CA2631876C - Aminophenyl derivatives as inhibitors of histone deacetylase - Google Patents
Aminophenyl derivatives as inhibitors of histone deacetylase Download PDFInfo
- Publication number
- CA2631876C CA2631876C CA2631876A CA2631876A CA2631876C CA 2631876 C CA2631876 C CA 2631876C CA 2631876 A CA2631876 A CA 2631876A CA 2631876 A CA2631876 A CA 2631876A CA 2631876 C CA2631876 C CA 2631876C
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- Prior art keywords
- 6alkyl
- compound
- hydrogen
- compounds
- amino
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- -1 Aminophenyl Chemical class 0.000 title claims description 50
- 102000003964 Histone deacetylase Human genes 0.000 title abstract description 44
- 108090000353 Histone deacetylase Proteins 0.000 title abstract description 44
- 239000003112 inhibitor Substances 0.000 title description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 160
- 239000003814 drug Substances 0.000 claims abstract description 23
- 239000001257 hydrogen Substances 0.000 claims description 49
- 229910052739 hydrogen Inorganic materials 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 23
- 150000002431 hydrogen Chemical group 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 239000002585 base Substances 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 125000001544 thienyl group Chemical group 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 230000002062 proliferating effect Effects 0.000 claims description 8
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- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 4
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| BR0307607A (pt) | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivados de carbonilamino como inibidores de histona desacetilase |
| EP1485354B1 (en) | 2002-03-13 | 2008-05-28 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
| JP4725944B2 (ja) | 2002-03-13 | 2011-07-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの阻害剤 |
| UA86066C2 (ru) * | 2004-07-28 | 2009-03-25 | Янссен Фармацевтика Н.В. | Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы |
| EA010652B1 (ru) * | 2004-07-28 | 2008-10-30 | Янссен Фармацевтика Н.В. | Замещенные индолильные алкиламинопроизводные в качестве новых ингибиторов гистондеацетилазы |
| JP5055268B2 (ja) | 2005-05-18 | 2012-10-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としての置換されたアミノプロペニルピペリジンまたはモルホリン誘導体 |
| CA2623360C (en) * | 2005-10-27 | 2014-04-22 | Janssen Pharmaceutica N.V. | Squaric acid derivatives as inhibitors of histone deacetylase |
| CN101370789B (zh) | 2006-01-19 | 2012-05-30 | 詹森药业有限公司 | 作为组蛋白脱乙酰酶抑制剂的吡啶和嘧啶衍生物 |
| RS51191B (sr) | 2006-01-19 | 2010-10-31 | Janssen Pharmaceutica N.V. | Derivati aminofenila kao novi inhibitori histon deacetilaze |
| CA2630717C (en) | 2006-01-19 | 2015-02-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
| CN101370791B (zh) * | 2006-01-19 | 2012-05-02 | 詹森药业有限公司 | 作为组蛋白脱乙酰基酶抑制剂的吡啶和嘧啶衍生物 |
| US7834025B2 (en) * | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
| DK2274301T3 (da) | 2008-03-27 | 2013-01-02 | Janssen Pharmaceutica Nv | Azabicyclohexylsubstituerede indolylalkylaminoderivater som hidtil ukendte inhibitorer af histondeacetylase |
| BRPI0915720A2 (pt) * | 2008-06-12 | 2015-08-04 | Janssen Pharmaceutica Nv | Moduladores de diaminopiridina, pirimidina, e piridazina do receptor de histamina h4 |
| EP2330894B8 (en) | 2008-09-03 | 2017-04-19 | BioMarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| PT2680694T (pt) | 2011-02-28 | 2019-03-14 | Biomarin Pharm Inc | Inibidores de histona deacetilase |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| CN103648492A (zh) | 2011-03-09 | 2014-03-19 | 赛伦诺科学有限公司 | 利用组蛋白脱乙酰酶抑制物改善受损的内源纤维蛋白溶解作用的化合物和方法 |
| WO2014143666A1 (en) | 2013-03-15 | 2014-09-18 | Biomarin Pharmaceutical Inc. | Hdac inhibitors |
| DE102015106979B4 (de) * | 2015-05-05 | 2023-01-12 | Infineon Technologies Austria Ag | Halbleiterwafer und Verfahren zum Herstellen von Halbleitervorrichtungen in einem Halbleiterwafer |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
