JP2016529324A5 - - Google Patents
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- Publication number
- JP2016529324A5 JP2016529324A5 JP2016540848A JP2016540848A JP2016529324A5 JP 2016529324 A5 JP2016529324 A5 JP 2016529324A5 JP 2016540848 A JP2016540848 A JP 2016540848A JP 2016540848 A JP2016540848 A JP 2016540848A JP 2016529324 A5 JP2016529324 A5 JP 2016529324A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- solvate
- acceptable salt
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CP(*)(N(*)CC(O)=O)=[U] Chemical compound CP(*)(N(*)CC(O)=O)=[U] 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1351026 | 2013-09-04 | ||
| SE1351026-8 | 2013-09-04 | ||
| SE1351169 | 2013-10-03 | ||
| SE1351169-6 | 2013-10-03 | ||
| SE1450152 | 2014-02-12 | ||
| SE1450152-2 | 2014-02-12 | ||
| PCT/SE2014/051005 WO2015034420A1 (en) | 2013-09-04 | 2014-09-02 | Hcv polymerase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018193251A Division JP2019065011A (ja) | 2013-09-04 | 2018-10-12 | Ｈｃｖポリメラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529324A JP2016529324A (ja) | 2016-09-23 |
| JP2016529324A5 true JP2016529324A5 (enExample) | 2017-10-19 |
| JP6456958B2 JP6456958B2 (ja) | 2019-01-23 |
Family
ID=52628746
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540848A Active JP6456958B2 (ja) | 2013-09-04 | 2014-09-02 | Ｈｃｖポリメラーゼ阻害剤 |
| JP2018193251A Ceased JP2019065011A (ja) | 2013-09-04 | 2018-10-12 | Ｈｃｖポリメラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018193251A Ceased JP2019065011A (ja) | 2013-09-04 | 2018-10-12 | Ｈｃｖポリメラーゼ阻害剤 |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9481703B2 (enExample) |
| EP (2) | EP3041855B1 (enExample) |
| JP (2) | JP6456958B2 (enExample) |
| KR (1) | KR20160078337A (enExample) |
| CN (3) | CN108676047B (enExample) |
| AU (2) | AU2014315715B2 (enExample) |
| BR (1) | BR112016004919A2 (enExample) |
| CA (1) | CA2921899A1 (enExample) |
| CL (2) | CL2016000493A1 (enExample) |
| CR (1) | CR20160123A (enExample) |
| CY (1) | CY1119587T1 (enExample) |
| DK (1) | DK3041855T3 (enExample) |
| EA (1) | EA028974B1 (enExample) |
| HR (1) | HRP20171435T1 (enExample) |
| HU (1) | HUE036365T2 (enExample) |
| IL (2) | IL244389B (enExample) |
| ME (1) | ME02875B (enExample) |
| MX (1) | MX2016002849A (enExample) |
| MY (1) | MY177804A (enExample) |
| PH (2) | PH12016500402B1 (enExample) |
| PL (1) | PL3041855T3 (enExample) |
| PT (1) | PT3041855T (enExample) |
| RS (1) | RS56383B1 (enExample) |
| SA (1) | SA516370684B1 (enExample) |
| SG (2) | SG10201700647PA (enExample) |
| SI (1) | SI3041855T1 (enExample) |
| UA (1) | UA117375C2 (enExample) |
| WO (1) | WO2015034420A1 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2480559T3 (da) | 2009-09-21 | 2013-08-05 | Gilead Sciences Inc | Fremgangsmåder og mellemprodukter til fremstillingen af 1'-cyano-carbanukleosid-analoger |
| MA34470B1 (fr) | 2010-07-22 | 2013-08-01 | Gilead Sciences Inc | Procédés et composés pour traiter des infections à virus paramyxoviridae |
| CN110156838A (zh) * | 2013-05-14 | 2019-08-23 | 北京美倍他药物研究有限公司 | 磷酸/膦酸衍生物及其医药用途 |
| UA117375C2 (uk) | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
| EP3074399A1 (en) * | 2013-11-27 | 2016-10-05 | Idenix Pharmaceuticals LLC | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
