JP2011500758A5 - - Google Patents
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- Publication number
- JP2011500758A5 JP2011500758A5 JP2010530433A JP2010530433A JP2011500758A5 JP 2011500758 A5 JP2011500758 A5 JP 2011500758A5 JP 2010530433 A JP2010530433 A JP 2010530433A JP 2010530433 A JP2010530433 A JP 2010530433A JP 2011500758 A5 JP2011500758 A5 JP 2011500758A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- alkyloxy
- hydroxy
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 50
- 239000001257 hydrogen Substances 0.000 claims 50
- 125000003545 alkoxy group Chemical group 0.000 claims 31
- 150000002431 hydrogen Chemical class 0.000 claims 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- 125000000623 heterocyclic group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 10
- -1 cyano, hydroxy Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 3
- 125000000815 N-oxide group Chemical group 0.000 claims 2
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002534 radiation-sensitizing agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07119417 | 2007-10-26 | ||
| EP07119417.9 | 2007-10-26 | ||
| PCT/EP2008/064243 WO2009053373A1 (en) | 2007-10-26 | 2008-10-22 | Quinolinone derivatives as parp inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500758A JP2011500758A (ja) | 2011-01-06 |
| JP2011500758A5 true JP2011500758A5 (enExample) | 2011-12-08 |
| JP5525447B2 JP5525447B2 (ja) | 2014-06-18 |
Family
ID=39345428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530433A Active JP5525447B2 (ja) | 2007-10-26 | 2008-10-22 | Ｐａｒｐ阻害剤としてのキノリノン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8404713B2 (enExample) |
| EP (1) | EP2215075B1 (enExample) |
| JP (1) | JP5525447B2 (enExample) |
| ES (1) | ES2448870T3 (enExample) |
| PL (1) | PL2215075T3 (enExample) |
| WO (1) | WO2009053373A1 (enExample) |
Families Citing this family (59)
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| WO2013169964A1 (en) * | 2012-05-09 | 2013-11-14 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| WO2014085486A2 (en) | 2012-11-30 | 2014-06-05 | Waters Technologies Corporation | Methods and apparatus for the analysis of vitamin d metabolites |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| JP6563017B2 (ja) | 2014-08-28 | 2019-08-21 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
| PH12017502228B1 (en) * | 2015-06-09 | 2022-08-03 | Onconic Therapeutics Inc | Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| EP3419976B1 (en) | 2016-02-25 | 2021-04-07 | Asceneuron SA | Acid addition salts of piperazine derivatives |
| CA3012560A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S.A. | Glycosidase inhibitors |
| CA3012624A1 (en) | 2016-02-25 | 2017-08-31 | Asceneuron S.A. | Glycosidase inhibitors |
| MX2019010085A (es) | 2017-02-24 | 2019-11-21 | Asceneuron S A | Inhibidores de la glicosidasa de sulfoximina. |
| WO2019037860A1 (en) | 2017-08-24 | 2019-02-28 | Asceneuron S.A. | LINEAR INHIBITORS OF GLYCOSIDASE |
| US11458140B2 (en) | 2017-08-24 | 2022-10-04 | Asceneuron Sa | Annulated glycosidase inhibitors |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
