JP2017505293A5 - - Google Patents
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- Publication number
- JP2017505293A5 JP2017505293A5 JP2016541177A JP2016541177A JP2017505293A5 JP 2017505293 A5 JP2017505293 A5 JP 2017505293A5 JP 2016541177 A JP2016541177 A JP 2016541177A JP 2016541177 A JP2016541177 A JP 2016541177A JP 2017505293 A5 JP2017505293 A5 JP 2017505293A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- amino
- butanoic acid
- tetrazol
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 31
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 125000005843 halogen group Chemical group 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
- 125000005842 heteroatom Chemical group 0.000 claims description 10
- 150000002367 halogens Chemical group 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- -1 C 1 -C 6 alkyl Chemical group 0.000 claims description 5
- 125000002950 monocyclic group Chemical group 0.000 claims description 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 4
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 101000619898 Homo sapiens Leukotriene A-4 hydrolase Proteins 0.000 claims description 3
- 102100022118 Leukotriene A-4 hydrolase Human genes 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- AJYSLYWMYBDWJJ-CYBMUJFWSA-N (3R)-3-amino-4-[3-[4-(4-chlorophenoxy)phenyl]-1,2,4-oxadiazol-5-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CC1=NC(=NO1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl AJYSLYWMYBDWJJ-CYBMUJFWSA-N 0.000 claims description 2
- VBELOCUBMPPWLD-CYBMUJFWSA-N (3R)-3-amino-4-[5-(3-phenoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(O)=O)Cn1nnc(n1)-c1cccc(Oc2ccccc2)c1 VBELOCUBMPPWLD-CYBMUJFWSA-N 0.000 claims description 2
- XBZMWHJDOWZNMN-OAHLLOKOSA-N (3R)-3-amino-4-[5-(3-phenylmethoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OCC1=CC=CC=C1 XBZMWHJDOWZNMN-OAHLLOKOSA-N 0.000 claims description 2
- RGMVLBIPDAEPCG-GFCCVEGCSA-N (3R)-3-amino-4-[5-(4-butoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OCCCC RGMVLBIPDAEPCG-GFCCVEGCSA-N 0.000 claims description 2
- UBJBMJVCOROOEO-CYBMUJFWSA-N (3R)-3-amino-4-[5-(4-pentoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OCCCCC UBJBMJVCOROOEO-CYBMUJFWSA-N 0.000 claims description 2
- FLTRUVRXQVPFKZ-OAHLLOKOSA-N (3R)-3-amino-4-[5-(4-phenylmethoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OCC1=CC=CC=C1 FLTRUVRXQVPFKZ-OAHLLOKOSA-N 0.000 claims description 2
- WVQUADUONXDXFD-GFCCVEGCSA-N (3R)-3-amino-4-[5-[3-(1,3-benzothiazol-2-yloxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC=1SC2=C(N=1)C=CC=C2 WVQUADUONXDXFD-GFCCVEGCSA-N 0.000 claims description 2
- WSYHVXHEKZGHQY-CYBMUJFWSA-N (3R)-3-amino-4-[5-[3-(3,5-difluorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=CC(=CC(=C1)F)F WSYHVXHEKZGHQY-CYBMUJFWSA-N 0.000 claims description 2
- WAUSGRYCAMLOIZ-GFCCVEGCSA-N (3R)-3-amino-4-[5-[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=NC=C(C=C1)C(F)(F)F WAUSGRYCAMLOIZ-GFCCVEGCSA-N 0.000 claims description 2
- WOCAXANSPDAXAZ-GFCCVEGCSA-N (3R)-3-amino-4-[5-[4-(1,3-benzothiazol-2-yloxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC=1SC2=C(N=1)C=CC=C2 WOCAXANSPDAXAZ-GFCCVEGCSA-N 0.000 claims description 2
- SMOJYQNGBVHPTC-LLVKDONJSA-N (3R)-3-amino-4-[5-[4-(3-chloro-4-fluorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC(=C(C=C1)F)Cl SMOJYQNGBVHPTC-LLVKDONJSA-N 0.000 claims description 2
- DXKOUSSDXQOMCK-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-chlorophenoxy)phenyl]-1,3,4-oxadiazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CC=1OC(=NN=1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl DXKOUSSDXQOMCK-CYBMUJFWSA-N 0.000 claims description 2
