MX2010009727A - Amidas selectivas del subtipo del receptor nicotinico de acetilcolina de diazabicicloalcanos. - Google Patents
Amidas selectivas del subtipo del receptor nicotinico de acetilcolina de diazabicicloalcanos.Info
- Publication number
- MX2010009727A MX2010009727A MX2010009727A MX2010009727A MX2010009727A MX 2010009727 A MX2010009727 A MX 2010009727A MX 2010009727 A MX2010009727 A MX 2010009727A MX 2010009727 A MX2010009727 A MX 2010009727A MX 2010009727 A MX2010009727 A MX 2010009727A
- Authority
- MX
- Mexico
- Prior art keywords
- nicotinic acetylcholine
- diazabicycloal
- kanes
- compounds
- acetylcholine receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se relaciona con compuestos de la siguiente fórmula (I), (ver fórmula (I)) que se unen a, y modulan la actividad de los receptores nicotínicos neuronales de la acetilcolina, con procesos para preparar estos compuestos, con composiciones farmacéuticas que contienen estos compuestos, y con métodos para utilizar estos compuestos para tratar una amplia variedad de condiciones y trastornos, incluyendo aquellos asociados con la disfunción del sistema nervioso central (CNS).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3395908P | 2008-03-05 | 2008-03-05 | |
PCT/US2009/036009 WO2009111550A1 (en) | 2008-03-05 | 2009-03-04 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloal kanes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010009727A true MX2010009727A (es) | 2010-09-28 |
Family
ID=40566370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010009727A MX2010009727A (es) | 2008-03-05 | 2009-03-04 | Amidas selectivas del subtipo del receptor nicotinico de acetilcolina de diazabicicloalcanos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110071180A1 (es) |
EP (1) | EP2257549A1 (es) |
JP (1) | JP2011513421A (es) |
KR (1) | KR20100122508A (es) |
CN (1) | CN101959888A (es) |
AU (1) | AU2009221860A1 (es) |
CA (1) | CA2716863A1 (es) |
IL (1) | IL207678A0 (es) |
MX (1) | MX2010009727A (es) |
RU (1) | RU2010140613A (es) |
WO (1) | WO2009111550A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011071758A1 (en) | 2009-12-07 | 2011-06-16 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands |
FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
CN104557568B (zh) * | 2010-05-27 | 2017-04-12 | 塔加西普特公司 | 烟碱受体非竞争性拮抗剂 |
CN102875550B (zh) * | 2011-07-12 | 2016-01-06 | 常州合全药业有限公司 | 1,3,7-三取代-3,7-二氮杂双环[3,3,1]壬烷衍生物及制备方法 |
EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
WO2014011863A1 (en) * | 2012-07-12 | 2014-01-16 | Targacept, Inc. | Method of treatment with 3-cyclopropylcarbonyl-3,6-diazabicyclo[3.1.1]heptane |
MX2015017961A (es) * | 2013-07-03 | 2016-10-14 | Abide Therapeutics Inc | Compuestos orgánicos pirrolo-pirrol carbamato y relacionados, composiciones farmacéuticas y usos médicos de los mismos. |
US9597284B2 (en) | 2014-10-20 | 2017-03-21 | Oyster Point Pharma, Inc. | Dry eye treatments |
CN114432313A (zh) | 2016-04-07 | 2022-05-06 | 奥伊斯特普安生物制药公司 | 治疗眼部病状的方法 |
CN109496213B (zh) | 2016-05-12 | 2022-03-04 | H.隆德贝克有限公司 | 螺环化合物及其制备和使用方法 |
JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
KR20200046061A (ko) | 2017-08-29 | 2020-05-06 | 룬드벡 라 졸라 리서치 센터 인코포레이티드 | 스피로사이클 화합물 및 이를 제조하고 사용하는 방법 |
PE20200665A1 (es) | 2017-08-29 | 2020-06-11 | Lundbeck La Jolla Research Center Inc | Compuestos espirociclicos y sus metodos de preparacion y uso |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852041A (en) * | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
US5493026A (en) * | 1993-10-25 | 1996-02-20 | Organix, Inc. | Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders |
US5468858A (en) * | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
US5604231A (en) * | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
US5583140A (en) * | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
US5616716A (en) * | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
US5663356A (en) * | 1996-04-23 | 1997-09-02 | Ruecroft; Graham | Method for preparation of aryl substituted alefinic secondary amino compounds |
US5726189A (en) * | 1996-05-03 | 1998-03-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes |
JP3613179B2 (ja) * | 1998-02-04 | 2005-01-26 | 萬有製薬株式会社 | N−アシル環状アミン誘導体 |
US5952339A (en) * | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
GB9821503D0 (en) * | 1998-10-02 | 1998-11-25 | Novartis Ag | Organic compounds |
ATE289607T1 (de) * | 1999-12-14 | 2005-03-15 | Neurosearch As | Neue heteroaryl-diazabizykloalkane |
US6809105B2 (en) * | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
WO2002070523A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
CN1950082B (zh) * | 2004-03-03 | 2013-02-06 | 凯莫森特里克斯股份有限公司 | 双环和桥连的含氮杂环化物 |
JP5236944B2 (ja) * | 2004-07-22 | 2013-07-17 | カムブァ、アイピー、ヴェンチュァズ、エル、ピー | 微生物感染を治療するためのリファマイシン誘導体 |
TWI405763B (zh) * | 2006-11-02 | 2013-08-21 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
-
2009
- 2009-03-04 RU RU2010140613/04A patent/RU2010140613A/ru not_active Application Discontinuation
- 2009-03-04 JP JP2010549847A patent/JP2011513421A/ja active Pending
- 2009-03-04 EP EP09716691A patent/EP2257549A1/en not_active Withdrawn
- 2009-03-04 WO PCT/US2009/036009 patent/WO2009111550A1/en active Application Filing
- 2009-03-04 CN CN2009801077510A patent/CN101959888A/zh active Pending
- 2009-03-04 KR KR1020107021884A patent/KR20100122508A/ko not_active Application Discontinuation
- 2009-03-04 US US12/919,970 patent/US20110071180A1/en not_active Abandoned
- 2009-03-04 MX MX2010009727A patent/MX2010009727A/es not_active Application Discontinuation
- 2009-03-04 CA CA2716863A patent/CA2716863A1/en not_active Abandoned
- 2009-03-04 AU AU2009221860A patent/AU2009221860A1/en not_active Abandoned
-
2010
- 2010-08-18 IL IL207678A patent/IL207678A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2009221860A1 (en) | 2009-09-11 |
RU2010140613A (ru) | 2012-04-10 |
CA2716863A1 (en) | 2009-09-11 |
US20110071180A1 (en) | 2011-03-24 |
IL207678A0 (en) | 2010-12-30 |
WO2009111550A1 (en) | 2009-09-11 |
CN101959888A (zh) | 2011-01-26 |
JP2011513421A (ja) | 2011-04-28 |
KR20100122508A (ko) | 2010-11-22 |
EP2257549A1 (en) | 2010-12-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |