JP2020532547A5 - - Google Patents
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- Publication number
- JP2020532547A5 JP2020532547A5 JP2020512612A JP2020512612A JP2020532547A5 JP 2020532547 A5 JP2020532547 A5 JP 2020532547A5 JP 2020512612 A JP2020512612 A JP 2020512612A JP 2020512612 A JP2020512612 A JP 2020512612A JP 2020532547 A5 JP2020532547 A5 JP 2020532547A5
- Authority
- JP
- Japan
- Prior art keywords
- acceptable salt
- compound according
- drug
- drug biological
- biological acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762551714P | 2017-08-29 | 2017-08-29 | |
| US62/551,714 | 2017-08-29 | ||
| PCT/US2018/048388 WO2019046330A1 (en) | 2017-08-29 | 2018-08-28 | SPIROCYCLIC COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532547A JP2020532547A (ja) | 2020-11-12 |
| JP2020532547A5 true JP2020532547A5 (enExample) | 2021-10-07 |
| JP7177825B2 JP7177825B2 (ja) | 2022-11-24 |
Family
ID=65526036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512612A Active JP7177825B2 (ja) | 2017-08-29 | 2018-08-28 | スピロ環化合物並びにその作製及び使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11161856B2 (enExample) |
| EP (1) | EP3675848B1 (enExample) |
| JP (1) | JP7177825B2 (enExample) |
| KR (1) | KR20200046053A (enExample) |
| CN (1) | CN111032034B (enExample) |
| AU (1) | AU2018326497A1 (enExample) |
| BR (1) | BR112020003946A2 (enExample) |
| CA (1) | CA3072926A1 (enExample) |
| CL (1) | CL2020000463A1 (enExample) |
| CO (1) | CO2020001715A2 (enExample) |
| CR (1) | CR20200088A (enExample) |
| DO (1) | DOP2020000040A (enExample) |
| EA (1) | EA202090296A1 (enExample) |
| EC (1) | ECSP20013332A (enExample) |
| ES (1) | ES2914363T3 (enExample) |
| IL (1) | IL272578A (enExample) |
| JO (1) | JOP20200022A1 (enExample) |
| MA (1) | MA50045A (enExample) |
| MX (1) | MX2020002254A (enExample) |
| PE (1) | PE20200665A1 (enExample) |
| PH (1) | PH12020500371A1 (enExample) |
| RU (1) | RU2020107039A (enExample) |
| SG (1) | SG11202000984YA (enExample) |
| WO (1) | WO2019046330A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2800565T1 (sl) | 2012-01-06 | 2020-10-30 | Lundbeck La Jolla Research Center, Inc. | Karbamatne spojine in metode izdelave in uporabe le-teh |
| EP3455226B1 (en) | 2016-05-12 | 2020-12-30 | Lundbeck La Jolla Research Center, Inc. | Spirocycle compounds and methods of making and using same |
| US10899737B2 (en) | 2016-09-19 | 2021-01-26 | Lundbeck La Jolla Research Center, Inc. | Piperazine carbamates and methods of making and using same |
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| PE20200664A1 (es) | 2017-08-29 | 2020-06-11 | Lundbeck La Jolla Research Center Inc | Compuestos espirociclicos y sus metodos de preparacion y uso |
| BR112020003946A2 (pt) | 2017-08-29 | 2020-09-08 | Lundbeck La Jolla Research Center, Inc. | compostos de espirociclo e métodos para produzir e usar os mesmos |
| TW201946906A (zh) * | 2018-05-15 | 2019-12-16 | 美商阿拜德生物製藥公司 | Magl抑制劑 |
| CN111505410B (zh) * | 2020-04-02 | 2022-07-29 | 矽力杰半导体技术(杭州)有限公司 | 调光模式检测电路、方法和无调光检测电路及照明系统 |
| US11702393B2 (en) | 2020-04-21 | 2023-07-18 | H. Lundbeck A/S | Synthesis of a monoacylglycerol lipase inhibitor |
| UY39516A (es) | 2020-11-13 | 2022-05-31 | H Lundbeck As | Composición para el tratamiento de una enfermedad vascular, composición para la prevención de una enfermedad vascular, composición para el tratamiento de la hipertensión, y composición para la prevención de la hipertensión |
| WO2022165513A1 (en) | 2021-01-29 | 2022-08-04 | Cedilla Therapeutics, Inc. | Cdk2 inhibitors and methods of using the same |
| CN117561058A (zh) | 2021-06-26 | 2024-02-13 | 塞迪拉治疗股份有限公司 | Cdk2抑制剂及其使用方法 |
| JP7777891B2 (ja) | 2021-12-29 | 2025-12-01 | サイ セラピューティクス インコーポレイテッド | モノアシルグリセロールリパーゼ（ｍａｇｌ）の阻害 |
| KR20250005229A (ko) * | 2022-05-04 | 2025-01-09 | 하. 룬드벡 아크티에셀스카브 | 모노아실글리세롤 리파제 억제제로서 1,1,1,3,3,3-헥사플루오로프로판-2-일 (s)-1-(피리다진-3-일카르바모일)-6 아자스피로[2.5]옥탄-6-카르복실레이트의 결정질 형태 |