- VSQILWJHLPJYGP-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-chlorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl VSQILWJHLPJYGP-CYBMUJFWSA-N 0.000 claims description 2
- UYFSPUCKNPJDAQ-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-fluorophenoxy)phenyl]-1,3,4-oxadiazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CC=1OC(=NN=1)C1=CC=C(C=C1)OC1=CC=C(C=C1)F UYFSPUCKNPJDAQ-CYBMUJFWSA-N 0.000 claims description 2
- FOCXWYINTPLCHG-CYBMUJFWSA-N (3R)-3-amino-4-[5-[4-(4-fluorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)F FOCXWYINTPLCHG-CYBMUJFWSA-N 0.000 claims description 2
- LPZGCTYDLGGZAA-CQSZACIVSA-N (3R)-3-amino-4-[5-[4-(4-methylphenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)C LPZGCTYDLGGZAA-CQSZACIVSA-N 0.000 claims description 2
- ZEGMEJVULDALSH-LLVKDONJSA-N (3R)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1F)Cl ZEGMEJVULDALSH-LLVKDONJSA-N 0.000 claims description 2
- SGMMCFXAIWSCKS-GFCCVEGCSA-N (3R)-3-amino-4-[5-[4-(5-chloropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1)Cl SGMMCFXAIWSCKS-GFCCVEGCSA-N 0.000 claims description 2
- JVHCOXOIUBKBEW-OAHLLOKOSA-N (3R)-3-amino-4-[5-[4-[4-(1,3-oxazol-2-yl)phenoxy]phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)C=1OC=CN=1 JVHCOXOIUBKBEW-OAHLLOKOSA-N 0.000 claims description 2
- QKWKGNNRYDXRSQ-GFCCVEGCSA-N (3R)-3-amino-4-[5-[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1)C(F)(F)F QKWKGNNRYDXRSQ-GFCCVEGCSA-N 0.000 claims description 2
- QGUBGJLWZLQAET-INIZCTEOSA-N (3S)-3-amino-4-[4-[4-(4-chlorophenoxy)phenyl]pyrazol-1-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=CC(=C1)C1=CC=C(C=C1)OC1=CC=C(C=C1)Cl QGUBGJLWZLQAET-INIZCTEOSA-N 0.000 claims description 2
- VBELOCUBMPPWLD-ZDUSSCGKSA-N (3S)-3-amino-4-[5-(3-phenoxyphenyl)tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=CC=CC=C1 VBELOCUBMPPWLD-ZDUSSCGKSA-N 0.000 claims description 2
- WOCAXANSPDAXAZ-LBPRGKRZSA-N (3S)-3-amino-4-[5-[4-(1,3-benzothiazol-2-yloxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC=1SC2=C(N=1)C=CC=C2 WOCAXANSPDAXAZ-LBPRGKRZSA-N 0.000 claims description 2
- LPZGCTYDLGGZAA-AWEZNQCLSA-N (3S)-3-amino-4-[5-[4-(4-methylphenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=C(C=C1)C LPZGCTYDLGGZAA-AWEZNQCLSA-N 0.000 claims description 2
- VSQILWJHLPJYGP-ZDUSSCGKSA-N (3s)-3-amino-4-[5-[4-(4-chlorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound OC(=O)C[C@H](N)CN1N=NC(C=2C=CC(OC=3C=CC(Cl)=CC=3)=CC=2)=N1 VSQILWJHLPJYGP-ZDUSSCGKSA-N 0.000 claims description 2
- YAZLIBDHESBJAD-CYBMUJFWSA-N N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=CC=C1 Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=CC=CC=C1 YAZLIBDHESBJAD-CYBMUJFWSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- GRPSEETXRKKMSI-CYBMUJFWSA-N (3R)-3-amino-4-[5-[3-(4-chlorophenoxy)phenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@H](CC(=O)O)CN1N=C(N=N1)C1=CC(=CC=C1)OC1=CC=C(C=C1)Cl GRPSEETXRKKMSI-CYBMUJFWSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 8
- 239000000203 mixture Substances 0.000 description 2
- ZEGMEJVULDALSH-NSHDSACASA-N (3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid Chemical compound N[C@@H](CC(=O)O)CN1N=C(N=N1)C1=CC=C(C=C1)OC1=NC=C(C=C1F)Cl ZEGMEJVULDALSH-NSHDSACASA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199138.2 | 2013-12-20 | ||
| EP13199138 | 2013-12-20 | ||
| EP14181155.4 | 2014-08-15 | ||
| EP14181155 | 2014-08-15 | ||
| PCT/IB2014/067086 WO2015092740A1 (en) | 2013-12-20 | 2014-12-18 | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505293A JP2017505293A (ja) | 2017-02-16 |
