|
US8993808B2
(en)
|
2009-01-21 |
2015-03-31 |
Oryzon Genomics, S.A. |
Phenylcyclopropylamine derivatives and their medical use
|
|
US8859555B2
(en)
|
2009-09-25 |
2014-10-14 |
Oryzon Genomics S.A. |
Lysine Specific Demethylase-1 inhibitors and their use
|
|
EP2486002B1
(en)
|
2009-10-09 |
2019-03-27 |
Oryzon Genomics, S.A. |
Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
|
|
US9616058B2
(en)
|
2010-02-24 |
2017-04-11 |
Oryzon Genomics, S.A. |
Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
|
|
WO2011106573A2
(en)
|
2010-02-24 |
2011-09-01 |
Oryzon Genomics, S.A. |
Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
|
|
MX2012012111A
(es)
|
2010-04-19 |
2013-05-30 |
Oryzon Genomics Sa |
Inhibidores de demetilasa-1 especifica de lisina y su uso.
|
|
SI2598482T1
(sl)
|
2010-07-29 |
2018-09-28 |
Oryzon Genomics, S.A. |
Inhibitorji demetilaze lsd1 na osnovi arilciklopropilamina in njihova medicinska uporaba
|
|
WO2012013727A1
(en)
|
2010-07-29 |
2012-02-02 |
Oryzon Genomics S.A. |
Cyclopropylamine derivatives useful as lsd1 inhibitors
|
|
WO2012045883A1
(en)
|
2010-10-08 |
2012-04-12 |
Oryzon Genomics S.A. |
Cyclopropylamine inhibitors of oxidases
|
|
WO2012072713A2
(en)
|
2010-11-30 |
2012-06-07 |
Oryzon Genomics, S.A. |
Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
|
|
WO2012107498A1
(en)
|
2011-02-08 |
2012-08-16 |
Oryzon Genomics S.A. |
Lysine demethylase inhibitors for myeloproliferative disorders
|
|
UA114406C2
(uk)
*
|
2011-08-09 |
2017-06-12 |
Такеда Фармасьютікал Компані Лімітед |
Похідні циклопропанаміну як інгібітори lsd1
|
|
CN107266345B
(zh)
*
|
2011-10-20 |
2021-08-17 |
奥瑞泽恩基因组学股份有限公司 |
作为lsd1抑制剂的(杂)芳基环丙胺化合物
|
|
RS58475B1
(sr)
|
2011-10-20 |
2019-04-30 |
Oryzon Genomics Sa |
Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori
|
|
BR112015007083A2
(pt)
|
2012-10-02 |
2017-07-04 |
Epitherapeutics Aps |
inibidores de histona demetilases
|
|
US9751885B2
(en)
|
2012-10-12 |
2017-09-05 |
Takeda Pharmaceutical Company Limited |
Cyclopropanamine compound and use thereof
|
|
EP2740474A1
(en)
|
2012-12-05 |
2014-06-11 |
Instituto Europeo di Oncologia S.r.l. |
Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
|
|
PE20151667A1
(es)
|
2013-02-27 |
2015-11-27 |
Epitherapeutics Aps |
Inhibidores de histona desmetilasas
|
|
US9918983B2
(en)
|
2013-05-30 |
2018-03-20 |
The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas |
Suicidal LSD1 inhibitors targeting SOX2-expressing cancer cells
|
|
US9771348B2
(en)
*
|
2013-07-25 |
2017-09-26 |
Dong-A St Co., Ltd |
Method for preparing benzamide derivative, novel intermediate used in preparation of benzamide, and method for preparing novel intermediate
|
|
AU2014306149B2
(en)
*
|
