JP2011500758A5 - - Google Patents
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- Publication number
- JP2011500758A5 JP2011500758A5 JP2010530433A JP2010530433A JP2011500758A5 JP 2011500758 A5 JP2011500758 A5 JP 2011500758A5 JP 2010530433 A JP2010530433 A JP 2010530433A JP 2010530433 A JP2010530433 A JP 2010530433A JP 2011500758 A5 JP2011500758 A5 JP 2011500758A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- alkyloxy
- hydroxy
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 50
- 239000001257 hydrogen Substances 0.000 claims 50
- 125000003545 alkoxy group Chemical group 0.000 claims 31
- 150000002431 hydrogen Chemical class 0.000 claims 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- 125000000623 heterocyclic group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 10
- -1 cyano, hydroxy Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 3
- 125000000815 N-oxide group Chemical group 0.000 claims 2
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002534 radiation-sensitizing agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07119417.9 | 2007-10-26 | ||
| EP07119417 | 2007-10-26 | ||
| PCT/EP2008/064243 WO2009053373A1 (en) | 2007-10-26 | 2008-10-22 | Quinolinone derivatives as parp inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500758A JP2011500758A (ja) | 2011-01-06 |
| JP2011500758A5 true JP2011500758A5 (enExample) | 2011-12-08 |
| JP5525447B2 JP5525447B2 (ja) | 2014-06-18 |
Family
ID=39345428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530433A Active JP5525447B2 (ja) | 2007-10-26 | 2008-10-22 | Ｐａｒｐ阻害剤としてのキノリノン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8404713B2 (enExample) |
| EP (1) | EP2215075B1 (enExample) |
| JP (1) | JP5525447B2 (enExample) |
| ES (1) | ES2448870T3 (enExample) |
| PL (1) | PL2215075T3 (enExample) |
| WO (1) | WO2009053373A1 (enExample) |
Families Citing this family (59)
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| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| JP6345651B2 (ja) * | 2012-05-09 | 2018-06-20 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ヘテロアリール化合物及びその使用方法 |
| WO2014085486A2 (en) | 2012-11-30 | 2014-06-05 | Waters Technologies Corporation | Methods and apparatus for the analysis of vitamin d metabolites |
| EP2970177A1 (en) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indole compounds that activate ampk |
| CN107108601B (zh) | 2014-08-28 | 2021-08-20 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| BR112017026392B1 (pt) * | 2015-06-09 | 2023-12-26 | Onconic Therapeutics Inc | Composto derivado tricíclico, método para sua preparação e seu uso |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| US10696668B2 (en) | 2016-02-25 | 2020-06-30 | Asceneuron Sa | Acid addition salts of piperazine derivatives |
| US11612599B2 (en) | 2016-02-25 | 2023-03-28 | Asceneuron Sa | Glycosidase inhibitors |
| MX2018010191A (es) | 2016-02-25 | 2019-05-20 | Asceneuron S A | Inhibidores de glucosidasa. |
| EP3585783A2 (en) | 2016-02-25 | 2020-01-01 | Asceneuron SA | Sulfoximine glycosidase inhibitors |
| EP3672959A1 (en) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Linear glycosidase inhibitors |
| EP3672958B1 (en) | 2017-08-24 | 2023-08-02 | Asceneuron SA | Annulated glycosidase inhibitors |
| WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
| US12016852B2 (en) | 2018-08-22 | 2024-06-25 | Asceneuron Sa | Pyrrolidine glycosidase inhibitors |
| WO2020039028A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| SG11202101651RA (en) | 2018-08-22 | 2021-03-30 | Asceneuron S A | Succinate and fumarate acid addition salts of piperazine derivatives useful as glycosidase inhibitors |
| WO2020169804A1 (en) | 2019-02-22 | 2020-08-27 | Asceneuron Sa | Fused glycosidase inhibitors |
| EP3999506B1 (en) * | 2019-07-19 | 2025-01-15 | Astrazeneca AB | Parp1 inhibitors |
| EP4003358B1 (en) * | 2019-07-26 | 2025-12-31 | Health Research, Inc. | TREATMENT OF P53 DEFICIENCY CANCERS |
| US11795158B2 (en) * | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
| US20240208969A1 (en) * | 2021-04-12 | 2024-06-27 | Impact Therapeutics (Shanghai), Inc. | Substituted fused bicyclic compounds as parp inhibitors and the use thereof |
