JP2019501879A5 - - Google Patents
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- Publication number
- JP2019501879A5 JP2019501879A5 JP2018527221A JP2018527221A JP2019501879A5 JP 2019501879 A5 JP2019501879 A5 JP 2019501879A5 JP 2018527221 A JP2018527221 A JP 2018527221A JP 2018527221 A JP2018527221 A JP 2018527221A JP 2019501879 A5 JP2019501879 A5 JP 2019501879A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pharmaceutically acceptable
- stereoisomer
- cooh
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 5
- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 241000712461 unidentified influenza virus Species 0.000 claims description 3
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 229960003971 influenza vaccine Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 6
- 239000012453 solvate Substances 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 125000004043 oxo group Chemical group O=* 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15196811.2 | 2015-11-27 | ||
| EP15196811 | 2015-11-27 | ||
| PCT/EP2016/078778 WO2017089518A1 (en) | 2015-11-27 | 2016-11-25 | Heterocyclic indoles for use in influenza virus infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501879A JP2019501879A (ja) | 2019-01-24 |
| JP2019501879A5 true JP2019501879A5 (enExample) | 2021-05-13 |
| JP6903658B2 JP6903658B2 (ja) | 2021-07-14 |
Family
ID=54707665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018527221A Expired - Fee Related JP6903658B2 (ja) | 2015-11-27 | 2016-11-25 | インフルエンザウィルス感染に使用するための複素環インドール |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10626108B2 (enExample) |
| EP (1) | EP3380467B1 (enExample) |
| JP (1) | JP6903658B2 (enExample) |
| KR (1) | KR20180087290A (enExample) |
| CN (1) | CN108290869B (enExample) |
| AU (1) | AU2016359907B2 (enExample) |
| CA (1) | CA3005514A1 (enExample) |
| DK (1) | DK3380467T3 (enExample) |
| EA (1) | EA201891278A1 (enExample) |
| ES (1) | ES2882671T3 (enExample) |
| HR (1) | HRP20211223T1 (enExample) |
| HU (1) | HUE055200T2 (enExample) |
| LT (1) | LT3380467T (enExample) |
| MA (1) | MA43298A (enExample) |
| SI (1) | SI3380467T1 (enExample) |
| WO (1) | WO2017089518A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEAP202213376A (en) | 2009-06-17 | 2022-02-25 | Vertex Pharmaceuticals Incorporated Us | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | インフルエンザウイルスの複製の阻害剤 |
| WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| DK3405466T3 (da) | 2016-01-20 | 2021-02-01 | Janssen Sciences Ireland Unlimited Co | Arylsubstituerede pyrimidiner til anvendelse ved influenzavirusinfektion |
| WO2018033082A1 (en) * | 2016-08-16 | 2018-02-22 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
| WO2018041091A1 (en) | 2016-08-30 | 2018-03-08 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
| EP3555095B1 (en) | 2016-12-15 | 2023-04-12 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| CA3047404A1 (en) * | 2016-12-23 | 2018-06-28 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use |
| WO2018127096A1 (en) | 2017-01-05 | 2018-07-12 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
| US10927118B2 (en) | 2017-03-02 | 2021-02-23 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2532667A1 (en) | 2005-09-30 | 2012-12-12 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| EP2040546A4 (en) * | 2006-06-22 | 2009-12-23 | Merck & Co Inc | tyrosine kinase inhibitor |
| BRPI0807087A2 (pt) | 2007-02-08 | 2014-06-10 | Tibotec Pharm Ltd | Inibidores de hcv macrocíclicos substituídos de pirimidina |
| GEAP202213376A (en) | 2009-06-17 | 2022-02-25 | Vertex Pharmaceuticals Incorporated Us | Inhibitors of influenza viruses replication |
| WO2012032065A1 (en) | 2010-09-08 | 2012-03-15 | Glaxo Group Limited | Indazole derivatives for use in the treatment of influenza virus infection |
| CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
| JP2013545818A (ja) * | 2010-12-16 | 2013-12-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製阻害物質 |
| KR101946499B1 (ko) | 2011-04-08 | 2019-02-11 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 치료를 위한 피리미딘 유도체 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP2858984A1 (en) | 2012-06-08 | 2015-04-15 | Vertex Pharmaceuticals Inc. | Inhibitors of influenza viruses replication |
| LT2909195T (lt) | 2012-10-16 | 2017-09-25 | Janssen Sciences Ireland Uc | Antivirusiniai rsv junginiai |
| KR102225233B1 (ko) | 2013-02-21 | 2021-03-09 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체 |
| DK3405466T3 (da) | 2016-01-20 | 2021-02-01 | Janssen Sciences Ireland Unlimited Co | Arylsubstituerede pyrimidiner til anvendelse ved influenzavirusinfektion |
-
2016
- 2016-11-25 CA CA3005514A patent/CA3005514A1/en not_active Abandoned
- 2016-11-25 HU HUE16801246A patent/HUE055200T2/hu unknown
- 2016-11-25 WO PCT/EP2016/078778 patent/WO2017089518A1/en not_active Ceased
- 2016-11-25 DK DK16801246.6T patent/DK3380467T3/da active
- 2016-11-25 KR KR1020187016921A patent/KR20180087290A/ko not_active Ceased
- 2016-11-25 AU AU2016359907A patent/AU2016359907B2/en not_active Ceased
- 2016-11-25 US US15/779,468 patent/US10626108B2/en not_active Expired - Fee Related
- 2016-11-25 EP EP16801246.6A patent/EP3380467B1/en active Active
- 2016-11-25 HR HRP20211223TT patent/HRP20211223T1/hr unknown
- 2016-11-25 SI SI201631276T patent/SI3380467T1/sl unknown
- 2016-11-25 EA EA201891278A patent/EA201891278A1/ru unknown
- 2016-11-25 JP JP2018527221A patent/JP6903658B2/ja not_active Expired - Fee Related
- 2016-11-25 MA MA043298A patent/MA43298A/fr unknown
- 2016-11-25 ES ES16801246T patent/ES2882671T3/es active Active
- 2016-11-25 CN CN201680068994.8A patent/CN108290869B/zh not_active Expired - Fee Related
- 2016-11-25 LT LTEPPCT/EP2016/078778T patent/LT3380467T/lt unknown
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