2013-08-06 |
2019-09-19 |
Imago Biosciences Inc. |
KDM1A inhibitors for the treatment of disease
|
|
US9527835B2
(en)
|
2014-02-13 |
2016-12-27 |
Incyte Corporation |
Cyclopropylamines as LSD1 inhibitors
|
|
NZ723203A
(en)
|
2014-02-13 |
2020-08-28 |
Incyte Corp |
Cyclopropylamines as lsd1 inhibitors
|
|
KR102421235B1
(ko)
*
|
2014-02-13 |
2022-07-15 |
인사이트 코포레이션 |
Lsd1 저해제로서 사이클로프로필아민
|
|
EP3392244A1
(en)
*
|
2014-02-13 |
2018-10-24 |
Incyte Corporation |
Cyclopropylamines as lsd1 inhibitors
|
|
CN104042616B
(zh)
*
|
2014-02-20 |
2016-08-24 |
复旦大学附属眼耳鼻喉科医院 |
赖氨酸特异性去甲基化酶1抑制剂的应用
|
|
SG11201608340UA
(en)
|
2014-04-11 |
2016-11-29 |
Takeda Pharmaceuticals Co |
Cyclopropanamine compound and use thereof
|
|
HUE057895T2
(hu)
|
2014-05-01 |
2022-06-28 |
Celgene Quanticel Res Inc |
Lizinspecifikus demetiláz-1 inhibitorai
|
|
WO2016007731A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Imidazopyridines and imidazopyrazines as lsd1 inhibitors
|
|
US9758523B2
(en)
|
2014-07-10 |
2017-09-12 |
Incyte Corporation |
Triazolopyridines and triazolopyrazines as LSD1 inhibitors
|
|
WO2016007722A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Triazolopyridines and triazolopyrazines as lsd1 inhibitors
|
|
US9695180B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
|
|
EA201790154A1
(ru)
|
2014-08-27 |
2017-08-31 |
Джилид Сайэнс, Инк. |
Соединения и способы для ингибирования гистоновых деметилаз
|
|
WO2016055935A1
(en)
*
|
2014-10-06 |
2016-04-14 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Combination of lysine-specific demethylase 1 inhibitor and thrombopoietin agonist
|
|
EA039196B1
(ru)
*
|
2014-10-08 |
2021-12-16 |
Инсайт Корпорейшн |
Циклопропиламины в качестве ингибиторов lsd1
|
|
WO2016123387A1
(en)
*
|
2015-01-30 |
2016-08-04 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
KR102626978B1
(ko)
|
2015-02-12 |
2024-01-18 |
이마고 바이오사이언시즈 인코포레이티드 |
질환 치료를 위한 kdm1a 저해제
|
|
UA122688C2
(uk)
|
2015-04-03 |
2020-12-28 |
Інсайт Корпорейшн |
Гетероциклічні сполуки як інгібітори lsd1
|
|
US10526287B2
(en)
|
2015-04-23 |
2020-01-07 |
Constellation Pharmaceuticals, Inc. |
LSD1 inhibitors and uses thereof
|
|
EP3090998A1
(en)
|
2015-05-06 |
2016-11-09 |
F. Hoffmann-La Roche AG |
Solid forms
|
|
AU2016275702A1
(en)
|
2015-06-12 |
2017-12-21 |
Oryzon Genomics, S.A. |
Biomarkers associated with LSD1 inhibitors and uses thereof
|
|
WO2017013061A1
(en)
|
2015-07-17 |
2017-01-26 |
Oryzon Genomics, S.A. |
Biomarkers associated with lsd1 inhibitors and uses thereof
|
|
JP7427363B2
(ja)
*
|
2015-08-12 |
2024-02-05 |
インサイト・ホールディングス・コーポレイション |
Lsd1阻害剤の塩
|
|
MA42683A
(fr)
|
2015-08-27 |
2018-07-04 |
Genentech Inc |
Composés thérapeutiques et leurs méthodes utilisation
