ECSP19034535A - Inhibidores de la magl - Google Patents

Inhibidores de la magl

Info

Publication number
ECSP19034535A
ECSP19034535A ECSENADI201934535A ECDI201934535A ECSP19034535A EC SP19034535 A ECSP19034535 A EC SP19034535A EC SENADI201934535 A ECSENADI201934535 A EC SENADI201934535A EC DI201934535 A ECDI201934535 A EC DI201934535A EC SP19034535 A ECSP19034535 A EC SP19034535A
Authority
EC
Ecuador
Prior art keywords
compounds
compositions
magl inhibitors
magl
useful
Prior art date
Application number
ECSENADI201934535A
Other languages
English (en)
Inventor
Michael B Shaghafi
Daniel J Buzard
Cheryl A Grice
Original Assignee
Abide Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62145825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP19034535(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abide Therapeutics Inc filed Critical Abide Therapeutics Inc
Publication of ECSP19034535A publication Critical patent/ECSP19034535A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

En el presente documento se proporcionan carbamatos espirocíclicos y bicíclicos fusionados y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos y composiciones en cuestión son útiles como moduladores de la MAGL. Además, los presentes compuestos y composiciones son útiles para el tratamiento del dolor.
ECSENADI201934535A 2016-11-16 2019-05-15 Inhibidores de la magl ECSP19034535A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662423102P 2016-11-16 2016-11-16

Publications (1)

Publication Number Publication Date
ECSP19034535A true ECSP19034535A (es) 2019-05-31

Family

ID=62145825

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201934535A ECSP19034535A (es) 2016-11-16 2019-05-15 Inhibidores de la magl

Country Status (27)

Country Link
US (2) US11059822B2 (es)
EP (1) EP3541820B1 (es)
JP (1) JP7042468B2 (es)
KR (1) KR20190080935A (es)
CN (1) CN110267962B (es)
AU (1) AU2017361253B2 (es)
BR (1) BR112019009880A2 (es)
CA (1) CA3043617A1 (es)
CL (1) CL2019001336A1 (es)
CO (1) CO2019004945A2 (es)
CR (1) CR20190239A (es)
DO (1) DOP2019000118A (es)
EA (1) EA038150B1 (es)
EC (1) ECSP19034535A (es)
ES (1) ES2952582T3 (es)
IL (1) IL266547B (es)
JO (1) JOP20190107A1 (es)
MA (1) MA46855A (es)
MX (1) MX2019005773A (es)
NI (1) NI201900049A (es)
PE (1) PE20191145A1 (es)
PH (1) PH12019501079A1 (es)
RU (1) RU2019115784A (es)
TN (1) TN2019000149A1 (es)
UA (1) UA125523C2 (es)
WO (1) WO2018093949A1 (es)
ZA (1) ZA201903099B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017197192A1 (en) * 2016-05-12 2017-11-16 Abide Therapeutics, Inc. Spirocycle compounds and methods of making and using same
SI3541807T1 (sl) 2016-11-16 2022-01-31 H. Lundbeck A/S Kristalinična oblika zaviralca MAGL
JOP20190105A1 (ar) * 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
BR112019009992A2 (pt) 2016-11-16 2019-08-27 Abide Therapeutics Inc formulações farmacêuticas
PL3630744T3 (pl) 2017-05-23 2023-05-15 H. Lundbeck A/S Pirazolowe inhibitory magl
MX2020002251A (es) 2017-08-29 2020-07-20 Lundbeck La Jolla Research Center Inc Compuestos espirociclicos y sus metodos de preparacion y uso.
EA202090296A1 (ru) 2017-08-29 2020-08-03 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Спироциклические соединения и способы их получения и применения
MX2021000549A (es) * 2018-07-19 2021-03-25 Pfizer Compuestos espiro heterociclicos como inhibidores de magl.
JP2023523219A (ja) 2020-04-21 2023-06-02 ハー・ルンドベック・アクチエゼルスカベット モノアシルグリセロールリパーゼ阻害剤の合成
TW202229255A (zh) 2020-11-13 2022-08-01 丹麥商Ｈ 朗德貝克公司 Magl抑制劑

