UA100400C2 - Похідні спіроциклічних амідів - Google Patents

Похідні спіроциклічних амідів

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Publication number
UA100400C2
UA100400C2 UAA201008895A UAA201008895A UA100400C2 UA 100400 C2 UA100400 C2 UA 100400C2 UA A201008895 A UAA201008895 A UA A201008895A UA A201008895 A UAA201008895 A UA A201008895A UA 100400 C2 UA100400 C2 UA 100400C2
Authority
UA
Ukraine
Prior art keywords
amide derivatives
spirocyclic amide
spirocyclic
adreno
diazaspiro
Prior art date
Application number
UAA201008895A
Other languages
English (en)
Russian (ru)
Inventor
Ліліан Алькараз
Ендрю Бейлі
Річард Джеймс Булл
Тімоті Джонсон
Ніколас Девід Кіндон
Ендрю Стюарт Лістер
Ендрю Джеймс Роббінс
Майкл Джон Стокс
Баррі Джон Теобальд
Original Assignee
Астразенека Аб
Пульмаґен Терапеутікс (Сінерджі) Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0802192A external-priority patent/GB0802192D0/en
Priority claimed from GB0822437A external-priority patent/GB0822437D0/en
Application filed by Астразенека Аб, Пульмаґен Терапеутікс (Сінерджі) Лімітед filed Critical Астразенека Аб
Publication of UA100400C2 publication Critical patent/UA100400C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems
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  • Organic Chemistry (AREA)
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  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

Заявлений винахід стосується похідних спіроциклічних амідів формули І EMBED ISISServer , (I) їх фармацевтично прийнятних солей, способу їх отримання, фармацевтичних композицій, що їх містять, та їх застосування у терапії.
UAA201008895A 2008-02-06 2009-02-04 Похідні спіроциклічних амідів UA100400C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0802192A GB0802192D0 (en) 2008-02-06 2008-02-06 Compounds
GB0822437A GB0822437D0 (en) 2008-12-09 2008-12-09 Compounds
PCT/GB2009/000298 WO2009098448A1 (en) 2008-02-06 2009-02-04 Compounds

Publications (1)

Publication Number Publication Date
UA100400C2 true UA100400C2 (uk) 2012-12-25

Family

ID=40474981

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201008895A UA100400C2 (uk) 2008-02-06 2009-02-04 Похідні спіроциклічних амідів

Country Status (39)

Country Link
US (2) US8148373B2 (uk)
EP (1) EP2242759B1 (uk)
JP (1) JP4934223B2 (uk)
KR (1) KR101273200B1 (uk)
CN (1) CN102083839B (uk)
AR (1) AR070571A1 (uk)
AU (1) AU2009211251B2 (uk)
BR (1) BRPI0908353B8 (uk)
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Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
UA100400C2 (uk) 2008-02-06 2012-12-25 Астразенека Аб Похідні спіроциклічних амідів
AU2008356409B2 (en) 2008-05-13 2012-01-19 Astrazeneca Ab Quinuclidine derivatives as muscarinic M3 receptor antagonists
WO2010067102A1 (en) * 2008-12-09 2010-06-17 Astrazeneca Ab Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
NZ595810A (en) 2009-04-30 2013-05-31 Teijin Pharma Ltd Quaternary ammonium salt compound
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
GB0913345D0 (en) * 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
US8680098B2 (en) 2010-03-05 2014-03-25 Janssen Pharmaceutica, Nv Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201107985D0 (en) * 2011-05-13 2011-06-29 Astrazeneca Ab Process
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
HUE032035T2 (en) * 2012-03-02 2017-08-28 Genentech Inc Amido spirocyclic amide and sulfonamide derivatives
JP6041643B2 (ja) * 2012-11-30 2016-12-14 関東電化工業株式会社 3,3,3−トリフルオロプロピオニル化合物の製造方法
EA201500651A1 (ru) 2012-12-18 2015-11-30 Альмираль, С.А. НОВЫЕ ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛ- И ХИНУКЛИДИНИЛКАРБАМАТА, ОБЛАДАЮЩИЕ АГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К β2 АДРЕНЕРГИЧЕСКОМУ РЕЦЕПТОРУ И АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К МУСКАРИНОВОМУ РЕЦЕПТОРУ М3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有maba化合物和皮質類固醇之組合
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之1-氧雜-4,9-二氮雜螺十一烷化合物之烷基與芳基衍生物
TW201615642A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之醯胺衍生物
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之烷基衍生物
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物
TW201731853A (zh) 2015-10-23 2017-09-16 艾斯提夫博士實驗股份有限公司 具有抗疼痛活性之氧雜-二氮雜螺環化合物
SG11201803153RA (en) 2015-11-16 2018-06-28 Esteve Labor Dr Oxadiazaspiro compounds for the treatment of drug abuse and addiction
WO2018059537A1 (zh) * 2016-09-30 2018-04-05 四川海思科制药有限公司 一种二氮杂螺[5.5]十一碳烷衍生物及其用途
AU2017376363B2 (en) 2016-12-14 2020-02-06 Beijing Showby Pharmaceutical Co., Ltd. Class of bifunctional compounds with quaternary ammonium salt structure
CN108264456A (zh) * 2016-12-30 2018-07-10 湖北尚赛光电材料有限公司 2,8-二溴屈的合成方法及其合成中间体
FI3697795T3 (fi) 2017-10-17 2024-02-23 Acondicionamiento Tarrasense (R)-9-(2,5-difluorifenetyyli)-4-etyyli-2-metyyli-1-oksa-4,9-diatsaspiro[5.5]undekan-3-onin suoloja
CN111349003B (zh) * 2018-12-20 2023-10-03 四川科瑞德制药股份有限公司 一种丙戊酸钠的制备方法
EP4129402A4 (en) 2020-03-31 2024-06-12 Mitsubishi Tanabe Pharma Corp HYDROXYPYRROLIDINE DERIVATIVE AND MEDICAL USE THEREOF
WO2023213922A1 (en) * 2022-05-04 2023-11-09 Symrise Ag PRECURSORS FOR THE CONTROLLED RELEASE OF α,β-UNSATURATED ALDEHYDES OR KETONES AND OTHER HIGH IMPACT FRAGRANCE SUBSTANCES

