JP2017522273A5 - - Google Patents

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Publication number
JP2017522273A5
JP2017522273A5 JP2016570242A JP2016570242A JP2017522273A5 JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5 JP 2016570242 A JP2016570242 A JP 2016570242A JP 2016570242 A JP2016570242 A JP 2016570242A JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5
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Japan
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substituted
unsubstituted
alkyl
heteroaryl
aryl
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JP2016570242A
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Japanese (ja)
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JP2017522273A (ja
JP6768522B2 (ja
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Priority claimed from PCT/US2015/034281 external-priority patent/WO2015187998A2/en
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Publication of JP2017522273A5 publication Critical patent/JP2017522273A5/ja
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JP2016570242A 2014-06-04 2015-06-04 Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用 Active JP6768522B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462007702P 2014-06-04 2014-06-04
US62/007,702 2014-06-04
PCT/US2015/034281 WO2015187998A2 (en) 2014-06-04 2015-06-04 Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020066803A Division JP2020125302A (ja) 2014-06-04 2020-04-02 Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用

Publications (3)

Publication Number Publication Date
JP2017522273A JP2017522273A (ja) 2017-08-10
JP2017522273A5 true JP2017522273A5 (enExample) 2018-07-12
JP6768522B2 JP6768522B2 (ja) 2020-10-14

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ID=54767596

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016570242A Active JP6768522B2 (ja) 2014-06-04 2015-06-04 Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用
JP2020066803A Pending JP2020125302A (ja) 2014-06-04 2020-04-02 Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020066803A Pending JP2020125302A (ja) 2014-06-04 2020-04-02 Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用

Country Status (5)

