SG11202000984YA - Spirocycle compounds and methods of making and using same - Google Patents
Spirocycle compounds and methods of making and using sameInfo
- Publication number
- SG11202000984YA SG11202000984YA SG11202000984YA SG11202000984YA SG11202000984YA SG 11202000984Y A SG11202000984Y A SG 11202000984YA SG 11202000984Y A SG11202000984Y A SG 11202000984YA SG 11202000984Y A SG11202000984Y A SG 11202000984YA SG 11202000984Y A SG11202000984Y A SG 11202000984YA
- Authority
- SG
- Singapore
- Prior art keywords
- making
- methods
- same
- spirocycle
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762551714P | 2017-08-29 | 2017-08-29 | |
| PCT/US2018/048388 WO2019046330A1 (en) | 2017-08-29 | 2018-08-28 | Spirocycle compounds and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202000984YA true SG11202000984YA (en) | 2020-03-30 |
Family
ID=65526036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202000984YA SG11202000984YA (en) | 2017-08-29 | 2018-08-28 | Spirocycle compounds and methods of making and using same |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11161856B2 (en) |
| EP (1) | EP3675848B1 (en) |
| JP (1) | JP7177825B2 (en) |
| KR (1) | KR20200046053A (en) |
| CN (1) | CN111032034B (en) |
| AU (1) | AU2018326497A1 (en) |
| BR (1) | BR112020003946A2 (en) |
| CA (1) | CA3072926A1 (en) |
| CL (1) | CL2020000463A1 (en) |
| CO (1) | CO2020001715A2 (en) |
| CR (1) | CR20200088A (en) |
| DO (1) | DOP2020000040A (en) |
| EA (1) | EA202090296A1 (en) |
| EC (1) | ECSP20013332A (en) |
| ES (1) | ES2914363T3 (en) |
| IL (1) | IL272578A (en) |
| JO (1) | JOP20200022A1 (en) |
| MA (1) | MA50045A (en) |
| MX (1) | MX2020002254A (en) |
| PE (1) | PE20200665A1 (en) |
| PH (1) | PH12020500371A1 (en) |
| RU (1) | RU2020107039A (en) |
| SG (1) | SG11202000984YA (en) |
| WO (1) | WO2019046330A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107982266B (en) | 2012-01-06 | 2021-07-30 | H.隆德贝克有限公司 | Carbamate compounds and methods of making and using the same |
| US10781211B2 (en) | 2016-05-12 | 2020-09-22 | Lundbeck La Jolla Research Center, Inc. | Spirocycle compounds and methods of making and using same |
| WO2018053447A1 (en) | 2016-09-19 | 2018-03-22 | Abide Therapeutics, Inc. | Piperazine carbamates and methods of making and using same |
| JOP20190107A1 (en) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | Magl inhibitors |
| MA50041A (en) | 2017-08-29 | 2020-07-08 | Lundbeck La Jolla Research Center Inc | SPIROCYCLIC COMPOUNDS AND METHODS FOR THE PREPARATION AND USE OF THE SAME |
| KR20200046053A (en) | 2017-08-29 | 2020-05-06 | 룬드벡 라 졸라 리서치 센터 인코포레이티드 | Spirocycle compounds and methods of making and using them |
| TW201946906A (en) * | 2018-05-15 | 2019-12-16 | 美商阿拜德生物製藥公司 | MAGL inhibitors |
| CN111505410B (en) * | 2020-04-02 | 2022-07-29 | 矽力杰半导体技术(杭州)有限公司 | Dimming mode detection circuit and method, no-dimming detection circuit and lighting system |
| WO2021214550A1 (en) | 2020-04-21 | 2021-10-28 | H. Lundbeck A/S | Synthesis of a monoacylglycerol lipase inhibitor |
| TW202229255A (en) | 2020-11-13 | 2022-08-01 | 丹麥商Ｈ 朗德貝克公司 | A magl inhibitor |
| US20230357190A1 (en) * | 2022-05-04 | 2023-11-09 | H. Lundbeck A/S | Crystalline forms of a magl inhibitor |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2440803A1 (en) | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| EP2065369A4 (en) * | 2006-08-23 | 2011-12-28 | Astellas Pharma Inc | Urea compound or salt thereof |
| AU2009221860A1 (en) | 2008-03-05 | 2009-09-11 | Targacept, Inc. | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloal kanes |
| WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| JP5759470B2 (en) | 2009-10-23 | 2015-08-05 | ヤンセン ファーマシューティカ エヌ．ベー． | Disubstituted octahydropyrrolo [3,4-c] pyrrole as an orexin receptor modulator |
| CA2791672A1 (en) | 2010-03-04 | 2011-09-09 | Merck Sharp & Dohme Corp. | Positive allosteric modulators of mglur2 |
| FR2960875B1 (en) | 2010-06-04 | 2012-12-28 | Sanofi Aventis | HEXAFLUOROISOPROPYL CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| EP2444084A1 (en) | 2010-10-21 | 2012-04-25 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Use of PI3K inibitors for the treatment of obesity |
