MX2012004771A - Potenciadores alostericos mglur4, composiciones y metodos para tratar disfunciones neurologicas. - Google Patents

Potenciadores alostericos mglur4, composiciones y metodos para tratar disfunciones neurologicas.

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Publication number
MX2012004771A
MX2012004771A MX2012004771A MX2012004771A MX2012004771A MX 2012004771 A MX2012004771 A MX 2012004771A MX 2012004771 A MX2012004771 A MX 2012004771A MX 2012004771 A MX2012004771 A MX 2012004771A MX 2012004771 A MX2012004771 A MX 2012004771A
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MX
Mexico
Prior art keywords
methods
treating neurological
compositions
compounds
neurological dysfunction
Prior art date
Application number
MX2012004771A
Other languages
English (en)
Inventor
Craig W Lindsley
P Jeffrey Conn
Colleen M Niswender
Corey R Hopkins
Rocco D Gogliotti
James M Salovich
Original Assignee
Univ Vanderbilt
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Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of MX2012004771A publication Critical patent/MX2012004771A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • Pyrrole Compounds (AREA)

Abstract

Compuestos pirrol útiles como potenciadores alostéricos/moduladore s alostéricos positivos del subtipo 4 del receptor de glutamato metabotrópico (mGluR4); métodos sintéticos para hacer los compuestos; composiciones farmacéuticas que comprenden los compuestos; y métodos para utilizar los compuestos, por ejemplo, en el tratamiento de trastornos neurológicos y psiquiátricos u otros estados de enfermedad asociados con la disfunción de glutamato.
MX2012004771A 2009-10-22 2010-10-22 Potenciadores alostericos mglur4, composiciones y metodos para tratar disfunciones neurologicas. MX2012004771A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25406209P 2009-10-22 2009-10-22
US29272510P 2010-01-06 2010-01-06
PCT/US2010/053837 WO2011050316A1 (en) 2009-10-22 2010-10-22 Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Publications (1)

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MX2012004771A true MX2012004771A (es) 2012-05-23

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MX2012004774A MX2012004774A (es) 2009-10-22 2010-10-22 Potenciadores alostericos mglur4, composiciones y metodos para tratar disfunciones neurologicas.
MX2012004771A MX2012004771A (es) 2009-10-22 2010-10-22 Potenciadores alostericos mglur4, composiciones y metodos para tratar disfunciones neurologicas.

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US (2) US20130338154A1 (es)
EP (2) EP2490529A4 (es)
JP (2) JP2013508412A (es)
KR (2) KR20120088755A (es)
CN (2) CN102665411A (es)
AU (2) AU2010310440A1 (es)
BR (2) BR112012009576A2 (es)
CA (2) CA2779292A1 (es)
IL (2) IL219296A0 (es)
MX (2) MX2012004774A (es)
RU (2) RU2012121633A (es)
WO (2) WO2011050316A1 (es)

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EP2393785A4 (en) 2009-01-28 2013-10-30 Univ Vanderbilt SUBSTITUTED 1,1,3,3-TETRAOXIDOBENZO [D] [1,3,2] DITHIAZOLE AS ALLOSTERIC MGLUR4 POTENTIATORS, COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS
US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
MA34234B1 (fr) 2010-04-07 2013-05-02 Hoffmann La Roche Composes pyrazol-4-yl-heterocyclyle-carboxamide et leurs procedes d'utilisation
RU2638552C2 (ru) 2011-09-27 2017-12-14 Ф. Хоффманн-Ля Рош Аг Пиразол-4-ил-гетероциклил-карбоксамидные соединения и способы применения
EP2853532B1 (en) 2013-09-28 2020-12-09 Instytut Farmakologii Polskiej Akademii Nauk 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
WO2016115272A1 (en) 2015-01-13 2016-07-21 Vanderbilt University Benzothiazole and benzisothiazole-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2016123629A1 (en) 2015-01-30 2016-08-04 Vanderbilt University Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
US10227343B2 (en) 2015-01-30 2019-03-12 Vanderbilt University Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2016179351A1 (en) 2015-05-05 2016-11-10 Northwestern University Treatment of levodopa-induced dyskinesias
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