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| US3966743A (en) | 1968-07-23 | 1976-06-29 | Boehringer Mannheim G.M.B.H. | Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives |
| US4049811A (en) | 1968-07-23 | 1977-09-20 | Boehringer Mannheim G.M.B.H. | Compositions using cycloalkano-quinolone derivatives and their method of use |
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| DE2939292A1 (de) | 1979-09-28 | 1981-04-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | N-phenoxyalkylpiperidin-derivate, verfahrenn zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
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| US4734418A (en) | 1984-12-14 | 1988-03-29 | Mitsui Petrochemical Industries, Ltd. | Quinazoline compounds and antihypertensives |
| HU206337B (en) | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
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| US5342846A (en) | 1990-12-05 | 1994-08-30 | Synphar Laboratories, Inc. | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents |
| DE4228792A1 (de) | 1992-08-29 | 1994-03-03 | Hoechst Ag | Pyridylaminopiperidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und deren Verwendung als Fungizide |
| US5338738A (en) | 1993-04-19 | 1994-08-16 | Bristol-Myers Squibb Company | Cerebral function enhancers: acyclic amide derivatives of pyrimidinylpiperidines |
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| ES2104509B1 (es) | 1995-06-13 | 1998-07-01 | Ferrer Int | Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina. |
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| EP0827742A1 (en) | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
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| ATE264311T1 (de) | 1999-04-01 | 2004-04-15 | Pfizer Prod Inc | Verbindungen zur behandlung und vorsorge bei diabetes |
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-
2007
- 2007-01-16 RS RSP-2009/0384A patent/RS51191B/sr unknown
- 2007-01-16 PL PL07703891T patent/PL1981874T3/pl unknown
- 2007-01-16 US US12/160,140 patent/US8119650B2/en active Active
- 2007-01-16 CN CN2007800030170A patent/CN101370804B/zh active Active
- 2007-01-16 EP EP07703891A patent/EP1981874B1/en active Active
- 2007-01-16 ME MEP-2009-276A patent/ME01060B/me unknown
- 2007-01-16 AT AT07703891T patent/ATE432272T1/de active
- 2007-01-16 DK DK07703891T patent/DK1981874T3/da active
- 2007-01-16 ES ES07703891T patent/ES2327972T3/es active Active
- 2007-01-16 SI SI200730065T patent/SI1981874T1/sl unknown
- 2007-01-16 CA CA2631876A patent/CA2631876C/en active Active
- 2007-01-16 HR HR20090459T patent/HRP20090459T1/hr unknown
- 2007-01-16 AU AU2007206946A patent/AU2007206946B2/en not_active Ceased
- 2007-01-16 PT PT07703891T patent/PT1981874E/pt unknown
- 2007-01-16 JP JP2008550742A patent/JP5225104B2/ja active Active
- 2007-01-16 WO PCT/EP2007/050376 patent/WO2007082878A1/en not_active Ceased
- 2007-01-16 DE DE602007001190T patent/DE602007001190D1/de active Active
-
2009
- 2009-08-27 CY CY20091100896T patent/CY1109331T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI1981874T1 (sl) | 2009-10-31 |
| CA2631876A1 (en) | 2007-07-26 |
| HRP20090459T1 (hr) | 2009-09-30 |
| PT1981874E (pt) | 2009-09-02 |
| WO2007082878A1 (en) | 2007-07-26 |
| DE602007001190D1 (de) | 2009-07-09 |
| AU2007206946A1 (en) | 2007-07-26 |
| ATE432272T1 (de) | 2009-06-15 |
| CY1109331T1 (el) | 2014-07-02 |
| HK1128283A1 (en) | 2009-10-23 |
| EP1981874B1 (en) | 2009-05-27 |
| EP1981874A1 (en) | 2008-10-22 |
| US8119650B2 (en) | 2012-02-21 |
| PL1981874T3 (pl) | 2009-10-30 |
| JP5225104B2 (ja) | 2013-07-03 |
| ES2327972T3 (es) | 2009-11-05 |
| CN101370804A (zh) | 2009-02-18 |
| RS51191B (sr) | 2010-10-31 |
| US20090018152A1 (en) | 2009-01-15 |
| JP2009523760A (ja) | 2009-06-25 |
| CN101370804B (zh) | 2013-05-29 |
| DK1981874T3 (da) | 2009-09-28 |
| ME01060B (me) | 2012-10-20 |
| AU2007206946B2 (en) | 2011-12-15 |
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