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2707186A (en) 1954-05-06 1955-04-26 Hoffmann La Roche Imidazolone derivatives
GB9604578D0 (en) 1996-03-04 1996-05-01 Sericol Ltd Photocurable compositions
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
AU6539400A (en) 1999-08-13 2001-03-13 Gore Enterprise Holdings, Inc. Fibrous polymeric material and its composites
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
WO2001092224A1 (en) 2000-05-31 2001-12-06 Astrazeneca Ab Indole derivatives with vascular damaging activity
CA2411160A1 (en) 2000-07-07 2002-01-17 Angiogene Pharmaceuticals Limited Colchinol derivatives as vascular damaging agents
MXPA02012903A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como inhibidores de angiogenesis.
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
US7317102B2 (en) * 2003-04-01 2008-01-08 Theravance, Inc. Diarylmethyl and related compounds
US7358244B2 (en) * 2003-05-28 2008-04-15 Theravance, Inc. Azabicycloalkane compounds
US7504400B2 (en) 2004-03-10 2009-03-17 Janssen Pharmaceutica N.V. MTP inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles
CN1934104A (zh) * 2004-03-23 2007-03-21 辉瑞大药厂 用于治疗疾病的化合物
EP1833822A2 (en) * 2004-08-16 2007-09-19 Theravance, Inc. Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
WO2006088173A1 (ja) 2005-02-21 2006-08-24 Shionogi & Co., Ltd. Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体
TW200738659A (en) 2005-08-29 2007-10-16 Astrazeneca Ab Novel compounds
TW200734342A (en) 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
KR20080087841A (ko) * 2005-12-22 2008-10-01 버텍스 파마슈티칼스 인코포레이티드 무스카린 수용체의 조절제
TW200745084A (en) * 2006-03-08 2007-12-16 Astrazeneca Ab Novel compounds
TW200811105A (en) * 2006-04-25 2008-03-01 Theravance Inc Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
GB0613154D0 (en) * 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
CA2672792A1 (en) 2006-12-20 2008-06-26 Astrazeneca Ab Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases
WO2008096129A1 (en) 2007-02-07 2008-08-14 Argenta Discovery Ltd Nitrogen containing hetrocyclic compounds useful as bifunctional modulators of m3 receptors and beta- 2 receptors
GB0702413D0 (en) 2007-02-07 2007-03-21 Argenta Discovery Ltd New chemical compounds
UA100400C2 (uk) 2008-02-06 2012-12-25 Астразенека Аб Похідні спіроциклічних амідів
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802

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