| AU2014354775A1 (en) | 2013-11-27 | 2016-05-19 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of liver cancer |
| EP3134423A4 (en) * | 2014-04-24 | 2017-11-29 | Cocrystal Pharma, Inc. | 2' -disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
| CN105315319B (zh) * | 2014-07-30 | 2020-11-20 | 南京圣和药业股份有限公司 | 丙型肝炎病毒抑制剂及其应用 |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| UA121561C2 (uk) | 2014-12-30 | 2020-06-25 | Дау Аґросаєнсиз Елелсі | Застосування сполук аміду як фунгіцидів |
| MX2017008418A (es) | 2014-12-30 | 2017-09-28 | Dow Agrosciences Llc | Picolinamidas con actividad fungicida. |
| EP3240413B1 (en) * | 2014-12-30 | 2020-05-13 | Dow Agrosciences LLC | Picolinamide compounds with fungicidal activity |
| WO2016109302A1 (en) | 2014-12-30 | 2016-07-07 | Dow Agrosciences Llc | Picolinamide compounds with fungicidal activity |
| WO2016134057A1 (en) * | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Anti-viral compounds |
| WO2016140615A1 (en) * | 2015-03-02 | 2016-09-09 | Medivir Ab | Nucleotide derivatives which are hcv inhibitors for use in the treatment of hepatitis c |
| AU2016226647A1 (en) * | 2015-03-02 | 2017-09-21 | Medivir Ab | Nucleotide phosphoramidate formulation |
| WO2016160646A1 (en) * | 2015-04-02 | 2016-10-06 | Merck Sharp & Dohme Corp. | Process for making phosphoramidate protected nucleoside compounds |
| WO2016178876A2 (en) | 2015-05-01 | 2016-11-10 | Cocrystal Pharma, Inc. | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
| WO2017040896A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040892A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040889A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| EP3344642A1 (en) * | 2015-09-02 | 2018-07-11 | AbbVie Inc. | Anti-viral tetrahydrofurane derivatives |
| WO2017040898A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| WO2017040895A1 (en) * | 2015-09-02 | 2017-03-09 | Abbvie Inc. | Anti-viral compounds |
| MX394858B (es) | 2015-09-16 | 2025-03-24 | Gilead Sciences Inc | Compuestos de formula i para usarse en el tratamiento de infecciones por virus arenaviridae y coronaviridae |
| CN105367505A (zh) * | 2015-12-01 | 2016-03-02 | 苏利制药科技江阴有限公司 | 一种新型合成3,6-二甲基-2,5-哌嗪二酮的方法 |
| CA3011538A1 (en) | 2016-01-18 | 2017-07-27 | Arisan Therapeutics | Adamantane derivatives for the treatment of filovirus infection |
| US20190185507A1 (en) * | 2016-08-19 | 2019-06-20 | Sandoz Ag | Sofosbuvir Derivatives for the Treatment of Hepatitis C |
| CA3056072C (en) | 2017-03-14 | 2022-08-23 | Gilead Sciences, Inc. | Methods of treating feline coronavirus infections |
| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
| TWI774761B (zh) | 2017-05-02 | 2022-08-21 | 美商科迪華農業科技有限責任公司 | 用於穀物中的真菌防治之協同性混合物 |
| CN110996665B (zh) | 2017-05-02 | 2021-10-26 | 陶氏益农公司 | 无环吡啶酰胺化合物作为针对草坪草上的真菌病害的杀真菌剂的用途 |
| TW201842851A (zh) | 2017-05-02 | 2018-12-16 | 美商陶氏農業科學公司 | 用於穀類中的真菌防治之協同性混合物 |
| EP4512475A3 (en) | 2017-07-11 | 2025-05-14 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
| BR102019004480B1 (pt) | 2018-03-08 | 2023-03-28 | Dow Agrosciences Llc | Picolinamidas como fungicidas |
| JP7337855B2 (ja) | 2018-03-09 | 2023-09-04 | メディヴィル・アクチエボラーグ | （２，２－ビスヒドロキシメチル）メチレンシクロプロパンヌクレオチドを用いたがんの治療 |
| US11639334B2 (en) | 2018-10-15 | 2023-05-02 | Corteva Agriscience Llc | Methods for synthesis of oxypicolinamides |
