|
BE788516A
(fr)
|
1971-09-10 |
1973-03-07 |
Lonza Ag |
Procede de fabrication d'esters alcoxyacetylacetiques
|
|
GB1528382A
(en)
|
1974-12-26 |
1978-10-11 |
Teijin Ltd |
Cyclopentene diols and acyl esters thereof and processes for their preparation
|
|
DE2658401A1
(de)
|
1976-12-23 |
1978-07-06 |
Merck Patent Gmbh |
Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
|
|
US4575694A
(en)
|
1984-03-05 |
1986-03-11 |
Allied Corporation |
Coaxial connector
|
|
DE3900735A1
(de)
|
1989-01-12 |
1990-07-26 |
Hoechst Ag |
Neue mehrfunktionelle (alpha)-diazo-(beta)-ketoester, verfahren zu ihrer herstellung und deren verwendung
|
|
US6703396B1
(en)
|
1990-02-01 |
2004-03-09 |
Emory University |
Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
|
|
US5204466A
(en)
|
1990-02-01 |
1993-04-20 |
Emory University |
Method and compositions for the synthesis of bch-189 and related compounds
|
|
US6642245B1
(en)
|
1990-02-01 |
2003-11-04 |
Emory University |
Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
|
|
DE4014649A1
(de)
|
1990-05-08 |
1991-11-14 |
Hoechst Ag |
Neue mehrfunktionelle verbindungen mit (alpha)-diazo-ss-ketoester- und sulfonsaeureester-einheiten, verfahren zu ihrer herstellung und deren verwendung
|
|
GB9301000D0
(en)
|
1993-01-20 |
1993-03-10 |
Glaxo Group Ltd |
Chemical compounds
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
SE9702772D0
(sv)
|
1997-07-22 |
1997-07-22 |
Astra Pharma Prod |
Novel compounds
|
|
US5935946A
(en)
|
1997-07-25 |
1999-08-10 |
Gilead Sciences, Inc. |
Nucleotide analog composition and synthesis method
|
|
AU1403099A
(en)
|
1997-11-14 |
1999-06-07 |
Merck & Co., Inc. |
Alpha-1a adrenergic receptor antagonists
|
|
JP2002529455A
(ja)
|
1998-11-09 |
2002-09-10 |
ジェームズ・ブラック・ファウンデーション・リミテッド |
ガストリンおよびコレシストキニン受容体リガンド類
|
|
GB2345058A
(en)
|
1998-12-01 |
2000-06-28 |
Cerebrus Pharm Ltd |
Hydroxypyridone compounds useful in the treatment of oxidative damage to the central nervous system
|
|
DE69939749D1
(de)
|
1998-12-25 |
2008-11-27 |
Shionogi & Co |
Aromatische heterocyclen mit hiv integrase inhibierenden eigenschaften
|
|
AU2001262732A1
(en)
|
2000-06-14 |
2001-12-24 |
Shionogi And Co., Ltd. |
Inhibitor for enzyme having two divalent metal ions as active centers
|
|
ATE530520T1
(de)
|
2001-08-10 |
2011-11-15 |
Shionogi & Co |
Antivirales mittel
|
|
US6727275B2
(en)
|
2001-10-03 |
2004-04-27 |
Ucb, S.A./N.V. |
Pyrrolidinone derivatives
|
|
CA2463976C
(en)
|
2001-10-26 |
2007-02-13 |
Benedetta Crescenzi |
N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
|
|
DE60231425D1
(de)
|
2001-11-13 |
2009-04-16 |
Shiseido Co Ltd |
Azabicycloverbindung, matrixmetallproteaseinhibitor und zubereitung für haut
|
|
WO2004004657A2
(en)
|
2002-07-09 |
2004-01-15 |
Bristol-Myers Squibb Company |
Hiv integrase inhibitors
|
|
CA2498111A1
(en)
|
2002-09-11 |
2004-03-25 |
Merck & Co., Inc. |
Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
|
|
CA2470365C
(en)
|
2002-11-20 |
2011-05-17 |
Japan Tobacco Inc. |
4-oxoquinoline compound and use thereof as hiv integrase inhibitor
|
|
PL408254A1
(pl)
|
2003-01-14 |
2014-07-21 |
Gilead Sciences Inc. |
Kompozycje i i sposoby wykorzystywane w skojarzonej terapii przeciwwirusowej
|
|
TW200510425A
(en)
|
2003-08-13 |
2005-03-16 |
Japan Tobacco Inc |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
|
|
TW200528440A
(en)
|
2003-10-31 |
2005-09-01 |
Fujisawa Pharmaceutical Co |
2-cyanopyrrolidinecarboxamide compound
|
|
CN101014571A
