PT1543011E - Composto de tienopirrolilo e furanopirrolilo e sua utilizacao como ligandos do receptor h4 da histamina - Google Patents
Composto de tienopirrolilo e furanopirrolilo e sua utilizacao como ligandos do receptor h4 da histaminaInfo
- Publication number
- PT1543011E PT1543011E PT03754461T PT03754461T PT1543011E PT 1543011 E PT1543011 E PT 1543011E PT 03754461 T PT03754461 T PT 03754461T PT 03754461 T PT03754461 T PT 03754461T PT 1543011 E PT1543011 E PT 1543011E
- Authority
- PT
- Portugal
- Prior art keywords
- histamine
- receptor
- tienopyrolyl
- furanopyrolyl
- ligands
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40872302P | 2002-09-06 | 2002-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1543011E true PT1543011E (pt) | 2006-08-31 |
Family
ID=31978666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT03754461T PT1543011E (pt) | 2002-09-06 | 2003-09-05 | Composto de tienopirrolilo e furanopirrolilo e sua utilizacao como ligandos do receptor h4 da histamina |
Country Status (12)
Country | Link |
---|---|
US (3) | US7226938B2 (pt) |
EP (1) | EP1543011B1 (pt) |
JP (1) | JP4596915B2 (pt) |
AT (1) | ATE325125T1 (pt) |
AU (1) | AU2003272285A1 (pt) |
CA (1) | CA2497868C (pt) |
CY (1) | CY1105080T1 (pt) |
DE (1) | DE60305052T2 (pt) |
DK (1) | DK1543011T3 (pt) |
ES (1) | ES2264534T3 (pt) |
PT (1) | PT1543011E (pt) |
WO (1) | WO2004022537A2 (pt) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2264534T3 (es) * | 2002-09-06 | 2007-01-01 | Janssen Pharmaceutica N.V. | Compuestos de tienopirrolilo y furanopirrolilo y su utilizacion como ligandos del receptor histaminico h4. |
GB0222912D0 (en) * | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
GB0222909D0 (en) * | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
EP1685406A4 (en) * | 2003-09-26 | 2008-11-12 | Janssen Pharmaceutica Nv | ANALYSIS OF THE HISTAMINE H SB 4 / SB RECEPTOR MEDIA EFFECTS IN WHOLE BLOOD |
US7488747B2 (en) * | 2003-12-29 | 2009-02-10 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
CN101006053A (zh) | 2004-06-18 | 2007-07-25 | 比奥里波克斯公司 | 用于治疗炎症的吲哚 |
EP1812113A1 (en) * | 2004-11-11 | 2007-08-01 | Argenta Discovery Limited | Pyrimidine compounds as histamine modulators |
EP1776982A1 (en) * | 2005-10-18 | 2007-04-25 | Argenta Discovery Limited | Pyrimidine compounds as histamine modulators |
CA2587141A1 (en) * | 2004-11-24 | 2006-06-01 | Pfizer Inc. | Octahydropyrrolo[3,4-c]pyrrole derivatives |
EP1671972A1 (en) * | 2004-11-24 | 2006-06-21 | Pfizer Limited | Octahydropyrrolo[3,4-c]pyrrole derivatives |
JP2008527029A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
WO2007006003A2 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
EP1767537A1 (en) * | 2005-09-21 | 2007-03-28 | Cellzome (UK) Ltd. | Pyrimidine compounds for the treatment of inflammatory disorders |
NL2000323C2 (nl) * | 2005-12-20 | 2007-11-20 | Pfizer Ltd | Pyrimidine-derivaten. |
CN101394847B (zh) * | 2006-01-06 | 2017-05-24 | 塞普拉柯公司 | 作为单胺重摄取抑制剂的环烷基胺类 |
JP5438975B2 (ja) | 2006-01-06 | 2014-03-12 | サノビオン ファーマシューティカルズ インク | テトラロン系モノアミン再取り込み阻害剤 |
WO2007117399A2 (en) | 2006-03-31 | 2007-10-18 | Janssen Pharmaceutica N.V. | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor |
DK2013835T3 (en) | 2006-03-31 | 2015-12-14 | Sunovion Pharmaceuticals Inc | Preparation of chiral amides and AMINES |
EP2010177A2 (en) * | 2006-04-10 | 2009-01-07 | Janssen Pharmaceutica N.V. | Combination histamine h1r and h4r antagonist therapy for treating pruritus |
US20080058395A1 (en) * | 2006-06-30 | 2008-03-06 | Sepracor Inc. | Fused heterocyclic inhibitors of D-amino acid oxidase |
US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
MX2008016525A (es) * | 2006-06-30 | 2009-03-09 | Sepracor Inc | Inhibidores heterocíclicos fusionados de d-amino ácido oxidasa. |
US20080082066A1 (en) * | 2006-10-02 | 2008-04-03 | Weyerhaeuser Co. | Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks |
US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
EP2077267A4 (en) | 2006-10-18 | 2010-04-07 | Takeda Pharmaceutical | FUSED HETEROCYCLIC COMPOUND |