| CN109762040A (zh) * | 2019-01-14 | 2019-05-17 | 歌礼生物制药(杭州)有限公司 | 一种核苷类ns5b聚合酶抑制剂的制备方法 |
| EP4044811A4 (en) | 2019-10-18 | 2023-09-27 | Corteva Agriscience LLC | METHOD FOR SYNTHESIS OF PICOLINAMIDS |
| AU2021214911A1 (en) | 2020-01-27 | 2022-07-21 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CN111269263A (zh) * | 2020-03-09 | 2020-06-12 | 上海龙翔生物医药开发有限公司 | 一种瑞德西韦侧链中间体及其制备方法 |
| KR20220153619A (ko) | 2020-03-12 | 2022-11-18 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 뉴클레오사이드의 제조 방법 |
| WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| CN111848679A (zh) * | 2020-04-17 | 2020-10-30 | 山东科巢生物制药有限公司 | 一种利用微通道反应技术合成瑞德西韦的方法 |
| JP7664287B2 (ja) | 2020-05-29 | 2025-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | レムデシビル治療方法 |
| AU2021296841B2 (en) | 2020-06-24 | 2025-01-23 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
| KR20250111239A (ko) | 2020-08-27 | 2025-07-22 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스 감염 치료를 위한 화합물 및 방법 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CA3244278A1 (en) | 2022-03-02 | 2023-09-07 | Gilead Sciences Inc | COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS |
| CN116199679A (zh) * | 2022-12-23 | 2023-06-02 | 吉斯凯(苏州)制药有限公司 | 一种拉米夫定的工业化制备方法 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (28)
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| DE674513T1 (de) | 1992-12-29 | 1996-01-18 | Abbott Lab | Inhibitoren der retroviralen protease. |
| IL110752A (en) | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
| US5559158A (en) | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
| IL111991A (en) | 1994-01-28 | 2000-07-26 | Abbott Lab | Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| EP1411954B1 (en) * | 2000-10-18 | 2010-12-15 | Pharmasset, Inc. | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| US20090298708A1 (en) * | 2006-08-23 | 2009-12-03 | Masad Damha J | 2'-deoxy-2'-fluoro-beta-d-arabinonucleoside 5'-triphosphates and their use in enzymatic nucleic acid synthesis |
| DE602007011658D1 (de) * | 2006-10-10 | 2011-02-10 | Medivir Ab | Hcv-nukleosidinhibitor |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| US7964580B2 (en) * | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| JP2011508740A (ja) | 2007-12-27 | 2011-03-17 | エピファニー バイオサイエンシズ， インク． | 抗ウイルス化合物 |
| US8173621B2 (en) * | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
| AP2011005929A0 (en) * | 2009-03-20 | 2011-10-31 | Alios Biopharma Inc | Substituted nucleoside and nucleotide analogs. |
| CN101591371B (zh) * | 2009-06-30 | 2012-05-30 | 连云港金康医药科技有限公司 | 一种通过卤交换氟化制备吉西他滨或其类似物的方法 |
| JP5872539B2 (ja) | 2010-03-31 | 2016-03-01 | ギリアド ファーマセット エルエルシー | プリンヌクレオシドホスホルアミダート |
| US8402690B2 (en) | 2010-09-09 | 2013-03-26 | Sterling International Inc. | Bedbug trap |
| WO2012040126A1 (en) * | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| SG188497A1 (en) * | 2010-09-22 | 2013-05-31 | Alios Biopharma Inc | Substituted nucleotide analogs |
| EA201391519A1 (ru) | 2011-04-13 | 2014-03-31 | Мерк Шарп И Доум Корп. | 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний |
| TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
| SI2794627T1 (sl) | 2011-12-22 | 2019-02-28 | Alios Biopharma, Inc. | Substituirani nukleozidi, nukleotidi in njihovi analogi |
| US20140140951A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-Alanine Ester of Rp-Nucleoside Analog |
