DOP2010000246A - Compuestos - Google Patents

Compuestos

Info

Publication number
DOP2010000246A
DOP2010000246A DO2010000246A DO2010000246A DOP2010000246A DO P2010000246 A DOP2010000246 A DO P2010000246A DO 2010000246 A DO2010000246 A DO 2010000246A DO 2010000246 A DO2010000246 A DO 2010000246A DO P2010000246 A DOP2010000246 A DO P2010000246A
Authority
DO
Dominican Republic
Prior art keywords
compounds
Prior art date
Application number
DO2010000246A
Other languages
English (en)
Inventor
Lilian Alcaraz
Andrew Bailey
Timothy Johnson
Nicholas David Kindon
Andrew Stuart Lister
Andrew James Robbins
Michael John Stocks
Barry John Teobald
Richard James Bull
Original Assignee
Astrazeneca Ab
Pulmagen Therapeutics Synergy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0802192A external-priority patent/GB0802192D0/en
Priority claimed from GB0822437A external-priority patent/GB0822437D0/en
Application filed by Astrazeneca Ab, Pulmagen Therapeutics Synergy filed Critical Astrazeneca Ab
Publication of DOP2010000246A publication Critical patent/DOP2010000246A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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DO2010000246A 2008-02-06 2010-08-06 Compuestos DOP2010000246A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0802192A GB0802192D0 (en) 2008-02-06 2008-02-06 Compounds
GB0822437A GB0822437D0 (en) 2008-12-09 2008-12-09 Compounds

Publications (1)

Publication Number Publication Date
DOP2010000246A true DOP2010000246A (es) 2010-11-15

Family

ID=40474981

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2010000246A DOP2010000246A (es) 2008-02-06 2010-08-06 Compuestos

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US (2) US8148373B2 (es)
EP (1) EP2242759B1 (es)
JP (1) JP4934223B2 (es)
KR (1) KR101273200B1 (es)
CN (1) CN102083839B (es)
AR (1) AR070571A1 (es)
AU (1) AU2009211251B2 (es)
BR (1) BRPI0908353B8 (es)
CA (1) CA2713322C (es)
CL (1) CL2009000271A1 (es)
CO (1) CO6290662A2 (es)
CR (1) CR11623A (es)
CU (1) CU23911B1 (es)
CY (1) CY1113734T1 (es)
DK (1) DK2242759T3 (es)
DO (1) DOP2010000246A (es)
EA (1) EA018711B1 (es)
EC (1) ECSP10010390A (es)
ES (1) ES2394547T3 (es)
HK (1) HK1149258A1 (es)
HN (1) HN2010001563A (es)
HR (1) HRP20120968T1 (es)
IL (1) IL207038A (es)
ME (1) ME01532B (es)
MX (1) MX2010008577A (es)
MY (1) MY149731A (es)
NI (1) NI201000138A (es)
NZ (1) NZ586872A (es)
PE (1) PE20091572A1 (es)
PL (1) PL2242759T3 (es)
PT (1) PT2242759E (es)
RS (1) RS52557B (es)
SA (1) SA109300094B1 (es)
SI (1) SI2242759T1 (es)
SV (1) SV2010003642A (es)
TW (1) TWI453209B (es)
UA (1) UA100400C2 (es)
UY (1) UY31639A1 (es)
WO (1) WO2009098448A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
PL2242759T3 (pl) 2008-02-06 2013-06-28 Astrazeneca Ab Związki
MX2010012189A (es) 2008-05-13 2011-03-02 Astrazeneca Ab Derivados de quinuclidina como antagonistas del receptor m3 muscarinico.
WO2010067102A1 (en) * 2008-12-09 2010-06-17 Astrazeneca Ab Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
AU2010242646A1 (en) 2009-04-30 2011-11-03 Teijin Pharma Limited Quaternary ammonium salt compound
GB0913342D0 (en) * 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
GB0913345D0 (en) * 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
US8680098B2 (en) 2010-03-05 2014-03-25 Janssen Pharmaceutica, Nv Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201107985D0 (en) * 2011-05-13 2011-06-29 Astrazeneca Ab Process
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
AU2013225533B2 (en) * 2012-03-02 2017-08-03 Forma Tm, Llc. Amido spirocyclic amide and sulfonamide derivatives
JP6041643B2 (ja) * 2012-11-30 2016-12-14 関東電化工業株式会社 3,3,3−トリフルオロプロピオニル化合物の製造方法
JP6307091B2 (ja) 2012-12-18 2018-04-04 アルミラル・ソシエダッド・アノニマAlmirall, S.A. β2アドレナリンアゴニスト活性およびM3ムスカリンアンタゴニスト活性を有する新規のシクロヘキシルおよびキヌクリジニルカルバメート誘導体
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有maba化合物和皮質類固醇之組合
TW201615642A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之醯胺衍生物
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之1-氧雜-4,9-二氮雜螺十一烷化合物之烷基與芳基衍生物
TWI685497B (zh) * 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之烷基衍生物
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物
TN2018000091A1 (en) 2015-10-23 2019-07-08 Esteve Labor Dr Oxa-diazaspiro compounds having activity against pain
ES2932000T3 (es) 2015-11-16 2023-01-09 Esteve Pharmaceuticals Sa Compuestos de oxadiazaspiro para el tratamiento del abuso de drogas y adicciones
WO2018059537A1 (zh) * 2016-09-30 2018-04-05 四川海思科制药有限公司 一种二氮杂螺[5.5]十一碳烷衍生物及其用途
KR102278197B1 (ko) 2016-12-14 2021-07-15 베이징 서우바이 파마슈티컬 컴퍼니 리미티드 4차 암모늄염 구조의 이중기능 화합물
CN108264456A (zh) * 2016-12-30 2018-07-10 湖北尚赛光电材料有限公司 2,8-二溴屈的合成方法及其合成中间体
AU2018353107B2 (en) 2017-10-17 2023-07-06 Esteve Pharmaceuticals, S.A. Salts of (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
CN111349003B (zh) * 2018-12-20 2023-10-03 四川科瑞德制药股份有限公司 一种丙戊酸钠的制备方法
WO2021201036A1 (ja) 2020-03-31 2021-10-07 田辺三菱製薬株式会社 ヒドロキシピロリジン誘導体およびその医薬用途
WO2023213922A1 (en) * 2022-05-04 2023-11-09 Symrise Ag PRECURSORS FOR THE CONTROLLED RELEASE OF α,β-UNSATURATED ALDEHYDES OR KETONES AND OTHER HIGH IMPACT FRAGRANCE SUBSTANCES