| EP4665718A1 (en) | 2023-02-13 | 2025-12-24 | Apogee Pharmaceuticals, Inc. | Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2440803A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| US20110172230A1 (en) * | 2006-08-23 | 2011-07-14 | Takahiro Ishii | Urea compound or salt thereof |
| WO2009111550A1 (en) | 2008-03-05 | 2009-09-11 | Targacept, Inc. | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloal kanes |
| US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| CA2778484C (en) | 2009-10-23 | 2018-07-31 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| US9108937B2 (en) | 2010-03-04 | 2015-08-18 | Merck Sharp & Dohme Corp. | Positive allosteric modulators of mGluR2 |
| FR2960875B1 (fr) * | 2010-06-04 | 2012-12-28 | Sanofi Aventis | Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique |
| EP2444084A1 (en) | 2010-10-21 | 2012-04-25 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Use of PI3K inibitors for the treatment of obesity |
| SI2800565T1 (sl) | 2012-01-06 | 2020-10-30 | Lundbeck La Jolla Research Center, Inc. | Karbamatne spojine in metode izdelave in uporabe le-teh |
| DK2900669T3 (da) | 2012-09-25 | 2019-11-04 | Hoffmann La Roche | Hexahydropyrrolo[3,4-C]pyrrolderivater og relaterede forbindelser som autotaxin (ATX)-inhibitorer og som inhibitorer af lysophosphatidsyre (LPA)-produktion til behandling af f.eks. nyresygdomme |
| JP6647592B2 (ja) | 2013-07-03 | 2020-02-14 | ルンドベック ラ ホーヤ リサーチ センター，インク． | ピロロピロールカルバメート、および関連する有機化合物、医薬組成物、ならびにその医学的使用 |
| EP3271352B1 (en) * | 2015-03-18 | 2021-05-12 | H. Lundbeck A/S | Piperazine carbamates and methods of making and using same |
| EA035823B1 (ru) | 2015-07-31 | 2020-08-17 | Пфайзер Инк. | 1,1,1-трифтор-3-гидроксипропан-2-ил карбаматные производные и 1,1,1-трифтор-4-гидроксибутан-2-ил карбаматные производные в качестве ингибиторов magl |
| US10519134B2 (en) | 2015-11-20 | 2019-12-31 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
| EP3455226B1 (en) | 2016-05-12 | 2020-12-30 | Lundbeck La Jolla Research Center, Inc. | Spirocycle compounds and methods of making and using same |
| JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| PE20200664A1 (es) | 2017-08-29 | 2020-06-11 | Lundbeck La Jolla Research Center Inc | Compuestos espirociclicos y sus metodos de preparacion y uso |
| BR112020003946A2 (pt) | 2017-08-29 | 2020-09-08 | Lundbeck La Jolla Research Center, Inc. | compostos de espirociclo e métodos para produzir e usar os mesmos |
-
2018
- 2018-08-28 BR BR112020003946-2A patent/BR112020003946A2/pt not_active Application Discontinuation
- 2018-08-28 ES ES18852217T patent/ES2914363T3/es active Active
- 2018-08-28 AU AU2018326497A patent/AU2018326497A1/en not_active Abandoned
- 2018-08-28 MA MA050045A patent/MA50045A/fr unknown
- 2018-08-28 CN CN201880054296.1A patent/CN111032034B/zh active Active
- 2018-08-28 RU RU2020107039A patent/RU2020107039A/ru unknown
- 2018-08-28 CR CR20200088A patent/CR20200088A/es unknown
- 2018-08-28 MX MX2020002254A patent/MX2020002254A/es unknown
- 2018-08-28 CA CA3072926A patent/CA3072926A1/en not_active Abandoned
- 2018-08-28 EA EA202090296A patent/EA202090296A1/ru unknown
- 2018-08-28 KR KR1020207007712A patent/KR20200046053A/ko not_active Withdrawn
- 2018-08-28 EP EP18852217.1A patent/EP3675848B1/en active Active
- 2018-08-28 SG SG11202000984YA patent/SG11202000984YA/en unknown
- 2018-08-28 US US16/642,713 patent/US11161856B2/en active Active
- 2018-08-28 WO PCT/US2018/048388 patent/WO2019046330A1/en not_active Ceased
- 2018-08-28 JO JOP/2020/0022A patent/JOP20200022A1/ar unknown
- 2018-08-28 PE PE2020000297A patent/PE20200665A1/es unknown
- 2018-08-28 JP JP2020512612A patent/JP7177825B2/ja active Active
-
2020
- 2020-02-10 IL IL272578A patent/IL272578A/en unknown
- 2020-02-14 CO CONC2020/0001715A patent/CO2020001715A2/es unknown
- 2020-02-21 DO DO2020000040A patent/DOP2020000040A/es unknown
- 2020-02-21 EC ECSENADI202013332A patent/ECSP20013332A/es unknown
- 2020-02-24 PH PH12020500371A patent/PH12020500371A1/en unknown
- 2020-02-25 CL CL2020000463A patent/CL2020000463A1/es unknown