MD20160116A2 - Inhibitori spirociclici substituiţi ai autotaxinei - Google Patents

Inhibitori spirociclici substituiţi ai autotaxinei Download PDF

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Publication number
MD20160116A2
MD20160116A2 MDA20160116A MD20160116A MD20160116A2 MD 20160116 A2 MD20160116 A2 MD 20160116A2 MD A20160116 A MDA20160116 A MD A20160116A MD 20160116 A MD20160116 A MD 20160116A MD 20160116 A2 MD20160116 A2 MD 20160116A2
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MD
Moldova
Prior art keywords
autotaxin
substituted spirocyclic
inhibitors
spirocyclic inhibitors
atx
Prior art date
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MDA20160116A
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English (en)
Russian (ru)
Inventor
Ли БАБИСС
Мэттью Кларк
Энтони Д. Киф
Марк Дж. Малвихилл
Хайхун Ни
Луи РЕНЗЕТТИ
Фрэнк РУЕБСАМ
Ван
Чжифэн Се
Чжан
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X-Rx Discovery, Inc
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Publication of MD20160116A2 publication Critical patent/MD20160116A2/ro

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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Abstract

Prezenta invenţie se referă la compuşi cu Formula I:Işi săruri acceptabile farmaceutic, sinteză, intermediari, formulări şi metode de tratare cu acestea a bolilor, inclusiv a cancerului, homing-ului limfocitar, inflamaţiei cronice, durerii neuropatice, bolilor fibrotice, trombozei şi pruritului colestatic, mediate cel puţin parţial de autotaxină (ATX).
MDA20160116A 2014-04-04 2015-04-03 Inhibitori spirociclici substituiţi ai autotaxinei MD20160116A2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461975123P 2014-04-04 2014-04-04
PCT/US2015/024338 WO2015154023A1 (en) 2014-04-04 2015-04-03 Substituted spirocydic inhibitors of autotaxin

Publications (1)

Publication Number Publication Date
MD20160116A2 true MD20160116A2 (ro) 2017-04-30

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MDA20160116A MD20160116A2 (ro) 2014-04-04 2015-04-03 Inhibitori spirociclici substituiţi ai autotaxinei

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US (3) US10011601B2 (ro)
EP (1) EP3125895A4 (ro)
JP (2) JP6616821B2 (ro)
KR (1) KR20160133004A (ro)
CN (1) CN107106559A (ro)
AP (1) AP2016009496A0 (ro)
AU (2) AU2015240519B2 (ro)
CA (1) CA2943874A1 (ro)
CL (1) CL2016002516A1 (ro)
CR (1) CR20160496A (ro)
CU (1) CU24442B1 (ro)
DO (1) DOP2016000270A (ro)
EA (1) EA201691840A1 (ro)
EC (1) ECSP16084293A (ro)
IL (1) IL248050A0 (ro)
MD (1) MD20160116A2 (ro)
MX (1) MX2016013049A (ro)
PE (1) PE20170206A1 (ro)
PH (1) PH12016501922A1 (ro)
SG (1) SG11201607920RA (ro)
WO (1) WO2015154023A1 (ro)

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