JP2017522273A5 - - Google Patents
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- Publication number
- JP2017522273A5 JP2017522273A5 JP2016570242A JP2016570242A JP2017522273A5 JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5 JP 2016570242 A JP2016570242 A JP 2016570242A JP 2016570242 A JP2016570242 A JP 2016570242A JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007702P | 2014-06-04 | 2014-06-04 | |
| US62/007,702 | 2014-06-04 | ||
| PCT/US2015/034281 WO2015187998A2 (en) | 2014-06-04 | 2015-06-04 | Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020066803A Division JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522273A JP2017522273A (ja) | 2017-08-10 |
| JP2017522273A5 true JP2017522273A5 (enExample) | 2018-07-12 |
| JP6768522B2 JP6768522B2 (ja) | 2020-10-14 |
Family
ID=54767596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570242A Active JP6768522B2 (ja) | 2014-06-04 | 2015-06-04 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
| JP2020066803A Pending JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020066803A Pending JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10300074B2 (enExample) |
| EP (1) | EP3151920B1 (enExample) |
| JP (2) | JP6768522B2 (enExample) |
| CA (1) | CA2950911C (enExample) |
| WO (1) | WO2015187998A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6382831B2 (ja) | 2012-11-30 | 2018-08-29 | サンフォード−バーンハム メディカル リサーチ インスティテュート | アポトーシス阻害タンパク質(iap)のアンタゴニスト |
| EP3013329B1 (en) * | 2013-06-25 | 2020-08-05 | The Walter and Eliza Hall Institute of Medical Research | Smac mimetics for the treatment of persistent intracellular hbv infection |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| CA2950911C (en) | 2014-06-04 | 2023-10-10 | Sanford-Burnham Medical Research Institute | Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| CN113453678A (zh) * | 2018-11-26 | 2021-09-28 | 德彪药业国际股份公司 | Hiv感染的联合治疗 |
| EP4342473A3 (en) * | 2018-11-30 | 2024-05-15 | GlaxoSmithKline Intellectual Property Development Limited | Compounds useful in hiv therapy |
| US10870663B2 (en) | 2018-11-30 | 2020-12-22 | Glaxosmithkline Intellectual Property Development Limited | Compounds useful in HIV therapy |
| CN110028508B (zh) * | 2019-05-16 | 2021-05-28 | 南京华威医药科技集团有限公司 | 一种抗肿瘤的重氮双环类细胞凋亡蛋白抑制剂 |
| EP4010081A4 (en) | 2019-08-08 | 2023-07-26 | Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center | POLYTHERAPY FOR THE TREATMENT OF CANCER |
| JP7273173B2 (ja) * | 2019-09-26 | 2023-05-12 | 富士フイルム株式会社 | 皮膚感作性測定試薬、皮膚感作性の測定方法、及び化合物 |
| US20230115837A1 (en) * | 2019-11-08 | 2023-04-13 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitor of apoptosis (iap) protein antagonists |
| US20230295181A1 (en) * | 2020-04-30 | 2023-09-21 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitor of apoptosis (iap) protein antagonists |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| AR131299A1 (es) | 2022-12-09 | 2025-03-05 | Debiopharm Int Sa | Nuevos inhibidores de iap, métodos para fabricarlos y usos de los mismos |
| EP4712960A2 (en) * | 2023-05-15 | 2026-03-25 | Recludix Pharma, Inc. | Stat degraders and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5455242A (en) | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| US5457196A (en) | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| CA2146238C (en) | 1992-10-30 | 2001-03-13 | Gary A. Flynn | Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| EP1578777B1 (en) | 2002-07-15 | 2008-11-26 | The Trustees of Princeton University | Iap binding compounds |
