EA202090296A1 - Спироциклические соединения и способы их получения и применения - Google Patents

Спироциклические соединения и способы их получения и применения

Info

Publication number
EA202090296A1
EA202090296A1 EA202090296A EA202090296A EA202090296A1 EA 202090296 A1 EA202090296 A1 EA 202090296A1 EA 202090296 A EA202090296 A EA 202090296A EA 202090296 A EA202090296 A EA 202090296A EA 202090296 A1 EA202090296 A1 EA 202090296A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
methods
application
spirocyclic compounds
compounds
Prior art date
Application number
EA202090296A
Other languages
English (en)
Inventor
Шерил А. Грайс
Оливия Д. Вебер
Дэниэл Дж. Бузард
Майкл Б. Шагхафай
Original Assignee
Лундбекк Ла-Хойя Рисерч Сентер, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лундбекк Ла-Хойя Рисерч Сентер, Инк. filed Critical Лундбекк Ла-Хойя Рисерч Сентер, Инк.
Publication of EA202090296A1 publication Critical patent/EA202090296A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Abstract

В данном документе представлены соединения и композиции, пригодные в качестве модуляторов MAGL. Кроме того, соединения и композиции по настоящему изобретению являются пригодными для устранения боли.
EA202090296A 2017-08-29 2018-08-28 Спироциклические соединения и способы их получения и применения EA202090296A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762551714P 2017-08-29 2017-08-29
PCT/US2018/048388 WO2019046330A1 (en) 2017-08-29 2018-08-28 SPIROCYCLIC COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF

Publications (1)

Publication Number Publication Date
EA202090296A1 true EA202090296A1 (ru) 2020-08-03

Family

ID=65526036

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090296A EA202090296A1 (ru) 2017-08-29 2018-08-28 Спироциклические соединения и способы их получения и применения

Country Status (24)

Country Link
US (1) US11161856B2 (ru)
EP (1) EP3675848B1 (ru)
JP (1) JP7177825B2 (ru)
KR (1) KR20200046053A (ru)
CN (1) CN111032034B (ru)
AU (1) AU2018326497A1 (ru)
BR (1) BR112020003946A2 (ru)
CA (1) CA3072926A1 (ru)
CL (1) CL2020000463A1 (ru)
CO (1) CO2020001715A2 (ru)
CR (1) CR20200088A (ru)
DO (1) DOP2020000040A (ru)
EA (1) EA202090296A1 (ru)
EC (1) ECSP20013332A (ru)
ES (1) ES2914363T3 (ru)
IL (1) IL272578A (ru)
JO (1) JOP20200022A1 (ru)
MA (1) MA50045A (ru)
MX (1) MX2020002254A (ru)
PE (1) PE20200665A1 (ru)
PH (1) PH12020500371A1 (ru)
RU (1) RU2020107039A (ru)
SG (1) SG11202000984YA (ru)
WO (1) WO2019046330A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3698782B1 (en) 2012-01-06 2024-05-15 H. Lundbeck A/S Carbamate compounds for use in therapy
WO2017197192A1 (en) 2016-05-12 2017-11-16 Abide Therapeutics, Inc. Spirocycle compounds and methods of making and using same
JP7042804B2 (ja) 2016-09-19 2022-03-28 ルンドベック ラ ホーヤ リサーチ センター，インク． ピペラジンカルバメート、及びその製造と使用の方法
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
MX2020002251A (es) 2017-08-29 2020-07-20 Lundbeck La Jolla Research Center Inc Compuestos espirociclicos y sus metodos de preparacion y uso.
EA202090296A1 (ru) 2017-08-29 2020-08-03 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Спироциклические соединения и способы их получения и применения
US10570106B2 (en) 2018-05-15 2020-02-25 Lundbeck La Jolla Research Center, Inc. MAGL inhibitors
CN111505410B (zh) * 2020-04-02 2022-07-29 矽力杰半导体技术(杭州)有限公司 调光模式检测电路、方法和无调光检测电路及照明系统
JP2023523219A (ja) 2020-04-21 2023-06-02 ハー・ルンドベック・アクチエゼルスカベット モノアシルグリセロールリパーゼ阻害剤の合成
TW202229255A (zh) 2020-11-13 2022-08-01 丹麥商Ｈ 朗德貝克公司 Magl抑制劑
WO2023213854A1 (en) * 2022-05-04 2023-11-09 H. Lundbeck A/S Crystalline form of 1,1,1,3,3,3-hexafluoropropan-2-yl (s)-1-(pyridazin-3-ylcarbamoyl)-6 azaspiro[2.5]octane-6-carboxylate as monoacylglycerol lipase inhibitor.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070523A1 (en) * 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
CA2665804A1 (en) * 2006-08-23 2008-02-28 Astellas Pharma Inc. Urea compound or salt thereof
RU2010140613A (ru) 2008-03-05 2012-04-10 Таргасепт, Инк. (Us) Амиды диазабициклоалканов, селективные в отношении подтипа никотиновых ацетилхолиновых рецепторов
WO2010141817A1 (en) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
JP5759470B2 (ja) 2009-10-23 2015-08-05 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての二置換オクタヒドロピロロ［３，４−ｃ］ピロール
EP2542083B1 (en) 2010-03-04 2015-05-06 Merck Sharp & Dohme Corp. Positive allosteric modulators of mglur2
FR2960875B1 (fr) * 2010-06-04 2012-12-28 Sanofi Aventis Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique
EP2444084A1 (en) 2010-10-21 2012-04-25 Centro Nacional de Investigaciones Oncológicas (CNIO) Use of PI3K inibitors for the treatment of obesity
EP3698782B1 (en) * 2012-01-06 2024-05-15 H. Lundbeck A/S Carbamate compounds for use in therapy
EP3590940B1 (en) 2012-09-25 2021-06-09 F. Hoffmann-La Roche AG Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
WO2015003002A1 (en) 2013-07-03 2015-01-08 Abide Therapeutics, Inc. Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof
CA2979537C (en) * 2015-03-18 2023-08-29 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
BR112018000041A2 (pt) 2015-07-31 2018-09-04 Pfizer Inc. Derivados de carbamato de 1,1,1-trifluoro-3- hidroxipropan-2-ila e derivados de carbamato de 1,1,1-trifluoro-4-hidroxibutan-2-ila como inibidores de magl
CN108601769B (zh) * 2015-11-20 2021-09-03 H.隆德贝克有限公司 吡唑化合物及其制备和使用方法
WO2017197192A1 (en) 2016-05-12 2017-11-16 Abide Therapeutics, Inc. Spirocycle compounds and methods of making and using same
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
MX2020002251A (es) 2017-08-29 2020-07-20 Lundbeck La Jolla Research Center Inc Compuestos espirociclicos y sus metodos de preparacion y uso.
EA202090296A1 (ru) 2017-08-29 2020-08-03 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Спироциклические соединения и способы их получения и применения