| KR102839500B1 (ko) | 2018-08-22 | 2025-07-28 | 아셰뉴론 에스아 | 글리코시다제 억제제로서 유용한 피페라진 유도체의 숙시네이트 및 푸마레이트 산 부가염 |
| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| US20220143042A1 (en) | 2019-02-22 | 2022-05-12 | Asceneuron Sa | Fused glycosidase inhibitors |
| CN114144413B (zh) * | 2019-07-19 | 2024-08-16 | 阿斯利康(瑞典)有限公司 | Parp1抑制剂 |
| CA3148767A1 (en) * | 2019-07-26 | 2021-02-04 | Health Research, Inc. | Treatment of p53-deficient cancers |
| US11795158B2 (en) * | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
| EP4326713A4 (en) * | 2021-04-12 | 2025-03-19 | Impact Therapeutics (Shanghai), Inc. | Substituted fused bicyclic compounds as parp inhibitors and the use thereof |
| WO2022225934A1 (en) | 2021-04-19 | 2022-10-27 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| CA3213029A1 (en) * | 2021-04-22 | 2022-10-27 | Yuli Xie | Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof |
| CN115232154A (zh) * | 2021-04-23 | 2022-10-25 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| TW202304911A (zh) * | 2021-04-23 | 2023-02-01 | 大陸商南京明德新藥研發有限公司 | 吡啶醯胺類化合物 |
| CN116710433A (zh) * | 2021-04-23 | 2023-09-05 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
| WO2022222964A1 (zh) * | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 吡啶衍生物及其在医药上的应用 |
| MX2023013890A (es) | 2021-05-24 | 2023-12-11 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Compuesto heterociclico que contiene nitrogeno, metodo de preparacion del mismo y aplicacion del mismo en medicamentos. |
| WO2023036285A1 (zh) * | 2021-09-09 | 2023-03-16 | 南京奥利墨斯医药科技有限公司 | 一种杂芳环类化合物及其应用 |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046149A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 喹喔啉类化合物及其医药用途 |
| WO2023051716A1 (zh) * | 2021-09-30 | 2023-04-06 | 海思科医药集团股份有限公司 | 杂芳基衍生物parp抑制剂及其用途 |
| US20240391937A1 (en) * | 2021-09-30 | 2024-11-28 | Xizang Haisco Pharmaceutical Co., Ltd. | Bicyclic derivative parp inhibitor and use thereof |
| CN118043322A (zh) * | 2021-09-30 | 2024-05-14 | 西藏海思科制药有限公司 | 含氮杂环衍生物parp抑制剂及其用途 |
| PE20241129A1 (es) * | 2021-10-01 | 2024-05-24 | Xinthera Inc | Inhibidores de parp1 de azetidina y pirrolidina y usos de estos |
| US20250222116A1 (en) * | 2021-10-22 | 2025-07-10 | Xizang Haisco Pharmaceutical Co., Ltd. | Parp-1 degradation agent and use thereof |
| MX2024006074A (es) * | 2021-11-19 | 2024-06-28 | Kangbaida Sichuan Biotechnology Co Ltd | Inhibidor de parp1 selectivo y aplicacion del mismo. |
| KR20240144125A (ko) * | 2021-12-17 | 2024-10-02 | 키테라 (쑤저우) 바이오-파마슈티컬스 컴퍼니 리미티드 | Parp 억제제, 이를 포함하는 약제학적 조성물, 및 이의 용도 |
| CN118434725A (zh) * | 2022-01-20 | 2024-08-02 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| CN118804916B (zh) | 2022-01-21 | 2025-04-01 | 新特拉有限公司 | Parp1抑制剂及其用途 |
| KR20240139604A (ko) * | 2022-01-27 | 2024-09-23 | 신테라, 인크. | Parp1 저해제 및 이의 용도 |
| AU2023212785A1 (en) * | 2022-01-28 | 2024-08-15 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| EP4493551A1 (en) | 2022-03-14 | 2025-01-22 | Slap Pharmaceuticals LLC | Multicyclic compounds |
| WO2023207284A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Piperazine derivatives as parp1 inhibitiors |
