JP2013542267A5 - - Google Patents
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- Publication number
- JP2013542267A5 JP2013542267A5 JP2013539003A JP2013539003A JP2013542267A5 JP 2013542267 A5 JP2013542267 A5 JP 2013542267A5 JP 2013539003 A JP2013539003 A JP 2013539003A JP 2013539003 A JP2013539003 A JP 2013539003A JP 2013542267 A5 JP2013542267 A5 JP 2013542267A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- aliphatic
- compound according
- substituted
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 131
- 125000001424 substituent group Chemical group 0.000 claims description 44
- 208000010877 cognitive disease Diseases 0.000 claims description 28
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 27
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
- 125000001072 heteroaryl group Chemical group 0.000 claims description 24
- 208000028698 Cognitive impairment Diseases 0.000 claims description 20
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 18
- -1 1,2-methylenedioxy Chemical group 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- 125000006717 (C3-C10) cycloalkenyl group Chemical group 0.000 claims description 12
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 12
- 125000004429 atom Chemical group 0.000 claims description 12
- 125000005842 heteroatom Chemical group 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 12
- 208000015114 central nervous system disease Diseases 0.000 claims description 11
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 125000006714 (C3-C10) heterocyclyl group Chemical group 0.000 claims description 8
- MZAGXDHQGXUDDX-JSRXJHBZSA-N (e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/C(N)=O MZAGXDHQGXUDDX-JSRXJHBZSA-N 0.000 claims description 8
- 208000024827 Alzheimer disease Diseases 0.000 claims description 8
- 125000001931 aliphatic group Chemical group 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 8
- 125000004043 oxo group Chemical group O=* 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 125000000464 thioxo group Chemical group S=* 0.000 claims description 8
- 206010012289 Dementia Diseases 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 210000003169 central nervous system Anatomy 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 6
- 125000004076 pyridyl group Chemical group 0.000 claims description 6
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 230000007000 age related cognitive decline Effects 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 2
- 201000002832 Lewy body dementia Diseases 0.000 claims description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 2
- 201000004810 Vascular dementia Diseases 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 206010027175 memory impairment Diseases 0.000 claims description 2
- 238000011275 oncology therapy Methods 0.000 claims description 2
- 201000000980 schizophrenia Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 11
- 150000007824 aliphatic compounds Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 description 12
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- 229940044601 receptor agonist Drugs 0.000 description 2
- 0 Bc1c(*)nnc(*)c1C(O)=O Chemical compound Bc1c(*)nnc(*)c1C(O)=O 0.000 description 1
- DYJNGHZAXRFAJZ-UHFFFAOYSA-N Cc1n[o]c(-c(c(-c2ccccc2)nnc2)c2-c2cccc(C#N)c2)n1 Chemical compound Cc1n[o]c(-c(c(-c2ccccc2)nnc2)c2-c2cccc(C#N)c2)n1 DYJNGHZAXRFAJZ-UHFFFAOYSA-N 0.000 description 1
- MGFXJIWEVFFSHA-UHFFFAOYSA-N NC(c(c(-c1ccccc1)nnc1)c1-c1ccccc1)=O Chemical compound NC(c(c(-c1ccccc1)nnc1)c1-c1ccccc1)=O MGFXJIWEVFFSHA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41397110P | 2010-11-15 | 2010-11-15 | |
| US61/413,971 | 2010-11-15 | ||
| PCT/US2011/060854 WO2012068161A1 (en) | 2010-11-15 | 2011-11-15 | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013542267A JP2013542267A (ja) | 2013-11-21 |
| JP2013542267A5 true JP2013542267A5 (enExample) | 2015-01-08 |
| JP5916746B2 JP5916746B2 (ja) | 2016-05-11 |
Family
ID=46084380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539003A Active JP5916746B2 (ja) | 2010-11-15 | 2011-11-15 | 認知障害を処置するためのピリダジン誘導体、組成物、および方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9145372B2 (enExample) |
| EP (2) | EP3034079B1 (enExample) |
| JP (1) | JP5916746B2 (enExample) |
| CN (1) | CN103313712B (enExample) |
| AU (1) | AU2011328993B2 (enExample) |
| BR (1) | BR112013012062B1 (enExample) |
| CA (1) | CA2818025A1 (enExample) |
| DK (2) | DK3034079T3 (enExample) |
| EA (1) | EA027840B1 (enExample) |
| MX (2) | MX346185B (enExample) |
| NO (1) | NO3034079T3 (enExample) |
| WO (1) | WO2012068161A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011328993B2 (en) | 2010-11-15 | 2017-03-02 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
| WO2012071584A2 (en) * | 2010-11-26 | 2012-05-31 | Brigham And Women's Hospital, Inc. | Method for assessing repetitive head injuries with tow-dimensional magnetic resonance spectorscopy |
| CA2885148A1 (en) | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| WO2014078377A1 (en) * | 2012-11-14 | 2014-05-22 | Agenebio, Inc. | Methods and compositions for treating schizophrenia |
| EP4032889B1 (en) | 2013-12-20 | 2026-05-06 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| EP3310785B1 (en) | 2015-06-19 | 2024-11-20 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| TWI697485B (zh) | 2015-07-21 | 2020-07-01 | 日商捷恩智股份有限公司 | 含唑啉環的化合物、含有其的電子輸送/注入層用材料、使用其的有機電致發光元件、顯示裝置及照明裝置 |
| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| AU2019288382B2 (en) | 2018-06-19 | 2024-07-25 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CN113840569B (zh) | 2019-03-19 | 2025-01-07 | 剑桥认知有限公司 | 诊断精神病症和推荐用于精神病症的治疗的方法和用途 |
| AU2022349463A1 (en) * | 2021-09-24 | 2024-03-14 | Xenon Pharmaceuticals Inc. | Pyridinyl derivatives as sodium channel activators |
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| NL7305644A (enExample) | 1972-04-20 | 1973-10-23 | ||
| NL7605526A (nl) | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
| JPS54130587A (en) | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| DE2856393C2 (de) | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
| US4804663A (en) | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
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-
2011
- 2011-11-15 AU AU2011328993A patent/AU2011328993B2/en not_active Ceased
- 2011-11-15 US US13/885,569 patent/US9145372B2/en not_active Expired - Fee Related
- 2011-11-15 MX MX2013005442A patent/MX346185B/es active IP Right Grant
- 2011-11-15 DK DK15187794.1T patent/DK3034079T3/en active
- 2011-11-15 WO PCT/US2011/060854 patent/WO2012068161A1/en not_active Ceased
- 2011-11-15 EP EP15187794.1A patent/EP3034079B1/en active Active
- 2011-11-15 CN CN201180063261.2A patent/CN103313712B/zh not_active Expired - Fee Related
- 2011-11-15 EA EA201390712A patent/EA027840B1/ru not_active IP Right Cessation
- 2011-11-15 CA CA2818025A patent/CA2818025A1/en not_active Abandoned
- 2011-11-15 NO NO15187794A patent/NO3034079T3/no unknown
- 2011-11-15 JP JP2013539003A patent/JP5916746B2/ja active Active
- 2011-11-15 EP EP11841746.8A patent/EP2640391B1/en active Active
- 2011-11-15 MX MX2017003111A patent/MX383953B/es unknown
- 2011-11-15 DK DK11841746.8T patent/DK2640391T3/da active
- 2011-11-15 BR BR112013012062-2A patent/BR112013012062B1/pt not_active IP Right Cessation
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2015
- 2015-09-18 US US14/858,959 patent/US9801879B2/en not_active Expired - Fee Related