MX2012003394A - Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5. - Google Patents
Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5.Info
- Publication number
- MX2012003394A MX2012003394A MX2012003394A MX2012003394A MX2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A MX 2012003394 A MX2012003394 A MX 2012003394A
- Authority
- MX
- Mexico
- Prior art keywords
- positive allosteric
- allosteric modulators
- compounds
- nicotinamide analogs
- benzyl
- Prior art date
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Abstract
En un aspecto, la invención se refiere a análogos de la nicotinamida de O-bencilo, derivados de la misma y compuestos relacionados, los cuales son útiles como moduladores alostéricos del receptor de glutamato metabotrópico del subtipo 5 (mGluR5); métodos sintéticos para fabricar los compuestos; composiciones farmacéuticas que comprenden los compuestos; y métodos de tratar trastornos neurológicos y psiquiátricos asociadas con la disfunción del glutamato utilizando los compuestos y composiciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24441709P | 2009-09-21 | 2009-09-21 | |
PCT/US2010/049697 WO2011035324A1 (en) | 2009-09-21 | 2010-09-21 | O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012003394A true MX2012003394A (es) | 2012-08-15 |
Family
ID=43759065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012003394A MX2012003394A (es) | 2009-09-21 | 2010-09-21 | Analogos de la nicotinamida de o-bencilo como moduladores alostéricos positivos del mglur5. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110183980A1 (es) |
EP (1) | EP2482657A4 (es) |
JP (1) | JP2013505297A (es) |
CN (1) | CN102638979A (es) |
AU (1) | AU2010295288A1 (es) |
BR (1) | BR112012006330A2 (es) |
CA (1) | CA2774981A1 (es) |
IL (1) | IL218772A0 (es) |
IN (1) | IN2012DN03322A (es) |
MX (1) | MX2012003394A (es) |
RU (1) | RU2012116124A (es) |
WO (1) | WO2011035324A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US8772301B2 (en) | 2009-12-18 | 2014-07-08 | Sunovion Pharmaceuticals, Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
CN103037693A (zh) * | 2010-05-24 | 2013-04-10 | 范德比尔特大学 | 作为mglur5正向变构调节剂的取代的6-甲基烟酰胺 |
RU2542100C1 (ru) * | 2013-12-24 | 2015-02-20 | Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской Академии Наук (ИХС РАН) | Сокристаллическая форма теофиллина с дифлунисалом или диклофенаком |
TWI713497B (zh) | 2015-02-26 | 2020-12-21 | 南韓商愛思開生物製藥股份有限公司 | 咪唑并嘧啶及咪唑并三衍生物及包含該衍生物之醫藥組成物 |
WO2021007477A1 (en) | 2019-07-11 | 2021-01-14 | E-Scape Bio, Inc. | Indazoles and azaindazoles as lrrk2 inhibitors |
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JP2002322163A (ja) * | 2001-04-20 | 2002-11-08 | Sumitomo Pharmaceut Co Ltd | ピペラジン誘導体 |
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US8853392B2 (en) * | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
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RU2484091C2 (ru) * | 2007-12-04 | 2013-06-10 | Ф. Хоффманн-Ля Рош Аг | Производные изоксазоло-пиридина |
US7897621B2 (en) * | 2008-03-31 | 2011-03-01 | Hoffmann-La Roche Inc. | 2-trifluoromethylnicotinamide derivatives as HDL-cholesterol raising agents |
EP3725775A1 (en) * | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- and pyrimidinecarboxamides as cxcr2 modulators |
US8222246B2 (en) * | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
SG175318A1 (en) * | 2009-05-07 | 2011-11-28 | Hoffmann La Roche | Isoxazole-pyridine derivatives as gaba modulators |
-
2010
- 2010-09-21 WO PCT/US2010/049697 patent/WO2011035324A1/en active Application Filing
- 2010-09-21 AU AU2010295288A patent/AU2010295288A1/en not_active Abandoned
- 2010-09-21 IN IN3322DEN2012 patent/IN2012DN03322A/en unknown
- 2010-09-21 RU RU2012116124/13A patent/RU2012116124A/ru not_active Application Discontinuation
- 2010-09-21 US US12/886,950 patent/US20110183980A1/en not_active Abandoned
- 2010-09-21 BR BR112012006330A patent/BR112012006330A2/pt not_active IP Right Cessation
- 2010-09-21 EP EP10818037.3A patent/EP2482657A4/en not_active Withdrawn
- 2010-09-21 MX MX2012003394A patent/MX2012003394A/es not_active Application Discontinuation
- 2010-09-21 JP JP2012530978A patent/JP2013505297A/ja active Pending
- 2010-09-21 CA CA2774981A patent/CA2774981A1/en not_active Abandoned
- 2010-09-21 CN CN2010800523979A patent/CN102638979A/zh active Pending
-
2012
- 2012-03-21 IL IL218772A patent/IL218772A0/en unknown
Also Published As
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BR112012006330A2 (pt) | 2017-07-04 |
EP2482657A1 (en) | 2012-08-08 |
JP2013505297A (ja) | 2013-02-14 |
IN2012DN03322A (es) | 2015-10-23 |
EP2482657A4 (en) | 2013-05-15 |
AU2010295288A1 (en) | 2012-05-03 |
RU2012116124A (ru) | 2013-10-27 |
CN102638979A (zh) | 2012-08-15 |
WO2011035324A1 (en) | 2011-03-24 |
CA2774981A1 (en) | 2011-03-24 |
IL218772A0 (en) | 2012-06-28 |
US20110183980A1 (en) | 2011-07-28 |
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