| IL316278A (en) | 2022-04-28 | 2024-12-01 | Xinthera Inc | TRICYCLIC PARP1 INHIBITORS AND THEIR USES |
| CN119487027A (zh) * | 2022-04-28 | 2025-02-18 | 宁波新湾科技发展有限公司 | 作为parp1抑制剂的化合物 |
| WO2023227052A1 (zh) * | 2022-05-25 | 2023-11-30 | 西藏海思科制药有限公司 | 双环衍生物parp抑制剂及其用途 |
| CN119677736A (zh) * | 2022-08-24 | 2025-03-21 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途 |
| WO2024041608A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂的晶体形式及其用途 |
| CN117658983A (zh) * | 2022-09-01 | 2024-03-08 | 浙江文达医药科技有限公司 | 选择性parp1抑制剂 |
| CN120112531A (zh) * | 2022-10-20 | 2025-06-06 | 成都赜灵生物医药科技有限公司 | 并杂环类化合物及其用途 |
| CN120019054A (zh) * | 2022-10-20 | 2025-05-16 | 成都赜灵生物医药科技有限公司 | 取代四氢吡啶类化合物及其用途 |
| IL320998A (en) | 2022-11-23 | 2025-07-01 | Jiangsu Hengrui Pharmaceuticals Co Ltd | A pharmaceutically acceptable salt of a nitrogen-containing heterocyclic compound, its crystalline form and a method for preparing them |
| KR20250117449A (ko) * | 2022-12-23 | 2025-08-04 | 제지앙 양리 파마슈티칼 테크놀로지 씨오., 엘티디. | Parp1 억제제 |
| CN117903159A (zh) * | 2022-12-30 | 2024-04-19 | 成都硕德药业有限公司 | 一种内酰胺类衍生物、其制备方法及用途 |
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| KR101118582B1 (ko) | 2003-11-20 | 2012-02-27 | 얀센 파마슈티카 엔.브이. | 폴리(ａｄｐ-리보스)폴리머라제 저해제로서의 6-알케닐 및6-페닐알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논 |
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| JP4948178B2 (ja) * | 2003-12-10 | 2012-06-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤としての置換６−シクロヘキシルアルキル置換２−キノリノンおよび２−キノキサリノン |
| PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
| JP4991527B2 (ja) | 2004-06-01 | 2012-08-01 | ユニバーシティ オブ バージニア パテント ファンデーション | 二つの部分からなる低分子量の癌および血管新生の抑制剤 |
| CN1980674B (zh) | 2004-06-30 | 2011-05-25 | 詹森药业有限公司 | 作为parp抑制剂的2,3-二氮杂萘衍生物 |
| EA012837B1 (ru) | 2004-06-30 | 2009-12-30 | Янссен Фармацевтика Н.В. | Производные хиназолинона в качестве ингибиторов parp |
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| ES2545382T3 (es) * | 2005-04-28 | 2015-09-10 | Mitsubishi Tanabe Pharma Corporation | Derivado de cianopiridina y su uso como medicamento |
| KR20080039508A (ko) | 2005-08-24 | 2008-05-07 | 이노텍 파마슈티컬스 코포레이션 | 인데노이소퀴놀리논 유사체 및 이의 사용 방법 |
| ATE555091T1 (de) | 2006-02-03 | 2012-05-15 | Bionomics Ltd | Substituierte benzofurane, benzothiophene, benzoselenophene und indole und ihre verwendung als tubulinpolymerisationsinhibitoren |
| BRPI0707902A2 (pt) | 2006-02-15 | 2011-05-17 | Abbott Lab | pirazoloquinolonas são potentes inibidores parp |
| US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| ATE542799T1 (de) | 2007-03-08 | 2012-02-15 | Janssen Pharmaceutica Nv | Chinolinonderivate als parp und tank-inhibitoren |
| CA2690378A1 (en) * | 2007-06-25 | 2008-12-31 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
-
2008
- 2008-10-22 EP EP08841176.4A patent/EP2215075B1/en active Active
- 2008-10-22 JP JP2010530433A patent/JP5525447B2/ja active Active
- 2008-10-22 US US12/681,790 patent/US8404713B2/en active Active
- 2008-10-22 PL PL08841176T patent/PL2215075T3/pl unknown
- 2008-10-22 WO PCT/EP2008/064243 patent/WO2009053373A1/en not_active Ceased
- 2008-10-22 ES ES08841176.4T patent/ES2448870T3/es active Active
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