KR101581289B1 - 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민 - Google Patents

모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민 Download PDF

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KR101581289B1
KR101581289B1 KR1020097024132A KR20097024132A KR101581289B1 KR 101581289 B1 KR101581289 B1 KR 101581289B1 KR 1020097024132 A KR1020097024132 A KR 1020097024132A KR 20097024132 A KR20097024132 A KR 20097024132A KR 101581289 B1 KR101581289 B1 KR 101581289B1
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compound
substituted
pharmaceutically acceptable
unsubstituted
pain
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KR20100019982A (ko
Inventor
리밍 샤오
펭지앙 왕
스코트 크리스토퍼 말콤
마이클 찰스 휴잇
지안구오 마
세스 리베
마크 에이. 바니
우나 캠벨
샤론 래 엥겔
래리 웬델 하디
패트릭 코크
루디 슈라이버
케리 엘. 스피어
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세프라코 아이엔시.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020097024132A 2007-05-31 2008-06-02 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민 Expired - Fee Related KR101581289B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94124207P 2007-05-31 2007-05-31
US60/941,242 2007-05-31

Publications (2)

Publication Number Publication Date
KR20100019982A KR20100019982A (ko) 2010-02-19
KR101581289B1 true KR101581289B1 (ko) 2015-12-31

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US (3) US8669291B2 (enExample)
EP (3) EP2617704B1 (enExample)
JP (3) JP5420534B2 (enExample)
KR (1) KR101581289B1 (enExample)
CN (3) CN103936605B (enExample)
AU (1) AU2008259841B2 (enExample)
BR (1) BRPI0811639A2 (enExample)
CA (1) CA2688493C (enExample)
IL (1) IL202405A (enExample)
MX (1) MX2009012685A (enExample)
NZ (1) NZ580429A (enExample)
RU (1) RU2470011C2 (enExample)
WO (1) WO2008151156A1 (enExample)
ZA (1) ZA200907171B (enExample)

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JP5438975B2 (ja) 2006-01-06 2014-03-12 サノビオン ファーマシューティカルズ インク テトラロン系モノアミン再取り込み阻害剤
KR101294014B1 (ko) 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
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CN101472887A (zh) 2006-06-23 2009-07-01 艾博特公司 作为组胺h3受体调节物的环丙胺衍生物
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
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US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
BRPI0811639A2 (pt) * 2007-05-31 2014-09-30 Sepracor Inc Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
WO2010017418A1 (en) * 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
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WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
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US9126891B2 (en) * 2014-01-29 2015-09-08 MediSynergics, LLC Cycloalkyl-diamines
US9381170B2 (en) * 2013-01-30 2016-07-05 MediSynergics, LLC Cycloalkyl-diamines for neurodegenerative disorders
US9283196B1 (en) * 2013-01-30 2016-03-15 MediSynergics, LLC Cycloalkyl-diamines for CNS disorders
JP2017523967A (ja) * 2014-07-18 2017-08-24 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 植物の非生物的なストレスに対する活性剤としての置換されているビニルシアノシクロアルカノール類、アルキニルシアノシクロアルカノール類、ビニルシアノヘテロシクロアルカノール類及びアルキニルシアノヘテロシクロアルカノール類
CN109476583B (zh) * 2016-05-12 2025-09-23 研究三角协会 作为神经递质释放剂的插烯苯乙胺
US20230212121A1 (en) 2020-05-29 2023-07-06 Daegu-Gyeongbuk Medical Innovation Foundation Sulfonamide derivative and pharmaceutical composition comprising same as active ingredient for preventing or treating mental illness
US20240018119A1 (en) 2020-05-29 2024-01-18 Daegu-Gyeongbuk Medical Innovation Foundation Carboxamide derivative and pharmaceutical composition comprising same as active ingredient for preventing or treating mental illness
WO2021241982A1 (ko) 2020-05-29 2021-12-02 재단법인 대구경북첨단의료산업진흥재단 N을 하나 이상 포함하는 5원자의 헤테로아릴 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
WO2025232878A1 (zh) * 2024-05-09 2025-11-13 苏州旺山旺水生物医药股份有限公司 一类含取代的苯基的胺类化合物、其制备方法和用途

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