| UA117375C2 (uk) * | 2013-09-04 | 2018-07-25 | Медівір Аб | Інгібітори полімерази hcv |
| EP3074399A1 (en) * | 2013-11-27 | 2016-10-05 | Idenix Pharmaceuticals LLC | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
| AU2014354775A1 (en) * | 2013-11-27 | 2016-05-19 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of liver cancer |
| EP3134423A4 (en) | 2014-04-24 | 2017-11-29 | Cocrystal Pharma, Inc. | 2' -disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
-
2014
- 2014-02-09 UA UAA201602085A patent/UA117375C2/uk unknown
- 2014-09-02 HR HRP20171435TT patent/HRP20171435T1/hr unknown
- 2014-09-02 EP EP14789434.9A patent/EP3041855B1/en active Active
- 2014-09-02 CN CN201810472644.9A patent/CN108676047B/zh active Active
- 2014-09-02 WO PCT/SE2014/051005 patent/WO2015034420A1/en not_active Ceased
- 2014-09-02 SG SG10201700647PA patent/SG10201700647PA/en unknown
- 2014-09-02 PT PT147894349T patent/PT3041855T/pt unknown
- 2014-09-02 MX MX2016002849A patent/MX2016002849A/es unknown
- 2014-09-02 PL PL14789434T patent/PL3041855T3/pl unknown
- 2014-09-02 CA CA2921899A patent/CA2921899A1/en not_active Abandoned
- 2014-09-02 RS RS20170949A patent/RS56383B1/sr unknown
- 2014-09-02 CN CN201480060874.4A patent/CN105705510B/zh active Active
- 2014-09-02 DK DK14789434.9T patent/DK3041855T3/en active
- 2014-09-02 KR KR1020167008381A patent/KR20160078337A/ko not_active Withdrawn
- 2014-09-02 CN CN201810473163.XA patent/CN108558973A/zh active Pending
- 2014-09-02 MY MYPI2016700722A patent/MY177804A/en unknown
- 2014-09-02 BR BR112016004919A patent/BR112016004919A2/pt not_active Application Discontinuation
- 2014-09-02 EP EP17176973.0A patent/EP3252066B1/en active Active
- 2014-09-02 JP JP2016540848A patent/JP6456958B2/ja active Active
- 2014-09-02 AU AU2014315715A patent/AU2014315715B2/en not_active Ceased
- 2014-09-02 SI SI201430401T patent/SI3041855T1/sl unknown
- 2014-09-02 HU HUE14789434A patent/HUE036365T2/hu unknown
- 2014-09-02 ME MEP-2017-229A patent/ME02875B/me unknown
- 2014-09-02 SG SG11201601474UA patent/SG11201601474UA/en unknown
- 2014-09-02 EA EA201690452A patent/EA028974B1/ru not_active IP Right Cessation
-
2015
- 2015-02-27 US US14/634,449 patent/US9481703B2/en active Active
-
2016
- 2016-02-29 PH PH12016500402A patent/PH12016500402B1/en unknown
- 2016-03-02 IL IL244389A patent/IL244389B/en not_active IP Right Cessation
- 2016-03-03 CL CL2016000493A patent/CL2016000493A1/es unknown
- 2016-03-06 SA SA516370684A patent/SA516370684B1/ar unknown
- 2016-03-10 CR CR20160123A patent/CR20160123A/es unknown
- 2016-07-14 US US15/210,500 patent/US9540411B2/en not_active Expired - Fee Related
- 2016-11-23 US US15/360,360 patent/US9828408B2/en not_active Expired - Fee Related
-
2017
- 2017-06-13 AU AU2017203954A patent/AU2017203954B2/en not_active Ceased
- 2017-10-04 CY CY20171101032T patent/CY1119587T1/el unknown
- 2017-11-27 US US15/823,224 patent/US10106571B2/en not_active Expired - Fee Related
-
2018
- 2018-05-02 PH PH12018500931A patent/PH12018500931A1/en unknown
- 2018-09-12 IL IL261702A patent/IL261702B/en not_active IP Right Cessation
- 2018-10-12 JP JP2018193251A patent/JP2019065011A/ja not_active Ceased
- 2018-10-22 US US16/166,578 patent/US20190085010A1/en not_active Abandoned
-
2019
- 2019-02-01 CL CL2019000271A patent/CL2019000271A1/es unknown