| EP4326720A4 (en) | 2021-04-19 | 2025-03-19 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| WO2022222921A1 (zh) * | 2021-04-22 | 2022-10-27 | 微境生物医药科技(上海)有限公司 | 含哌嗪结构的parp抑制剂、其制备方法及医药用途 |
| CN116867783A (zh) * | 2021-04-23 | 2023-10-10 | 成都百裕制药股份有限公司 | 吡啶衍生物及其在医药上的应用 |
| WO2022222966A1 (zh) * | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
| WO2022222995A1 (zh) * | 2021-04-23 | 2022-10-27 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
| CN115232154A (zh) * | 2021-04-23 | 2022-10-25 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| MX2023013890A (es) | 2021-05-24 | 2023-12-11 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Compuesto heterociclico que contiene nitrogeno, metodo de preparacion del mismo y aplicacion del mismo en medicamentos. |
| CN118119618A (zh) * | 2021-09-09 | 2024-05-31 | 南京奥利墨斯医药科技有限公司 | 一种杂芳环类化合物及其应用 |
| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046149A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 喹喔啉类化合物及其医药用途 |
| CN118019740A (zh) * | 2021-09-30 | 2024-05-10 | 海思科医药集团股份有限公司 | 杂芳基衍生物parp抑制剂及其用途 |
| EP4410791A4 (en) * | 2021-09-30 | 2025-10-22 | Xizang Haisco Pharmaceutical Co Ltd | BICYCLIC DERIVATIVE PARP INHIBITOR AND ITS USE |
| CN118043322A (zh) * | 2021-09-30 | 2024-05-14 | 西藏海思科制药有限公司 | 含氮杂环衍生物parp抑制剂及其用途 |
| KR20250145706A (ko) | 2021-10-01 | 2025-10-13 | 신테라, 인크. | 아제티딘 및 피롤리딘 parp1 저해제, 및 이의 용도 |
| AU2022373697A1 (en) * | 2021-10-22 | 2024-05-30 | Xizang Haisco Pharmaceutical Co., Ltd. | Parp-1 degradation agent and use thereof |
| MX2024006074A (es) * | 2021-11-19 | 2024-06-28 | Kangbaida Sichuan Biotechnology Co Ltd | Inhibidor de parp1 selectivo y aplicacion del mismo. |
| CN118382624A (zh) * | 2021-12-17 | 2024-07-23 | 凯复(苏州)生物医药有限公司 | Parp抑制剂、包含其的药物组合物及其用途 |
| CN118434725B (zh) * | 2022-01-20 | 2026-01-02 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| CN120081844A (zh) * | 2022-01-21 | 2025-06-03 | 新特拉有限公司 | Parp1抑制剂及其用途 |
| WO2023146957A1 (en) * | 2022-01-27 | 2023-08-03 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| JP2025503116A (ja) * | 2022-01-28 | 2025-01-30 | シンセラ， インコーポレイテッド | Ｐａｒｐ１阻害薬及びその使用 |
| US20250214980A1 (en) | 2022-03-14 | 2025-07-03 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| EP4514795A4 (en) * | 2022-04-28 | 2025-12-31 | Ningbo Newbay Tech Development Co Ltd | COMPOUNDS USED AS PARP1 INHIBITORS |
| EP4355749B1 (en) | 2022-04-28 | 2025-06-04 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
| WO2023207284A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Piperazine derivatives as parp1 inhibitiors |
| AU2023275808A1 (en) * | 2022-05-25 | 2024-12-12 | Xizang Haisco Pharmaceutical Co., Ltd. | Bicyclic derivative parp inhibitor and use thereof |
| WO2024041608A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂的晶体形式及其用途 |
| WO2024041605A1 (zh) * | 2022-08-24 | 2024-02-29 | 四川海思科制药有限公司 | 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途 |
| CN117658983A (zh) * | 2022-09-01 | 2024-03-08 | 浙江文达医药科技有限公司 | 选择性parp1抑制剂 |
| WO2024083201A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 并杂环类化合物及其用途 |
| WO2024083218A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 取代四氢吡啶类化合物及其用途 |
| TW202421139A (zh) | 2022-11-23 | 2024-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種含氮雜環類化合物的可藥用鹽、晶型及製備方法 |
| AU2023412594A1 (en) * | 2022-12-23 | 2025-07-10 | Zhejiang Yangli Pharmaceutical Technology Co., Ltd. | Parp1 inhibitors |
| CN117903159A (zh) * | 2022-12-30 | 2024-04-19 | 成都硕德药业有限公司 | 一种内酰胺类衍生物、其制备方法及用途 |
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| US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| AU2008223793B2 (en) | 2007-03-08 | 2012-08-23 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| EP2170866B1 (en) | 2007-06-25 | 2014-08-13 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
-
2008
- 2008-10-22 PL PL08841176T patent/PL2215075T3/pl unknown
- 2008-10-22 JP JP2010530433A patent/JP5525447B2/ja active Active
- 2008-10-22 ES ES08841176.4T patent/ES2448870T3/es active Active
- 2008-10-22 WO PCT/EP2008/064243 patent/WO2009053373A1/en not_active Ceased
- 2008-10-22 EP EP08841176.4A patent/EP2215075B1/en active Active
- 2008-10-22 US US12/681,790 patent/US8404713B2/en active Active
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