Also Published As

Publication number Publication date
BR112020003946A2 (pt) 2020-09-08
AU2018326497A1 (en) 2020-02-20
ES2914363T3 (es) 2022-06-09
JOP20200022A1 (ar) 2020-02-02
RU2020107039A (ru) 2021-09-30
CA3072926A1 (en) 2019-03-07
US11161856B2 (en) 2021-11-02
MX2020002254A (es) 2020-07-20
KR20200046053A (ko) 2020-05-06
PE20200665A1 (es) 2020-06-11
CL2020000463A1 (es) 2020-07-10
CN111032034B (zh) 2023-05-02
CR20200088A (es) 2020-04-08
MA50045A (fr) 2020-07-08
PH12020500371A1 (en) 2020-12-07
CN111032034A (zh) 2020-04-17
IL272578A (en) 2020-03-31
DOP2020000040A (es) 2020-08-31
JP7177825B2 (ja) 2022-11-24
EP3675848B1 (en) 2022-03-23
CO2020001715A2 (es) 2020-02-28
US20210214375A1 (en) 2021-07-15
WO2019046330A1 (en) 2019-03-07
SG11202000984YA (en) 2020-03-30
EP3675848A1 (en) 2020-07-08
EP3675848A4 (en) 2021-03-10
ECSP20013332A (es) 2020-04-22
JP2020532547A (ja) 2020-11-12

Similar Documents

Publication Publication Date Title
EA202090296A1 (ru) Спироциклические соединения и способы их получения и применения
EA202090312A1 (ru) Спироциклические соединения и способы их получения и применения
EA201891200A1 (ru) Композиции, содержащие бактериальные штаммы
EA201990043A1 (ru) Антибактериальные соединения
EA201890204A1 (ru) Антибактериальные соединения
EA201991073A1 (ru) Ингибиторы magl
EA201890754A1 (ru) Соединения и способы их применения
EA201991029A1 (ru) Ингибиторы magl
EA201991074A1 (ru) Ингибиторы magl
MX2017011997A (es) Carbamatos de piperacina y metodos de preparacion y uso.
EA201790273A1 (ru) Флагеллиновые композиции и их применение
EA201991720A1 (ru) Антитела к альфа-синуклеину и их применения
EA201792348A1 (ru) Биарильные соединения, применяемые при лечении заболеваний человека в онкологии, нефрологии и иммунологии
EA202092586A1 (ru) Ингибиторы magl
EA201691272A1 (ru) Тетрагидропиридопиразины в качестве модуляторов gpr6
EA201992504A1 (ru) Ингибиторы magl на основе пиразола
EA201491505A1 (ru) Соединения для лечения спинальной мышечной атрофии
EA202190609A1 (ru) Антитела против hla-g, композиции, содержащие антитела против hla-g, и способы применения антител против hla-g
EA201591728A1 (ru) Гетероциклические соединения и способы их применения
EA201892225A1 (ru) АНТИТЕЛА К ФАКТОРУ Bb КОМПЛЕМЕНТА И ИХ ПРИМЕНЕНИЕ
EA201992409A1 (ru) Ингибиторы magl на основе пиразола
EA201791814A1 (ru) Имидазолильные трициклические еноны как антиоксидантные модуляторы воспаления
EA201792262A1 (ru) Пироглутамат вортиоксетина
EA201691896A1 (ru) Соединения и способы их применения
EA201990064A1 (ru) Противомалярийные композиции и варианты их применения