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JP2009514935A (ja) * 2005-11-05 2009-04-09 アストラゼネカ・アクチエボラーグ 新規化合物
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RU2010140613A (ru) 2008-03-05 2012-04-10 Таргасепт, Инк. (Us) Амиды диазабициклоалканов, селективные в отношении подтипа никотиновых ацетилхолиновых рецепторов
FR2941696B1 (fr) 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
WO2010141817A1 (en) 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase
CA2775703C (en) 2009-09-29 2014-07-08 Polyone Corporation Polyester articles having simulated metallic or pearlescent appearance
JP5759470B2 (ja) 2009-10-23 2015-08-05 ヤンセン ファーマシューティカ エヌ．ベー． オレキシン受容体調節因子としての二置換オクタヒドロピロロ［３，４−ｃ］ピロール
EP2542083B1 (en) 2010-03-04 2015-05-06 Merck Sharp & Dohme Corp. Positive allosteric modulators of mglur2
FR2960875B1 (fr) 2010-06-04 2012-12-28 Sanofi Aventis Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique
EP2444084A1 (en) 2010-10-21 2012-04-25 Centro Nacional de Investigaciones Oncológicas (CNIO) Use of PI3K inibitors for the treatment of obesity
EP3698782B1 (en) * 2012-01-06 2024-05-15 H. Lundbeck A/S Carbamate compounds for use in therapy
JP2014005245A (ja) * 2012-06-26 2014-01-16 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体を含有する医薬組成物
EP3590940B1 (en) 2012-09-25 2021-06-09 F. Hoffmann-La Roche AG Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
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MD20160116A2 (ro) * 2014-04-04 2017-04-30 X-Rx Discovery, Inc Inhibitori spirociclici substituiţi ai autotaxinei
WO2015179559A2 (en) 2014-05-21 2015-11-26 Abide Therapeutics, Inc. Pyrazole compounds and methods of making and using same
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KR20180004263A (ko) 2015-05-11 2018-01-10 어바이드 테라퓨틱스, 인크. 염증 또는 신경병성 통증의 치료 방법
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WO2017197192A1 (en) 2016-05-12 2017-11-16 Abide Therapeutics, Inc. Spirocycle compounds and methods of making and using same
JOP20190050A1 (ar) 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي
SI3541807T1 (sl) 2016-11-16 2022-01-31 H. Lundbeck A/S Kristalinična oblika zaviralca MAGL
JOP20190105A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190106A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
BR112019009992A2 (pt) 2016-11-16 2019-08-27 Abide Therapeutics Inc formulações farmacêuticas
KR102613364B1 (ko) 2017-03-13 2023-12-14 룬드벡 라 졸라 리서치 센터 인코포레이티드 이중 magl 및 faah 저해제
JOP20190267A1 (ar) 2017-05-23 2019-11-18 Lundbeck La Jolla Research Center Inc مثبطات بيرازول magl
PL3630744T3 (pl) 2017-05-23 2023-05-15 H. Lundbeck A/S Pirazolowe inhibitory magl
MX2020002251A (es) 2017-08-29 2020-07-20 Lundbeck La Jolla Research Center Inc Compuestos espirociclicos y sus metodos de preparacion y uso.
EA202090296A1 (ru) 2017-08-29 2020-08-03 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Спироциклические соединения и способы их получения и применения
TW202229255A (zh) 2020-11-13 2022-08-01 丹麥商Ｈ 朗德貝克公司 Magl抑制劑

Also Published As

Publication number Publication date
JOP20190107A1 (ar) 2019-05-09
EP3541820B1 (en) 2023-07-05
CN110267962A (zh) 2019-09-20
TN2019000149A1 (en) 2020-10-05
US20220135563A1 (en) 2022-05-05
EA201991029A1 (ru) 2019-12-30
BR112019009880A2 (pt) 2019-08-13
MX2019005773A (es) 2019-12-05
JP2020500178A (ja) 2020-01-09
PE20191145A1 (es) 2019-09-02
US11691975B2 (en) 2023-07-04
ES2952582T3 (es) 2023-11-02
RU2019115784A3 (es) 2021-03-12
US11059822B2 (en) 2021-07-13
UA125523C2 (uk) 2022-04-13
WO2018093949A1 (en) 2018-05-24
CA3043617A1 (en) 2018-05-24
ZA201903099B (en) 2021-01-27
NI201900049A (es) 2019-10-30
EP3541820C0 (en) 2023-07-05
NZ753471A (en) 2021-01-29
JP7042468B2 (ja) 2022-03-28
DOP2019000118A (es) 2019-09-30
RU2019115784A (ru) 2020-12-17
MA46855A (fr) 2021-05-19
AU2017361253A1 (en) 2019-05-30
AU2017361253B2 (en) 2021-08-05
CN110267962B (zh) 2022-04-01
PH12019501079A1 (en) 2019-08-19
CO2019004945A2 (es) 2019-05-21
EP3541820A4 (en) 2020-06-10
CL2019001336A1 (es) 2019-10-04
KR20190080935A (ko) 2019-07-08
EP3541820A1 (en) 2019-09-25
IL266547A (en) 2019-07-31
US20200291023A1 (en) 2020-09-17
EA038150B1 (ru) 2021-07-14
CR20190239A (es) 2019-06-26
IL266547B (en) 2022-06-01

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