TW200716616A - Modulators of CCR-5 activity - Google Patents
Modulators of CCR-5 activityInfo
- Publication number
- TW200716616A TW200716616A TW095118810A TW95118810A TW200716616A TW 200716616 A TW200716616 A TW 200716616A TW 095118810 A TW095118810 A TW 095118810A TW 95118810 A TW95118810 A TW 95118810A TW 200716616 A TW200716616 A TW 200716616A
- Authority
- TW
- Taiwan
- Prior art keywords
- ccr
- modulators
- activity
- compounds
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ths present invention relates to low molecular weight compounds, including compounds of Formulas I and II as defined herein, and pharmaceutical compositions thereof, useful as modulators of CCR-5 activity. The invention further relates to the use of such compounds and compositions in treating disorders mediated by CCR-5 such as viral infections and inflammatory diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68514705P | 2005-05-27 | 2005-05-27 | |
US78509006P | 2006-03-22 | 2006-03-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200716616A true TW200716616A (en) | 2007-05-01 |
Family
ID=37482161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095118810A TW200716616A (en) | 2005-05-27 | 2006-05-26 | Modulators of CCR-5 activity |
Country Status (2)
Country | Link |
---|---|
TW (1) | TW200716616A (en) |
WO (1) | WO2006130426A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
GB201321748D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
US10138255B2 (en) | 2014-03-10 | 2018-11-27 | Merck Sharp & Dohme Corp. | Piperazine derivatives as HIV protease inhibitors |
WO2015135091A1 (en) * | 2014-03-10 | 2015-09-17 | Merck Sharp & Dohme Corp. | Piperazine derivatives as hiv protease inhibitors |
CA2944069C (en) * | 2014-04-01 | 2022-03-08 | William Hawkins | Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof |
CN104083386B (en) * | 2014-07-08 | 2016-07-06 | 滨州医学院 | Amprenavir application in the medicine of preparation prevention or treatment acute lung injury/acute respiratory distress syndrome and pulmonary fibrosis |
CN104387379B (en) * | 2014-11-26 | 2017-01-11 | 扬州氟药科技有限公司 | Difluoro methylene piperidine carboxamide derivative as well as preparation method and application thereof |
SG11201707429VA (en) | 2015-04-02 | 2017-10-30 | Proximagen Ltd | Novel therapies for cancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1180513A4 (en) * | 1999-04-28 | 2002-07-10 | Takeda Chemical Industries Ltd | Cyclic amide compounds, process for the preparation of the same and uses thereof |
PE20010628A1 (en) * | 1999-10-01 | 2001-06-18 | Takeda Chemical Industries Ltd | CYCLIC AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE |
-
2006
- 2006-05-25 WO PCT/US2006/020255 patent/WO2006130426A2/en active Application Filing
- 2006-05-26 TW TW095118810A patent/TW200716616A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2006130426A2 (en) | 2006-12-07 |
WO2006130426A3 (en) | 2007-06-21 |
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