JP2009523760A5 - - Google Patents
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- Publication number
- JP2009523760A5 JP2009523760A5 JP2008550742A JP2008550742A JP2009523760A5 JP 2009523760 A5 JP2009523760 A5 JP 2009523760A5 JP 2008550742 A JP2008550742 A JP 2008550742A JP 2008550742 A JP2008550742 A JP 2008550742A JP 2009523760 A5 JP2009523760 A5 JP 2009523760A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- amino
- phenyl
- alkyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- -1 hydroxy, amino Chemical group 0.000 claims description 10
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 7
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 7
- 125000001544 thienyl group Chemical group 0.000 claims description 7
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 6
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 5
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 3
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims description 3
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
- 150000001204 N-oxides Chemical class 0.000 claims description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims description 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 2
- 125000001041 indolyl group Chemical group 0.000 claims description 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229910052783 alkali metal Chemical group 0.000 claims 1
- 150000001340 alkali metals Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 6
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100584 | 2006-01-19 | ||
| EP06100584.9 | 2006-01-19 | ||
| PCT/EP2007/050376 WO2007082878A1 (en) | 2006-01-19 | 2007-01-16 | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523760A JP2009523760A (ja) | 2009-06-25 |
| JP2009523760A5 true JP2009523760A5 (enExample) | 2012-01-19 |
| JP5225104B2 JP5225104B2 (ja) | 2013-07-03 |
Family
ID=36579211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550742A Active JP5225104B2 (ja) | 2006-01-19 | 2007-01-16 | 新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8119650B2 (enExample) |
| EP (1) | EP1981874B1 (enExample) |
| JP (1) | JP5225104B2 (enExample) |
| CN (1) | CN101370804B (enExample) |
| AT (1) | ATE432272T1 (enExample) |
| AU (1) | AU2007206946B2 (enExample) |
| CA (1) | CA2631876C (enExample) |
| CY (1) | CY1109331T1 (enExample) |
| DE (1) | DE602007001190D1 (enExample) |
| DK (1) | DK1981874T3 (enExample) |
| ES (1) | ES2327972T3 (enExample) |
| HR (1) | HRP20090459T1 (enExample) |
| ME (1) | ME01060B (enExample) |
| PL (1) | PL1981874T3 (enExample) |
| PT (1) | PT1981874E (enExample) |
| RS (1) | RS51191B (enExample) |
| SI (1) | SI1981874T1 (enExample) |
| WO (1) | WO2007082878A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040094672A (ko) | 2002-03-13 | 2004-11-10 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로서의설포닐아미노-유도체 |
| WO2003076400A1 (en) | 2002-03-13 | 2003-09-18 | Janssen Pharmaceutica N.V. | New inhibitors of histone deacetylase |
| HRP20040804A2 (en) | 2002-03-13 | 2005-02-28 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
| CN100503599C (zh) | 2002-03-13 | 2009-06-24 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶的新颖抑制剂的羰基氨基衍生物 |
| UA86066C2 (ru) * | 2004-07-28 | 2009-03-25 | Янссен Фармацевтика Н.В. | Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы |
| US8193205B2 (en) * | 2004-07-28 | 2012-06-05 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
| EP1885710B1 (en) | 2005-05-18 | 2015-08-19 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
| EP1943232B1 (en) * | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Squaric acid derivatives as inhibitors of histone deacetylase |
| ES2396986T3 (es) * | 2006-01-19 | 2013-03-01 | Janssen Pharmaceutica N.V. | Derivados de piridina y pirimidina como inhibidores de histona desacetilasa |
| CA2635015C (en) | 2006-01-19 | 2014-06-03 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| EP1979328B1 (en) * | 2006-01-19 | 2012-12-26 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| PT1981874E (pt) | 2006-01-19 | 2009-09-02 | Janssen Pharmactuica N V | Derivados de aminofenil como novos inibidores de histonadesacetilase |
| ES2395347T3 (es) | 2008-03-27 | 2013-02-12 | Janssen Pharmaceutica, N.V. | Derivados de indolilalquilamino sustituidos con aza-biciclohexilo como inhibidores novedosos de histona desacetilasa |
