EA201692176A1 - Полифторзамещенное соединение в качестве ингибитора тирозинкиназы брутона (btk) - Google Patents
Полифторзамещенное соединение в качестве ингибитора тирозинкиназы брутона (btk)Info
- Publication number
- EA201692176A1 EA201692176A1 EA201692176A EA201692176A EA201692176A1 EA 201692176 A1 EA201692176 A1 EA 201692176A1 EA 201692176 A EA201692176 A EA 201692176A EA 201692176 A EA201692176 A EA 201692176A EA 201692176 A1 EA201692176 A1 EA 201692176A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- poliftoro
- butute
- btk
- substituted compound
- disorders
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract
Представленное в настоящем описании представляет собой новые полифторзамещенные пиразолопиримидиновые соединения или их соли, способы их получения и терапевтические методами с помощью введения соединений и их составов для лечения и ингибирования аутоиммунных заболеваний или нарушений, гетероиммунных заболеваний или нарушений, воспалительных заболеваний и рака или нарушений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410175783.7A CN105017256A (zh) | 2014-04-29 | 2014-04-29 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
PCT/CN2015/000290 WO2015165279A1 (zh) | 2014-04-29 | 2015-04-27 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
Publications (2)
Publication Number | Publication Date |
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EA201692176A1 true EA201692176A1 (ru) | 2017-03-31 |
EA032100B1 EA032100B1 (ru) | 2019-04-30 |
Family
ID=54358137
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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EA201692176A EA032100B1 (ru) | 2014-04-29 | 2015-04-27 | Полифторзамещенное соединение в качестве ингибитора тирозинкиназы брутона (btk) |
EA201892740A EA037227B1 (ru) | 2014-04-29 | 2015-04-27 | СПОСОБ ПОЛУЧЕНИЯ 1-((R)-3-(4-АМИНО-3-(2-ФТОР-4-(2,3,5,6-ТЕТРАФТОРФЕНОКСИ)ФЕНИЛ)-1H-ПИРАЗОЛО[3,4-d]ПИРИМИДИН-1-ИЛ))ПРОП-2-ЕН-1-ОНА И СМЕСИ 1-((R)-3-(4-АМИНО-3-(2-ФТОР-4-(2,3,5,6-ТЕТРАФТОРФЕНОКСИ)ФЕНИЛ)-1H-ПИРАЗОЛО[3,4-d]ПИРИМИДИН-1-ИЛ)ПИРРОЛИДИН-1-ИЛ)ПРОП-2-ЕН-1-ОНА И 1-((S)-3-(4-АМИНО-3-(2-ФТОР-4-(2,3,5,6-ТЕТРАФТОРФЕНОКСИ)ФЕНИЛ)-1H-ПИРАЗОЛО[3,4-d]ПИРИМИДИН-1-ИЛ)ПИРРОЛИДИН-1-ИЛ)ПРОП-2-ЕН-1-ОНА |
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EP (1) | EP3138842B1 (ru) |
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CN (3) | CN105017256A (ru) |
AU (1) | AU2015252654C1 (ru) |
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CA (1) | CA2947338C (ru) |
EA (2) | EA032100B1 (ru) |
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HK (1) | HK1256857A1 (ru) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2809188C2 (ru) * | 2018-09-29 | 2023-12-07 | Транстера Сайенсиз (Наньцзин), Инк. | Аминонорборнановое производное и способ его получения, а также его применение |
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