-30

Family

ID=45004801

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013512231A Expired - Fee Related JP5911476B2 (ja) 2010-05-26 2011-05-26 ヘテロアリール化合物及びその使用方法
JP2015191866A Pending JP2016028092A (ja) 2010-05-26 2015-09-29 ヘテロアリール化合物及びその使用方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2013512231A Expired - Fee Related JP5911476B2 (ja) 2010-05-26 2011-05-26 ヘテロアリール化合物及びその使用方法

Country Status (10)

Country Link
US (3) US8969349B2 (enExample)
EP (2) EP3318561B1 (enExample)
JP (2) JP5911476B2 (enExample)
CN (1) CN103038229B (enExample)
AU (1) AU2011258217B2 (enExample)
CA (1) CA2800618C (enExample)
IL (2) IL223240B (enExample)
MX (1) MX351368B (enExample)
NZ (2) NZ705135A (enExample)
WO (1) WO2011150156A2 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
KR101653842B1 (ko) 2008-01-04 2016-09-02 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
EP2343294A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
TWI487705B (zh) * 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
EP3318561B1 (en) 2010-05-26 2021-12-22 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
AR084824A1 (es) 2011-01-10 2013-06-26 Intellikine Inc Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
CA2824047C (en) 2011-01-11 2019-06-18 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
MX2013009575A (es) 2011-02-18 2014-10-14 Exonhit Therapeutics Sa Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a).
WO2013005798A1 (ja) * 2011-07-06 2013-01-10 持田製薬株式会社 新規含窒素複素環誘導体
WO2013050527A1 (en) * 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors
TWI570124B (zh) * 2011-12-21 2017-02-11 Ｈ 朗德貝克公司 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物
US9138494B2 (en) * 2011-12-23 2015-09-22 Abbvie Inc. Radiolabeled PDE10A ligands
BR112014028006A2 (pt) * 2012-05-30 2017-06-27 Hoffmann La Roche heterociclos de pirrolidino
EP2855455B1 (en) * 2012-05-30 2017-11-08 F. Hoffmann-La Roche AG Triazolo compounds as pde10 inhibitors
AU2012382875B2 (en) * 2012-06-15 2017-04-20 Curegenix Inc. Compound as WNT signaling inhibitor, composition, and use thereof
JP6236439B2 (ja) * 2012-06-19 2017-11-22 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ヘテロアリール化合物及びその使用方法
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
JP6193374B2 (ja) * 2012-08-13 2017-09-06 武田薬品工業株式会社 Ｇｐｒ６モジュレーターとしてのキノキサリン誘導体
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
WO2014071109A1 (en) 2012-11-01 2014-05-08 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
WO2014085284A1 (en) * 2012-11-29 2014-06-05 Sunovion Pharmaceuticals Inc. Triazolo-pyrazine derivatives useful in the treatment of disorders of the central nervous system
AU2013364068B2 (en) 2012-12-21 2016-10-20 Gilead Calistoga Llc Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors
EP2935246B1 (en) 2012-12-21 2018-07-25 Gilead Calistoga LLC Isoquinolinone or quinazolinone phosphatidylinositol 3-kinase inhibitors
ES2480341B1 (es) 2013-01-24 2015-01-22 Palobiofarma S.L Nuevos derivados de pirimidina como inhibidores de la fosfodiesterasa 10 (PDE-10)
KR102216091B1 (ko) 2013-02-07 2021-02-16 사이플루어 라이프 사이언시즈, 인크 플루오르화 인테그린 길항제
US8901144B2 (en) 2013-02-07 2014-12-02 Scifluor Life Sciences, Llc Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives
WO2014142322A1 (ja) 2013-03-15 2014-09-18 第一三共株式会社 ベンゾチオフェン誘導体
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
EP2981525A4 (en) * 2013-04-02 2016-12-21 Annji Pharm Co Ltd MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS
US9302992B2 (en) 2013-04-02 2016-04-05 Annji Pharmaceutical Co., Ltd. Multifunctional quinoline derivatives as anti-neurodegenerative agents
WO2014200885A1 (en) * 2013-06-11 2014-12-18 Janssen Pharmaceutica Nv PDE10a INHIBITORS FOR THE TREATMENT OF TYPE II DIABETES
WO2014200882A1 (en) 2013-06-11 2014-12-18 Janssen Pharmaceutica Nv PDE10a INHIBITORS FOR THE TREATMENT OF TYPE II DIABETES
AR096621A1 (es) 2013-06-14 2016-01-20 Gilead Sciences Inc Inhibidores de isómeros de la fosfatidilinositol 3-quinasa (pi3k)
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
KR20160089474A (ko) * 2013-11-28 2016-07-27 에프. 호프만-라 로슈 아게 이미다졸 유도체
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
WO2015123505A1 (en) 2014-02-14 2015-08-20 Takeda Pharmaceutical Company Limited Pyridopyrazines modulators of gpr6
