JP2013508279A5 - - Google Patents
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- Publication number
- JP2013508279A5 JP2013508279A5 JP2012534259A JP2012534259A JP2013508279A5 JP 2013508279 A5 JP2013508279 A5 JP 2013508279A5 JP 2012534259 A JP2012534259 A JP 2012534259A JP 2012534259 A JP2012534259 A JP 2012534259A JP 2013508279 A5 JP2013508279 A5 JP 2013508279A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- salt
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25183909P | 2009-10-15 | 2009-10-15 | |
| US61/251,839 | 2009-10-15 | ||
| US30333410P | 2010-02-11 | 2010-02-11 | |
| US61/303,334 | 2010-02-11 | ||
| PCT/US2010/052126 WO2011046851A1 (en) | 2009-10-15 | 2010-10-11 | Spiropiperidine compounds and pharmaceutical use thereof for treating diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013508279A JP2013508279A (ja) | 2013-03-07 |
| JP2013508279A5 true JP2013508279A5 (enExample) | 2013-11-07 |
Family
ID=43719548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534259A Withdrawn JP2013508279A (ja) | 2009-10-15 | 2010-10-11 | スピロピペリジン化合物および糖尿病治療のためのその医薬用途 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8383642B2 (enExample) |
| EP (1) | EP2488500A1 (enExample) |
| JP (1) | JP2013508279A (enExample) |
| KR (1) | KR20120051777A (enExample) |
| CN (1) | CN102574807A (enExample) |
| AR (1) | AR078522A1 (enExample) |
| AU (1) | AU2010307094A1 (enExample) |
| BR (1) | BR112012008889A2 (enExample) |
| CA (1) | CA2777775A1 (enExample) |
| CL (1) | CL2012000921A1 (enExample) |
| CO (1) | CO6531458A2 (enExample) |
| CR (1) | CR20120177A (enExample) |
| DO (1) | DOP2012000105A (enExample) |
| EA (1) | EA201270560A1 (enExample) |
| EC (1) | ECSP12011799A (enExample) |
| IL (1) | IL218344A0 (enExample) |
| MA (1) | MA33662B1 (enExample) |
| MX (1) | MX2012004420A (enExample) |
| NZ (1) | NZ598972A (enExample) |
| PE (1) | PE20121437A1 (enExample) |
| PH (1) | PH12012500705A1 (enExample) |
| TN (1) | TN2012000152A1 (enExample) |
| TW (1) | TW201124415A (enExample) |
| WO (1) | WO2011046851A1 (enExample) |
| ZA (1) | ZA201202560B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20120834A1 (es) | 2009-03-23 | 2012-07-25 | Glenmark Pharmaceuticals Sa | Derivados de furopirimidindiona como moduladores de trpa1 |
| ES2456515T3 (es) | 2009-03-23 | 2014-04-22 | Glenmark Pharmaceuticals S.A. | Derivados de pirimidindiona fusionados como moduladores de TRPA1 |
| AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
| PH12012501456A1 (en) | 2009-12-25 | 2012-10-29 | Mochida Pharm Co Ltd | Novel 3-hydroxy -5- arylisothiazole derivative |
| AU2011313191A1 (en) | 2010-10-08 | 2013-05-02 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
| EP2683251B1 (en) | 2011-03-11 | 2021-08-25 | Intercontinental Great Brands LLC | Method of forming multilayer confectionery |
| AR085990A1 (es) | 2011-04-27 | 2013-11-13 | Mochida Pharm Co Ltd | Derivados de 1-oxido de 3-hidroxiisotiazol utiles en el tratamiento de la diabetes y composiciones farmaceuticas que los contienen |
| JPWO2012147516A1 (ja) | 2011-04-28 | 2014-07-28 | 持田製薬株式会社 | 環状アミド誘導体 |
| AR087451A1 (es) | 2011-08-17 | 2014-03-26 | Lilly Co Eli | Derivado de 1,2,3,4-tetrahidroquinolina util para tratamiento de diabetes |
| WO2013139341A1 (en) * | 2012-03-20 | 2013-09-26 | Syddansk Universitet | Gpr120 receptor modulators |
| WO2013185766A1 (en) * | 2012-06-15 | 2013-12-19 | Syddansk Universitet | Gpr120 receptor modulators |
| UY35143A (es) | 2012-11-16 | 2014-05-30 | Bristol Myers Squibb Co | Derivados de dihidropirazol como moduladores del receptor acoplado a la proteína gpr40 g |
| KR101569522B1 (ko) * | 2013-04-18 | 2015-11-17 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| CN105722841A (zh) * | 2013-11-14 | 2016-06-29 | 卡迪拉保健有限公司 | 新型杂环化合物 |