WO2008074445A1 (en) * | 2006-12-18 | 2008-06-26 | Ucb Pharma, S.A. | Novel tricyclic and heterotricyclic derivatives, processes for preparing them, pharmaceutical compositions thereof |
US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
ZA200904686B (en) * | 2007-01-18 | 2010-09-29 | Sepracor Inc | Inhibitiors of D-amino acid oxidase |
JP5420534B2 (ja) | 2007-05-31 | 2014-02-19 | サノビオン ファーマシューティカルズ インク | モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン |
NZ589531A (en) | 2008-06-12 | 2012-08-31 | Janssen Pharmaceutica Nv | Use of histamine H4 antagonist for the treatment of post-operative tissue adhesions after surgical procedures |
US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
US20100120740A1 (en) * | 2008-08-07 | 2010-05-13 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
US20120277238A1 (en) * | 2009-07-31 | 2012-11-01 | Shionogi & Co., Ltd | Pharmaceutical composition containing fused hetero-ring derivative |
US20110034434A1 (en) * | 2009-08-07 | 2011-02-10 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
EP2858647B1 (en) | 2012-06-08 | 2018-05-23 | Sensorion | H4 receptor inhibitors for treating tinnitus |
UY35370A (es) | 2013-03-06 | 2014-09-30 | Janssen Pharmaceutica Nv | Moduladores benzoimidazol-2-il pirimidina del receptor de histamina h4 |
TW201729810A (zh) | 2015-10-26 | 2017-09-01 | 札爾科製藥公司 | 嘧啶組成物、其超純組成物及鹽類、製造彼之方法、及使用彼於治療組織胺h4受體(h 4 )仲介之疾病與病情之方法 |
CN109499595B (zh) * | 2018-11-16 | 2021-10-08 | 中国林业科学研究院林产化学工业研究所 | 一种氧还原反应(orr)催化剂gpncs及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2571723B1 (fr) * | 1984-10-12 | 1988-08-26 | Lipha | Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant |
NZ223654A (en) | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
GB9803228D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
EP1088824B1 (en) | 1999-09-30 | 2004-01-07 | Pfizer Products Inc. | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors |
EP1136071A3 (en) | 2000-03-22 | 2003-03-26 | Pfizer Products Inc. | Use of glycogen phosphorylase inhibitors |
JP4544820B2 (ja) * | 2001-03-09 | 2010-09-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 複素環化合物 |
ES2264534T3 (es) * | 2002-09-06 | 2007-01-01 | Janssen Pharmaceutica N.V. | Compuestos de tienopirrolilo y furanopirrolilo y su utilizacion como ligandos del receptor histaminico h4. |
-
2003
- 2003-09-05 ES ES03754461T patent/ES2264534T3/es not_active Expired - Lifetime
- 2003-09-05 DK DK03754461T patent/DK1543011T3/da active
- 2003-09-05 DE DE60305052T patent/DE60305052T2/de not_active Expired - Lifetime
- 2003-09-05 CA CA2497868A patent/CA2497868C/en not_active Expired - Fee Related
- 2003-09-05 US US10/656,059 patent/US7226938B2/en active Active
- 2003-09-05 JP JP2004534722A patent/JP4596915B2/ja not_active Expired - Fee Related
- 2003-09-05 EP EP03754461A patent/EP1543011B1/en not_active Expired - Lifetime
- 2003-09-05 AT AT03754461T patent/ATE325125T1/de active
- 2003-09-05 AU AU2003272285A patent/AU2003272285A1/en not_active Abandoned
- 2003-09-05 WO PCT/US2003/028017 patent/WO2004022537A2/en active IP Right Grant
- 2003-09-05 PT PT03754461T patent/PT1543011E/pt unknown
-
2006
- 2006-07-07 CY CY20061100955T patent/CY1105080T1/el unknown
-
2007
- 2007-04-13 US US11/735,311 patent/US20070185131A1/en not_active Abandoned
- 2007-04-13 US US11/735,306 patent/US7645758B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE60305052T2 (de) | 2006-12-21 |
DE60305052D1 (de) | 2006-06-08 |
CA2497868A1 (en) | 2004-03-18 |
WO2004022537A2 (en) | 2004-03-18 |
US20040048878A1 (en) | 2004-03-11 |
DK1543011T3 (da) | 2006-08-07 |
JP2006500394A (ja) | 2006-01-05 |
US7645758B2 (en) | 2010-01-12 |
AU2003272285A8 (en) | 2004-03-29 |
ES2264534T3 (es) | 2007-01-01 |
EP1543011A2 (en) | 2005-06-22 |
ATE325125T1 (de) | 2006-06-15 |
WO2004022537A3 (en) | 2004-05-06 |
AU2003272285A1 (en) | 2004-03-29 |
CY1105080T1 (el) | 2009-11-04 |
US20070185120A1 (en) | 2007-08-09 |
EP1543011B1 (en) | 2006-05-03 |
JP4596915B2 (ja) | 2010-12-15 |
US20070185131A1 (en) | 2007-08-09 |
CA2497868C (en) | 2010-11-30 |
US7226938B2 (en) | 2007-06-05 |
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