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
EP3259271B1 (en) 2015-02-19 2021-05-05 SciFluor Life Sciences, Inc. Fluorinated derivatives of 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid and uses thereof
JP6449482B2 (ja) 2015-03-24 2019-01-09 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合環誘導体、その製造方法、中間体、薬学的組成物及び応用
WO2016160362A1 (en) 2015-03-31 2016-10-06 Allergan, Inc. Cyclosporins modified on the mebmt sidechain by heterocyclic rings
CA3030582A1 (en) * 2015-07-22 2017-01-26 The Royal Institution For The Advancement Of Learning/Mcgill University Compounds and uses thereof in the treatment of cancers and other medical conditions
DE102015011861B4 (de) 2015-09-10 2018-03-01 Rudolf Schindler Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren
JP6916175B2 (ja) 2015-10-26 2021-08-11 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての縮合二環式ヘテロ環誘導体
CN109311848B (zh) 2016-06-07 2022-02-01 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
PE20190971A1 (es) 2016-06-13 2019-07-09 Glaxosmithkline Ip Dev Ltd Compuestos quimicos
RU2754507C2 (ru) 2016-06-24 2021-09-02 Инфинити Фармасьютикалз, Инк. Комбинированная терапия
AU2017291827B2 (en) 2016-07-07 2021-10-21 Cyclerion Therapeutics, Inc. Novel processes for preparation of soluble guanylate cyclase stimulators
MX2019000536A (es) 2016-07-14 2019-04-01 Pfizer Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1.
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
AU2017359030A1 (en) 2016-11-08 2019-06-20 Bristol-Myers Squibb Company Pyrrole amides as alpha v integrin inhibitors
SMT202400385T1 (it) 2017-03-23 2024-11-15 Jacobio Pharmaceuticals Co Ltd Nuovi derivati eterociclici utili come inibitori di shp2
TWI846350B (zh) * 2017-09-15 2024-06-21 美商佛瑪治療公司 作為ＣＢＰ／ｐ３００抑制劑之四氫－咪唑並喹啉化合物
US11292802B2 (en) 2017-11-07 2022-04-05 Bristol-Myers Squibb Company Substituted tetrahydropyrrolo[1,2-a]pyrazines as alpha v integrin inhibitors
CN107793353A (zh) * 2017-11-08 2018-03-13 中山大学 牛奶树碱类化合物及其应用
EP3587418B1 (en) * 2018-06-29 2021-09-01 Forma Therapeutics, Inc. Inhibitors of creb binding protein (cbp)
MX2023013508A (es) * 2018-06-29 2023-12-13 Forma Therapeutics Inc Inhibicion de la proteina de union a creb (cbp).
WO2020061103A1 (en) 2018-09-18 2020-03-26 Nikang Therapeutics, Inc. Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
CN113784967B (zh) * 2019-03-15 2024-07-26 福马治疗股份有限公司 用于治疗雄激素受体阳性形式的癌症的组合物和方法
TW202102494A (zh) 2019-03-15 2021-01-16 美商弗瑪治療公司 抑制環amp-反應元件-結合蛋白(creb)
JPWO2021070957A1 (enExample) * 2019-10-09 2021-04-15
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH348967A (de) * 1956-12-21 1960-09-30 Geigy Ag J R Verfahren zur Herstellung von Benzimidazolen
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3897432A (en) * 1971-04-21 1975-07-29 Merck & Co Inc Substituted benzimidazole derivatives
NL7204972A (enExample) 1971-04-21 1972-10-24
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4036840A (en) 1972-06-07 1977-07-19 Icn Pharmaceuticals 2-Substituted-s-triazolo[1,5a]pyrimidines
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
US4045564A (en) 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
JP2598100B2 (ja) 1988-08-31 1997-04-09 キヤノン株式会社 電子写真感光体
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5217980A (en) * 1990-07-19 1993-06-08 Janssen Pharmaceutica N.V. Oxazolyl and piperidinyl substituted benimidazolyl compounds
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
JP2646995B2 (ja) * 1993-01-28 1997-08-27 武田薬品工業株式会社 キノリンまたはキナゾリン誘導体およびそれらを含んでなる医薬
IL108524A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Imidazodiazepine analogs
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
JPH0769890A (ja) * 1993-06-29 1995-03-14 Takeda Chem Ind Ltd キノリンまたはキナゾリン誘導体を含んでなる医薬組成物
EP0634169B1 (en) * 1993-06-29 2000-01-05 Takeda Chemical Industries, Ltd. Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
JPH1067658A (ja) * 1995-09-13 1998-03-10 Takeda Chem Ind Ltd 免疫抑制剤
WO1997040050A1 (en) * 1996-04-25 1997-10-30 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their use
JP2002505288A (ja) * 1998-03-02 2002-02-19 コセンシス，インコーポレイテッド 置換キナゾリンおよびアナログならびにそれらの使用
JPH11279177A (ja) * 1998-03-27 1999-10-12 Taisho Pharmaceut Co Ltd ベンゾチアゾール誘導体
EP1147094A1 (en) * 1999-01-15 2001-10-24 Novo Nordisk A/S Non-peptide glp-1 agonists