Country Link
US (2) US10300074B2 (enExample)
EP (1) EP3151920B1 (enExample)
JP (2) JP6768522B2 (enExample)
CA (1) CA2950911C (enExample)
WO (1) WO2015187998A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2896577C (en) 2012-11-30 2024-01-23 Sanford-Burnham Medical Research Institute Inhibitor of apoptosis protein (iap) antagonists
MX381320B (es) * 2013-06-25 2025-03-12 Walter & Eliza Hall Inst Medical Res Usos de antagonistas de iap en infecciones intracelulares.
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
EP3151920B1 (en) 2014-06-04 2025-08-06 Sanford-Burnham Medical Research Institute Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy
CN118436801A (zh) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
US20220016079A1 (en) 2018-11-26 2022-01-20 Debiopharm International S.A. Combination treatment of hiv infections
AR117206A1 (es) * 2018-11-30 2021-07-21 Glaxosmithkline Ip Dev Ltd Derivados de octahidropirrolo[2,1-b][1,3]tiazepin-7-carboxamido útiles en la terapia para el vih y para el tratamiento del cáncer
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
CN110028508B (zh) * 2019-05-16 2021-05-28 南京华威医药科技集团有限公司 一种抗肿瘤的重氮双环类细胞凋亡蛋白抑制剂
WO2021026349A1 (en) 2019-08-08 2021-02-11 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Combination therapy for treatment of cancer
EP4036570B1 (en) * 2019-09-26 2025-03-05 FUJIFILM Corporation Reagent for measuring skin sensitization, method for measuring skin sensitization, and compound
WO2021092500A1 (en) * 2019-11-08 2021-05-14 Sanford Burnham Prebys Medical Discovery Institute Inhibitor of apoptosis (iap) protein antagonists
US20230295181A1 (en) * 2020-04-30 2023-09-21 Sanford Burnham Prebys Medical Discovery Institute Inhibitor of apoptosis (iap) protein antagonists
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
AR131299A1 (es) 2022-12-09 2025-03-05 Debiopharm Int Sa Nuevos inhibidores de iap, métodos para fabricarlos y usos de los mismos
EP4712960A2 (en) * 2023-05-15 2026-03-25 Recludix Pharma, Inc. Stat degraders and uses thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5455242A (en) 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
PT669936E (pt) 1992-10-30 2001-04-30 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5508272A (en) 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US7718600B2 (en) 2000-09-29 2010-05-18 The Trustees Of Princeton University IAP binding compounds
MXPA06008095A (es) 2004-01-16 2007-03-28 Univ Michigan Mimeticos de smac conformacionalmente restringidos y sus usos.
AU2005218555B2 (en) 2004-03-01 2008-01-03 Board Of Regents, The University Of Texas System Dimeric small molecule potentiators of apoptosis
CA2558615C (en) 2004-03-23 2013-10-29 Genentech, Inc. Azabicyclo-octane inhibitors of iap
RS52545B (sr) 2004-04-07 2013-04-30 Novartis Ag Inhibitori protein apoptoze (iap)
CA2570321C (en) 2004-07-02 2013-10-08 Genentech, Inc. Inhibitors of iap
WO2006010118A2 (en) 2004-07-09 2006-01-26 The Regents Of The University Of Michigan Conformationally constrained smac mimetics and the uses thereof
BRPI0513310A (pt) 2004-07-12 2008-05-06 Idun Pharmaceuticals Inc análogos de tetrapeptìdeo
WO2006020060A2 (en) 2004-07-15 2006-02-23 Tetralogic Pharmaceuticals Corporation Iap binding compounds
KR20120127754A (ko) 2004-12-20 2012-11-23 제넨테크, 인크. Ｉａｐ의 피롤리딘 억제제
DK1851200T3 (da) 2005-02-25 2014-04-14 Tetralogic Pharm Corp Dimere iap-inhibitorer
MX2007015419A (es) 2005-06-08 2008-02-21 Novartis Ag Compuestos organicos.
WO2007041775A1 (en) * 2005-10-10 2007-04-19 The University Of Queensland Cysteine protease inhibitors incorporating azide groups
RU2418807C2 (ru) 2005-10-25 2011-05-20 Аегера Терапьютикс Инк. Соединения, связывающие bir домены iap
WO2007101347A1 (en) 2006-03-07 2007-09-13 Aegera Therapeutics Inc. Bir domain binding compounds
HRP20141253T1 (en) 2006-05-05 2015-03-13 The Regents Of The Universitiy Of Michigan Intermediates for the preparation of bivalent smac mimetics
CA2670726A1 (en) 2006-12-07 2008-06-19 Novartis Ag 6-oxo-1, 6-dihydropyrimidin-2-yls in the treatment of proliferative diseases
WO2008124129A2 (en) * 2007-04-09 2008-10-16 University Of Massachusetts Treating hiv with a m-csf effector kinase inhibitor like imatinib
WO2008128121A1 (en) 2007-04-12 2008-10-23 Joyant Pharmaceuticals, Inc. Smac mimetic dimers and trimers useful as anti-cancer agents
HRP20140885T1 (hr) * 2007-04-13 2014-11-21 The Regents Of The University Of Michigan Diazo bicikliäśki smac mimetici i njihove primjene
NZ598890A (en) 2007-04-30 2013-10-25 Genentech Inc Inhibitors of iap
EP2058312A1 (en) 2007-11-09 2009-05-13 Universita' degli Studi di Milano SMAC mimetic compounds as apoptosis inducers
JP5887134B2 (ja) 2008-04-11 2016-03-16 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ヘテロアリールによって置換されている二環式のＳｍａｃの模倣物
AU2010339456A1 (en) * 2009-12-30 2012-07-05 Celgene Avilomics Research, Inc. Ligand-directed covalent modification of protein
UA105556C2 (uk) 2010-01-27 2014-05-26 Віів Гелскер Компані Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
WO2012125622A1 (en) 2011-03-14 2012-09-20 Bristol-Myers Squibb Company Substituted adipic acid amides and uses thereof
CA2875624A1 (en) * 2012-06-06 2013-12-12 Bionor Immuno As Hiv vaccine
CA2896577C (en) 2012-11-30 2024-01-23 Sanford-Burnham Medical Research Institute Inhibitor of apoptosis protein (iap) antagonists
EP3151920B1 (en) 2014-06-04 2025-08-06 Sanford-Burnham Medical Research Institute Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy

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