AU2011328993B2 - Pyridazine derivatives, compositions and methods for treating cognitive impairment - Google Patents

Pyridazine derivatives, compositions and methods for treating cognitive impairment Download PDF

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Publication number
AU2011328993B2
AU2011328993B2 AU2011328993A AU2011328993A AU2011328993B2 AU 2011328993 B2 AU2011328993 B2 AU 2011328993B2 AU 2011328993 A AU2011328993 A AU 2011328993A AU 2011328993 A AU2011328993 A AU 2011328993A AU 2011328993 B2 AU2011328993 B2 AU 2011328993B2
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independently selected
aliphatic
substituted
compound according
compound
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AU2011328993A
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AU2011328993A1 (en
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John A. Lowe Iii
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Agenebio Inc
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Agenebio Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2011328993A 2010-11-15 2011-11-15 Pyridazine derivatives, compositions and methods for treating cognitive impairment Ceased AU2011328993B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41397110P 2010-11-15 2010-11-15
US61/413,971 2010-11-15
PCT/US2011/060854 WO2012068161A1 (en) 2010-11-15 2011-11-15 Pyridazine derivatives, compositions and methods for treating cognitive impairment

Publications (2)

Publication Number Publication Date
AU2011328993A1 AU2011328993A1 (en) 2013-06-06
AU2011328993B2 true AU2011328993B2 (en) 2017-03-02

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AU2011328993A Ceased AU2011328993B2 (en) 2010-11-15 2011-11-15 Pyridazine derivatives, compositions and methods for treating cognitive impairment

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US (2) US9145372B2 (enExample)
EP (2) EP3034079B1 (enExample)
JP (1) JP5916746B2 (enExample)
CN (1) CN103313712B (enExample)
AU (1) AU2011328993B2 (enExample)
BR (1) BR112013012062B1 (enExample)
CA (1) CA2818025A1 (enExample)
DK (2) DK3034079T3 (enExample)
EA (1) EA027840B1 (enExample)
MX (2) MX346185B (enExample)
NO (1) NO3034079T3 (enExample)
WO (1) WO2012068161A1 (enExample)

Families Citing this family (11)

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AU2011328993B2 (en) 2010-11-15 2017-03-02 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
WO2012071584A2 (en) * 2010-11-26 2012-05-31 Brigham And Women's Hospital, Inc. Method for assessing repetitive head injuries with tow-dimensional magnetic resonance spectorscopy
CA2885148A1 (en) 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma
WO2014078377A1 (en) * 2012-11-14 2014-05-22 Agenebio, Inc. Methods and compositions for treating schizophrenia
EP4032889B1 (en) 2013-12-20 2026-05-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (en) 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
TWI697485B (zh) 2015-07-21 2020-07-01 日商捷恩智股份有限公司 含唑啉環的化合物、含有其的電子輸送/注入層用材料、使用其的有機電致發光元件、顯示裝置及照明裝置
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
AU2019288382B2 (en) 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN113840569B (zh) 2019-03-19 2025-01-07 剑桥认知有限公司 诊断精神病症和推荐用于精神病症的治疗的方法和用途
AU2022349463A1 (en) * 2021-09-24 2024-03-14 Xenon Pharmaceuticals Inc. Pyridinyl derivatives as sodium channel activators

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20060235021A1 (en) * 2002-08-13 2006-10-19 Wesley Blackaby Phenylpyridazine derivatives as ligands for gaba receptors

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Also Published As

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EP2640391B1 (en) 2015-11-11
US20160008357A1 (en) 2016-01-14
CN103313712B (zh) 2016-10-26
EP3034079A1 (en) 2016-06-22
CN103313712A (zh) 2013-09-18
US20130237545A1 (en) 2013-09-12
DK3034079T3 (en) 2018-02-05
MX346185B (es) 2017-03-10
DK2640391T3 (da) 2016-02-15
MX2013005442A (es) 2013-10-03
EP3034079B1 (en) 2018-01-10
AU2011328993A1 (en) 2013-06-06
MX383953B (es) 2025-03-14
EA027840B1 (ru) 2017-09-29
EP2640391A1 (en) 2013-09-25
EA201390712A1 (ru) 2013-11-29
US9145372B2 (en) 2015-09-29
JP5916746B2 (ja) 2016-05-11
CA2818025A1 (en) 2012-05-24
BR112013012062B1 (pt) 2020-06-02
NO3034079T3 (enExample) 2018-06-09
JP2013542267A (ja) 2013-11-21
US9801879B2 (en) 2017-10-31
WO2012068161A1 (en) 2012-05-24
BR112013012062A2 (pt) 2016-08-16
EP2640391A4 (en) 2014-05-07

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