JP2016510038A5 - - Google Patents
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- JP2016510038A5 JP2016510038A5 JP2015560381A JP2015560381A JP2016510038A5 JP 2016510038 A5 JP2016510038 A5 JP 2016510038A5 JP 2015560381 A JP2015560381 A JP 2015560381A JP 2015560381 A JP2015560381 A JP 2015560381A JP 2016510038 A5 JP2016510038 A5 JP 2016510038A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- independently
- alkyl
- optionally substituted
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims description 113
- 150000001875 compounds Chemical class 0.000 claims description 96
- 150000003839 salts Chemical class 0.000 claims description 94
- 125000000623 heterocyclic group Chemical group 0.000 claims description 86
- 229910052736 halogen Inorganic materials 0.000 claims description 63
- 150000002367 halogens Chemical class 0.000 claims description 63
- 239000003112 inhibitor Substances 0.000 claims description 61
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 41
- 125000001188 haloalkyl group Chemical group 0.000 claims description 37
- 125000003342 alkenyl group Chemical group 0.000 claims description 35
- 125000000304 alkynyl group Chemical group 0.000 claims description 35
- 125000001072 heteroaryl group Chemical group 0.000 claims description 35
- 125000003118 aryl group Chemical group 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 30
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 claims description 24
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 22
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims description 17
- 239000002777 nucleoside Substances 0.000 claims description 16
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 16
- 208000031886 HIV Infections Diseases 0.000 claims description 14
- 208000037357 HIV infectious disease Diseases 0.000 claims description 14
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 14
- 229940099797 HIV integrase inhibitor Drugs 0.000 claims description 12
- 239000003084 hiv integrase inhibitor Substances 0.000 claims description 12
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 12
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims description 11
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 10
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 10
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 10
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims description 8
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims description 8
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims description 8
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 8
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 8
- 210000000234 capsid Anatomy 0.000 claims description 8
- 230000003197 catalytic effect Effects 0.000 claims description 8
- 239000002773 nucleotide Substances 0.000 claims description 8
- 125000003729 nucleotide group Chemical group 0.000 claims description 8
- 238000006116 polymerization reaction Methods 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 229940122440 HIV protease inhibitor Drugs 0.000 claims description 7
- 125000002619 bicyclic group Chemical group 0.000 claims description 7
- 125000002837 carbocyclic group Chemical group 0.000 claims description 7
- 239000004030 hiv protease inhibitor Substances 0.000 claims description 7
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 229940124784 gp41 inhibitor Drugs 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 229940124597 therapeutic agent Drugs 0.000 claims description 5
- 108010002459 HIV Integrase Proteins 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000000169 tricyclic heterocycle group Chemical group 0.000 claims description 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 6
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 2
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- 125000005059 halophenyl group Chemical group 0.000 description 4
- -1 methoxy, dimethylamino Chemical group 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 108010010369 HIV Protease Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 1
- 125000005216 haloheteroaryl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018114786A JP6893899B2 (ja) | 2013-03-01 | 2018-06-15 | Ｈｉｖの処置のためのアミド化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771655P | 2013-03-01 | 2013-03-01 | |
| US61/771,655 | 2013-03-01 | ||
| US201361857636P | 2013-07-23 | 2013-07-23 | |
| US61/857,636 | 2013-07-23 | ||