| JP2017505293A5 true JP2017505293A5 (enExample) | 2017-12-28 |
| JP6500024B2 JP6500024B2 (ja) | 2019-04-10 |
Family
ID=52434892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016541177A Active JP6500024B2 (ja) | 2013-12-20 | 2014-12-18 | Ｌｔａ４ｈ阻害剤としてのヘテロアリールブタン酸誘導体 |
Country Status (38)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ719169A (en) | 2013-12-20 | 2018-08-31 | Novartis Ag | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
| WO2017175185A1 (en) | 2016-04-08 | 2017-10-12 | Novartis Ag | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
| MY198220A (en) | 2018-05-15 | 2023-08-14 | Alkahest Inc | Treatment Of Aging-Associated Disease With Modulators Of Leukotriene A4 Hydrolase |
| KR20210038877A (ko) | 2018-07-25 | 2021-04-08 | 노파르티스 아게 | Nlrp3 인플라마좀 억제제 |
| CN112513026B (zh) | 2018-07-31 | 2025-02-25 | 诺华股份有限公司 | Lta4h抑制剂的晶型 |
| EP3878836B1 (en) * | 2018-11-07 | 2025-07-23 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| TWI828839B (zh) * | 2019-01-11 | 2024-01-11 | 瑞士商諾華公司 | 使用lta4h抑制劑治療化膿性汗腺炎之方法 |
| US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
| AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
| TW202122078A (zh) | 2019-09-06 | 2021-06-16 | 瑞士商諾華公司 | 使用lta4h抑制劑治療肝臟疾病之方法 |
| JP7545570B2 (ja) | 2020-08-14 | 2024-09-04 | ノバルティス アーゲー | ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用 |
| US11932630B2 (en) * | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2549831A1 (fr) | 1983-07-27 | 1985-02-01 | Rhone Poulenc Agrochimie | Nouveaux derives d'acides aryloxybenzoiques, et leur utilisation comme herbicides |
| US4708965A (en) | 1985-09-16 | 1987-11-24 | Morgan Lee R | Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives |
| DE3770095D1 (de) | 1986-08-21 | 1991-06-20 | Pfizer | Chinazolindione und pyridopyrimidindione. |
| US5272167A (en) | 1986-12-10 | 1993-12-21 | Schering Corporation | Pharmaceutically active compounds |
| US4851423A (en) | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| US5750532A (en) | 1986-12-10 | 1998-05-12 | Schering Corporation | Pharmaceutically active compounds |
| CA1315279C (en) | 1987-01-12 | 1993-03-30 | Nancy Grace Bollinger | Anti-inflammatory agents |
| US4820723A (en) * | 1987-08-14 | 1989-04-11 | Eli Lilly And Company | Disubstituted tetrazole leukotriene antagonists and methods for their use thereas |
| US5055481A (en) | 1989-03-24 | 1991-10-08 | Wakamoto Pharmaceutical Co., Ltd. | Tetrazole derivatives and aldose reductase inhibition therewith |
| WO1991000858A1 (en) | 1989-07-07 | 1991-01-24 | Schering Corporation | Pharmaceutically active compounds |
| CA2221692A1 (en) * | 1995-05-19 | 1996-11-21 | G.D. Searle & Co. | Substituted oxazoles for the treatment of inflammation |
| US6037345A (en) | 1998-01-13 | 2000-03-14 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to quinazolinedione and pyridopyrimidinedione derivatives |
| ES2251976T3 (es) | 1999-02-11 | 2006-05-16 | Emisphere Technologies, Inc. | Compuestos y composiciones de oxadiazol para aportar agentes activos. |
| ATE341615T1 (de) | 1999-02-26 | 2006-10-15 | Jesper Z Haeggstroem | Auf der dreidimensionalen struktur von lta4 hydrolase basierender entwurf von arzneimitteln |
| TW502019B (en) | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| JP2003532675A (ja) | 2000-05-09 | 2003-11-05 | クレイトン ユニバーシティ | 癌細胞の増殖を阻害しそのアポトーシスを誘導する方法 |
| US20020107244A1 (en) | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
| US20020123490A1 (en) | 2001-03-01 | 2002-09-05 | Pfizer Inc. | Combination treatment for anxiety, depression, obsessive compulsive disorder and psychosis |
| US20020183306A1 (en) | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
