CN103038229B - 杂芳基化合物及其使用方法 - Google Patents
杂芳基化合物及其使用方法 Download PDFInfo
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- CN103038229B CN103038229B CN201180036842.7A CN201180036842A CN103038229B CN 103038229 B CN103038229 B CN 103038229B CN 201180036842 A CN201180036842 A CN 201180036842A CN 103038229 B CN103038229 B CN 103038229B
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- 0 CCCC(C*C1)C(CC2)C1C=*[C@](C)C(C)CC2C1CCCC1 Chemical compound CCCC(C*C1)C(CC2)C1C=*[C@](C)C(C)CC2C1CCCC1 0.000 description 29
- INQGSCNJCJRANF-WCIBSUBMSA-N C/C=C(/c1cccc(C)c1)\NC Chemical compound C/C=C(/c1cccc(C)c1)\NC INQGSCNJCJRANF-WCIBSUBMSA-N 0.000 description 1
- MSYCMCSHRDYWRZ-QCCKHQCCSA-N C/C=C\C/C=C1/N=C(/C=C/c2ccc(C=Cc3c(C4)nccc3C)c4n2)C=CC1=C Chemical compound C/C=C\C/C=C1/N=C(/C=C/c2ccc(C=Cc3c(C4)nccc3C)c4n2)C=CC1=C MSYCMCSHRDYWRZ-QCCKHQCCSA-N 0.000 description 1
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- GEEROORCIQOMER-UHFFFAOYSA-O CC(CCC(N=CC=Cc1ncccc1[NH3+])=N)=Nc(cccc1)c1N Chemical compound CC(CCC(N=CC=Cc1ncccc1[NH3+])=N)=Nc(cccc1)c1N GEEROORCIQOMER-UHFFFAOYSA-O 0.000 description 1
- NSOAWDDYLHFQNB-UHFFFAOYSA-O CC(Cc1nc(cccc2)c2cc1)C(N=C(C=C1)[NH2+]c2c1nccc2)=N Chemical compound CC(Cc1nc(cccc2)c2cc1)C(N=C(C=C1)[NH2+]c2c1nccc2)=N NSOAWDDYLHFQNB-UHFFFAOYSA-O 0.000 description 1
- BFDDRMFGMIQVQV-UHFFFAOYSA-N CC1=NC2=CC=CCC=C2C=C1 Chemical compound CC1=NC2=CC=CCC=C2C=C1 BFDDRMFGMIQVQV-UHFFFAOYSA-N 0.000 description 1
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- TVLXRRLHNXTHRO-UHFFFAOYSA-N CNC(CC=Cc1ncccc11)=C1N Chemical compound CNC(CC=Cc1ncccc11)=C1N TVLXRRLHNXTHRO-UHFFFAOYSA-N 0.000 description 1
- QLQIWRCWPJRJJA-UHFFFAOYSA-O Cc1[nH+]c(-c2ccccc2)c(-c2ccccc2)[o]1 Chemical compound Cc1[nH+]c(-c2ccccc2)c(-c2ccccc2)[o]1 QLQIWRCWPJRJJA-UHFFFAOYSA-O 0.000 description 1
- KIWHWEDXEGNASX-UHFFFAOYSA-N Cc1nc2cccnc2cc1 Chemical compound Cc1nc2cccnc2cc1 KIWHWEDXEGNASX-UHFFFAOYSA-N 0.000 description 1
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- SZXMDUKWIYIKKS-UHFFFAOYSA-N O=Cc1cc(-c2ccccc2)n[o]1 Chemical compound O=Cc1cc(-c2ccccc2)n[o]1 SZXMDUKWIYIKKS-UHFFFAOYSA-N 0.000 description 1
- PWDKEYCSWLSVEY-UHFFFAOYSA-N O=Cc1nc(-c2ccccc2)c(-c2ccccc2)[o]1 Chemical compound O=Cc1nc(-c2ccccc2)c(-c2ccccc2)[o]1 PWDKEYCSWLSVEY-UHFFFAOYSA-N 0.000 description 1
- CITYOBPAADIHAD-UHFFFAOYSA-N OCc1cc(-c2ccccc2)n[o]1 Chemical compound OCc1cc(-c2ccccc2)n[o]1 CITYOBPAADIHAD-UHFFFAOYSA-N 0.000 description 1
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- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
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| PCT/US2011/038057 WO2011150156A2 (en) | 2010-05-26 | 2011-05-26 | Heteroaryl compounds and methods of use thereof |
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| US10562916B2 (en) | 2020-02-18 |
| MX351368B (es) | 2017-10-12 |
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| US8969349B2 (en) | 2015-03-03 |
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| EP2576540B1 (en) | 2019-09-04 |
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| IL266168A (en) | 2019-06-30 |
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| EP3318561B1 (en) | 2021-12-22 |
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| EP3318561A1 (en) | 2018-05-09 |
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| AU2011258217A1 (en) | 2012-12-20 |
| MX2012013624A (es) | 2013-02-11 |
| JP5911476B2 (ja) | 2016-04-27 |
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