(zh)
|
2004-01-30 |
2007-08-08 |
默克公司 |
用作hiv整合酶抑制剂的n-苄基-3,4-二羟基吡啶-2-羧酰胺类和n-苄基-2,3-二羟基吡啶-4-羧酰胺类化合物
|
|
US7619086B2
(en)
|
2004-03-09 |
2009-11-17 |
Merck & Co., Inc. |
HIV integrase inhibitors
|
|
WO2005110399A2
(en)
|
2004-04-29 |
2005-11-24 |
The Regents Of The University Of California |
Zinc-binding groups for metalloprotein inhibitors
|
|
EP1755586A2
(en)
|
2004-04-29 |
2007-02-28 |
The Regents of the University of California |
Hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone metalloprotein inhibitors
|
|
CA2564372C
(en)
|
2004-05-07 |
2011-10-11 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
US7273859B2
(en)
|
2004-05-12 |
2007-09-25 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors: cyclic pyrimidinone compounds
|
|
WO2005113509A1
(en)
|
2004-05-20 |
2005-12-01 |
Japan Tobacco Inc. |
Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
|
|
MY134672A
(en)
|
2004-05-20 |
2007-12-31 |
Japan Tobacco Inc |
Stable crystal of 4-oxoquinoline compound
|
|
US8633219B2
(en)
|
2004-05-21 |
2014-01-21 |
Japan Tobacco Inc. |
Combination therapy
|
|
EP1790638B1
(en)
|
2004-09-15 |
2013-04-03 |
Shionogi Co., Ltd. |
Carbamoylpyridone derivative having hiv integrase inhibitory activity
|
|
WO2006066414A1
(en)
|
2004-12-23 |
2006-06-29 |
Virochem Pharma Inc. |
Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
|
|
WO2006088173A1
(ja)
|
2005-02-21 |
2006-08-24 |
Shionogi & Co., Ltd. |
Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体
|
|
PT3284520T
(pt)
|
2005-04-28 |
2019-09-10 |
Shionogi & Co |
Derivado policíclico de carbamoílpiridona possuindo atividade inibidora de integrase do hiv
|
|
TW200716632A
(en)
|
2005-05-16 |
2007-05-01 |
Gilead Sciences Inc |
Integrase inhibitor compounds
|
|
EP1906971A2
(en)
|
2005-07-27 |
2008-04-09 |
Gilead Sciences, Inc. |
Antiviral compounds
|
|
WO2007049675A1
(ja)
|
2005-10-27 |
2007-05-03 |
Shionogi & Co., Ltd. |
Hivインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体
|
|
CA2847871C
(en)
|
2005-12-30 |
2016-07-26 |
Gilead Sciences, Inc. |
Methods for improving the pharmacokinetics of hiv integrase inhibitors
|
|
US7601844B2
(en)
|
2006-01-27 |
2009-10-13 |
Bristol-Myers Squibb Company |
Piperidinyl derivatives as modulators of chemokine receptor activity
|
|
WO2007089030A1
(en)
|
2006-02-01 |
2007-08-09 |
Japan Tobacco Inc. |
Use of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or salt thereof for treating retrovirus infection
|
|
WO2007102499A1
(ja)
|
2006-03-06 |
2007-09-13 |
Japan Tobacco Inc. |
4-オキソキノリン化合物の製造方法
|
|
IN2014CN00613A
(enExample)
|
2006-03-06 |
2015-08-21 |
Japan Tobacco Inc |
|
|
US7893055B2
(en)
|
2006-06-28 |
2011-02-22 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
EP2046328A4
(en)
|
2006-07-19 |
2009-10-28 |
Univ Georgia Res Found |
PYRIDINONE DIKETOIC ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY
|
|
EP2395005A1
(en)
|
2006-09-07 |
2011-12-14 |
Industrial Research Limited |
Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
|
|
ES2536923T3
(es)
|
2006-09-12 |
2015-05-29 |
Gilead Sciences, Inc. |
Proceso e intermedios para preparar inhibidores de la integrasa del VIH
|
|
EP2084160A1
(en)
|
2006-10-18 |
2009-08-05 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
LT2487166T
(lt)
|
2007-02-23 |
2016-11-10 |
Gilead Sciences, Inc. |
Terapinių agentų farmakokinetinių savybių moduliatoriai
|
|
US20080280945A1
(en)
|
2007-05-09 |
2008-11-13 |
Sachin Lohani |