| US7087630B2 (en) * | 2002-06-27 | 2006-08-08 | Nitromed, Inc. | Cyclooxygenase 2 selective inhibitors, compositions and methods of use |
| CA2502357A1 (en) | 2002-10-17 | 2004-04-29 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction; methods of treatment |
| WO2005027886A2 (en) | 2003-09-17 | 2005-03-31 | Decode Genetics Ehf. | Methods of preventing or treating recurrence of myocardial infarction |
| GB0230025D0 (en) * | 2002-12-23 | 2003-01-29 | Pfizer Ltd | Novel pharmaceuticals |
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| WO2004099783A2 (en) | 2003-05-06 | 2004-11-18 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor ltb4 (ltb4) |
| US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| GB0410103D0 (en) | 2004-05-06 | 2004-06-09 | Biolipox Ab | New method |
| WO2006008142A1 (en) | 2004-07-20 | 2006-01-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and therapy of psoriasis vulgaris |
| EP1757290A1 (en) | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors |
| GB0524786D0 (en) * | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Compounds |
| US7728032B2 (en) | 2006-08-04 | 2010-06-01 | Decode Genetics Ehf | Phenoxymethylalkyne inhibitors of LTA4H for treating inflammation |
| EP2066800A2 (en) | 2006-08-04 | 2009-06-10 | Decode Genetics EHF | Aryl amino acid derivatives as inhibitors of lta4h (leukotriene a4 hydrolase) for treating inflammation |
| AU2007338792B2 (en) | 2006-12-20 | 2012-05-31 | Amgen Inc. | Substituted heterocycles and methods of use |
| EP1958631A1 (en) | 2007-02-14 | 2008-08-20 | AEterna Zentaris GmbH | Novel triazole derivatives as ligands of G-protein coupled receptors |
| TW200906396A (en) | 2007-02-14 | 2009-02-16 | Janssen Pharmaceutica Nv | LTA4H modulators and uses thereof |
| US8288357B2 (en) | 2007-03-23 | 2012-10-16 | Korea University Research & Business Foundation | Use of inhibitors of leukotriene B4 receptor BLT2 for treating human cancers |
| US9617197B2 (en) | 2010-08-04 | 2017-04-11 | University Of Virginia Patent Foundation | Compositions and methods for treating inflammatory diseases |
| US9688668B2 (en) * | 2012-02-08 | 2017-06-27 | University Of Virginia Patent Foundation | Long chain base sphingosine kinase inhibitors |
| WO2013142369A1 (en) | 2012-03-23 | 2013-09-26 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of pulmonary hypertension with leukotriene inhibitors |
| AR091786A1 (es) | 2012-07-17 | 2015-02-25 | Boehringer Ingelheim Int | Inhibidores de la produccion de leucotrienos |
| WO2014165090A1 (en) | 2013-03-13 | 2014-10-09 | The Broad Institute, Inc. | Compounds for the treatment of tuberculosis |
| WO2015009609A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| NZ719169A (en) | 2013-12-20 | 2018-08-31 | Novartis Ag | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
-
2014
- 2014-12-18 NZ NZ719169A patent/NZ719169A/en not_active IP Right Cessation
- 2014-12-18 US US15/104,729 patent/US9981926B2/en active Active
- 2014-12-18 CA CA2927564A patent/CA2927564C/en active Active
- 2014-12-18 EA EA201691293A patent/EA034436B1/ru not_active IP Right Cessation
- 2014-12-18 RS RS20181042A patent/RS57642B1/sr unknown
- 2014-12-18 MY MYPI2016701308A patent/MY180165A/en unknown
- 2014-12-18 JP JP2016541177A patent/JP6500024B2/ja active Active
- 2014-12-18 PT PT14833234T patent/PT3083564T/pt unknown
- 2014-12-18 SI SI201430884T patent/SI3083564T1/sl unknown
- 2014-12-18 WO PCT/IB2014/067086 patent/WO2015092740A1/en not_active Ceased
- 2014-12-18 CN CN201480069263.6A patent/CN105829286B/zh active Active
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