JP6936236B2 - 治療化合物、組成物及びその方法の使用 - Google Patents
治療化合物、組成物及びその方法の使用 Download PDFInfo
- Publication number
- JP6936236B2 JP6936236B2 JP2018539129A JP2018539129A JP6936236B2 JP 6936236 B2 JP6936236 B2 JP 6936236B2 JP 2018539129 A JP2018539129 A JP 2018539129A JP 2018539129 A JP2018539129 A JP 2018539129A JP 6936236 B2 JP6936236 B2 JP 6936236B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- group
- mmol
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[C@]1(C(Nc2c(-c(cc(cc3)[Rn])c3OC(F)F)[n]nc2)=O)N2N=C(*)C=CC2=NC1* Chemical compound C[C@]1(C(Nc2c(-c(cc(cc3)[Rn])c3OC(F)F)[n]nc2)=O)N2N=C(*)C=CC2=NC1* 0.000 description 5
- BNWCETAHAJSBFG-UHFFFAOYSA-N CC(C)(C)OC(CBr)=O Chemical compound CC(C)(C)OC(CBr)=O BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297061P | 2016-02-18 | 2016-02-18 | |
| US62/297,061 | 2016-02-18 | ||
| PCT/EP2017/053576 WO2017140825A1 (en) | 2016-02-18 | 2017-02-17 | Therapeutic compounds, compositions and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505529A JP2019505529A (ja) | 2019-02-28 |
| JP2019505529A5 JP2019505529A5 (enExample) | 2020-03-26 |
| JP6936236B2 true JP6936236B2 (ja) | 2021-09-15 |
Family
ID=58054137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018539129A Expired - Fee Related JP6936236B2 (ja) | 2016-02-18 | 2017-02-17 | 治療化合物、組成物及びその方法の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20180354959A1 (enExample) |
| EP (1) | EP3416967B1 (enExample) |
| JP (1) | JP6936236B2 (enExample) |
| CN (1) | CN108473501B (enExample) |
| WO (1) | WO2017140825A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3215511B1 (en) | 2014-11-06 | 2024-04-17 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| WO2017176961A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| KR20180133461A (ko) | 2016-04-06 | 2018-12-14 | 리소소말 테라퓨틱스 인크. | 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물 및 의학적 장애의 치료에서의 그의 용도 |
| MX388912B (es) | 2016-04-06 | 2025-03-20 | Lysosomal Therapeutics Inc | Compuestos de pirrol[1,2-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos |
| WO2017192930A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| MX2019007339A (es) | 2016-12-29 | 2019-09-06 | Hoffmann La Roche | Compuestos de pirazolopirimidina y metodos de uso de los mismos. |
| JP2020510061A (ja) * | 2017-03-14 | 2020-04-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピラゾロクロロフェニル化合物、組成物及びその使用方法 |
| WO2018215390A1 (en) * | 2017-05-22 | 2018-11-29 | F. Hoffmann-La Roche Ag | Therapeutic compounds and compositions, and methods of use thereof |
| JP7256757B2 (ja) | 2017-05-22 | 2023-04-12 | エフ． ホフマン－ラ ロシュ アーゲー | 処置用化合物及び組成物、並びにその使用方法 |
| JP7657740B2 (ja) | 2019-06-18 | 2025-04-07 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｊａｋキナーゼのピラゾロピリミジンスルホン阻害剤およびその使用 |
| CN114026096B (zh) | 2019-06-18 | 2025-02-07 | 豪夫迈·罗氏有限公司 | 四唑取代的吡唑并嘧啶类jak激酶抑制剂及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009259853A1 (en) | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine JAK inhibitor compounds and methods |
| UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| EP2892899B1 (en) * | 2012-09-06 | 2018-03-21 | Bristol-Myers Squibb Company | Imidazopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
| CA2929316C (en) * | 2013-11-08 | 2021-12-28 | Takeda Pharmaceutical Company Limited | Pyrazole for the treatment autoimmune disorders |
| HRP20210935T1 (hr) * | 2014-05-23 | 2021-08-06 | F. Hoffmann - La Roche Ag | Spojevi 5-kloro-2-difluorometoksifenil pirazolopirimidina koji predstavljaju inhibitore jak |
-
2017
- 2017-02-17 WO PCT/EP2017/053576 patent/WO2017140825A1/en not_active Ceased
- 2017-02-17 JP JP2018539129A patent/JP6936236B2/ja not_active Expired - Fee Related
- 2017-02-17 CN CN201780005254.4A patent/CN108473501B/zh not_active Expired - Fee Related
- 2017-02-17 EP EP17705622.3A patent/EP3416967B1/en active Active
-
2018
- 2018-08-17 US US16/104,347 patent/US20180354959A1/en not_active Abandoned
-
2020
- 2020-09-21 US US17/027,352 patent/US11795170B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019505529A (ja) | 2019-02-28 |
| US11795170B2 (en) | 2023-10-24 |
| EP3416967B1 (en) | 2022-02-09 |
| WO2017140825A1 (en) | 2017-08-24 |
| CN108473501A (zh) | 2018-08-31 |
| US20180354959A1 (en) | 2018-12-13 |
| CN108473501B (zh) | 2021-07-16 |
| US20210009599A1 (en) | 2021-01-14 |
| HK1259372A1 (zh) | 2019-11-29 |
| EP3416967A1 (en) | 2018-12-26 |
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| JP6914933B2 (ja) | ヤヌスキナーゼ、並びにその組成物及びその使用 | |
| JP6900491B2 (ja) | ピラゾロピリミジン化合物及びその使用方法 | |
| JP7256757B2 (ja) | 処置用化合物及び組成物、並びにその使用方法 | |
| JP7059268B2 (ja) | ＩＲＡＫ４モデュレーターとしてのピラゾロ［１，５ａ］ピリミジン誘導体 | |
| JP2020524692A (ja) | Ｉｒａｋ４調節因子としてのベンゾフラン | |
| US11649241B2 (en) | Pyrazolochlorophenyl compounds, compositions and methods of use thereof | |
| US20230242530A1 (en) | 8-(azetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridinyl compounds, compositions and methods of use thereof | |
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| HK40009645B (en) | 8-(azetidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridinyl compounds, compositions and methods of use thereof | |
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| HK40019825A (en) | Therapeutic compounds and compositions, and methods of use thereof |
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