Crystalline forms of an HIV integrase inhibitor
|
|
AR067184A1
(es)
|
2007-06-29 |
2009-09-30 |
Gilead Sciences Inc |
Uso de 6-(3-cloro-2-fluorbencil)-1-[(2s)-1-hidroxi-3-metilbutan-2-il]-7-metoxi-4-oxo-1,4-dihidroquinolina-3-carboxilico. composicion farmaceutica
|
|
CN101686972B
(zh)
|
2007-06-29 |
2013-08-14 |
吉里德科学公司 |
治疗用组合物和方法
|
|
US20090258939A1
(en)
|
2007-07-31 |
2009-10-15 |
Wendye Robbins |
Pyrone analog compositions and methods
|
|
AR068403A1
(es)
|
2007-09-11 |
2009-11-18 |
Gilead Sciences Inc |
Proceso e intermediarios para la preparacion de inhibidores de integrasa
|
|
EA201200631A1
(ru)
|
2007-11-16 |
2012-11-30 |
Джилид Сайенсиз, Инк. |
Ингибиторы репликации вируса иммунодефицита человека
|
|
GB0803019D0
(en)
|
2008-02-19 |
2008-03-26 |
Btg Int Ltd |
Fluorinated compounds
|
|
US8129398B2
(en)
|
2008-03-19 |
2012-03-06 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
US20100272811A1
(en)
|
2008-07-23 |
2010-10-28 |
Alkermes,Inc. |
Complex of trospium and pharmaceutical compositions thereof
|
|
WO2010011818A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
EP2330902B1
(en)
|
2008-07-25 |
2012-11-14 |
GlaxoSmithKline LLC |
Chemical compounds
|
|
WO2010011819A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011815A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
EP2320908B9
(en)
|
2008-07-25 |
2014-06-18 |
VIIV Healthcare Company |
Dolutegravir Prodrugs
|
|
EP2320909B8
(en)
|
2008-07-25 |
2016-03-30 |
VIIV Healthcare Company |
Chemical compounds
|
|
JP5572168B2
(ja)
|
2008-12-11 |
2014-08-13 |
ビーブ・ヘルスケア・カンパニー |
カルバモイルピリドンhivインテグラーゼ阻害剤の製造方法および中間体
|
|
EP3210603A1
(en)
|
2008-12-11 |
2017-08-30 |
Shionogi & Co., Ltd |
Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
|
|
TWI518084B
(zh)
|
2009-03-26 |
2016-01-21 |
鹽野義製藥股份有限公司 |
哌喃酮與吡啶酮衍生物之製造方法
|
|
EP2412708A4
(en)
|
2009-03-26 |
2014-07-23 |
Shionogi & Co |
SUBSTITUTED 3-HYDROXY-4-PYRIDONE DERIVATIVE
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
TR201808501T4
(tr)
|
2009-06-15 |
2018-07-23 |
Shionogi & Co |
Sübstitüe polisiklik karbamoilpiridon türevi.
|
|
WO2011028044A2
(ko)
|
2009-09-02 |
2011-03-10 |
이화여자대학교 산학협력단 |
피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물
|
|
CA2967453C
(en)
|
2010-01-27 |
2018-07-17 |
Viiv Healthcare Company |
Combinations for use in the inhibition of hiv-1
|
|
NZ601847A
(en)
|
2010-02-26 |
2014-03-28 |
Japan Tobacco Inc |
1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine derivative and use of same as hiv integrase inhibitor
|
|
TWI582097B
(zh)
|
2010-03-23 |
2017-05-11 |
Viiv醫療保健公司 |
製備胺甲醯吡啶酮衍生物及中間體之方法
|
|
WO2011139637A1
(en)
|
2010-05-03 |
2011-11-10 |
Philadelphia Health & Education Corporation |
Small-molecule modulators of hiv-1 capsid stability and methods thereof
|
|
AU2011274322B2
(en)
|
2010-07-02 |
2015-08-13 |
Gilead Sciences, Inc. |
Naphth- 2 -ylacetic acid derivatives to treat AIDS
|
|
BR112012033689A2
(pt)
|
2010-07-02 |
2019-09-24 |
Gilead Sciences Inc |
derivados de ácido 2-quinolinil-acético como compostos de hiv antivirais
|
|
EP2595986A2
(en)
|
2010-07-14 |
2013-05-29 |
Addex Pharma SA |
Novel 2-amino-4-pyrazolyl-thiazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors
|
|
SG187683A1
(en)
|
2010-08-05 |
2013-03-28 |
Shionogi & Co |
Process for preparing compound having hiv integrase inhibitory activity
|
|
BR112013006722B1
(pt)
|
2010-09-24 |
2020-11-03 |
Shionogi & Co., Ltd |
profármaco de derivado de carbamoilpiridona policíclica substituída
|
|