|
|
US10059668B2
(en)
*
|
2015-11-05 |
2018-08-28 |
Mirati Therapeutics, Inc. |
LSD1 inhibitors
|
|
CN108495851A
(zh)
|
2015-11-25 |
2018-09-04 |
基因泰克公司 |
取代的苯甲酰胺及其使用方法
|
|
WO2017097865A1
(en)
*
|
2015-12-07 |
2017-06-15 |
Istituto Europeo Di Oncologia |
Combination of caloric restriction (cr) or igf1/insulin receptor inhibitor with lsd1 inhibitor
|
|
SG11201805645QA
(en)
|
2015-12-29 |
2018-07-30 |
Mirati Therapeutics Inc |
Lsd1 inhibitors
|
|
BR112018013074A2
(en)
|
2015-12-30 |
2018-12-11 |
Novartis Ag |
immune effector cell therapies with enhanced efficacy
|
|
US11013698B2
(en)
|
2016-03-15 |
2021-05-25 |
Oryzon Genomics S.A. |
Combinations of LSD1 inhibitors for the treatment of hematological malignancies
|
|
ES3057783T3
(en)
|
2016-03-15 |
2026-03-04 |
Oryzon Genomics Sa |
Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
|
|
CN107200706A
(zh)
*
|
2016-03-16 |
2017-09-26 |
中国科学院上海药物研究所 |
一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途
|
|
WO2017158136A1
(en)
|
2016-03-16 |
2017-09-21 |
Oryzon Genomics, S.A. |
Methods to determine kdm1a target engagement and chemoprobes useful therefor
|
|
EP3854782A1
(en)
|
2016-03-30 |
2021-07-28 |
Genentech, Inc. |
Substituted benzamides and methods of use thereof
|
|
US10166221B2
(en)
|
2016-04-22 |
2019-01-01 |
Incyte Corporation |
Formulations of an LSD1 inhibitor
|
|
CN107459476B
(zh)
*
|
2016-06-03 |
2022-06-24 |
中国科学院上海药物研究所 |
反吲哚啉环丙胺类化合物及其制备方法、药物组合物和用途
|
|
PL3307267T3
(pl)
|
2016-06-10 |
2019-10-31 |
Oryzon Genomics Sa |
Leczenie stwardnienia rozsianego
|
|
WO2018020366A1
(en)
|
2016-07-26 |
2018-02-01 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Crystalline (r)-mandelate salt of (1r,2s)-2-phenylcyclopropylamine
|
|
SG10201610038SA
(en)
*
|
2016-07-29 |
2017-12-28 |
Apple Inc |
Systems and methods for management of asymmetrical multi-tapped battery packs
|
|
US11390590B2
(en)
|
2016-08-16 |
2022-07-19 |
Imago Biosciences, Inc. |
Methods and processes for the preparation of KDM1A inhibitors
|
|
SG11201903348UA
(en)
|
2016-10-17 |
2019-05-30 |
Genentech Inc |
Therapeutic compounds and methods of use thereof
|
|
WO2018083189A1
(en)
|
2016-11-03 |
2018-05-11 |
Oryzon Genomics, S.A. |
Biomarkers for determining responsiveness to lsd1 inhibitors
|
|
WO2018083138A1
(en)
|
2016-11-03 |
2018-05-11 |
Oryzon Genomics, S.A. |
Pharmacodynamic biomarkers for personalized cancer care using epigenetic modifying agents
|
|
WO2018106984A1
(en)
|
2016-12-09 |
2018-06-14 |
Constellation Pharmaceuticals, Inc. |
Markers for personalized cancer treatment with lsd1 inhibitors
|
|
JP7217712B2
(ja)
*
|
2017-01-24 |
2023-02-03 |
シーエスピーシー ジョォンチィ ファーマシューティカル テクノロジー (シージアジョァン)カンパニー,リミテッド |
Lsd1阻害剤、その製造方法及び応用
|
|