| US7932382B2 (en) | 2004-01-16 | 2011-04-26 | The Regents Of The University Of Michigan | Conformationally constrained Smac mimetics and the uses thereof |
| US7309792B2 (en) | 2004-03-01 | 2007-12-18 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
| AU2005228950B2 (en) | 2004-03-23 | 2012-02-02 | Genentech, Inc. | Azabicyclo-octane inhibitors of IAP |
| RS52545B (sr) | 2004-04-07 | 2013-04-30 | Novartis Ag | Inhibitori protein apoptoze (iap) |
| NZ588799A (en) | 2004-07-02 | 2012-06-29 | Genentech Inc | Inhibitors of iap |
| WO2006010118A2 (en) | 2004-07-09 | 2006-01-26 | The Regents Of The University Of Michigan | Conformationally constrained smac mimetics and the uses thereof |
| EP2457895A1 (en) | 2004-07-12 | 2012-05-30 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
| ES2475207T3 (es) | 2004-07-15 | 2014-07-10 | Tetralogic Pharmaceuticals Corporation | Compuestos de unión a IAP |
| DK1836201T4 (da) | 2004-12-20 | 2013-11-11 | Genentech Inc | Pyrrolidininhibitorer af IAP. |
| PL1851200T3 (pl) | 2005-02-25 | 2014-06-30 | Tetralogic Pharm Corp | Dimeryczne inhibitory IAP |
| KR20080022092A (ko) | 2005-06-08 | 2008-03-10 | 노파르티스 아게 | 유기 화합물 |
| WO2007041775A1 (en) * | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
| KR20080067357A (ko) | 2005-10-25 | 2008-07-18 | 에게라 쎄라퓨틱스 인코포레이티드 | Iap bir 도메인 결합 화합물 |
| WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| CN101484151B (zh) | 2006-05-05 | 2012-11-21 | 密执安州立大学董事会 | 二价smac模拟物及其应用 |
| US8048886B2 (en) | 2006-12-07 | 2011-11-01 | Novartis Ag | Substituted pyrazine-3-one-derivatives as IAP inhibitors |
| US20090010941A1 (en) * | 2007-04-09 | 2009-01-08 | University Of Massachusetts | Methods for treating HIV |
| EP2079309B1 (en) | 2007-04-12 | 2015-11-11 | Joyant Pharmaceuticals Inc | SMAC MIMEE DIMERS AND TRIMERS USEFUL AS ANTICANCER AGENTS |
| EP2139490B1 (en) * | 2007-04-13 | 2014-07-02 | The Regents of the University of Michigan | Diazo bicyclic smac mimetics and the uses thereof |
| TWI432212B (zh) | 2007-04-30 | 2014-04-01 | Genentech Inc | Iap抑制劑 |
| EP2058312A1 (en) | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
| US8445473B2 (en) | 2008-04-11 | 2013-05-21 | The Regents Of The University Of Michigan | Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof |
| US20110269244A1 (en) * | 2009-12-30 | 2011-11-03 | Petter Russell C | Ligand-directed covalent modification of protein |
| RS54123B1 (sr) * | 2010-01-27 | 2015-12-31 | Viiv Healthcare Company | Terapeutska kombinacija koja sadrži dolutegravir, abacavir i lamivudine |
| WO2012125622A1 (en) | 2011-03-14 | 2012-09-20 | Bristol-Myers Squibb Company | Substituted adipic acid amides and uses thereof |
| US20150174235A1 (en) * | 2012-06-06 | 2015-06-25 | Bionor Immuno As | Vaccine |
| JP6382831B2 (ja) | 2012-11-30 | 2018-08-29 | サンフォード−バーンハム メディカル リサーチ インスティテュート | アポトーシス阻害タンパク質(iap)のアンタゴニスト |
| CA2950911C (en) | 2014-06-04 | 2023-10-10 | Sanford-Burnham Medical Research Institute | Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy |
-
2015
- 2015-06-04 CA CA2950911A patent/CA2950911C/en active Active
- 2015-06-04 EP EP15803740.8A patent/EP3151920B1/en active Active
- 2015-06-04 WO PCT/US2015/034281 patent/WO2015187998A2/en not_active Ceased
- 2015-06-04 JP JP2016570242A patent/JP6768522B2/ja active Active
- 2015-06-04 US US15/313,286 patent/US10300074B2/en active Active
-
2019
- 2019-05-24 US US16/421,966 patent/US10864217B2/en active Active
-
2020
- 2020-04-02 JP JP2020066803A patent/JP2020125302A/ja active Pending
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