WO2012106534A2
(en)
|
2011-02-02 |
2012-08-09 |
The Regents Of The University Of California |
Hiv integrase inhibitors
|
|
EA024952B1
(ru)
|
2011-04-21 |
2016-11-30 |
Джилид Сайэнс, Инк. |
Бензотиазолы и их применение для лечения вич-инфекции
|
|
WO2012151361A1
(en)
|
2011-05-03 |
2012-11-08 |
Concert Pharmaceuticals Inc. |
Carbamoylpyridone derivatives
|
|
US9328075B2
(en)
|
2011-05-05 |
2016-05-03 |
St. Jude Children's Research Hospital |
Pyrimidinone compounds and methods for treating influenza
|
|
EP2729448B1
(en)
|
2011-07-06 |
2015-09-09 |
Gilead Sciences, Inc. |
Compounds for the treatment of hiv
|
|
CN102863512B
(zh)
|
2011-07-07 |
2016-04-20 |
上海泓博智源医药技术有限公司 |
抗病毒化合物
|
|
WO2013038407A1
(en)
|
2011-09-14 |
2013-03-21 |
Mapi Pharma Ltd. |
Amorphous form of dolutegravir
|
|
AU2012321762A1
(en)
|
2011-10-12 |
2014-04-17 |
Shionogi & Co., Ltd. |
Polycyclic pyridone derivative having integrase-inhibiting activity
|
|
US9643974B2
(en)
|
2011-12-12 |
2017-05-09 |
Bayer Intellectual Property Gmbh |
Amino-substituted imidazopyridazines
|
|
ES2668422T3
(es)
|
2012-04-20 |
2018-05-18 |
Gilead Sciences, Inc. |
Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH
|
|
WO2014008636A1
(en)
|
2012-07-11 |
2014-01-16 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as hiv integrase inhibitors
|
|
EP2875024A4
(en)
|
2012-07-20 |
2015-12-23 |
Merck Sharp & Dohme |
HIV TREATMENT WITH AMIDOSUBSTITUTED PYRIMIDINONE DERIVATIVES
|
|
WO2014018449A1
(en)
|
2012-07-25 |
2014-01-30 |
Merck Sharp & Dohme Corp. |
Substituted naphthyridinedione derivatives as hiv integrase inhibitors
|
|
IN2015DN01688A
(enExample)
|
2012-08-03 |
2015-07-03 |
Gilead Sciences Inc |
|
|
MX2015005562A
(es)
|
2012-11-08 |
2015-07-23 |
Squibb Bristol Myers Co |
Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa.
|
|
MX2015007563A
(es)
|
2012-12-14 |
2015-10-14 |
Glaxosmithkline Llc |
Composiciones farmaceuticas.
|
|
US9714243B2
(en)
|
2012-12-17 |
2017-07-25 |
Merck Sharp & Dohme Corp. |
4-pyridinonetriazine derivatives as HIV integrase inhibitors
|
|
US20160000721A1
(en)
|
2012-12-21 |
2016-01-07 |
Merck Sharp & Dohme Corp. |
Gastro-retentive formulations
|
|
US20140221355A1
(en)
|
2012-12-21 |
2014-08-07 |
Gilead Sciences, Inc. |
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
|
|
EA037633B1
(ru)
|
2012-12-21 |
2021-04-23 |
Джилид Сайэнс, Инк. |
Полициклические карбамоилпиридоновые соединения, их фармацевтические композиции и применение
|
|
TW201431859A
(zh)
|
2012-12-27 |
2014-08-16 |
Japan Tobacco Inc |
經取代之螺吡啶並[1,2-a]吡□衍生物及該衍生物作爲HIV整合酶抑制劑之醫藥用途
|
|
WO2014200880A1
(en)
|
2013-06-13 |
2014-12-18 |
Merck Sharp & Dohme Corp. |
Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
|
|
CA2916993C
(en)
*
|
2013-07-12 |
2019-01-15 |
Gilead Sciences, Inc. |
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
|
|
NO2865735T3
(enExample)
|
2013-07-12 |
2018-07-21 |
|
|
|
WO2015039348A1
(en)
*
|
2013-09-23 |
2015-03-26 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
MD4794B1
(ro)
|
2013-09-27 |
2022-02-28 |
Merck Sharp & Dohme Corp |
Derivaţi de chinolizină substituiţi utili ca inhibitori de integrază HIV
|
|
US20150146340A1
(en)
|
2013-11-26 |
2015-05-28 |
Qualcomm Incorporated |
Multilayer ceramic capacitor including at least one slot
|
|
WO2015089847A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
US9856271B2
(en)
|
2014-01-21 |
2018-01-02 |
Laurus Labs Limited |
Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
|