EA201991029A1 - Ингибиторы magl - Google Patents

Ингибиторы magl

Info

Publication number
EA201991029A1
EA201991029A1 EA201991029A EA201991029A EA201991029A1 EA 201991029 A1 EA201991029 A1 EA 201991029A1 EA 201991029 A EA201991029 A EA 201991029A EA 201991029 A EA201991029 A EA 201991029A EA 201991029 A1 EA201991029 A1 EA 201991029A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
useful
magl inhibitors
magl
compositions provided
Prior art date
Application number
EA201991029A
Other languages
English (en)
Other versions
EA038150B1 (ru
Inventor
Шерил А. Грайс
Дэниел Дж. Бузард
Майкл Б. Шагхафи
Original Assignee
Абайд Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62145825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201991029(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Абайд Терапьютикс, Инк. filed Critical Абайд Терапьютикс, Инк.
Publication of EA201991029A1 publication Critical patent/EA201991029A1/ru
Publication of EA038150B1 publication Critical patent/EA038150B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

В документе представлены спироциклические и конденсированные бициклические карбаматы и фармацевтические композиции, содержащие указанные соединения. Предусмотренные соединения и композиции применимы в качестве модуляторов MAGL. Кроме того, предусмотренные соединения и композиции применимы для лечения боли.
EA201991029A 2016-11-16 2017-11-15 Ингибиторы magl EA038150B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662423102P 2016-11-16 2016-11-16
PCT/US2017/061870 WO2018093949A1 (en) 2016-11-16 2017-11-15 Magl inhibitors

Publications (2)

Publication Number Publication Date
EA201991029A1 true EA201991029A1 (ru) 2019-12-30
EA038150B1 EA038150B1 (ru) 2021-07-14

Family

ID=62145825

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991029A EA038150B1 (ru) 2016-11-16 2017-11-15 Ингибиторы magl

Country Status (27)

Country Link
US (2) US11059822B2 (ru)
EP (1) EP3541820B1 (ru)
JP (1) JP7042468B2 (ru)
KR (1) KR20190080935A (ru)
CN (1) CN110267962B (ru)
AU (1) AU2017361253B2 (ru)
BR (1) BR112019009880A2 (ru)
CA (1) CA3043617A1 (ru)
CL (1) CL2019001336A1 (ru)
CO (1) CO2019004945A2 (ru)
CR (1) CR20190239A (ru)
DO (1) DOP2019000118A (ru)
EA (1) EA038150B1 (ru)
EC (1) ECSP19034535A (ru)
ES (1) ES2952582T3 (ru)
IL (1) IL266547B (ru)
JO (1) JOP20190107A1 (ru)
MA (1) MA46855A (ru)
MX (1) MX2019005773A (ru)
NI (1) NI201900049A (ru)
PE (1) PE20191145A1 (ru)
PH (1) PH12019501079A1 (ru)
RU (1) RU2019115784A (ru)
TN (1) TN2019000149A1 (ru)
UA (1) UA125523C2 (ru)
WO (1) WO2018093949A1 (ru)
ZA (1) ZA201903099B (ru)

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SI3541807T1 (sl) 2016-11-16 2022-01-31 H. Lundbeck A/S Kristalinična oblika zaviralca MAGL
JOP20190105A1 (ar) * 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
BR112019009992A2 (pt) 2016-11-16 2019-08-27 Abide Therapeutics Inc formulações farmacêuticas
PL3630744T3 (pl) 2017-05-23 2023-05-15 H. Lundbeck A/S Pirazolowe inhibitory magl
MX2020002251A (es) 2017-08-29 2020-07-20 Lundbeck La Jolla Research Center Inc Compuestos espirociclicos y sus metodos de preparacion y uso.
EA202090296A1 (ru) 2017-08-29 2020-08-03 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Спироциклические соединения и способы их получения и применения
MX2021000549A (es) * 2018-07-19 2021-03-25 Pfizer Compuestos espiro heterociclicos como inhibidores de magl.
JP2023523219A (ja) 2020-04-21 2023-06-02 ハー・ルンドベック・アクチエゼルスカベット モノアシルグリセロールリパーゼ阻害剤の合成
TW202229255A (zh) 2020-11-13 2022-08-01 丹麥商Ｈ 朗德貝克公司 Magl抑制劑

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JOP20190050A1 (ar) 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي
SI3541807T1 (sl) 2016-11-16 2022-01-31 H. Lundbeck A/S Kristalinična oblika zaviralca MAGL
JOP20190105A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190106A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
BR112019009992A2 (pt) 2016-11-16 2019-08-27 Abide Therapeutics Inc formulações farmacêuticas
KR102613364B1 (ko) 2017-03-13 2023-12-14 룬드벡 라 졸라 리서치 센터 인코포레이티드 이중 magl 및 faah 저해제
JOP20190267A1 (ar) 2017-05-23 2019-11-18 Lundbeck La Jolla Research Center Inc مثبطات بيرازول magl
PL3630744T3 (pl) 2017-05-23 2023-05-15 H. Lundbeck A/S Pirazolowe inhibitory magl
MX2020002251A (es) 2017-08-29 2020-07-20 Lundbeck La Jolla Research Center Inc Compuestos espirociclicos y sus metodos de preparacion y uso.
EA202090296A1 (ru) 2017-08-29 2020-08-03 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Спироциклические соединения и способы их получения и применения
TW202229255A (zh) 2020-11-13 2022-08-01 丹麥商Ｈ 朗德貝克公司 Magl抑制劑

Also Published As

Publication number Publication date
JOP20190107A1 (ar) 2019-05-09
EP3541820B1 (en) 2023-07-05
CN110267962A (zh) 2019-09-20
TN2019000149A1 (en) 2020-10-05
US20220135563A1 (en) 2022-05-05
BR112019009880A2 (pt) 2019-08-13
MX2019005773A (es) 2019-12-05
JP2020500178A (ja) 2020-01-09
PE20191145A1 (es) 2019-09-02
US11691975B2 (en) 2023-07-04
ES2952582T3 (es) 2023-11-02
RU2019115784A3 (ru) 2021-03-12
US11059822B2 (en) 2021-07-13
UA125523C2 (uk) 2022-04-13
WO2018093949A1 (en) 2018-05-24
CA3043617A1 (en) 2018-05-24
ZA201903099B (en) 2021-01-27
NI201900049A (es) 2019-10-30
EP3541820C0 (en) 2023-07-05
NZ753471A (en) 2021-01-29
JP7042468B2 (ja) 2022-03-28
DOP2019000118A (es) 2019-09-30
RU2019115784A (ru) 2020-12-17
MA46855A (fr) 2021-05-19
AU2017361253A1 (en) 2019-05-30
AU2017361253B2 (en) 2021-08-05
CN110267962B (zh) 2022-04-01
PH12019501079A1 (en) 2019-08-19
CO2019004945A2 (es) 2019-05-21
EP3541820A4 (en) 2020-06-10
CL2019001336A1 (es) 2019-10-04
KR20190080935A (ko) 2019-07-08
ECSP19034535A (es) 2019-05-31
EP3541820A1 (en) 2019-09-25
IL266547A (en) 2019-07-31
US20200291023A1 (en) 2020-09-17
EA038150B1 (ru) 2021-07-14
CR20190239A (es) 2019-06-26
IL266547B (en) 2022-06-01

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