WO2018175707A1
(en)
|
2017-03-24 |
2018-09-27 |
Genentech, Inc. |
4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
|
|
WO2018197583A1
(en)
|
2017-04-26 |
2018-11-01 |
Istituto Europeo Di Oncologia |
Use of a combinational therapy of lsd1 inhibitors with p21 activators in the treatment of cancer
|
|
CN110740991B
(zh)
|
2017-05-26 |
2023-07-04 |
大鹏药品工业株式会社 |
新型联苯化合物或其盐
|
|
HUE062769T2
(hu)
|
2017-05-26 |
2023-12-28 |
Taiho Pharmaceutical Co Ltd |
Antitumor potenciátor bifenil vegyület felhasználásával
|
|
EP3633380A4
(en)
|
2017-05-31 |
2021-02-24 |
Taiho Pharmaceutical Co., Ltd. |
METHOD OF PREDICTING THE THERAPEUTIC EFFECT OF LSD1 INHIBITORS ON THE BASIS OF THE EXPRESSION OF INSM1
|
|
KR20180134675A
(ko)
*
|
2017-06-09 |
2018-12-19 |
한미약품 주식회사 |
시클로프로필아민 유도체 화합물 및 이의 용도
|
|
JP2020152641A
(ja)
*
|
2017-07-07 |
2020-09-24 |
国立研究開発法人理化学研究所 |
リジン特異的脱メチル化酵素1阻害活性を有する新規化合物、その製造方法及びその用途
|
|
SI3661510T1
(sl)
|
2017-08-03 |
2025-03-31 |
Oryzon Genomics, S.A. |
Postopki zdravljenja vedenjskih sprememb
|
|
AR112900A1
(es)
|
2017-09-13 |
2019-12-26 |
Hanmi Pharm Ind Co Ltd |
Compuesto derivado de pirazol y uso de este
|
|
WO2019068326A1
(en)
|
2017-10-05 |
2019-04-11 |
Université D'aix-Marseille |
INHIBITORS OF LSD1 FOR THE TREATMENT AND PREVENTION OF CARDIOMYOPATHIES
|
|
KR20190040763A
(ko)
|
2017-10-11 |
2019-04-19 |
한미약품 주식회사 |
피라졸로피리딘 유도체 화합물 및 이의 용도
|
|
KR20190040783A
(ko)
|
2017-10-11 |
2019-04-19 |
한미약품 주식회사 |
라이신 특이적 데메틸라제-1 억제제로서의 피라졸 유도체
|
|
WO2019083971A1
(en)
|
2017-10-23 |
2019-05-02 |
Children's Medical Center Corporation |
METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY
|
|
WO2019109095A1
(en)
*
|
2017-12-01 |
2019-06-06 |
Beth Israel Deaconess Medical Center, Inc. |
Arsenic trioxide and retinoic acid compounds for treatment of idh2-associated disorders
|
|
CN108107199B
(zh)
*
|
2017-12-21 |
2019-02-12 |
广州市进德生物科技有限公司 |
一种酶化学发光法测定尿酸的检测试剂盒
|
|
EP3759098A1
(en)
|
2018-02-26 |
2021-01-06 |
Genentech, Inc. |
Pyridine-sulfonamide compounds and their use against pain and related conditions
|
|
EP3774801A1
(en)
|
2018-03-30 |
2021-02-17 |
F. Hoffmann-La Roche AG |
Fused ring hydro-pyrido compounds as sodium channel inhibitors
|
|
KR102684364B1
(ko)
|
2018-05-11 |
2024-07-11 |
이마고 바이오사이언시즈 인코포레이티드 |
질환의 치료를 위한 kdm1a 저해제
|
|
TW202003490A
(zh)
|
2018-05-22 |
2020-01-16 |
瑞士商赫孚孟拉羅股份公司 |
治療性化合物及其使用方法
|
|
WO2020015745A1
(zh)
*
|
2018-07-20 |
2020-01-23 |
南京明德新药研发有限公司 |
一种lsd1抑制剂的盐及其晶型
|
|
WO2020047198A1
(en)
|
2018-08-31 |
2020-03-05 |
Incyte Corporation |
Salts of an lsd1 inhibitor and processes for preparing the same
|
|
US11649245B2
(en)
|
2018-09-13 |
2023-05-16 |
Helioeast Pharmaceutical Co., Ltd. |
Cyclopropylamine compound as LSD1 inhibitor and use thereof