| CN107982266B (en) * | 2012-01-06 | 2021-07-30 | H.隆德贝克有限公司 | Carbamate compounds and methods of making and using the same |
| AR092645A1 (en) | 2012-09-25 | 2015-04-29 | Hoffmann La Roche | AUTOTAXINE INHIBITING BICYCLE DERIVATIVES (ATX) |
| WO2015003002A1 (en) | 2013-07-03 | 2015-01-08 | Abide Therapeutics, Inc. | Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof |
| MX2017011997A (en) * | 2015-03-18 | 2018-05-28 | Abide Therapeutics Inc | Piperazine carbamates and methods of making and using same. |
| UA121775C2 (en) | 2015-07-31 | 2020-07-27 | Пфайзер Інк. | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors |
| WO2017087854A1 (en) * | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
| US10781211B2 (en) | 2016-05-12 | 2020-09-22 | Lundbeck La Jolla Research Center, Inc. | Spirocycle compounds and methods of making and using same |
| JOP20190107A1 (en) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | Magl inhibitors |
| MA50041A (en) | 2017-08-29 | 2020-07-08 | Lundbeck La Jolla Research Center Inc | SPIROCYCLIC COMPOUNDS AND METHODS FOR THE PREPARATION AND USE OF THE SAME |
| KR20200046053A (en) | 2017-08-29 | 2020-05-06 | 룬드벡 라 졸라 리서치 센터 인코포레이티드 | Spirocycle compounds and methods of making and using them |
-
2018
- 2018-08-28 KR KR1020207007712A patent/KR20200046053A/en unknown
- 2018-08-28 MA MA050045A patent/MA50045A/en unknown
- 2018-08-28 CA CA3072926A patent/CA3072926A1/en not_active Abandoned
- 2018-08-28 US US16/642,713 patent/US11161856B2/en active Active
- 2018-08-28 JP JP2020512612A patent/JP7177825B2/en active Active
- 2018-08-28 ES ES18852217T patent/ES2914363T3/en active Active
- 2018-08-28 CN CN201880054296.1A patent/CN111032034B/en active Active
- 2018-08-28 AU AU2018326497A patent/AU2018326497A1/en not_active Abandoned
- 2018-08-28 EP EP18852217.1A patent/EP3675848B1/en active Active
- 2018-08-28 RU RU2020107039A patent/RU2020107039A/en unknown
- 2018-08-28 CR CR20200088A patent/CR20200088A/en unknown
- 2018-08-28 PE PE2020000297A patent/PE20200665A1/en unknown
- 2018-08-28 JO JOP/2020/0022A patent/JOP20200022A1/en unknown
- 2018-08-28 EA EA202090296A patent/EA202090296A1/en unknown
- 2018-08-28 WO PCT/US2018/048388 patent/WO2019046330A1/en unknown
- 2018-08-28 SG SG11202000984YA patent/SG11202000984YA/en unknown
- 2018-08-28 BR BR112020003946-2A patent/BR112020003946A2/en not_active Application Discontinuation
- 2018-08-28 MX MX2020002254A patent/MX2020002254A/en unknown
-
2020
- 2020-02-10 IL IL272578A patent/IL272578A/en unknown
- 2020-02-14 CO CONC2020/0001715A patent/CO2020001715A2/en unknown
- 2020-02-21 EC ECSENADI202013332A patent/ECSP20013332A/en unknown
- 2020-02-21 DO DO2020000040A patent/DOP2020000040A/en unknown
- 2020-02-24 PH PH12020500371A patent/PH12020500371A1/en unknown
- 2020-02-25 CL CL2020000463A patent/CL2020000463A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2914363T3 (en) | 2022-06-09 |
| JOP20200022A1 (en) | 2020-02-02 |
| PE20200665A1 (en) | 2020-06-11 |
| US11161856B2 (en) | 2021-11-02 |
| EA202090296A1 (en) | 2020-08-03 |
| CN111032034A (en) | 2020-04-17 |
| BR112020003946A2 (en) | 2020-09-08 |
| AU2018326497A1 (en) | 2020-02-20 |
| DOP2020000040A (en) | 2020-08-31 |
| IL272578A (en) | 2020-03-31 |
| MA50045A (en) | 2020-07-08 |
| US20210214375A1 (en) | 2021-07-15 |
| CO2020001715A2 (en) | 2020-02-28 |
| RU2020107039A (en) | 2021-09-30 |
| JP2020532547A (en) | 2020-11-12 |
| CL2020000463A1 (en) | 2020-07-10 |
| EP3675848A4 (en) | 2021-03-10 |
| CA3072926A1 (en) | 2019-03-07 |
| EP3675848A1 (en) | 2020-07-08 |
| KR20200046053A (en) | 2020-05-06 |
| CR20200088A (en) | 2020-04-08 |
| MX2020002254A (en) | 2020-07-20 |
| PH12020500371A1 (en) | 2020-12-07 |
| CN111032034B (en) | 2023-05-02 |
| EP3675848B1 (en) | 2022-03-23 |
| ECSP20013332A (en) | 2020-04-22 |
| JP7177825B2 (en) | 2022-11-24 |
| WO2019046330A1 (en) | 2019-03-07 |
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