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2707186A (en) * 1954-05-06 1955-04-26 Hoffmann La Roche Imidazolone derivatives
GB9604578D0 (en) 1996-03-04 1996-05-01 Sericol Ltd Photocurable compositions
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
AU6539400A (en) 1999-08-13 2001-03-13 Gore Enterprise Holdings, Inc. Fibrous polymeric material and its composites
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
MXPA02011770A (es) 2000-05-31 2003-04-10 Astrazeneca Ab Derivados de indol con actividad de dano vascular.
RU2003103603A (ru) 2000-07-07 2004-08-20 Энджиоджен Фармасьютикалз Лимитед (Gb) Производные колхинола в качестве ингибиторов ангиогенеза
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1615881A2 (en) * 2003-04-01 2006-01-18 Theravance, Inc. Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
EP1626970B1 (en) * 2003-05-28 2009-07-08 Theravance, Inc. Azabicycloalkane compounds as muscarinic receptor antagonists
ES2317206T3 (es) 2004-03-10 2009-04-16 Janssen Pharmaceutica Nv Aril piperidinas o piperazinas inhibidoras de mtp sustituidas con heterociclos de 5 miembros.
CN1934104A (zh) * 2004-03-23 2007-03-21 辉瑞大药厂 用于治疗疾病的化合物
WO2006023460A2 (en) * 2004-08-16 2006-03-02 Theravance, Inc. COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
WO2006088173A1 (ja) 2005-02-21 2006-08-24 Shionogi & Co., Ltd. Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体
TW200738659A (en) 2005-08-29 2007-10-16 Astrazeneca Ab Novel compounds
TW200734342A (en) 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
CA2634456A1 (en) * 2005-12-22 2007-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
TW200745084A (en) 2006-03-08 2007-12-16 Astrazeneca Ab Novel compounds
TW200811105A (en) * 2006-04-25 2008-03-01 Theravance Inc Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
GB0613154D0 (en) * 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
EP2094646A1 (en) 2006-12-20 2009-09-02 AstraZeneca AB Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases
WO2008096129A1 (en) 2007-02-07 2008-08-14 Argenta Discovery Ltd Nitrogen containing hetrocyclic compounds useful as bifunctional modulators of m3 receptors and beta- 2 receptors
GB0702413D0 (en) 2007-02-07 2007-03-21 Argenta Discovery Ltd New chemical compounds
PL2242759T3 (pl) 2008-02-06 2013-06-28 Astrazeneca Ab Związki
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802

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