MX2012003394A - Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5. - Google Patents

Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5.

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Publication number
MX2012003394A
MX2012003394A MX2012003394A MX2012003394A MX2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A
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MX
Mexico
Prior art keywords
positive allosteric
allosteric modulators
compounds
nicotinamide analogs
benzyl
Prior art date
Application number
MX2012003394A
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English (en)
Inventor
Richard Williams
P Jeffrey Conn
Craig W Lindsley
Charles David Weaver
Shaun R Stauffer
Gregor James Macdonald
Jose Manuel Bartolome-Nebreda
Ya Zhou
Original Assignee
Univ Vanderbilt
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Filing date
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Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of MX2012003394A publication Critical patent/MX2012003394A/es

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Abstract

En un aspecto, la invención se refiere a análogos de la nicotinamida de O-bencilo, derivados de la misma y compuestos relacionados, los cuales son útiles como moduladores alostéricos del receptor de glutamato metabotrópico del subtipo 5 (mGluR5); métodos sintéticos para fabricar los compuestos; composiciones farmacéuticas que comprenden los compuestos; y métodos de tratar trastornos neurológicos y psiquiátricos asociadas con la disfunción del glutamato utilizando los compuestos y composiciones.
MX2012003394A 2009-09-21 2010-09-21 Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5. MX2012003394A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24441709P 2009-09-21 2009-09-21
PCT/US2010/049697 WO2011035324A1 (en) 2009-09-21 2010-09-21 O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators

Publications (1)

Publication Number Publication Date
MX2012003394A true MX2012003394A (es) 2012-08-15

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MX2012003394A MX2012003394A (es) 2009-09-21 2010-09-21 Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5.

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Country Link
US (1) US20110183980A1 (es)
EP (1) EP2482657A4 (es)
JP (1) JP2013505297A (es)
CN (1) CN102638979A (es)
AU (1) AU2010295288A1 (es)
BR (1) BR112012006330A2 (es)
CA (1) CA2774981A1 (es)
IL (1) IL218772A0 (es)
IN (1) IN2012DN03322A (es)
MX (1) MX2012003394A (es)
RU (1) RU2012116124A (es)
WO (1) WO2011035324A1 (es)

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AU2010295288A1 (en) 2012-05-03
WO2011035324A1 (en) 2011-03-24
US20110183980A1 (en) 2011-07-28
CN102638979A (zh) 2012-08-15
EP2482657A1 (en) 2012-08-08
CA2774981A1 (en) 2011-03-24
JP2013505297A (ja) 2013-02-14
BR112012006330A2 (pt) 2017-07-04
RU2012116124A (ru) 2013-10-27

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