| PCT/US2014/019663 WO2014134566A2 (en) | 2013-03-01 | 2014-02-28 | Therapeutic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018114786A Division JP6893899B2 (ja) | 2013-03-01 | 2018-06-15 | Ｈｉｖの処置のためのアミド化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510038A JP2016510038A (ja) | 2016-04-04 |
| JP2016510038A5 true JP2016510038A5 (enExample) | 2017-03-30 |
| JP6519486B2 JP6519486B2 (ja) | 2019-05-29 |
Family
ID=50382584
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560381A Active JP6519486B2 (ja) | 2013-03-01 | 2014-02-28 | Ｈｉｖの処置のためのアミド化合物 |
| JP2018114786A Active JP6893899B2 (ja) | 2013-03-01 | 2018-06-15 | Ｈｉｖの処置のためのアミド化合物 |
| JP2019149366A Withdrawn JP2019214599A (ja) | 2013-03-01 | 2019-08-16 | Ｈｉｖの処置のためのアミド化合物 |
| JP2021177617A Withdrawn JP2022009742A (ja) | 2013-03-01 | 2021-10-29 | Ｈｉｖの処置のためのアミド化合物 |
| JP2023090106A Withdrawn JP2023101723A (ja) | 2013-03-01 | 2023-05-31 | Ｈｉｖの処置のためのアミド化合物 |
| JP2025039673A Withdrawn JP2025085700A (ja) | 2013-03-01 | 2025-03-12 | Ｈｉｖの処置のためのアミド化合物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018114786A Active JP6893899B2 (ja) | 2013-03-01 | 2018-06-15 | Ｈｉｖの処置のためのアミド化合物 |
| JP2019149366A Withdrawn JP2019214599A (ja) | 2013-03-01 | 2019-08-16 | Ｈｉｖの処置のためのアミド化合物 |
| JP2021177617A Withdrawn JP2022009742A (ja) | 2013-03-01 | 2021-10-29 | Ｈｉｖの処置のためのアミド化合物 |
| JP2023090106A Withdrawn JP2023101723A (ja) | 2013-03-01 | 2023-05-31 | Ｈｉｖの処置のためのアミド化合物 |
| JP2025039673A Withdrawn JP2025085700A (ja) | 2013-03-01 | 2025-03-12 | Ｈｉｖの処置のためのアミド化合物 |
Country Status (38)
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2840095A1 (en) | 2011-07-06 | 2013-01-10 | Gilead Sciences, Inc. | Compounds for the treatment of hiv |
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| CA2898680A1 (en) * | 2013-03-15 | 2014-09-18 | Genentech,Inc. | Substituted benzoxazoles and methods of use thereof |
| WO2015130964A1 (en) | 2014-02-28 | 2015-09-03 | Gilead Sciences, Inc. | Therapeutic compounds |
| US9873680B2 (en) | 2014-08-29 | 2018-01-23 | Gilead Sciences, Inc. | Therapeutic compounds |
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| US20160145344A1 (en) * | 2014-10-20 | 2016-05-26 | University Of Southern California | Murine and human innate lymphoid cells and lung inflammation |
| WO2016106050A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| WO2016123629A1 (en) * | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| AU2016250662A1 (en) | 2015-04-23 | 2017-11-16 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
| PT3286166T (pt) * | 2015-04-23 | 2020-08-18 | Viiv Healthcare Uk No 5 Ltd | Inibidores de replicação do vírus da imunodeficiência humana |
| US20170040479A1 (en) | 2015-08-07 | 2017-02-09 | Solaero Technologies Corp. | Reliable interconnection of solar cells |
| US20170081324A1 (en) * | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Triazolones derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| EP3478703A1 (en) | 2016-06-30 | 2019-05-08 | ViiV Healthcare UK (No.5) Limited | Triterpenoid inhibitors of human immunodeficiency virus replication |
| EP3478662B1 (en) | 2016-06-30 | 2020-09-16 | ViiV Healthcare UK (No.5) Limited | Azadecalin derivatives as inhibitors of human immunodeficiency virus replication |
| WO2018002847A1 (en) | 2016-06-30 | 2018-01-04 | VIIV Healthcare UK (No.5) Limited | Aza-substituted inhibitors of human immunodeficiency virus replication |
| LT3347352T (lt) | 2016-08-19 | 2019-08-12 | Gilead Sciences, Inc. | Terapiniai junginiai, naudotini živ viruso infekcijos profilaktikai arba terapiniam gydymui |
| EA036921B1 (ru) * | 2017-02-10 | 2021-01-15 | Джилид Сайэнс, Инк. | Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич |
| TW201906834A (zh) * | 2017-05-02 | 2019-02-16 | 英商Viiv醫療保健英國(No.5)有限公司 | 人類免疫不全病毒複製之抑制劑 |
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| RU2020116571A (ru) | 2017-12-07 | 2021-11-22 | Эмори Юниверсити | N4-гидроксицитидин и производные и связанные с этим противовирусные применения |
| WO2019161017A1 (en) * | 2018-02-15 | 2019-08-22 | Gilead Sciences, Inc. | Pyridine derivatives and their use for treating hiv infection |
| KR102847339B1 (ko) * | 2018-02-16 | 2025-08-19 | 길리애드 사이언시즈, 인코포레이티드 | 레트로비리다에 바이러스 감염의 치료에 유용한 치료 화합물을 제조하기 위한 방법 및 중간체 |
| WO2019198024A1 (en) | 2018-04-11 | 2019-10-17 | VIIV Healthcare UK (No.5) Limited | 4-oxo-3,4-dihydroquinazoline compounds as inhibitors of human immunodeficiency virus replication |
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