| US20150351889A1 (en) | 2014-06-05 | 2015-12-10 | Vivex Biomedical Inc. | Dynamic Biometric Mesh |
| EP3207928B1 (en) * | 2014-10-17 | 2021-03-10 | Hyundai Pharm Co., Ltd. | Composite preparation, containing novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ingredient, for preventing or treating metabolic diseases |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN109666027A (zh) * | 2017-10-17 | 2019-04-23 | 中国科学院上海药物研究所 | 一类酰胺结构的gpr40激动剂化合物及其用途 |
| DK3737470T5 (da) | 2018-01-08 | 2024-05-27 | Celon Pharma Sa | 3-phenyl-4-hexynsyrederivater som gpr40-agonister |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| MX2022010548A (es) | 2020-02-28 | 2022-09-23 | Kallyope Inc | Agonistas de gpr40. |
| MX2022014505A (es) | 2020-05-19 | 2022-12-13 | Kallyope Inc | Activadores de la ampk. |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2033644A1 (en) | 2001-04-18 | 2009-03-11 | Euro-Celtique S.A. | Spiroindene and spiroindane compounds |
| CA2520114A1 (en) * | 2003-04-04 | 2004-10-21 | Merck & Co., Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists |
| US7504506B2 (en) | 2003-11-04 | 2009-03-17 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
| EP1737809B1 (en) | 2004-02-27 | 2013-09-18 | Amgen, Inc | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
| JP4859665B2 (ja) | 2004-03-30 | 2012-01-25 | 武田薬品工業株式会社 | アルコキシフェニルプロパン酸誘導体 |
| US7582803B2 (en) | 2005-09-14 | 2009-09-01 | Amgen Inc. | Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders |
| EP2061760A1 (en) | 2006-09-07 | 2009-05-27 | Amgen, Inc | Benzo-fused compounds for use in treating metabolic disorders |
| TWI421070B (zh) | 2007-10-26 | 2014-01-01 | Japan Tobacco Inc | 螺化合物及其醫藥用途 |
| EP2224803B1 (en) | 2007-11-21 | 2014-04-02 | Janssen Pharmaceutica N.V. | Spiropiperidines for use as tryptase inhibitors |
| AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
-
2010
- 2010-10-04 AR ARP100103604A patent/AR078522A1/es not_active Application Discontinuation
- 2010-10-06 TW TW099134098A patent/TW201124415A/zh unknown
- 2010-10-11 CN CN2010800462763A patent/CN102574807A/zh active Pending
- 2010-10-11 CA CA2777775A patent/CA2777775A1/en not_active Abandoned
- 2010-10-11 KR KR1020127009501A patent/KR20120051777A/ko not_active Ceased
- 2010-10-11 EA EA201270560A patent/EA201270560A1/ru unknown
- 2010-10-11 MX MX2012004420A patent/MX2012004420A/es not_active Application Discontinuation
- 2010-10-11 NZ NZ598972A patent/NZ598972A/xx not_active IP Right Cessation
- 2010-10-11 US US12/901,597 patent/US8383642B2/en not_active Expired - Fee Related
- 2010-10-11 BR BR112012008889A patent/BR112012008889A2/pt not_active IP Right Cessation
- 2010-10-11 JP JP2012534259A patent/JP2013508279A/ja not_active Withdrawn
- 2010-10-11 PH PH1/2012/500705A patent/PH12012500705A1/en unknown
- 2010-10-11 PE PE2012000492A patent/PE20121437A1/es not_active Application Discontinuation
- 2010-10-11 AU AU2010307094A patent/AU2010307094A1/en not_active Abandoned
- 2010-10-11 WO PCT/US2010/052126 patent/WO2011046851A1/en not_active Ceased
- 2010-10-11 EP EP10793349A patent/EP2488500A1/en not_active Withdrawn
-
2012
- 2012-02-27 IL IL218344A patent/IL218344A0/en unknown
- 2012-04-02 TN TNP2012000152A patent/TN2012000152A1/en unknown
- 2012-04-09 MA MA34760A patent/MA33662B1/fr unknown
- 2012-04-10 ZA ZA2012/02560A patent/ZA201202560B/en unknown
- 2012-04-12 CL CL2012000921A patent/CL2012000921A1/es unknown
- 2012-04-12 CR CR20120177A patent/CR20120177A/es not_active Application Discontinuation
- 2012-04-13 EC ECSP12011799 patent/ECSP12011799A/es unknown
- 2012-04-13 DO DO2012000105A patent/DOP2012000105A/es unknown
- 2012-04-20 CO CO12065315A patent/CO6531458A2/es not_active Application Discontinuation