JP2013523733A5 - - Google Patents
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- Publication number
- JP2013523733A5 JP2013523733A5 JP2013502610A JP2013502610A JP2013523733A5 JP 2013523733 A5 JP2013523733 A5 JP 2013523733A5 JP 2013502610 A JP2013502610 A JP 2013502610A JP 2013502610 A JP2013502610 A JP 2013502610A JP 2013523733 A5 JP2013523733 A5 JP 2013523733A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically
- dihydroquinolin
- indazol
- methylpiperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- -1 3- (7-Methyl-1H-indazol-5-yl) -1- (4- (1-methylpiperidin-4-yl) piperazin-1-yl) -1-oxopropane -2-yl Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims 1
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 claims 1
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31901510P | 2010-03-30 | 2010-03-30 | |
| US61/319,015 | 2010-03-30 | ||
| PCT/US2011/028168 WO2011123232A1 (en) | 2010-03-30 | 2011-03-11 | Cgrp receptor antagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523733A JP2013523733A (ja) | 2013-06-17 |
| JP2013523733A5 true JP2013523733A5 (enExample) | 2014-04-24 |
| JP5908455B2 JP5908455B2 (ja) | 2016-04-26 |
Family
ID=43896902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013502610A Active JP5908455B2 (ja) | 2010-03-30 | 2011-03-11 | Ｃｇｒｐ受容体アンタゴニスト |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8481546B2 (enExample) |
| EP (1) | EP2552906B1 (enExample) |
| JP (1) | JP5908455B2 (enExample) |
| KR (3) | KR20180049168A (enExample) |
| CN (1) | CN102834388B (enExample) |
| AR (1) | AR080746A1 (enExample) |
| AU (1) | AU2011233627B2 (enExample) |
| BR (1) | BR112012024785B1 (enExample) |
| CA (1) | CA2794950C (enExample) |
| CL (1) | CL2012002739A1 (enExample) |
| CY (1) | CY1117593T1 (enExample) |
| DK (1) | DK2552906T3 (enExample) |
| EA (1) | EA022815B1 (enExample) |
| ES (1) | ES2562610T3 (enExample) |
| HR (1) | HRP20160287T1 (enExample) |
| HU (1) | HUE028735T2 (enExample) |
| IL (1) | IL221665A (enExample) |
| MX (1) | MX2012010725A (enExample) |
| NZ (1) | NZ603231A (enExample) |
| PE (1) | PE20130340A1 (enExample) |
| PL (1) | PL2552906T3 (enExample) |
| PT (1) | PT2552906E (enExample) |
| RS (1) | RS54608B1 (enExample) |
| SG (1) | SG183918A1 (enExample) |
| SI (1) | SI2552906T1 (enExample) |
| SM (1) | SMT201600078B (enExample) |
| TW (1) | TWI483937B (enExample) |
| WO (1) | WO2011123232A1 (enExample) |
| ZA (1) | ZA201207292B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201519195D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| GB201519196D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| GB201519194D0 (en) * | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| CN112888438A (zh) * | 2018-10-13 | 2021-06-01 | 拜尔哈文制药股份有限公司 | Cgrp拮抗剂的前药 |
| PH12021551689A1 (en) * | 2019-01-20 | 2022-05-11 | Pfizer Ireland Pharmaceuticals | Cgrp antagonists for treating migraine breakthrough |
| PH12021552546A1 (en) | 2019-04-11 | 2022-07-04 | Scherer Technologies Llc R P | Formulation for oral delivery of proteins, peptides and small molecules with poor permeability |
| JP2023507094A (ja) * | 2019-12-17 | 2023-02-21 | バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド | Ｃｇｒｐ阻害剤の鼻腔内医薬組成物 |
| CN116456981A (zh) * | 2020-11-19 | 2023-07-18 | 辉瑞爱尔兰制药公司 | 用于改善的grp抑制剂递送的组合物 |
| IL302948A (en) * | 2020-11-19 | 2023-07-01 | Pfizer Ireland Pharmaceuticals | Compositions for improved delivery of cgrp inhibitors |
| KR20230157986A (ko) | 2021-03-02 | 2023-11-17 | 체게에르페 다이어그노스틱스 게엠베하 | 편투통 발생의 치료 및/또는 저감 |
| EP4320113A1 (en) | 2021-04-09 | 2024-02-14 | Teva Czech Industries s.r.o. | Solid state forms of zavegepant and process for preparation thereof |
| WO2023026205A1 (en) | 2021-08-24 | 2023-03-02 | Cgrp Diagnostics Gmbh | Preventative treatment of migraine |
| CN117624191A (zh) * | 2022-08-30 | 2024-03-01 | 熙源安健医药（上海）有限公司 | 吲唑甲酰胺类衍生物及其制备方法和用途 |
| CA3252054A1 (en) | 2022-11-09 | 2024-05-16 | Tapi Czech Industries S.R.O. | SOLID FORMS OF ZAVÉGÉPANT HYDROCHLORIDE AND THEIR PREPARATION PROCESS |
| CN116003387B (zh) * | 2022-11-20 | 2024-03-26 | 药康众拓(北京)医药科技有限公司 | 一种氘代吲唑丙酰胺类化合物、药物组合物和用途 |
| WO2025003905A1 (en) | 2023-06-29 | 2025-01-02 | Pfizer Inc. | Solid forms of (r)-n-(3-(7-methyl-1h-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide |
| CN119462607B (zh) * | 2023-08-10 | 2025-11-28 | 南京宁丹新药技术股份有限公司 | 一类喹啉酮衍生物及其用途 |
| CN117551081A (zh) * | 2023-11-13 | 2024-02-13 | 北京康立生医药技术开发有限公司 | 一种偏头痛治疗药物新的制备方法 |
| ES3027457A1 (es) | 2023-12-13 | 2025-06-13 | Moehs Iberica Sl | Metodo de preparacion de zavegepant, intermedios de sintesis de zavegepant y metodos de preparacion de los mismos |
| WO2025238595A1 (en) | 2024-05-16 | 2025-11-20 | Olon S.P.A. | Process for preparing (r)-2-amino-3-(7-methyl-1h-indazol-5-yl) methyl propanoate, and use thereof as intermediate for the synthesis of zavegepant |
| CN119306698B (zh) * | 2024-10-09 | 2025-10-21 | 浙江工业大学 | 一种制备扎维吉泮中间体的新方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| MXPA04011960A (es) * | 2002-06-05 | 2005-03-31 | Squibb Bristol Myers Co | Antagonistas de receptores de peptidos relacionados con el gen de calcitonina. |
| EP1722792A1 (de) | 2004-03-03 | 2006-11-22 | Boehringer Ingelheim International GmbH | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| CN101495480B (zh) * | 2006-05-03 | 2013-07-10 | 百时美施贵宝公司 | 作为降钙素基因相关肽受体拮抗剂的受限化合物 |
| WO2010006168A2 (en) | 2008-07-09 | 2010-01-14 | University Of Rochester | Methods of treating cancer using and agent that modulates activity of the calcitonin-gene related peptide ("cgrp") receptor |
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2011
- 2011-03-02 US US13/038,550 patent/US8481546B2/en active Active
- 2011-03-11 RS RS20160164A patent/RS54608B1/sr unknown
- 2011-03-11 JP JP2013502610A patent/JP5908455B2/ja active Active
- 2011-03-11 EA EA201270751A patent/EA022815B1/ru not_active IP Right Cessation
- 2011-03-11 BR BR112012024785-9A patent/BR112012024785B1/pt active IP Right Grant
- 2011-03-11 PE PE2012001746A patent/PE20130340A1/es active IP Right Grant
- 2011-03-11 PL PL11710087T patent/PL2552906T3/pl unknown
- 2011-03-11 HR HRP20160287TT patent/HRP20160287T1/hr unknown
- 2011-03-11 SG SG2012065744A patent/SG183918A1/en unknown
- 2011-03-11 PT PT117100875T patent/PT2552906E/pt unknown
- 2011-03-11 WO PCT/US2011/028168 patent/WO2011123232A1/en not_active Ceased
- 2011-03-11 CN CN201180016888.2A patent/CN102834388B/zh active Active
- 2011-03-11 MX MX2012010725A patent/MX2012010725A/es active IP Right Grant
- 2011-03-11 KR KR1020187011875A patent/KR20180049168A/ko not_active Ceased
- 2011-03-11 SI SI201130765A patent/SI2552906T1/sl unknown
- 2011-03-11 ES ES11710087.5T patent/ES2562610T3/es active Active
- 2011-03-11 EP EP11710087.5A patent/EP2552906B1/en active Active
- 2011-03-11 HU HUE11710087A patent/HUE028735T2/en unknown
- 2011-03-11 CA CA2794950A patent/CA2794950C/en active Active
- 2011-03-11 KR KR1020127028213A patent/KR101747477B1/ko active Active
- 2011-03-11 DK DK11710087.5T patent/DK2552906T3/en active
- 2011-03-11 NZ NZ603231A patent/NZ603231A/en unknown
- 2011-03-11 KR KR1020177015456A patent/KR101854249B1/ko active Active
- 2011-03-11 AU AU2011233627A patent/AU2011233627B2/en active Active
- 2011-03-30 TW TW100111106A patent/TWI483937B/zh active
- 2011-03-30 AR ARP110101057A patent/AR080746A1/es not_active Application Discontinuation
-
2012
- 2012-08-27 IL IL221665A patent/IL221665A/en active IP Right Grant
- 2012-09-28 CL CL2012002739A patent/CL2012002739A1/es unknown
- 2012-09-28 ZA ZA2012/07292A patent/ZA201207292B/en unknown
-
2016
- 2016-03-21 SM SM201600078T patent/SMT201600078B/xx unknown
- 2016-03-24 CY CY20161100254T patent/CY1117593T1/el unknown