| CN102118969B (zh) | 2008-06-12 | 2017-03-08 | 詹森药业有限公司 | 组胺h4受体的二氨基吡啶、二氨基嘧啶和二氨基哒嗪调节剂 |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| JP6250403B2 (ja) | 2011-02-28 | 2017-12-20 | バイオマリン ファーマシューティカル インク | ヒストン脱アセチル化酵素阻害剤 |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| HUE053300T2 (hu) | 2011-03-09 | 2021-06-28 | Cereno Scient Ab | Vegyületek és eljárások károsodott endogén fibrinolízis javításához hiszton-deacetiláz inhibitorok használatával |
| JP6503338B2 (ja) | 2013-03-15 | 2019-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | Ｈｄａｃ阻害剤 |
| DE102015106979B4 (de) * | 2015-05-05 | 2023-01-12 | Infineon Technologies Austria Ag | Halbleiterwafer und Verfahren zum Herstellen von Halbleitervorrichtungen in einem Halbleiterwafer |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
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| US3966743A (en) * | 1968-07-23 | 1976-06-29 | Boehringer Mannheim G.M.B.H. | Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives |
| US4049811A (en) * | 1968-07-23 | 1977-09-20 | Boehringer Mannheim G.M.B.H. | Compositions using cycloalkano-quinolone derivatives and their method of use |
| GB1345872A (en) | 1970-09-03 | 1974-02-06 | Wyeth John & Brother Ltd | Amino-and acylamino-pyridine and hydropyridine derivatives |
| DE2939292A1 (de) * | 1979-09-28 | 1981-04-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | N-phenoxyalkylpiperidin-derivate, verfahrenn zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| CA1183847A (en) | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
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| US8193205B2 (en) | 2004-07-28 | 2012-06-05 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
| UA86066C2 (ru) * | 2004-07-28 | 2009-03-25 | Янссен Фармацевтика Н.В. | Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы |
| ATE432274T1 (de) | 2004-07-28 | 2009-06-15 | Janssen Pharmaceutica Nv | Substituierte propenylpiperazinderivate als neue inhibitoren von histondeacetylase |
| EP1885710B1 (en) | 2005-05-18 | 2015-08-19 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
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| EP1943232B1 (en) | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Squaric acid derivatives as inhibitors of histone deacetylase |
| CA2635015C (en) | 2006-01-19 | 2014-06-03 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| ES2396986T3 (es) * | 2006-01-19 | 2013-03-01 | Janssen Pharmaceutica N.V. | Derivados de piridina y pirimidina como inhibidores de histona desacetilasa |
| PT1981874E (pt) | 2006-01-19 | 2009-09-02 | Janssen Pharmactuica N V | Derivados de aminofenil como novos inibidores de histonadesacetilase |
| EP1979328B1 (en) * | 2006-01-19 | 2012-12-26 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| US8101616B2 (en) * | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| ES2376121T3 (es) * | 2006-01-19 | 2012-03-09 | Janssen Pharmaceutica, N.V. | Derivados de heterociclilalquilo como nuevos inhibidores de histona deacetilasa. |
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| WO2009077968A2 (en) * | 2007-12-14 | 2009-06-25 | Urban Aeronautics Ltd. | Redundancies and flows in vehicles |
-
2007
- 2007-01-16 PT PT07703891T patent/PT1981874E/pt unknown
- 2007-01-16 DK DK07703891T patent/DK1981874T3/da active
- 2007-01-16 AT AT07703891T patent/ATE432272T1/de active
- 2007-01-16 CA CA2631876A patent/CA2631876C/en active Active
- 2007-01-16 ME MEP-2009-276A patent/ME01060B/me unknown
- 2007-01-16 HR HR20090459T patent/HRP20090459T1/hr unknown
- 2007-01-16 ES ES07703891T patent/ES2327972T3/es active Active
- 2007-01-16 EP EP07703891A patent/EP1981874B1/en active Active
- 2007-01-16 CN CN2007800030170A patent/CN101370804B/zh active Active
- 2007-01-16 DE DE602007001190T patent/DE602007001190D1/de active Active
- 2007-01-16 JP JP2008550742A patent/JP5225104B2/ja active Active
- 2007-01-16 WO PCT/EP2007/050376 patent/WO2007082878A1/en not_active Ceased
- 2007-01-16 RS RSP-2009/0384A patent/RS51191B/sr unknown
- 2007-01-16 US US12/160,140 patent/US8119650B2/en active Active
- 2007-01-16 SI SI200730065T patent/SI1981874T1/sl unknown
- 2007-01-16 AU AU2007206946A patent/AU2007206946B2/en not_active Ceased
- 2007-01-16 PL PL07703891T patent/PL1981874T3/pl unknown
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2009
- 2009-08-27 CY CY20091100896T patent/CY1109331T1/el unknown