|
|
CN112672994B
(zh)
*
|
2018-09-13 |
2022-09-13 |
南昌弘益药业有限公司 |
作为lsd1抑制剂的杂螺环类化合物及其应用
|
|
EP3890715A4
(en)
*
|
2018-12-04 |
2023-03-29 |
The Board Of Regents Of The University Of Texas System |
ANTI-ADENOMATOUS POLYPOSIS COLI (APC) THERAPEUTICS FOR THE TREATMENT OF CANCER
|
|
JPWO2020138398A1
(ja)
*
|
2018-12-28 |
2021-11-04 |
国立研究開発法人理化学研究所 |
リジン特異的脱メチル化酵素1を阻害する新規化合物、その製造方法及びその用途
|
|
WO2020159285A1
(ko)
|
2019-02-01 |
2020-08-06 |
한미약품 주식회사 |
이미다조피리딘 유도체 화합물 및 이의 용도
|
|
EP3907225A4
(en)
|
2019-02-01 |
2022-09-14 |
Hanmi Pharm. Co., Ltd. |
COMPOUNDS DERIVED FROM IMIDAZOPYRIDINE AND THEIR USE
|
|
US20220151999A1
(en)
|
2019-03-20 |
2022-05-19 |
Oryzon Genomics, S.A. |
Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
|
|
US20220151998A1
(en)
|
2019-03-20 |
2022-05-19 |
Oryzon Genomics, S.A. |
Methods of treating borderline personality disorder
|
|
JP2022546908A
(ja)
|
2019-07-05 |
2022-11-10 |
オリゾン・ゲノミクス・ソシエダッド・アノニマ |
Kdm1a阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法
|
|
WO2021058024A1
(zh)
*
|
2019-09-29 |
2021-04-01 |
南京明德新药研发有限公司 |
Lsd1抑制剂
|
|
WO2021243135A1
(en)
*
|
2020-05-28 |
2021-12-02 |
Nike Innovate C.V. |
Foot support systems including fluid movement controllers and adjustable foot support pressure
|
|
EP3964204A1
(en)
|
2020-09-08 |
2022-03-09 |
Université d'Aix-Marseille |
Lsd1 inhibitors for use in the treatment and prevention of fibrosis of tissues
|
|
CN115485282B
(zh)
*
|
2021-02-09 |
2025-09-09 |
南昌弘益药业有限公司 |
一种氧氮杂螺环化合物、其盐型及其晶型
|
|
CA3231846A1
(en)
|
2021-04-08 |
2022-10-13 |
Tamara Maes |
Combinations of lsd1 inhibitors for treating myeloid cancers
|
|
CN116888122A
(zh)
*
|
2021-06-22 |
2023-10-13 |
南昌弘益药业有限公司 |
含氮氧杂螺环类化合物及其应用
|
|
CN113512031B
(zh)
*
|
2021-07-01 |
2024-01-30 |
都创(上海)医药开发有限公司 |
一种lsd1酶抑制剂tak-418中间体化合物制备方法
|
|
EP4419093A1
(en)
|
2021-10-20 |
2024-08-28 |
Queen Mary University of London |
Sequential treatments and biomarkers to reverse resistance to kinase inhibitors
|
|
GB202115017D0
(en)
|
2021-10-20 |
2021-12-01 |
Univ London Queen Mary |
Sequential treatments and biomarkers to reverse resistance to kinase inhibitors
|
|
EP4522136A1
(en)
|
2022-05-09 |
2025-03-19 |
Oryzon Genomics, S.A. |
Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
|
|
CN119497613A
(zh)
|
2022-05-09 |
2025-02-21 |
奥莱松基因组股份有限公司 |
使用lsd1抑制剂治疗nf1-突变肿瘤的方法
|
|
WO2024110649A1
(en)
|
2022-11-24 |
2024-05-30 |
Oryzon Genomics, S.A. |
Combinations of lsd1 inhibitors and menin inhibitors for treating cancer
|
|
CN121712509A
(zh)
|
2023-05-04 |
2026-03-20 |
锐新医药公司 |
用于ras相关疾病或病症的组合疗法
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
CN117164465B
(zh)
*
|
2023-09-04 |
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