JP2019505529A5 - - Google Patents
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- Publication number
- JP2019505529A5 JP2019505529A5 JP2018539129A JP2018539129A JP2019505529A5 JP 2019505529 A5 JP2019505529 A5 JP 2019505529A5 JP 2018539129 A JP2018539129 A JP 2018539129A JP 2018539129 A JP2018539129 A JP 2018539129A JP 2019505529 A5 JP2019505529 A5 JP 2019505529A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- group
- optionally substituted
- membered heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052736 halogen Inorganic materials 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000004043 oxo group Chemical group O=* 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 16
- 125000000623 heterocyclic group Chemical group 0.000 claims 16
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000006714 (C3-C10) heterocyclyl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 108010024121 Janus Kinases Proteins 0.000 claims 2
- 102000015617 Janus Kinases Human genes 0.000 claims 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 claims 1
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- -1 ethynyl compound Chemical class 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 Cc1c(C(Nc(c(*)n2)c[n]2I)=O)[n]2nc(*)c(*)c(*)c2n1 Chemical compound Cc1c(C(Nc(c(*)n2)c[n]2I)=O)[n]2nc(*)c(*)c(*)c2n1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297061P | 2016-02-18 | 2016-02-18 | |
| US62/297,061 | 2016-02-18 | ||
| PCT/EP2017/053576 WO2017140825A1 (en) | 2016-02-18 | 2017-02-17 | Therapeutic compounds, compositions and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505529A JP2019505529A (ja) | 2019-02-28 |
| JP2019505529A5 true JP2019505529A5 (enExample) | 2020-03-26 |
| JP6936236B2 JP6936236B2 (ja) | 2021-09-15 |
Family
ID=58054137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018539129A Expired - Fee Related JP6936236B2 (ja) | 2016-02-18 | 2017-02-17 | 治療化合物、組成物及びその方法の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20180354959A1 (enExample) |
| EP (1) | EP3416967B1 (enExample) |
| JP (1) | JP6936236B2 (enExample) |
| CN (1) | CN108473501B (enExample) |
| WO (1) | WO2017140825A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3215511B1 (en) | 2014-11-06 | 2024-04-17 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| WO2017176961A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| KR20180133461A (ko) | 2016-04-06 | 2018-12-14 | 리소소말 테라퓨틱스 인크. | 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물 및 의학적 장애의 치료에서의 그의 용도 |
| MX388912B (es) | 2016-04-06 | 2025-03-20 | Lysosomal Therapeutics Inc | Compuestos de pirrol[1,2-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos |
| WO2017192930A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| MX2019007339A (es) | 2016-12-29 | 2019-09-06 | Hoffmann La Roche | Compuestos de pirazolopirimidina y metodos de uso de los mismos. |
| JP2020510061A (ja) * | 2017-03-14 | 2020-04-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピラゾロクロロフェニル化合物、組成物及びその使用方法 |
| WO2018215390A1 (en) * | 2017-05-22 | 2018-11-29 | F. Hoffmann-La Roche Ag | Therapeutic compounds and compositions, and methods of use thereof |
| JP7256757B2 (ja) | 2017-05-22 | 2023-04-12 | エフ． ホフマン－ラ ロシュ アーゲー | 処置用化合物及び組成物、並びにその使用方法 |
| JP7657740B2 (ja) | 2019-06-18 | 2025-04-07 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｊａｋキナーゼのピラゾロピリミジンスルホン阻害剤およびその使用 |
| CN114026096B (zh) | 2019-06-18 | 2025-02-07 | 豪夫迈·罗氏有限公司 | 四唑取代的吡唑并嘧啶类jak激酶抑制剂及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009259853A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine JAK inhibitor compounds and methods |
| UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| EP2892899B1 (en) * | 2012-09-06 | 2018-03-21 | Bristol-Myers Squibb Company | Imidazopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
| CA2929316C (en) * | 2013-11-08 | 2021-12-28 | Takeda Pharmaceutical Company Limited | Pyrazole for the treatment autoimmune disorders |
| HRP20210935T1 (hr) * | 2014-05-23 | 2021-08-06 | F. Hoffmann - La Roche Ag | Spojevi 5-kloro-2-difluorometoksifenil pirazolopirimidina koji predstavljaju inhibitore jak |
-
2017
- 2017-02-17 WO PCT/EP2017/053576 patent/WO2017140825A1/en not_active Ceased
- 2017-02-17 JP JP2018539129A patent/JP6936236B2/ja not_active Expired - Fee Related
- 2017-02-17 CN CN201780005254.4A patent/CN108473501B/zh not_active Expired - Fee Related
- 2017-02-17 EP EP17705622.3A patent/EP3416967B1/en active Active
-
2018
- 2018-08-17 US US16/104,347 patent/US20180354959A1/en not_active Abandoned
-
2020
- 2020-09-21 US US17/027,352 patent/US11795170B2/en active Active