US6465486B1 (en) * 1999-03-12 2002-10-15 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl/quinolinyl imidazoles
US6355638B1 (en) * 1999-11-25 2002-03-12 Merck Sharp & Dohme Ltd. Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
US8124625B2 (en) * 2001-09-14 2012-02-28 Shionogi & Co., Ltd. Method of enhancing the expression of apolipoprotein AI using olefin derivatives
WO2004035522A1 (ja) * 2002-08-30 2004-04-29 Bf Research Institute, Inc. プリオン蛋白蓄積性疾患の診断プローブおよび治療薬ならびにプリオン蛋白の染色剤
US7091214B2 (en) * 2002-12-20 2006-08-15 3M Innovative Properties Co. Aryl substituted Imidazoquinolines
JP2006516144A (ja) * 2002-12-20 2006-06-22 ファルマシア・コーポレーション インテグリン受容体アンタゴニスト誘導体としてのチアゾール化合物
EP1594847A2 (en) * 2003-02-12 2005-11-16 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
MXPA05008839A (es) * 2003-02-25 2005-10-05 Altana Pharma Ag Derivados de imidazo[4,5-b]quinolina y su uso como inhibidores de no-sintasa.
RS20060195A (sr) * 2003-10-01 2008-08-07 Altana Pharma Ag., Imidazopiridinski derivati kao inhibitori inducibilne no-sintaze
CA2540230A1 (en) * 2003-10-01 2005-07-07 Altana Pharma Ag Aminopyridine-derivatives as inductible no-synthase inhibitors
CN102491969B (zh) 2005-01-07 2015-08-19 辉瑞产品公司 杂芳族喹啉化合物及其作为pde10抑制剂的用途
EP1871770A1 (en) * 2005-04-22 2008-01-02 Kalypsys, Inc. Ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders
NL2000397C2 (nl) 2006-01-05 2007-10-30 Pfizer Prod Inc Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
EP1991531A1 (en) * 2006-02-28 2008-11-19 Amgen Inc. Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors
JP2009535307A (ja) * 2006-04-28 2009-10-01 アベキサ・リミテッド インテグラーゼ阻害剤３
WO2007129183A2 (en) 2006-05-02 2007-11-15 Pfizer Products Inc. Bicyclic heteroaryl compounds as pde10 inhibitors
TW200815436A (en) * 2006-05-30 2008-04-01 Elbion Ag 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
AR061629A1 (es) * 2006-06-26 2008-09-10 Enanta Pharm Inc Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c. proceso de obtencion y composiciones farmaceuticas
WO2008020302A2 (en) 2006-08-17 2008-02-21 Pfizer Products Inc. Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
WO2008046757A1 (en) * 2006-10-19 2008-04-24 F. Hoffmann-La Roche Ag Aminomethyl-4-imidazoles
US9101628B2 (en) * 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
EP2562175A1 (en) * 2008-01-22 2013-02-27 Dow AgroSciences LLC 5-fluoro pyrimidine derivatives as fungicides
CA2724842A1 (en) * 2008-05-19 2009-11-26 Sunovion Pharmaceuticals Inc. Imidazo[1,2-a]pyridine compounds
TWI501965B (zh) 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
EP2168965A1 (en) 2008-09-25 2010-03-31 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyridine, imidazopyrazine, imidazopyridazine and imidazopyrimidine derivatives as melanocortin-4 receptor antagonists
JP2012508181A (ja) * 2008-11-06 2012-04-05 シェーリング コーポレイション γ−セクレターゼ調節剤
US20120028970A1 (en) 2009-04-28 2012-02-02 Msd K.K. Heteroarylthiomethyl pyridine derivative
US9040538B2 (en) 2009-05-21 2015-05-26 Universite Laval Pyrimidines as novel therapeutic agents
EP2493308A4 (en) 2009-10-30 2013-05-15 Merck Sharp & Dohme ARYLAMINOPYRIDIN PDE10 INHIBITORS
TWI485151B (zh) * 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
WO2011122815A2 (en) * 2010-03-29 2011-10-06 Dong-A Pharm.Co.,Ltd. Novel quinoxaline derivatives
EP3318561B1 (en) 2010-05-26 2021-12-22 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Similar Documents

Publication Publication Date Title
JP2016028092A5 (enExample)
JP2016065085A5 (enExample)
IL285650B (en) Hydroponic planter
JP2016028081A5 (enExample)
JP2016502162A5 (enExample)
JP2016196495A5 (enExample)
JP2017214405A5 (enExample)
LT3513809T (lt) Medicininė kompozicija, apimanti tivozanibą
LT3230281T (lt) 1,3-tiazol-2-ilu pakeisti benzamidai
JP2017137500A5 (enExample)
JP2018533683A5 (enExample)
KR20180084876A (ko) 내플라즈마성 부재
DK3402782T3 (da) 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decanderivater
JP2015173751A5 (enExample)
IL262851A (en) Combination prime: boost therapy
JP2015016294A5 (enExample)
JP2019505548A5 (enExample)
UY4430S (es) “motocicleta”.
JP2017149782A5 (enExample)
JP2017528459A5 (enExample)
JP2016053220A5 (enExample)
JP2016047837A5 (enExample)
EP3449805A4 (en) Resectoscope
JP2016054715A5 (enExample)
JP2015043197A5 (enExample)