JP2017522273A5 - - Google Patents
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- Publication number
- JP2017522273A5 JP2017522273A5 JP2016570242A JP2016570242A JP2017522273A5 JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5 JP 2016570242 A JP2016570242 A JP 2016570242A JP 2016570242 A JP2016570242 A JP 2016570242A JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007702P | 2014-06-04 | 2014-06-04 | |
| US62/007,702 | 2014-06-04 | ||
| PCT/US2015/034281 WO2015187998A2 (en) | 2014-06-04 | 2015-06-04 | Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020066803A Division JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522273A JP2017522273A (ja) | 2017-08-10 |
| JP2017522273A5 true JP2017522273A5 (enExample) | 2018-07-12 |
| JP6768522B2 JP6768522B2 (ja) | 2020-10-14 |
Family
ID=54767596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570242A Active JP6768522B2 (ja) | 2014-06-04 | 2015-06-04 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
| JP2020066803A Pending JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020066803A Pending JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10300074B2 (enExample) |
| EP (1) | EP3151920B1 (enExample) |
| JP (2) | JP6768522B2 (enExample) |
| CA (1) | CA2950911C (enExample) |
| WO (1) | WO2015187998A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2896577C (en) | 2012-11-30 | 2024-01-23 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (iap) antagonists |
| KR20160030099A (ko) * | 2013-06-25 | 2016-03-16 | 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 | 세포내 감염의 치료 방법 |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| JP6768522B2 (ja) | 2014-06-04 | 2020-10-14 | サンフォード−バーンハム メディカル リサーチ インスティテュート | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| JP2022511437A (ja) * | 2018-11-26 | 2022-01-31 | デバイオファーム インターナショナル エス.エー. | Hiv感染の組み合わせ治療 |
| US10870663B2 (en) | 2018-11-30 | 2020-12-22 | Glaxosmithkline Intellectual Property Development Limited | Compounds useful in HIV therapy |
| CN113613724B (zh) * | 2018-11-30 | 2024-11-08 | 葛兰素史克知识产权开发有限公司 | 可用于hiv疗法的化合物 |
| CN110028508B (zh) * | 2019-05-16 | 2021-05-28 | 南京华威医药科技集团有限公司 | 一种抗肿瘤的重氮双环类细胞凋亡蛋白抑制剂 |
| US12636370B2 (en) | 2019-08-08 | 2026-05-26 | Institute For Cancer Research | Combination therapy for treatment of cancer |
| WO2021060477A1 (ja) * | 2019-09-26 | 2021-04-01 | 富士フイルム株式会社 | 皮膚感作性測定試薬、皮膚感作性の測定方法、及び化合物 |
| US12678509B2 (en) | 2019-11-08 | 2026-07-14 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitor of apoptosis (IAP) protein antagonists |
| EP4143198A4 (en) * | 2020-04-30 | 2024-05-01 | Sanford Burnham Prebys Medical Discovery Institute | INHIBITOR OF APOPTOSIS PROTEIN ANTAGONISTS (API) |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| AR131299A1 (es) | 2022-12-09 | 2025-03-05 | Debiopharm Int Sa | Nuevos inhibidores de iap, métodos para fabricarlos y usos de los mismos |
| EP4712960A2 (en) * | 2023-05-15 | 2026-03-25 | Recludix Pharma, Inc. | Stat degraders and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5457196A (en) | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| US5455242A (en) | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| PT669936E (pt) | 1992-10-30 | 2001-04-30 | Merrell Pharma Inc | Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| WO2004007529A2 (en) | 2002-07-15 | 2004-01-22 | The Trustees Of Princeton University | Iap binding compounds |
| BRPI0506883A (pt) | 2004-01-16 | 2007-05-29 | Univ Michigan | miméticos de smac conformacionalmente comprimidos e seus usos |
