JP2013525356A5 - - Google Patents
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- Publication number
- JP2013525356A5 JP2013525356A5 JP2013506203A JP2013506203A JP2013525356A5 JP 2013525356 A5 JP2013525356 A5 JP 2013525356A5 JP 2013506203 A JP2013506203 A JP 2013506203A JP 2013506203 A JP2013506203 A JP 2013506203A JP 2013525356 A5 JP2013525356 A5 JP 2013525356A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- mono
- substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 72
- 125000005843 halogen group Chemical group 0.000 claims 40
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 35
- -1 substituted Chemical class 0.000 claims 32
- 125000001424 substituent group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000000168 pyrrolyl group Chemical group 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- 102100027297 Fatty acid 2-hydroxylase Human genes 0.000 claims 2
- 101000937693 Homo sapiens Fatty acid 2-hydroxylase Proteins 0.000 claims 2
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32669510P | 2010-04-22 | 2010-04-22 | |
| US61/326,695 | 2010-04-22 | ||
| PCT/US2011/032842 WO2011133447A1 (en) | 2010-04-22 | 2011-04-18 | Oxazole derivatives useful as modulators of faah |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525356A JP2013525356A (ja) | 2013-06-20 |
| JP2013525356A5 true JP2013525356A5 (enExample) | 2014-06-05 |
| JP5856606B2 JP5856606B2 (ja) | 2016-02-10 |
Family
ID=44834467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013506203A Expired - Fee Related JP5856606B2 (ja) | 2010-04-22 | 2011-04-18 | Ｆａａｈの調節薬として有用なオキサゾール誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9073879B2 (enExample) |
| EP (1) | EP2593102B1 (enExample) |
| JP (1) | JP5856606B2 (enExample) |
| CN (1) | CN103153307A (enExample) |
| AU (1) | AU2011242961B2 (enExample) |
| BR (1) | BR112012023971A2 (enExample) |
| CA (1) | CA2794724A1 (enExample) |
| WO (1) | WO2011133447A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| MX2014015265A (es) | 2012-06-14 | 2015-08-12 | Basf Se | Metodos plaguicidas que utilizan compuestos de 3-piridiltiazol sustituido y derivados para combatir plagas de animales. |
| MX363708B (es) | 2013-10-14 | 2019-03-29 | Eisai R&D Man Co Ltd | Compuestos de quinolina selectivamente sustituidos. |
| SG10201704327RA (en) | 2013-10-14 | 2017-06-29 | Eisai R&D Man Co Ltd | Selectively substituted quinoline compounds |
| EP3322419B1 (en) | 2015-07-15 | 2025-09-03 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| EP3725788A1 (en) | 2019-04-15 | 2020-10-21 | Bayer AG | Novel heteroaryl-substituted aminoalkyl azole compounds as pesticides |
| CN114502545B (zh) | 2019-07-23 | 2024-06-28 | 拜耳公司 | 作为农药的新的杂芳基-三唑化合物 |
| TW202136248A (zh) | 2019-11-25 | 2021-10-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
| US20230148601A1 (en) | 2020-02-18 | 2023-05-18 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| TWI891782B (zh) | 2020-05-06 | 2025-08-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基三唑化合物 |
| KR20240051198A (ko) | 2021-08-25 | 2024-04-19 | 바이엘 악티엔게젤샤프트 | 농약제로서 신규 피라지닐-트리아졸 화합물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8268817B2 (en) * | 2006-09-08 | 2012-09-18 | The Scripps Research Institute | Substituted oxazole ketone modulators of fatty acid amide hydrolase |
| WO2008100977A2 (en) * | 2007-02-14 | 2008-08-21 | N.V. Organon | Carbamates therapeutic release agents as amidase inhibitors |
| AU2008260496A1 (en) * | 2007-05-31 | 2008-12-11 | The Scripps Research Institute | Tricyclic inhibitors of fatty acid amide hydrolase |
| WO2009154785A2 (en) | 2008-06-19 | 2009-12-23 | The Scripps Research Institute | C4-substituted alpha-keto oxazoles |
| JP5698666B2 (ja) * | 2008-08-04 | 2015-04-08 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｆａａｈの阻害剤として有用なオキサゾール誘導体 |
-
2011
- 2011-04-18 WO PCT/US2011/032842 patent/WO2011133447A1/en not_active Ceased
- 2011-04-18 AU AU2011242961A patent/AU2011242961B2/en not_active Ceased
- 2011-04-18 JP JP2013506203A patent/JP5856606B2/ja not_active Expired - Fee Related
- 2011-04-18 BR BR112012023971A patent/BR112012023971A2/pt not_active IP Right Cessation
- 2011-04-18 US US13/635,286 patent/US9073879B2/en active Active
- 2011-04-18 CA CA2794724A patent/CA2794724A1/en not_active Abandoned
- 2011-04-18 EP EP11772492.2A patent/EP2593102B1/en active Active
- 2011-04-18 CN CN201180019926XA patent/CN103153307A/zh active Pending