| EP1723122B1 (en) | 2004-03-01 | 2014-11-19 | Board of Regents, The University of Texas System | Dimeric small molecule potentiators of apoptosis |
| US7345081B2 (en) | 2004-03-23 | 2008-03-18 | Genentech, Inc. | Azabicyclo-octane inhibitors of IAP |
| PL2253614T3 (pl) | 2004-04-07 | 2013-03-29 | Novartis Ag | Inhibitory IAP |
| KR100926203B1 (ko) | 2004-07-02 | 2009-11-09 | 제넨테크, 인크. | Iap의 억제제 |
| WO2006010118A2 (en) | 2004-07-09 | 2006-01-26 | The Regents Of The University Of Michigan | Conformationally constrained smac mimetics and the uses thereof |
| BRPI0513310A (pt) | 2004-07-12 | 2008-05-06 | Idun Pharmaceuticals Inc | análogos de tetrapeptìdeo |
| JP5230865B2 (ja) | 2004-07-15 | 2013-07-10 | テトラロジック ファーマシューティカルズ コーポレーション | Iap結合性化合物 |
| MX2007007195A (es) | 2004-12-20 | 2007-10-08 | Genentech Inc | Inhibidores de pirrolidina de iap. |
| EA012810B1 (ru) | 2005-02-25 | 2009-12-30 | Тетралоджик Фармасеутикалс | Димерные ингибиторы ингибиторов белков апоптоза (iap) |
| AU2006255084A1 (en) | 2005-06-08 | 2006-12-14 | Novartis Ag | Organic compounds |
| WO2007041775A1 (en) | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
| AU2006308453B9 (en) | 2005-10-25 | 2011-12-01 | Pharmascience Inc. | IAP BIR domain binding compounds |
| WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| ES2525585T3 (es) | 2006-05-05 | 2014-12-26 | The Regents Of The University Of Michigan | Intermedios para la preparación de miméticos de SMAC bivalentes |
| CA2670726A1 (en) | 2006-12-07 | 2008-06-19 | Novartis Ag | 6-oxo-1, 6-dihydropyrimidin-2-yls in the treatment of proliferative diseases |
| US20090010941A1 (en) * | 2007-04-09 | 2009-01-08 | University Of Massachusetts | Methods for treating HIV |
| CA2684169C (en) | 2007-04-12 | 2012-06-19 | Joyant Pharmaceuticals, Inc. | Smac mimetic dimers and trimers useful as anti-cancer agents |
| WO2008128171A2 (en) | 2007-04-13 | 2008-10-23 | The Regents Of The University Of Michigan | Diazo bicyclic smac mimetics and the uses thereof |
| NZ598890A (en) | 2007-04-30 | 2013-10-25 | Genentech Inc | Inhibitors of iap |
| EP2058312A1 (en) | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
| US8445473B2 (en) | 2008-04-11 | 2013-05-21 | The Regents Of The University Of Michigan | Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof |
| WO2011082285A1 (en) * | 2009-12-30 | 2011-07-07 | Avila Therapeutics, Inc. | Ligand-directed covalent modification of protein |
| EP3351249A1 (en) | 2010-01-27 | 2018-07-25 | VIIV Healthcare Company | Antiviral therapy |
| US9346852B2 (en) | 2011-03-14 | 2016-05-24 | Bristol-Myers Scuibb Company | Substituted adipic acid amides and uses thereof |
| US20150174235A1 (en) * | 2012-06-06 | 2015-06-25 | Bionor Immuno As | Vaccine |
| CA2896577C (en) * | 2012-11-30 | 2024-01-23 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (iap) antagonists |
| JP6768522B2 (ja) | 2014-06-04 | 2020-10-14 | サンフォード−バーンハム メディカル リサーチ インスティテュート | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
-
2015
- 2015-06-04 JP JP2016570242A patent/JP6768522B2/ja active Active
- 2015-06-04 WO PCT/US2015/034281 patent/WO2015187998A2/en not_active Ceased
- 2015-06-04 EP EP15803740.8A patent/EP3151920B1/en active Active
- 2015-06-04 CA CA2950911A patent/CA2950911C/en active Active
- 2015-06-04 US US15/313,286 patent/US10300074B2/en active Active
-
2019
- 2019-05-24 US US16/421,966 patent/US10864217B2/en active Active
-
2020
- 2020-04-02 JP JP2020066803A patent/JP2020125302A/ja active Pending
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